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Meutia Aulia Hakim; I Wayan Pastika; Ni Made Dhanawaty

Jurnal Rumpun Ilmu Bahasa dan Pendidikan 2026 Asosiasi Periset Bahasa Sastra Indonesia

This study aims to describe the lexical variations that emerge based on gender factor within the sociolinguistic context of SMP Bintang Persada Denpasar. This research employs a descriptive qualitative approach using the observational method and note-taking technique by presenting a list of glosses to 20 eight-grade students, consisting of 10 male and 10 female participants. The lexical data were analyzed using the intralingual and extralingual comparison methods. The findings reveal significant lexical differences between the two speaker groups. Female student tend to use more varied, complete, and expressive lexical forms, including full words and phrasal expressions. In contrast, male students show a tendency to use shorter, more efficient lexical forms dominated by abbreviations and rough expressions. These findings highlight that gender functions as a linguistic marker shaping distinct communicative patterns among adolescents, with female students prioritizing social expression and affection, while male students emphasize practicality and efficiency in language use.

Ismi Lailatul Maulida; Ahmad Heru Romadhon

Jurnal Hukum, Administrasi Publik dan Negara 2026 Asosiasi Peneliti Dan Pengajar Ilmu Sosial Indonesia

Contemporary digital advancements have significantly impacted the manner in which individuals engage in economic activities, as evidenced by the rising volume of online transactions. While offering convenience and efficiency, electronic transactions also provide numerous legal challenges, especially regarding seller defaults, including delayed delivery, goods that do not conform to the agreement, or sellers failing to meet their duties post-payment by consumers. This scenario may result in consumer losses, necessitating sufficient legal certainty and protection. This study seeks to analyze the legal regulations pertaining to contracts and defaults in digital platform transactions and to evaluate the types of legal liabilities that may be placed on sellers. This study employs normative legal research, focusing on legislative and conceptual approaches, and utilizes primary, secondary, and tertiary legal materials as data references. The study's findings reveal that seller liability regulations in electronic transactions are defined in the Civil Code, the Consumer Protection Law, and the Law on Electronic Information and Transactions. Nonetheless, its execution has several challenges, especially concerning evidence and the efficacy of law enforcement measures. Consequently, it is imperative to enhance the function of marketplaces and establish more adaptive legislative frameworks to guarantee consumer protection and restitution for losses in online commerce.  

Ramadhani Alfiko Rokhmatan; Rafi Maulana; Muhammad Imam Alghifari; Budiharjo Budiharjo

Mars: Jurnal Teknik Mesin, Industri, Elektro Dan Ilmu Komputer 2026 Asosiasi Riset Teknik Elektro dan Informatika Indonesia

This study aims to improve the quality of gallon water products and strengthen the competitiveness of CV. Anugerah Gemilang through the implementation of Quality Function Deployment (QFD) using the House of Quality (HoQ). The QFD approach is employed to translate the Voice of Customer (VoC) into technical product characteristics as well as service quality attributes that influence customer satisfaction. The research method applied is quantitative-descriptive with the support of qualitative data. Quantitative data were collected through questionnaires distributed to customers to measure the importance and satisfaction levels regarding product and service attributes, while qualitative data were obtained through in-depth interviews to reinforce and validate the questionnaire results. Subsequently, the VoC data were analyzed using the HoQ matrix to determine quality improvement priorities based on customer importance weights. This study is expected to produce strategic recommendations in the form of prioritized product and service quality enhancements focused on customer satisfaction, thereby supporting the sustainable improvement of the company’s competitiveness.

