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Nephrons are the smallest functional units in the kidneys that are responsible for filtering blood, regulating fluid balance, and excreting waste through urine. When nephrons are damaged or diseased, kidney function can be significantly impaired. Nephron damage is usually caused by various factors, such as hypertension, diabetes, kidney infections, or certain drug toxicity. In the early stages, nephron damage can cause a decrease in glomerular filtration rate (GFR). As a result, metabolic waste products such as urea and creatinine accumulate in the blood, known as azotemia. Over time, progressive damage to the nephrons can trigger chronic kidney disease (CKD). In more severe cases, when most of the nephrons are no longer functioning, the kidneys lose their ability to maintain the body's homeostasis. This results in electrolyte imbalance, metabolic acidosis, and excess fluid buildup, known as end-stage renal disease (ESRD). At this stage, patients require renal replacement therapy such as dialysis or kidney transplantation to survive. Prevention of nephron damage is very important, including through the management of comorbidities such as diabetes and hypertension, adequate fluid intake, and avoiding exposure to toxic substances that damage the kidneys. Thus, the risk of kidney failure can be minimized.

Background: Teenage pregnancy remains a significant public health concern due to its potential risks to both mother and child, including health complications, social challenges, and educational disruption. One of the factors influencing teenage pregnancy is parental patterns, which include parenting styles, communication, supervision, and emotional support. Studies have shown that adolescents from families with authoritarian or neglectful parenting are more likely to engage in risky sexual behavior, increasing the risk of early pregnancy. Understanding the relationship between parental patterns and teenage pregnancy can help develop targeted interventions to prevent adolescent pregnancies. Objective: This study aimed to examine the relationship between parental patterns and the incidence of teenage pregnancy. Methods: A quantitative analytical study with a cross-sectional design was conducted. The sample consisted of 30 teenage mothers selected using a total sampling technique. Data were collected through structured questionnaires assessing parental patterns, including communication, supervision, and emotional support, as well as information about pregnancy incidence. Data analysis was performed using the Wilcoxon signed-rank test to determine the statistical relationship between parental patterns and teenage pregnancy incidence. Results: The study found that 30 respondents (100%) reported experiencing parental patterns that influenced their behavior. Among them, teenagers from families with supportive and communicative parenting had a lower risk of teenage pregnancy. The Wilcoxon signed-rank test showed a significant relationship between parental patterns and the incidence of teenage pregnancy (p = 0.000), indicating that parental guidance and involvement play a critical role in preventing early pregnancy. Conclusion: There is a significant relationship between parental patterns and the incidence of teenage pregnancy. Supportive and communicative parental patterns reduce the likelihood of teenage pregnancy, while neglectful or authoritarian patterns increase the risk. These findings highlight the importance of parental involvement, education, and guidance in adolescent reproductive health.

Breast cancer and its consequences have become a public health problem globally due to the impact of health disorders caused and the most severe impact is leading to death. Changes in diet and eating culture (fast food and lack of intake of vegetables and fruits) are one of the lifestyle changes that occur in adolescents today. Teenagers are more likely to consume foods that follow trends without looking at the nutritional status or content contained in the food. Fast food (junk food) contains a lot of dyes, preservatives, artificial flavors and how to process them by frying at high temperatures or burning. The habit of not eating less fatty foods (fruits and vegetables) and the habit of consuming red and processed meat also triggers the occurrence of tumors. One of the prevention of breast cancer is by conducting early detection of breast cancer which can be done with breast self-examination (SADARI). The purpose of this community service activity is to increase adolescents' knowledge about breast cancer and detect the early occurrence of breast cancer through breast self-examination (SADARI), This service activity involves adolescent girls in grade VIII aged 13-15 years At SMP Negeri 1 Unter Iwes, the implementation has been carried out on August 19, 2024. Service is carried out starting from preparation to evaluation. The method used in service is the method of socialization and application (application) directly in the field. The results of the evaluation showed that there was an increase in the knowledge and skills of grade VIII students after being given health education. Judging from the results of the post test, which is higher than the average pre test. 

