Publication Search

Colorectal cancer (Ca Colon) is a malignancy originating from abnormal neoplastic masses in the epithelial tissue of the colon and rectum. It primarily affects the gastrointestinal tract, particularly the proximal colon and the distal rectum. The incidence of colorectal cancer has significantly increased since the 1900s due to economic and industrial advancements, making it the third leading cause of cancer-related deaths in both men and women in the United States. In Indonesia, colorectal cancer ranks second and third among cancer cases in men and women, respectively. This malignancy often manifests in the rectosigmoid region of the colon. Epidemiological data highlight geographical variations in colorectal cancer incidence, with higher rates observed in developed countries compared to developing nations. The etiology of colorectal cancer involves genetic and environmental factors, including dietary habits, lifestyle, and age. The pathophysiology involves genetic mutations leading to uncontrolled cell growth. Diagnosis is based on clinical symptoms, histological examination, and imaging techniques. Treatment options include surgery, chemotherapy, and radiation therapy, depending on the stage and location of the tumor. Early detection and intervention are crucial for improving prognosis and reducing mortality rates associated with colorectal cancer.

Posterior Capsule Opacification (PCO), also known as secondary cataract, is the most common complication following cataract surgery, particularly extracapsular cataract extraction (ECCE). PCO results from the proliferation, migration, and differentiation of residual lens epithelial cells within the posterior capsule, leading to the formation of structures such as Elsching pearls and Soemmering rings. The incidence of PCO is notably high among pediatric patients due to the increased mitotic activity of lens epithelial cells. Major risk factors include younger age, certain ocular conditions such as glaucoma and age-related macular degeneration, as well as the design and material of the implanted intraocular lens (IOL). Diagnosis is established through slit-lamp and ophthalmoscopic examinations, with decreased visual acuity being the primary clinical symptom. The current mainstay of treatment is Nd:YAG laser capsulotomy, which is effective and minimally invasive but may be associated with complications such as cystoid macular edema and retinal detachment. Preventive strategies focus on improved surgical techniques and appropriate IOL selection. With proper intervention, the incidence of PCO can be reduced, thereby improving postoperative visual outcomes.

Type 2 diabetes mellitus (T2DM), once primarily affecting adults, is now increasingly prevalent among adolescents due to lifestyle changes. Adolescents represent a critical age group for the development of healthy behaviors, making it essential to identify factors influencing T2DM preventive behavior. This study employed a quantitative approach with a cross-sectional design, conducted in Ciledug District, Tangerang City, from April to June 2025. A total of 224 adolescents aged 15–24 years were selected using stratified random sampling. Data were analyzed using the Chi-Square test. The results showed that 49.1% of adolescents exhibited poor preventive behavior against T2DM. Gender and perceived barriers were significantly associated with preventive behavior (p < 0.05), whereas other factors such as age, family history, and other Health Belief Model (HBM) constructs were not significantly related. In conclusion, adolescents’ preventive behavior toward T2DM remains relatively low and is influenced by perceived barriers. Therefore, interventions should focus on reducing perceived barriers while enhancing environmental support and self-motivation. Active involvement from schools, governments, families, and communities is crucial to foster positive behavioral change.

This study aims to determine factors including age, gender, education, tenure, and knowledge associated with the PPE use behavior of health workers at PT Kereta Commuter Indonesia. The study was conducted using a cross-sectional design with a quantitative approach. The sample consisted of 60 employees of the PT Kereta Commuter Indonesia Health Unit selected through total sampling. Primary data was collected using a questionnaire of OHS knowledge and behavior including age, gender, education, tenure and knowledge. Data analysis was performed by chi square test with the limit of significance used (P < 0.05). A total of 91.7% of health workers aged 18-35 years and as many as 98.3% of health workers had good knowledge by univariate analisys. There is a significant relationship between the age factor and the PPE use behavior of health workers with the results (p=0.039) and the knowledge factor with the PPE use behavior of health workers with the results (p=0.006). Age and knowledge of health workers at PT Kereta Commuter Indonesia have an influence on PPE use behavior. The company needs to develop programmed education and training, including supervision, monitoring and evaluation activities by management to increase motivation for implementing OSHs culture.