Simon Simarmata; Panser Karo karo

Programming and Algorithm Fundamentals 2026 Asosiasi Pengelola Jurnal Informatika dan Komputer Indonesia

This study compares the scalability and maintainability of three prominent programming paradigms-functional programming (FP), object-oriented programming (OOP), and declarative programming (DP)-in the context of distributed data processing systems. The research aims to evaluate how each paradigm performs under increased data volume and its ability to handle complex operations, while also assessing the ease of maintenance through code readability, modularity, and the flexibility of updating and debugging. The study employs a comparative experimental design, implementing identical data processing tasks, such as data aggregation, filtering, and transformation, across each paradigm. Key findings indicate that FP and DP outperform OOP in terms of scalability, with their stateless nature and high-level abstractions enabling efficient parallel processing and task distribution. FP, with its emphasis on immutability and concurrency, and DP, with its focus on describing desired outcomes rather than implementation specifics, both demonstrate superior performance in handling large datasets. However, while OOP excels in modularity and flexibility, its reliance on mutable state and shared resources hampers its scalability in distributed environments. In terms of maintainability, both FP and DP offer clearer, more maintainable code due to their abstraction levels, making them easier to update and extend. OOP, while modular, presents challenges in managing mutable state, complicating maintenance. This paper concludes with practical recommendations for developers on when to use each paradigm based on system requirements and suggests areas for future research, such as hybrid paradigms and long-term maintainability studies in real-world applications.

Ramadhani Alfiko Rokhmatan; Rafi Maulana; Muhammad Imam Alghifari; Budiharjo Budiharjo

Mars: Jurnal Teknik Mesin, Industri, Elektro Dan Ilmu Komputer 2026 Asosiasi Riset Ilmu Manajemen dan Bisnis Indonesia

This study aims to improve the quality of gallon water products and strengthen the competitiveness of CV. Anugerah Gemilang through the implementation of Quality Function Deployment (QFD) using the House of Quality (HoQ). The QFD approach is employed to translate the Voice of Customer (VoC) into technical product characteristics as well as service quality attributes that influence customer satisfaction. The research method applied is quantitative-descriptive with the support of qualitative data. Quantitative data were collected through questionnaires distributed to customers to measure the importance and satisfaction levels regarding product and service attributes, while qualitative data were obtained through in-depth interviews to reinforce and validate the questionnaire results. Subsequently, the VoC data were analyzed using the HoQ matrix to determine quality improvement priorities based on customer importance weights. This study is expected to produce strategic recommendations in the form of prioritized product and service quality enhancements focused on customer satisfaction, thereby supporting the sustainable improvement of the company’s competitiveness.

Arneta Wahyu Prabawati; Laudya Saraswati; Rizka Khoirunnisa Susanto; Siti Afifah Romadhoni; Zulaika Ratih Widhianti +1 more

Jurnal Pengabdian dan Keberlanjutan Masyarakat 2026 Lembaga Pengembangan Kinerja Dosen

Student organizations in schools play an important role as social institutions that support character building and the development of students’ social and leadership skills. However, in practice, many students still perceive school organizations merely as formal or administrative activities, resulting in low participation and limited understanding of their educational value. This condition highlights the need for socialization activities that emphasize meaningful organizational learning. This community service activity aims to strengthen students’ understanding of the role of school organizations as social learning spaces. A descriptive qualitative approach was employed involving 30 eleventh-grade students at SMK Muhammadiyah 04 Boyolali. Data were collected through observation, discussion notes, and students’ responses during interactive sessions.The activity was conducted through teacher coordination, material preparation, material presentation, and discussion and question-and-answer sessions. The results indicate an improvement in students’ understanding of the functions and benefits of student organizations as social institutions. Students showed increased awareness of the importance of cooperation, discipline, responsibility, and communication, as well as greater motivation to actively participate in school organizations. These findings suggest that participatory and dialogical socialization is effective in promoting meaningful organizational learning and supporting students’ character development.