Basic immunization is one of the prevention programs for communicable diseases to children. Immunization coverage rates in regions have not yet reached the target. This is caused by many factors. This study aimedto analyze factorsthatinfluencingto maternal behavior in fulfilling basic immunization for children aged 0-12 months in the Work Areaof the Sumobito Health Center in Jombang.The factors analyzed are not only internal factors of the individual, but also external factors, both family environment and the availability ofservices, whichare also determinants ofbehavior.This research was observational analytic with cross sectional approach. Data analysis used logistic regressiontest. The results of this study indicated that factorsinfluencedmaternal behavior in fulfilling childbasic immunization wereattitude (p = 0,000), trust (p = 0,002), family support (p = 0.006), access (p = 0,000), and information (p=0,000), while age (0,718) and work status (0,844) did not influence to maternal behavior in fulfilling child basic immunizationThis is because, during the COVID-19 pandemic, mothers worked at home so they had time to deliver their children to immunization

The implementation of Universal Precaution in hospitals is crucial to prevent the transmission of infectious diseases through blood and body fluids between patients and healthcare workers. This study aimed to evaluate the effectiveness of health promotion using leaflets in improving nurses' knowledge and skills regarding Universal Precaution for HIV/AIDS at Tere Margareth General Hospital Medan. The study employed a quasi-experimental design with a *Pre-Test and Post-Test with Non-Equivalent Control-Group Design* approach. The study population consisted of 36 nurses, all of whom were included as the sample using a saturated sampling technique. Data were analyzed using univariate, bivariate, and multivariate methods with a paired *t-test* at a 95% confidence level (P<0.05). The results showed that health promotion through leaflets significantly improved knowledge (sig. 0.004) and skills (sig. 0.000) of nurses regarding Universal Precaution for HIV/AIDS. It is recommended that nurses continue to enhance the implementation of Universal Precaution in hospital settings to optimize infection prevention. Education through leaflets can be an effective method to improve the understanding and skills of healthcare professionals. 

This study aims to address the challenges and propose solutions for the Optimization of Blockchain-Based Cybersecurity Systems to Enhance Resilience Against Ransomware Attacks using a Systematic Literature Review (SLR) approach. Blockchain is increasingly recognized as a transformative technology in cybersecurity due to its decentralized structure, transparency, and robustness in securing data. Despite these advantages, its widespread adoption is hindered by several challenges, including scalability, interoperability, high energy consumption, and limited access to representative ransomware datasets. This research highlights that integrating blockchain with advanced technologies such as data analytics, machine learning, and Explainable AI (XAI) can significantly enhance its effectiveness in combating ransomware.The findings reveal that Graph Convolutional Neural Networks (GCN) enable real-time detection of ransomware patterns in network traffic with an accuracy of up to 95%. Furthermore, Layer-2 solutions like the Lightning Network and sharding effectively alleviate the load on main blockchains, thereby increasing transaction throughput. Efficient consensus mechanisms, including Proof of Stake (PoS) and Delegated Proof of Stake (DPoS), address energy consumption issues, making blockchain more adaptable to IoT and resource-constrained environments. These approaches have proven successful in enabling early detection, mitigation, and prevention of ransomware in IoT systems, cloud infrastructures, and smart grid networks. The implications of this study underscore the potential of blockchain as a critical component of proactive and adaptive cybersecurity systems. However, overcoming existing challenges requires further development of hybrid frameworks that integrate blockchain with data analytics and machine learning technologies. In addition, efforts should focus on standardizing global security protocols to enhance interoperability and creating robust, diverse ransomware datasets to support more accurate detection systems. Future research should also explore methods to minimize latency and improve blockchain efficiency in real-time cybersecurity applications.

TB is a serious infection caused by the Mycobacterium tuberculosis. Even now, tuberculosis paru remains one of the world's most pressing health issues. Even though many nations have taken steps to combat this illness, if it is not treated, it could lead to kematian. The goal of health promotion is to increase awareness of how to prevent tuberculosis in children. In order to conduct a thorough investigation, this community's pengabdian uses a quantitative approach and a kuesioner's lembar to understand the experiences of TB patients and other members of the community. Following the dissemination of health education about TB Paru to the general public at Puskesmas Negeri Lima, the general public's knowledge increased by 70–80%. This score is higher than the pre-test score of roughly 62%. This health education is provided in a gentle manner via ceramah, discussion, and tanya jawab. The results of the test indicate that the general public's knowledge has increased.