Obesity is a growing global health issue affecting both developed and developing countries. Despite various preventive efforts, the prevalence of obesity continues to rise. One of the emerging approaches in managing obesity and its complications is by modulating gut microbiota balance. Gut microbiota plays a significant role in energy metabolism, inflammation regulation, and insulin sensitivity. An imbalance in gut microbiota, known as dysbiosis, is frequently observed in obese individuals and has been associated with increased insulin resistance, a key feature of type 2 diabetes mellitus. This study aims to systematically review the relationship between gut microbiota imbalance and insulin resistance in obese patients, based on literature from 2016 to 2024. The literature search was conducted through accredited databases such as PubMed, Google Scholar, and others using the keywords “Gut Microbes,” “Insulin Resistance,” and “Obesity.” From 500 initial articles, 10 highly relevant journals were selected for further analysis. The review findings reveal a strong association between dysbiosis and increased insulin resistance through various mechanisms, including short-chain fatty acid (SCFA) production, activation of inflammatory pathways, and disruption of glucose metabolism. Several studies also suggest that interventions such as probiotics, prebiotics, and fecal microbiota transplantation may improve insulin sensitivity. However, more longitudinal and interventional studies are needed to establish a strong causal relationship. These findings highlight the importance of maintaining gut microbiota balance as a potential strategy in managing obesity and insulin resistance.

This study aims to explore the subjective experience of loneliness in early adult Gen Z college students through group counseling with a humanistic approach. Using a qualitative phenomenological method, six female participants aged 20–22 years participated in four group counseling sessions. Data collection was conducted through an initial questionnaire to identify participants' levels of loneliness, followed by in-depth interviews after the counseling session to explore the meaning of their experiences more comprehensively. The results showed that loneliness was associated with a lack of emotional connection, unsupportive family relationships, and shallow social interactions through social media. Group counseling proved to be a safe space to share emotions and build self-awareness, helping participants manage loneliness more healthily.

The rapid development of technology and social media has given rise to new trends in marketing strategies, one of which is the use of Influencers as promotional media. Influencers are often utilized as intermediaries between brands and consumers due to their perceived ability to shape public opinion and influence purchasing decisions. However, various ethical issues have emerged in advertising practices involving Influencers, particularly concerning transparency, honesty, and social responsibility. Many Influencers promote products without disclosing that the content is paid advertising. Such practices can mislead consumers and damage the reputations of both the Influencer and the associated brand. Another critical issue is the promotion of products that do not align with the Influencer’s personal values, as well as the lack of protection for vulnerable groups, such as children. Therefore, the implementation of strict and comprehensive advertising ethics is essential. This study highlights the importance of digital ethics education for Influencers, the enforcement of clear regulations, and the active role of social media platforms in labeling sponsored content, in order to establish a healthy and responsible digital advertising ecosystem.

Financial distress refers to a company’s persistent inability to meet financial obligations, signaling severe monetary strain that precedes formal bankruptcy or liquidation proceedings. This study investigates the impact of intellectual capital (VAICTM), operational capacity (TATO), capital structure (DER), and operating cash flow (OCF) on financial distress (Altman Z-Score), with profitability (ROA) serving as a mediating variable. The theoretical framework of this research is grounded in signaling theory, agency theory, and resource-based view theory. The study focuses on basic materials companies listed on the Indonesia Stock Exchange (IDX) between 2019 and 2023. The study utilized criterion-based sampling to select qualified respondents. Secondary datasets were analyzed through panel regression and path analysis, with Eviews 12 as the computational tool. Key findings include: (1) intellectual capital and operating capacity demonstrate a statistically significant positive influence on profitability; (2) capital structure exerts a significant adverse impact on profitability; (3) operating cash flow exhibits no statistically discernible impact on profitability; (4) both operating cash flow and profitability are positively and significantly associated with increased financial distress; (5) capital structure displays a significant inverse relationship with financial distress severity; (6) intellectual capital and operating capacity show no statistically significant associations with direct financial distress prediction; (7) profitability partially mediates the influence of intellectual capital, operating capacity, and capital structure on financial distress; and (8) profitability does not serve as a mediating variable between operating cash flow and financial distress.

Digital lifestyle has become an integral part of university students' daily lives, involving the use of social media, digital devices, and digital content consumption. The development of digital technology has positive impacts, facilitating easy access to information and social interactions. However, excessive use can lead to digital stress, which negatively affects students' mental health. This study aims to identify the key factors influencing students' digital lifestyles and analyze their relationship with stress levels. A quantitative approach with a survey method was employed, using a questionnaire to measure digital lifestyle, including social media usage frequency and digital device interaction duration, along with the Perceived Stress Scale (PSS) to measure students' stress levels. The factor analysis results show that social media usage and prolonged interaction with digital devices are significant factors contributing to students' stress. Furthermore, sleep disturbances and social anxiety were identified as other significant factors associated with increased stress. The multivariate regression analysis confirmed that students who spent more time on social media reported higher stress levels, associated with social anxiety and sleep disturbances caused by digital addiction. This study suggests the importance of managing digital device usage and raising students' awareness of the negative impacts of excessive social media use. The findings imply the need for support from universities and mental health organizations to provide interventions that help students manage their digital lifestyles, reduce stress, and improve their mental well-being.