Chadija Chadija; Kasim, Amrah; Achruh, Andi; Syamsuddin Syamsuddin

International Journal of Educational Evaluation and Policy Analysis 2026 Asosiasi Riset Ilmu Pendidikan Indonesia

This study investigates how character education is embedded into the school culture of an Indonesian Islamic junior high school (madrasah), focusing on four core values: religiosity, honesty, tolerance, and discipline. Using a qualitative naturalistic approach, the research was conducted at MTsN 3 Halmahera Utara through in-depth interviews, participant observation, and document analysis involving school leaders, teachers, and students. The findings reveal that character education at the madrasah is not a standalone program but is institutionalized through consistent routines, religious practices, and role modeling. Religiosity is fostered through structured worship, integration of Islamic values into lessons, and spiritual habits. Honesty is promoted via trust-based learning environments, teacher exemplarity, and reinforcement of moral norms. Tolerance is cultivated through inclusive social interactions and respect for religious and cultural differences, while discipline is internalized through habitual rule-following, punctuality, and self-regulation. These findings align with existing theories and regional character education frameworks, confirming that character is best formed through embedded cultural processes and consistent adult exemplarity. The study contributes to the understanding of how Islamic schools can function as moral communities and highlights the importance of alignment between school culture, family support, and wider social contexts in achieving sustainable moral development.

Aurelia Putri Valencia Gawendaleng; Diana Shintawati Purwanto; Murniati Tiho

Jurnal Riset Rumpun Ilmu Kesehatan 2026 Pusat riset dan Inovasi Nasional

Diabetes mellitus (DM) is a global health problem characterized by increased blood glucose levels. Type 2 diabetes mellitus (T2DM) accounts for 90-95% of all diabetes cases and is characterized by insulin resistance. Persistent hyperglycemia in patients with T2DM increases the risk of various complications, including renal dysfunction. Therefore, monitoring HbA1c levels is important for assessing long-term glycemic control and preventing complications, one of which is impaired kidney function that can be detected through increased blood creatinine levels. To analyze the relationship between HbA1c levels and blood creatinine levels in type 2 diabetes mellitus patients at RSUD ODSK North Sulawesi Province. This study used an observational analytic design with a cross-sectional approach. This study was retrospective using secondary data in the form of medical record data for the period February 2024-August 2025. This study used a total sampling method with 71 patients who met the inclusion criteria. The findings showed that the majority of patients had HbA1c levels >6,5%, while most blood creatinine levels were within the normal range. Based on the results of the Spearman-Rank correlation test, a significance value of 0.040 (p-value <0.05) was obtained. There is a significant relationship between HbA1c levels and blood creatinine levels, with a negative correlation strength in patients with type 2 diabetes mellitus at RSUD ODSK North Sulawesi Province.

Juni Sarah Devi Sinambela; Murniati Tiho; Diana Shintawati Purwanto

Jurnal Riset Rumpun Ilmu Kesehatan 2026 Pusat riset dan Inovasi Nasional

Chronic kidney disease (CKD) is a global health problem with continuously increasing prevalence and mortality. This condition is characterized by a progressive and irreversible decline in kidney function, which is clinically assessed using the estimated glomerular filtration rate (eGFR) as one of the main parameters for staging and monitoring disease progression. Red blood cell distribution width (RDW) is a hematological parameter that reflects the degree of variation in erythrocyte size. In patients with CKD, elevated RDW levels are often associated with oxidative stress and chronic inflammation, which may accelerate kidney damage and increase mortality risk. To analyze the correlation between RDW and eGFR values in patients with chronic kidney disease at ODSK Hospital, North Sulawesi Province. This study used an analytical observational design with a cross‑sectional approach. It was conducted retrospectively using secondary data from the medical records of CKD patients at ODSK Hospital, North Sulawesi Province, from February 2024 to August 2025. This study used a total sampling method with 189 CKD patients who met the inclusion and exclusion criteria.  Based on Spearman-rank correlation analysis, the p‑value obtained was 0.129 (>0.05). There was no significant relationship between RDW and eGFR values in CKD patients at ODSK Hospital, North Sulawesi.Province.