Diabetes mellitus (DM) can cause serious complications, including impaired peripheral tissue perfusion that risks diabetic ulcers and amputation. The Self-Directed Learning (SDL) approach is an effective self-education strategy in improving the understanding and skills of DM patients in preventing these complications. This community service program aims to improve the understanding and skills of lower extremity care in DM patients through education and hands-on training. Activities include counseling, foot self-examination, and proper foot care practices. Evaluation results showed significant improvement in participants' understanding of diabetic ulcer prevention, awareness in maintaining blood sugar levels, and selection of appropriate footwear. In addition, skills in foot self-examination, proper nail trimming, and moisturizer application also improved. The SDL approach proved effective in increasing participants' engagement in the learning process, so they were more motivated to apply the knowledge gained in their daily lives. This program indicates that SDL-based education can be an effective strategy in improving the foot health of people with DM and preventing serious complications.

Adolescence is an important period for reproductive health because it is a period of behavioral formation, where at this time, teenagers begin to try new or challenging things, including in health behavior, one of which is free sex behavior. This free lifestyle behavior is greatly influenced by a correct understanding of adolescent reproductive health. The impact that can occur due to free sex behavior is early pregnancy or Unwanted Pregnancy. Adolescent pregnancy is one of the health problems that requires serious attention so that efforts are needed to increase awareness of reproductive health for all teenagers. The purpose of this community service is to increase the knowledge of teenagers at MAN Seram Bagian Barat about reproductive health and increase adolescent awareness in preventing early pregnancy. The method used is to provide education to teenagers at Madrasah Aliyah Negeri Seram Bagian Barat. Teenagers are very enthusiastic about this activity by asking various questions and the active discussion makes teenagers more enthusiastic. The final result is that 26 teenagers have good knowledge after being given education, from previously only 11 teenagers. The conclusion is that teenagers understand how to prevent early pregnancy in teenagers at MAN Seram Bagian Barat. It is hoped that good knowledge will prevent teenagers from engaging in free sex behavior that can result in pregnancy at a young age.

Indonesia needs get rid of terrorism For forever . Journal This aiming For describe and analyze with use approach various effort countermeasures crime terrorism in Indonesia. Methods research used​ in study This use approach qualitative descriptive For serve description about terrorism and some strategy For to fight crime This is in Indonesia. Formulation problem based on description background back on top is as following : what just factor crime terrorism in Indonesia and how method overcome crime terrorism in Indonesia. Terrorism is disturbing phenomenon . Efforts​ countermeasures crime terrorism committed​ Government implemented through effort repressive . There are five factors that cause crime terrorism in Indonesia, namely : ethnicity , nationalism / separatism , poverty and inequality and globalization , non-democracy , violations dignity humans and religious radicalism .

This research is a descriptive qualitative research, data collection techniques using interviews, observations, and documentation. The purpose of the study is to describe the role of the Manpower Office in the prevention of Manpower and to find out what obstacles are experienced by the Manpower Office in the context of preventing Illegal Labor in Sampang Regency. The research informant is the Head of the Office, Head of Placement and Expansion of TKI of the Sampang Regency Manpower and Transmigration Office. Data analysis uses an interactive model. The results of the study show that the Sampang Regency Government Manpower Office has a role as a regulator carried out through the provision of socialization and counseling to the community, providing supervision for normative issues to be handled. The role as a mediator is carried out by collecting data on prospective migrant workers who register themselves. The role as a facilitator is to respond to incoming reports and will later be handled according to existing procedures and regulations. The obstacles of the Manpower and Transmigration Office in the context of preventing Illegal Labor in Sampang Regency consist of Internal Obstacles related to the instability of this system as evidenced by the dual functions of BNP2TKI. Weak coordination between government agencies in charge of managing migrant workers. Weak supervision of PJTKI whose operational permits have expired. External obstacles include background, educational factors, knowledge/experience, condition of prospective kindergartens, low quality of human resources from prospective migrant workers