Background: The second stage of labor is a critical phase associated with risks of maternal and neonatal complications if it lasts too long. Nonpharmacological interventions such as the gymball method have the potential to accelerate labor progress by optimizing the position and mobilization of the mother in labor, but contextual evidence in primary health care facilities in Indonesia is still limited. Objective: This study aims to analyze the effect of the gymball method on accelerating the second stage of labor in laboring mothers at the Mananggu Community Health Center. Methods: This study used a quasi-experimental design with a posttest-only control group approach. The sample consisted of 30 laboring women divided into an intervention group (gymball) and a control group (standard care). The dependent variable was the duration of the second stage of labor. Data were collected using observation sheets and partographs, then analyzed using an independent t-test. Results: The average duration of the second stage of labor in the gymball group was significantly shorter than that in the control group (p < 0.05). Conclusion: The gymball method was proven to be effective in accelerating the second stage of labor. This intervention is safe, low-cost, and feasible to be implemented as part of midwifery care at community health centers to improve the quality of normal delivery services.

Uric acid (UA) is a waste product formed when the body breaks down purines, which are natural compounds found in the body and can be found in various types of foods such as alcohol, shellfish, and liver. Hyperuricemia is caused by increased uric acid production, decreased excretion, or a combination of both processes. Most people with hyperuricemia are asymptomatic (85% to 90%), but increased levels of uric acid in the blood or urine can cause gout or nephrolithiasis. Hyperuricemia and hyperuricosuria are also associated with other disorders such as metabolic syndrome, diabetes mellitus, cardiovascular disease, hypertension, atherosclerosis, obesity, and chronic kidney disease. The Community Service (PKM) activity held in Grogol Village, West Jakarta, aims to increase awareness of the elderly community regarding the importance of early detection of hyperuricemia. This program uses the Plan-Do-Check-Act (PDCA) approach, starting from planning uric acid level examinations and compiling educational materials, followed by implementing interactive screening and counseling, evaluating results, and following up in the form of medical referrals for participants with abnormal results. Of the 71 participants involved, only 1 person had uric acid levels above normal. Through education on low-purine diets, the importance of hydration, and physical exercise, this activity is expected to be able to reduce the incidence of hyperuricemia and its complications, as well as support the realization of a healthier elderly community that is aware of its metabolic health.

Anemia during pregnancy is a significant health issue that contributes to the incidence of low-birth-weight (LBW) babies. At the Bere-Bere Community Health Center, the prevalence of LBW is 15%, higher than the national average, and the prevalence of anemia in pregnant women is 30%. This study aimed to analyze the relationship between hemoglobin (Hb) levels in pregnant women and the incidence of LBW at the center. A cross-sectional design was used with 30 pregnant women selected via purposive sampling. Hb levels were categorized into anemia (Hb <11 g/dL) and normal (Hb ≥11 g/dL), while birth weight was categorized into LBW (<2500 grams) and normal (≥2500 grams). Data analysis was performed using univariate and bivariate analysis with the Chi-Square test. Results showed that 43.3% of pregnant women experienced anemia and 33.3% of babies had LBW. Of the 13 anemic mothers, 61.5% gave birth to LBW babies, while only 11.8% of mothers with normal Hb levels had LBW babies. The Chi-Square test revealed a significant relationship (p = 0.004, p < 0.05) between maternal Hb levels and LBW incidence. In conclusion, maternal anemia is significantly associated with LBW, highlighting the need for interventions such as iron supplementation, nutrition education, and regular check-ups to prevent anemia and reduce LBW rates.