Keshia Monika Prianto; Tomy Michael

Jurnal Riset Ilmu Hukum, Sosial dan Politik 2026 Asosiasi Peneliti dan Pengajar Ilmu Hukum Indonesia

This study examines the criteria of disgraceful conduct in the dismissal mechanism of regional heads in Indonesia following Constitutional Court Decision No. 2/PUU-XX/2022. The decision underscores the necessity of a constitutional interpretation of the requirement “never having committed disgraceful conduct” in order to prevent abuse of power and political injustice in regional governance. Employing a normative legal research method, this study analyzes primary legal materials, including Constitutional Court decisions and statutory regulations, as well as secondary legal literature. The findings reveal that the notion of disgraceful conduct had previously functioned as a vague norm, enabling subjective and politically motivated interpretations, particularly by regional legislative bodies. The Constitutional Court, through its decision, transformed this open norm into a more limitative and objective standard by specifying concrete forms of conduct, such as gambling, intoxication, drug abuse, adultery, and other serious violations of decency. Furthermore, the Court emphasized that allegations of disgraceful conduct must be supported by clear, lawful, and verifiable evidence, in line with the principles of due process of law. This reformulation strengthens legal certainty, protects the political rights of elected regional heads, and preserves the stability of local governance. The study recommends legislative synchronization through amendments to the Regional Government Law and the issuance of judicial guidelines to ensure uniform standards of proof in dismissal proceedings, thereby reinforcing constitutional justice and the rule of law in Indonesia.

Reni Ria Armayani Hasibuan; Deni Darmawansyah; Juwita Nur Pramita; Muhammad Zeki Abdillah

Pajak dan Manajemen Keuangan 2026 Asosiasi Riset Ekonomi dan Akuntansi Indonesia

The Financial Services Authority (OJK) is responsible for overseeing Indonesia's capital market, and this paper outlines its functions and powers. In order to promote financial system stability, safeguard the public interest, and boost the financial services industry's competitiveness, the OJK was founded to develop an integrated regulatory and supervisory structure. The OJK's responsibilities encompass policy formulation, business license issuance, oversight, inspection, law enforcement, and administrative penalties for infractions. Even though Indonesia's capital market has grown quickly, it still faces substantial obstacles like illicit investment and large losses from scandals and market manipulation, which emphasize the need for robust and independent oversight.

Theresia Chintia Herawati; Syeira Khaerani; Siti Sheila Mozza Fatihah W; Mutiara Astri Pradina; Dicky Pratama

Saturnus: Jurnal Teknologi dan Sistem Informasi 2026 Asosiasi Riset Teknik Elektro dan Informatika Indonesia

The use of Information Systems and Information Technology (IS/IT) is a crucial factor in improving the efficiency and accuracy of retail sector operations. PT XYZ, a retail-level staple goods provider, has implemented IS/IT to support sales recording, inventory management, security, and operational reporting. This study aims to assess the effectiveness, efficiency, security, and compliance of the information system used. The audit was conducted through observation, interviews, document review, and system testing, referring to the COBIT framework and the ISO/IEC 27001 standard. The audit results indicated that the system supported core operational functions, but weaknesses remained, including insufficient system documentation, limited access controls, and suboptimal data security and backup mechanisms. Furthermore, reliance on manual procedures has the potential to lead to errors and slow down service delivery. Therefore, system improvements, strengthening security controls, developing standard operating procedures, and enhancing the competency of human resources and IT infrastructure are needed. This audit is expected to support improved service quality and secure, effective, and sustainable IT governance at PT XYZ.

Gunawan Prayitno; Ronaldo Aprili

Integrated System and Management Technology 2026 Asosiasi Pengelola Jurnal Informatika dan Komputer Indonesia