Fraud in the government sector is a serious issue that can threaten the stability and efficiency of governance. This study aims to analyze the role of internal government auditors in mitigating fraud risk. The method used is a literature review with a qualitative descriptive approach, examining 10 relevant journals. The results indicate that internal auditors play a crucial role in detecting and preventing fraud by thoroughly examining internal control weaknesses and utilizing modern technology such as Whistleblowing Systems. The effectiveness of internal audits is supported by strong leadership and high awareness of fraud risks, as well as appropriate structural reform policies. The study concludes that effective internal auditing is essential in enhancing transparency and accountability and recommends the need for comparative analysis across regions to evaluate the diversity of internal audit practices. Additionally, further research is needed to explore the impact of information technology and Whistleblowing Systems in fraud prevention, as well as the role of leadership and organizational culture in supporting the internal audit function.

Chronic diseases are degenerative conditions that significantly impact an individual's quality of life. Various degenerative diseases, such as diabetes mellitus, hypertension, and heart stroke, require immediate attention. Indonesia faces a dual burden in healthcare, grappling with both rampant infectious diseases and the rising prevalence of chronic degenerative illnesses. Therefore, health promotion efforts are crucial in preventing degenerative diseases among adolescents. This initiative targets teenagers due to their unhealthy lifestyle choices, which are evident in their smoking habits, poor dietary practices, insufficient consumption of fruits and vegetables, and a lack of physical activity. The primary objective of this initiative is to enhance awareness regarding the prevention of degenerative diseases among youth and to address the emergence of such conditions in this age group. The results of the community service activities indicate a notable increase in average knowledge from 6.61 to 13.80 and an improvement in attitudes from 9.61 to 14.47. The community service activities were successfully executed, as evidenced by the smooth conduct of the events and the active participation of the adolescents. To improve health quality, it is essential to foster awareness and enhance education among teenagers about the prevention of degenerative diseases.

Familicide or murder of a nuclear family member. Urbanization in Japan has exacerbated the risk of familicide by changing patterns of social interaction and increasing life stress. Unfortunately, Japan's criminal policy still has weaknesses in detecting and preventing familicide. This study aims to explore the phenomenon of familicide in urban Japanese society through a critical analysis of existing criminal policies. This study uses a qualitative research method with a conceptual approach. The data collection method was collected using library research, then analyzed using qualitative methods and presented descriptively. The results of the study show that although the crime rate in Japan is relatively low, familicide remains a crucial issue that reveals fundamental weaknesses in the country's criminal policy. The legal approach that emphasizes post-incident responses, without being supported by adequate early prevention mechanisms, indicates an urgent need to reform the policy. Reforms must include proactive efforts to detect potential risks and implement coordinated interventions to prevent violence.

Chronic Energy Deficiency (CED) in pregnant women can cause children born with cognitive decline, risk of stunting, and risk of chronic diseases in adults. The problem of pregnant women in CED is caused by low nutritional intake. Pregnant women with anemia are at 4.13 times greater risk of giving birth to children with short birth length compared to mothers who are not anemic. CED in pregnant women can cause risks and complications including anemia, bleeding, maternal weight does not increase normally and contracting infectious diseases. CED in pregnant women can affect the growth process of the fetus and can cause miscarriage, abortion, stillbirth, neonatal death, congenital defects, anemia in infants, intrapartum asphyxia, and low birth weight (LBW). Based on a survey conducted at the Cendana Putih Health Center, 45 pregnant women experienced CED (12.4%) in 2023. The problems that occur can be overcome by holding a collaborative program that can improve the health of pregnant women. This program can be used to address problems appropriately, namely by empowering pregnant women and cadres through GerCep CED. The design used in this program is community service activities carried out in the form of education in the form of providing pocket books and conducting direct counseling during the schedule of pregnant women's classes and assistance in making PMT from local food ingredients. The conclusion of this activity is that participants who initially had a low level of knowledge of KEK in pregnant women became more knowledgeable about KEK in pregnant women.