This study investigates the relationship between intraoperative blood loss and the incidence of hypothermia in patients undergoing general anesthesia at PKU Muhammadiyah Yogyakarta Hospital. General anesthesia, while commonly used for its effectiveness and patient comfort, is associated with various physiological changes, including postoperative hypothermia. Hypothermia can lead to serious complications such as delayed recovery, increased bleeding, infection risk, and impaired wound healing. One contributing factor is blood loss during surgery, which reduces the body’s ability to regulate temperature. This research employed an observational analytic method with a cross-sectional approach involving surgical patients who received general anesthesia. Data were collected on the volume of intraoperative bleeding and the presence of hypothermia in the recovery phase. The findings indicate a significant correlation between the amount of blood lost during surgery and the occurrence of hypothermia. These results suggest that early identification and management of blood loss are essential to prevent hypothermia and its associated risks. The study emphasizes the importance of temperature monitoring and bleeding control in improving patient safety and outcomes during surgical procedures involving general anesthesia

Stage V chronic kidney disease (CKD) is a serious health challenge in Indonesia due to its increasing prevalence and high cost of treatment. Educational efforts and the implementation of digital technology-based self-care, particularly through mobile applications, are considered to have the potential to improve patients' quality of life. This study aims to evaluate the effectiveness of educational and self-care-based mobile applications on the quality of life, knowledge, self-efficacy, and medication adherence of stage V CKD patients undergoing treatment at Dr. Soedjono Class II Hospital. The study used a quasi-experimental design with a pretest–posttest control group approach. From a population of 185 patients, 140 respondents were divided into intervention (n=70) and control (n=70) groups. The intervention included the use of a mobile application equipped with health education features, medication reminders, symptom monitoring, and communication with medical personnel. The results showed that the intervention group experienced significant improvements compared to the control group, including quality of life (+12.6 vs +4.2; p<0.01), knowledge (+16.5 vs +5.7; p<0.001), self-efficacy (+9.3 vs +3.1; p<0.01), and medication adherence (+1.2 vs +0.4; p<0.01). Furthermore, the frequency of application use at least four times per week was positively associated with improved quality of life (r=0.41; p<0.01). These findings demonstrate that mobile applications can be an effective and cost-effective strategy to support the management of stage V CKD patients in Indonesia.

Nephrolithiasis, commonly known as kidney stone disease, can be experimentally induced in animal models using ethylene glycol (EG) in combination with ammonium chloride, which closely mimics calcium oxalate stone formation in humans. This condition is associated with significant renal tissue injury, including glomerular atrophy, tubular necrosis, and hyaline droplet accumulation, ultimately impairing kidney function. The present study aimed to investigate the histopathological changes in the kidneys of EG-induced rats and evaluate the nephroprotective potential of combined avocado (Persea americana) and gooseberry (Physalis angulata) leaf extracts. A total of 30 male Sprague Dawley rats were randomly divided into five groups: a standard control (no induction), a negative control (EG-induced without treatment), a positive control (EG-induced and treated with a commercial nephroprotective agent), and two treatment groups receiving the combined extracts at different doses. Nephrolithiasis induction was performed over 28 days, followed by oral administration of the respective treatments. At the end of the experiment, kidney tissues were collected and processed for histological examination using hematoxylin-eosin staining to assess the extent of tissue damage. The negative control group exhibited the most severe histopathological alterations, with hyaline droplet formation reaching 15.0 ± 5.25%. In contrast, extract-treated groups demonstrated a marked reduction in tissue damage, with the most significant improvement observed in the group receiving 300 mg/kg avocado extract and 100 mg/kg gooseberry extract, which recorded hyaline droplet formation of only 5.27 ± 2.74%, a result comparable to that of the standard control group. These findings suggest that the combination of P. americana and P. angulata leaf extracts confers protective effects against EG-induced renal injury. Therefore, this herbal combination may represent a promising natural nephroprotective agent that warrants further investigation in preclinical and clinical settings.

The government's efforts to reduce domestic violence (KDRT) in North Maluku Province have been carried out, among others, through the implementation of women’s empowerment programs. This study aims to examine whether the Gender Empowerment Index (IDG), Gross Regional Domestic Product (GRDP) percapita, women's involvement in home-based industries (IR), and the intensity of domestic violence socialization programs have a significant effect on domestic violence rates across districts/cities in North Maluku. This research utilizes panel data regression analysis with data spanning the years 2016–2024. The data were processed using Microsoft Excel and STATA14 software. The findings indicate that the increased participation of women in the economic and political sectors has not yet fully translated into a reduction in domestic violence, largely due to persistent social norms and patriarchal values within households. This suggests that economic factors alone are not sufficient to explain the prevalence of domestic violence. However, women's involvement in home-based industries was found to significantly improve their economic independence and bargaining power within the household. Furthermore, consistent government-led domestic violence awareness campaigns have proven effective in enhancing protection mechanisms for women at risk. In conclusion, the study finds that the Gender Empowerment Index (IDG) and GRDP per capita do not have a statistically significant impact on domestic violence rates. Conversely, women's participation in home-based industries and domestic violence socialization efforts are significantly associated with reductions in domestic violence in North Maluku Province.