This study investigates the role of Information Technology (IT) governance in enhancing risk management performance and ensuring regulatory compliance within multinational digital enterprises. As digital transformation continues to reshape the global business landscape, organizations face increasing challenges in managing technological risks and complying with complex regulatory requirements across various jurisdictions. The study adopts a quantitative approach, using a survey methodology to collect data from senior IT and compliance managers in multinational digital enterprises. The survey focuses on how IT governance frameworks, such as COBIT 2019 and ISO 27000, are utilized to align IT strategies with business objectives, mitigate risks, and maintain regulatory compliance. The findings indicate that organizations with well-established IT governance structures are better positioned to proactively identify and mitigate risks, ensuring greater consistency in meeting regulatory requirements. These organizations demonstrate improved risk management effectiveness, especially concerning cybersecurity, data privacy, and compliance with global regulations like GDPR. In contrast, organizations with ad hoc or decentralized governance structures struggle with fragmented risk management and compliance efforts. The study further highlights the importance of integrating IT governance frameworks with internal audit functions, specifically the Chief Audit Executive (CAE), to enhance cybersecurity resilience and ensure compliance with global standards. This research contributes to the literature by providing empirical evidence on the integration of IT governance, risk management, and regulatory compliance in multinational enterprises. It also highlights the need for a structured and systematic approach to IT governance to improve organizational performance in managing risks and ensuring consistent regulatory adherence. The study offers practical insights for organizations looking to optimize their IT governance structures in the face of rapid digital transformation.

Ahmad Budi Trisnawan; Muhammad Sholikhan; Iwan Koerniawan

Information System Analysis, Design and Development 2026 Asosiasi Pengelola Jurnal Informatika dan Komputer Indonesia

This study investigates the role of Enterprise Information Systems (EIS) in driving innovation within organizations. The research employs a mixed-method approach, combining survey-based structural analysis and in-depth organizational case studies to explore how different EIS capabilities influence organizational innovation. The study focuses on four key EIS capabilities: functional capabilities such as workforce management and customer value creation; technological capabilities including ERP systems and real-time analytics; dynamic capabilities, especially organizational learning; and collaborative innovation through external partnerships. The survey results reveal that EIS capabilities, particularly data analytics and integration, significantly enhance organizational agility, decision-making, and innovation outcomes. In-depth case studies provide detailed insights into how these capabilities are applied in real-world organizational settings, illustrating their impact on process and service innovation. The findings indicate that the effective integration of EIS across organizational functions, along with improved access to data, contributes to operational efficiency and innovation success. However, challenges such as integration issues, resistance to change, and lack of skilled personnel were also identified as barriers to successful EIS adoption. The study contributes to the literature by offering a comprehensive understanding of how EIS capabilities drive innovation and highlighting the importance of organizational culture and leadership in the adoption process. The research provides practical recommendations for organizations to leverage EIS for fostering innovation, such as focusing on EIS integration, overcoming organizational barriers, and ensuring leadership engagement. Finally, the study suggests future research directions, including the refinement of multi-method approaches and the need for longitudinal studies to better understand the long-term impact of EIS on innovation outcomes.

Amelia Fitri Indarti; Hanifa Putri Wardhani; Jovanka Jovanka; Siska Amalia; Erik Saut Hatoguan Hutahaean

Jurnal Pengabdian dan Keberlanjutan Masyarakat 2026 Lembaga Pengembangan Kinerja Dosen

Individuals with mental disabilities commonly experience difficulties in self-awareness and emotion regulation, which negatively affect social functioning and psychosocial well-being. These conditions were also observed among beneficiaries in the assisted community, who demonstrated limitations in recognizing emotions, expressing feelings, and engaging in social interactions. This community service program aimed to strengthen self-awareness and emotional regulation skills among individuals with mental disabilities through a psychosocial approach. The program employed activity-based psychoeducation using participatory and supportive methods, including emotional recognition training, self-reflection, positive emotional stimulation, and structured group support. The results indicated improvements in beneficiaries’ ability to identify and express basic emotions, increased self-confidence, enhanced emotional stability, and more active social participation. Qualitative observations revealed behavioral changes from passive tendencies to more responsive and cooperative involvement in group activities. These findings suggest that activity-based psychosocial interventions are effective in improving psychosocial well-being among individuals with mental disabilities.