Triglycerides are a type of fat found in the blood and serve as a source of energy. When levels rise beyond normal limits, triglycerides can become a risk factor for various health disorders. Hypertriglyceridemia requires prevention and early detection as essential steps in reducing the risk of metabolic disorders. This community service program utilized the Plan-Do-Check-Act (PDCA) approach to educate adults in the Krendang area on the importance of triglyceride screening and adopting a healthy lifestyle. The health education and routine screenings provided successfully increased public awareness of the risks associated with high triglyceride levels and encouraged healthier lifestyle changes. Program results showed that the community became more proactive in monitoring triglyceride levels and adopting healthy behaviors such as balanced diets and regular physical activity. Triglyceride screening and health education play a vital role in preventing metabolic disorders caused by hypertriglyceridemia, supporting preventive efforts to improve public health

The number of infectious diseases is still very high in Indonesia. The World Health Organization (WHO) estimates that around 2 billion people worldwide suffer from parasitic worms, which are most common in tropical and subtropical areas and areas with poor sanitation. The number of schoolchildren infected with worms in Europe is estimated at more than 4 million, with the highest prevalence in Central and South Asian countries. In general, the prevalence of worms in Indonesia is still high, ranging between 2.5% and 62%. This high prevalence is due to the fact that Indonesia is a country with a tropical and humid climate. The aim of this activity is to increase parents' knowledge regarding preventing worms in children. Socialization methods in the form of lectures and questions and answers are used in this activity using leaflets as media. Activity Results: Respondents were very enthusiastic about the material presented and there were several respondents who asked questions. The conclusion of this educational activity was successfully carried out to increase parents' knowledge and awareness regarding preventing worms in children.

The “Adu Sitomas” counseling held at MA Darussalam Jombang aims to improve students' knowledge, attitudes, and behavioral practices related to stunting. Stunting is a serious health problem that affects the physical growth and cognitive development of children. Through this program, students are provided with relevant information on the causes, impacts, and ways to prevent stunting. The results showed a significant increase in students' understanding, with the level of knowledge increasing from 60% to 90% after the counseling. Positive attitudes towards the issue of stunting also increased from 40% to 75%, while the practice of related behaviors increased from 70% to 90%. Student engagement in discussions reached 90%, reflecting their enthusiasm to learn more. These findings emphasize the importance of collaboration between educational institutions and public health programs in stunting prevention efforts, as well as the potential of students as agents of change in supporting the health of future generations.

Drug abuse (narcotics, psychotropics and other addictive substances) is a serious problem that can threaten physical, mental and social health, especially in adolescents. This outreach program aims to provide education about the negative impacts of drug abuse on teenagers at Karang Taruna Tanjung Pinang. The method used is the delivery of educational material and outreach. The results of this program show an increase in participants' understanding of the dangers of drugs. Thus, this outreach not only contributes to prevention efforts at the community level but also becomes a model that can be adapted for similar prevention programs in various regions.

This study aims to analyze the role of forensic audit, proactive fraud audit, good corporate governance (GCG), financial reporting compliance, organizational culture, human resource (HR) competency, and whistleblowing system in preventing fraud. The method used is a literature review with data sources from academic literature, scientific journals, and reliable reports. The results of the analysis show that forensic audit is effective in identifying and resolving fraud cases through in-depth investigations of the organization's financial system. Proactive fraud audit supports early detection by analyzing potential risks before violations occur. Good GCG implementation increases transparency and accountability, while compliance with financial reporting helps maintain data integrity and prevents manipulation. An organizational culture that prioritizes ethics and integrity, as well as adequate HR competency, creates a strong foundation to minimize the risk of fraud. In addition, a safe and confidential whistleblowing system allows for fearless reporting of violations, thereby strengthening early detection. The combination of these factors forms a comprehensive and effective approach to preventing fraud, providing significant benefits to organizations in building stakeholder trust and maintaining the sustainability of their operations .