Low birth weight (LBW) is a major concern in Indonesia due to its impact on neonatal health and growth. One of the contributing factors is maternal anemia during pregnancy, which limits oxygen and nutrient supply to the fetus. This study aimed to determine the relationship between maternal anemia and the incidence of LBW in the working area of the Cimerak Health Center, Pangandaran Regency. This research used a retrospective case-control design involving 124 mothers, divided into 62 cases and 62 controls. The results of the chi-square test showed a significant relationship between maternal anemia and the incidence of LBW (p = 0.000). It is concluded that maternal anemia is associated with a higher risk of LBW, thus emphasizing the need for improved maternal care and anemia prevention strategies.

Emesis gravidarum, characterized by nausea and vomiting during the first trimester of pregnancy, affects up to 80% of pregnant women. Although typically considered a normal physiological condition, persistent symptoms can significantly impact daily activities, nutritional intake, and quality of life. Concerns over fetal safety with pharmacological treatments have led to the exploration of non-pharmacological interventions, such as aromatherapy. Lemon (Citrus limon) aromatherapy, which contains limonene, is believed to reduce nausea by stimulating the limbic system through olfactory pathways. This observational study, conducted at Manembo-nembo Hospital in Bitung City in 2025, involved 30 first-trimester pregnant women selected through purposive sampling. The severity of emesis gravidarum was assessed using the Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) questionnaire before and after lemon aromatherapy. Results showed that most participants were aged 20–35 years (73.33%) and in the early first trimester (≤10 weeks). After lemon aromatherapy, the severity of nausea and vomiting decreased, with most participants shifting from moderate or severe to mild symptoms. Statistical analysis revealed a moderate negative correlation between lemon aromatherapy and the severity of emesis gravidarum (r = −0.586; p = 0.001). In conclusion, lemon aromatherapy was significantly associated with a reduction in nausea and vomiting severity in early pregnancy. This intervention offers a safe, simple, and complementary option in antenatal care to enhance maternal comfort during the first trimester.

Malaria remains a significant public health issue both globally and in Indonesia, particularly affecting high-risk groups such as infants, young children, and pregnant women. The increasing incidence of malaria is closely linked to environmental and behavioral factors. This study aims to examine the relationship between community behavior and environmental conditions with malaria incidence at the Arso City Health Center, Keerom Regency. A quantitative, cross-sectional design was used, allowing analysis of variables at a single point in time. The sample was selected through simple random sampling based on inclusion and exclusion criteria. Findings revealed that there is no significant relationship between the habit of going outside the house and malaria incidence (p = 0.07). However, there is a significant relationship between the use of mosquito repellent and malaria incidence (p = 0.000). Similarly, using mosquito nets and gauze also showed a significant relationship with reduced malaria cases. Environmental aspects such as mosquito breeding sites and unsealed house walls were also found to be significantly associated with malaria occurrence. These results suggest that both behavioral factors—particularly protective measures—and environmental conditions contribute to malaria transmission in the community. Public health efforts should prioritize education on preventive behaviors and improvements in living environments to reduce malaria risk.

Premenstrual Syndrome (PMS) is a collection of physical and emotional symptoms occurring prior to menstruation that can disrupt daily activities. Dietary patterns and nutritional status are known to influence PMS symptoms. This study aims to analyze the relationship between dietary intake (energy, carbohydrates, protein, fat, magnesium, and vitamin B6) and nutritional status (based on Body Mass Index/BMI) with the incidence of PMS among female students from both health and non-health study programs at Universitas Airlangga. This research employed an analytical observational study with a cross-sectional design. A total of 103 female students from the 4th semester of the Nutrition and Islamic Economics study programs were selected through proportional random sampling. Data were collected using questionnaires on respondent characteristics, a Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ), anthropometric measurements, and the Shortened Premenstrual Assessment Form (SPAF). Data analysis was performed descriptively and inferentially using Spearman's rank correlation test. The results showed a significant relationship between energy intake (p = 0.002) and fat intake (p = 0.001) with PMS. No significant relationship was found for carbohydrate, protein, magnesium, and vitamin B6 intake (p > 0.05). Additionally, nutritional status based on BMI was significantly associated with PMS (p = 0.001), indicating that both underweight and overweight students were more likely to experience PMS. These findings highlight that imbalanced energy and fat intake, as well as abnormal nutritional status, may be contributing factors to PMS. Therefore, increasing awareness of proper nutrition and reproductive health is essential to reduce PMS symptoms among female students.