Aliya Magfirra Abd Rahman; Nelly Daniarti; Maulindari; Wahyuni Sesda Putri; Intan Mutiara Putri

Inovasi Kesehatan Global 2026 Lembaga Pengembangan Kinerja Dosen

Postoperative pain is a common physiological response following surgical procedures, and its suboptimal management can have physiological and psychological effects, including sleep disturbances, decreased functional capacity, increased anxiety, and deterioration in quality of life. This scoping review aims to describe the empirical evidence regarding the effectiveness of music therapy in reducing the intensity of postoperative pain in surgical patients. A systematic search was conducted through four major databases (ScienceDirect, PubMed, Neliti, and Google Scholar) using Boolean operators and keywords such as ‘postoperative pain,’ ‘music therapy,’ and ‘pain scale.’ Inclusion criteria included articles published in the last decade, in English or Indonesian, and available in full text format. In accordance with PRISMA-ScR guidelines, this review analysed 10 articles. The synthesis of results showed that music therapy consistently reduced pain intensity, anxiety, and analgesic requirements through mechanisms such as increased endorphin secretion, decreased stress hormone levels, and activation of the gate control theory. Typically administered for 15–30 minutes, music therapy is a safe, cost-effective, and patient-acceptable non-pharmacological modality. This intervention is recommended as an adjunct component in perioperative pain management in nursing practice, although further standardised research is needed to improve consistency.

Olivia Charissa; Santoso, Alexander Halim; Wijaya, Bryan Anna

Jurnal Riset Rumpun Ilmu Kedokteran 2026 Pusat riset dan Inovasi Nasional

The increasing prevalence of metabolic syndrome and chronic kidney disease underscores the need for simple, low-cost, and community-applicable screening indicators. This study aimed to evaluate the association between basic anthropometric parameters and blood pressure, metabolic indicators, and renal function among adults in the Badui Luar community. A cross-sectional design was employed involving 41 participants who underwent anthropometric assessment, biochemical measurements, and blood pressure evaluation. Pearson correlation analysis was used to examine linear associations between variables. The results demonstrated that neck circumference exhibited significant correlations with dyslipidemia components, including LDL (r = 0.377), TC/HDL ratio (r = 0.516), and HDL (r = –0.433), indicating cervical adiposity as a strong marker of atherogenic risk. Calf circumference showed protective correlations with fasting glucose (r = –0.352) and eGFR (r = 0.322), suggesting the metabolic relevance of peripheral muscle mass in glycemic regulation and renal status. Body mass index showed a weak correlation with systolic blood pressure (r = 0.149), whereas waist and hip circumferences exhibited mild, clinically insignificant correlations with triglycerides and total cholesterol. Overall, these findings highlight that simple anthropometric measures—particularly neck and calf circumference—may serve as early indicators of cardiometabolic and renal risk in community-based screening. Further longitudinal studies with larger and more heterogeneous populations are required to validate these associations and determine the predictive power of anthropometric indicators.

Arnila Melina; Octariany, Octariany; Dewi Murni Manihuruk; Fahmi Nofriandi

Jurnal Riset Rumpun Ilmu Kedokteran 2026 Pusat riset dan Inovasi Nasional

Pulmonary tuberculosis (TB) remains a major public health problem in Indonesia. Despite the implementation of national TB control programs through the Directly Observed Treatment Shortcourse (DOTS) strategy, treatment success continues to face significant challenges, particularly related to patient adherence to anti-tuberculosis drug (ATD) therapy. Non-adherence to TB treatment can lead to treatment failure, disease relapse, and the development of drug-resistant tuberculosis, thereby increasing the overall burden of the disease.Treatment adherence in TB patients is influenced not only by medical factors but also by social and behavioral determinants. Family support plays a crucial role in encouraging patients to comply with treatment regimens by providing motivation, reminding medication schedules, and offering emotional support throughout the long duration of therapy. Patients who receive adequate family support tend to demonstrate higher levels of treatment adherence compared to those with limited support.In addition, the use of herbal medicine as a preventive and supportive health measure is common among the Indonesian population. Herbal medicine is often utilized to enhance immune function, reduce medication side effects, and improve patient comfort during TB treatment. However, the use of herbal remedies without proper medical guidance may lead to misconceptions regarding standard TB therapy.Therefore, it is important to examine the relationship between family support and the use of herbal medicine as preventive measures with treatment adherence among pulmonary TB patients in primary healthcare settings. Such evidence is expected to support a comprehensive family medicine approach and strengthen TB control programs in primary care services.

Ayu Zahrani; Tishya Fadiliafasha; Alif Rachman Chresandiputra; Najwa Chindykia Yuliasta; Moch Althof Naufal Ardhi +1 more

Jurnal Riset Rumpun Ilmu Kedokteran 2026 Pusat riset dan Inovasi Nasional

Benign Paroxysmal Positional Vertigo (BPPV) is the most common cause of peripheral vertigo, characterized by brief episodes of vertigo due to otoconia displacement. Although most previous studies have focused on intrinsic factors such as age, gender, osteoporosis, and metabolic disorders, evidence regarding the role of environmental factors, particularly occupational noise exposure, is limited. Chronic noise has the potential to affect vestibular function through both sensory and vascular mechanisms. This study aims to narratively review the effect of occupational noise exposure on the risk of BPPV by integrating clinical, epidemiological, and experimental findings. The method used is a literature-based narrative review of the PubMed, Scopus, Web of Science, and Google Scholar databases without year restrictions, using the keywords "BPPV", "occupational noise exposure", "vestibular dysfunction", "VEMP", and "otoconia displacement". The search results obtained 25 relevant articles linking BPPV to otolith, hormonal, vascular, lifestyle factors, and occupational noise exposure. The results indicate that chronic noise can cause sensory damage (otoconia and vestibular hair cells), vascular disorders (hypertension, cardiovascular disorders, and inner ear microvascular circulation disorders), and exacerbate lifestyle comorbidities (sedentary lifestyle, osteoporosis, hypertension, diabetes). The discussion confirms that these multifactorial mechanisms explain the susceptibility of industrial workers to BPPV despite normal hearing function. The conclusion of this study is that workplace noise exposure has been shown to play a significant role as a risk factor for BPPV, therefore, prevention strategies, vestibular health monitoring, and healthy lifestyle interventions need to be optimized in occupational health programs.

Rasool, Aqeel M.; Alaa Hussein J. Al-Qaisi

Jurnal Riset Ilmu Farmasi dan Kesehatan 2026 Asosiasi Riset Ilmu Kesehatan Indonesia

This study investigates the levels of asprosin and irisin in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN), and evaluates their relationships with insulin resistance, glycemic control, and renal function. Additionally, it explores their diagnostic performance as potential non-invasive biomarkers for the early detection of DN using ROC curve analysis. A controlled prospective study was conducted involving 130 participants, categorized into healthy controls, T2DM patients, and T2DM with DN. Serum asprosin, irisin, and insulin levels were measured using ELISA, while biochemical and renal parameters such as fasting blood glucose, HbA1c, creatinine, urea, and eGFR were assessed using standard spectrophotometric techniques. ROC analysis was employed to assess the diagnostic accuracy of asprosin and irisin. Asprosin levels were significantly elevated, while irisin levels were markedly reduced in DN patients compared to T2DM and control groups (p < 0.001). Moreover, DN patients exhibited higher levels of fasting glucose, HbA1c, HOMA-IR, creatinine, and urea, with lower eGFR, indicating substantial renal dysfunction. ROC analysis revealed that asprosin had an AUC of 0.910 (95% CI: 0.839–0.981), with 90.0% sensitivity and 88.9% specificity at a cutoff value of 11.27 ng/mL. Irisin showed an AUC of 0.886 (95% CI: 0.812–0.960), with 95.0% sensitivity and 71.1% specificity at a 158.25 ng/mL cutoff. Asprosin and irisin are strongly associated with insulin resistance and renal impairment in patients with T2DM and DN. Their high diagnostic performance supports their utility as promising non-invasive biomarkers for the early detection and monitoring of diabetic nephropathy progression.