Publication Search

The selection of appropriate solvents in sterile injection formulations plays a pivotal role in determining the stability, efficacy, and safety of pharmaceutical products. Among the commonly utilized solvents, Dimethyl Sulfoxide (DMSO), Polyethylene Glycol (PEG), and pyrogen-free water exhibit distinct physicochemical properties and functional roles. This study aims to analyze the characteristics, functions, and implications of these three solvents within the context of sterile injectable preparations. The research methodology involves a comprehensive review of six peer-reviewed scientific articles published within the last five years, focusing on solvent performance, compatibility, and safety profiles. Findings reveal that DMSO is highly effective in dissolving lipophilic compounds due to its strong solvating capacity. However, its use at elevated concentrations may lead to irritation and cytotoxicity, necessitating careful dosage regulation. PEG, particularly in its flexible molecular weight variants, serves as a co-solvent and viscosity modifier, enhancing solubility and stability of active pharmaceutical ingredients. Pyrogen-free water, characterized by its inertness and biocompatibility, remains the gold standard for injection solvents, offering minimal risk and broad applicability across drug classes. The study underscores the importance of aligning solvent selection with the physicochemical nature of the drug, intended route of administration, and patient safety considerations. Furthermore, the potential for combining solvents to achieve optimized formulations is highlighted as a promising avenue for future pharmaceutical development. Such combinations may offer enhanced solubility, reduced toxicity, and improved delivery mechanisms, particularly for complex or poorly soluble compounds. In conclusion, understanding the nuanced roles of DMSO, PEG, and pyrogen-free water is essential for formulating safe and effective sterile injections. This research contributes to the growing body of knowledge supporting rational solvent selection and encourages further exploration into innovative solvent systems for advanced drug delivery.

The criminal act of falsifying administrative documents related to civil registration is a form of crime that has serious implications for the order of state administration, public trust, and the validity of civil registration data. This study aims to analyse the motives and driving factors of perpetrators in falsifying administrative documents related to civil registration through the application of strain criminology theory. The research method used is normative legal research with a criminological approach, supported by a literature study of relevant laws, regulations, doctrines, literature, and court decisions. The results show that the falsification of administrative documents is influenced by the gap between the cultural goals of society—such as obtaining employment, education, and social status—and the limitations of available legal means. Social pressure, economic conditions, and negative experiences such as frustration and bureaucratic obstacles encourage individuals to commit illegal acts as a form of adaptation. In addition, other contributing factors include weak social control, opportunities created by an ineffective administrative system, and the influence of a permissive social environment on forgery practices. The conclusion of this study confirms that the crime of falsifying administrative documents is not solely an individual problem, but also a structural and systemic one. Therefore, prevention efforts must be comprehensive, not only through strict law enforcement, but also by improving the administrative system, strengthening bureaucratic oversight, and reducing the socio-economic pressures faced by the community.

Nephrolithiasis, commonly known as kidney stone disease, can be experimentally induced in animal models using ethylene glycol (EG) in combination with ammonium chloride, which closely mimics calcium oxalate stone formation in humans. This condition is associated with significant renal tissue injury, including glomerular atrophy, tubular necrosis, and hyaline droplet accumulation, ultimately impairing kidney function. The present study aimed to investigate the histopathological changes in the kidneys of EG-induced rats and evaluate the nephroprotective potential of combined avocado (Persea americana) and gooseberry (Physalis angulata) leaf extracts. A total of 30 male Sprague Dawley rats were randomly divided into five groups: a standard control (no induction), a negative control (EG-induced without treatment), a positive control (EG-induced and treated with a commercial nephroprotective agent), and two treatment groups receiving the combined extracts at different doses. Nephrolithiasis induction was performed over 28 days, followed by oral administration of the respective treatments. At the end of the experiment, kidney tissues were collected and processed for histological examination using hematoxylin-eosin staining to assess the extent of tissue damage. The negative control group exhibited the most severe histopathological alterations, with hyaline droplet formation reaching 15.0 ± 5.25%. In contrast, extract-treated groups demonstrated a marked reduction in tissue damage, with the most significant improvement observed in the group receiving 300 mg/kg avocado extract and 100 mg/kg gooseberry extract, which recorded hyaline droplet formation of only 5.27 ± 2.74%, a result comparable to that of the standard control group. These findings suggest that the combination of P. americana and P. angulata leaf extracts confers protective effects against EG-induced renal injury. Therefore, this herbal combination may represent a promising natural nephroprotective agent that warrants further investigation in preclinical and clinical settings.

Background: Government administration plays a crucial role in delivering public services and implementing policies effectively. However, many developing countries face significant challenges in administrative capacity, bureaucratic efficiency, and service delivery quality. Objective: This study aims to analyze the key factors contributing to administrative weaknesses in government and propose a comprehensive framework for strengthening government administration to improve public service delivery and governance effectiveness. Methods: This research employs a mixed-methods approach, combining literature review, case study analysis, and expert interviews. Data was collected from 150 government officials across three administrative levels (national, regional, and local) and analyzed using thematic analysis and statistical methods. Results: The study identified five critical areas for administrative strengthening: (1) Human resource development and capacity building, (2) Digital transformation and technology integration, (3) Process optimization and bureaucratic reform, (4) Performance management systems, and (5) Citizen engagement mechanisms. Implementation of these components showed significant improvements in service delivery efficiency (p < 0.001) and citizen satisfaction scores (p < 0.01). Conclusion: A comprehensive approach to strengthening government administration requires coordinated efforts across multiple dimensions. The proposed framework provides a roadmap for systematic administrative reform that can enhance governance effectiveness and public service quality.

Background: Islamic inheritance law represents a critical component of family law systems that extends beyond religious obligations to encompass significant socio-economic implications for asset distribution and intergenerational justice. While Malaysia and Brunei Darussalam have both incorporated Islamic law into their national legal frameworks, their implementation approaches demonstrate fundamental structural and procedural differences that warrant systematic comparative analysis. Objective: This study examines the institutional frameworks and implementation effectiveness of Islamic inheritance law systems in Malaysia and Brunei Darussalam, analyzing how constitutional arrangements and governmental approaches influence the practical application of faraid principles. Methods: This research employs a normative legal methodology utilizing comparative analysis of legal frameworks, institutional structures, and judicial decisions. The study analyzes primary legal sources including constitutional provisions, statutory laws, court decisions, and administrative guidelines from both jurisdictions. Data collection encompassed library research examining fiqh literature, national legislation, official documents, scholarly articles, and religious legal opinions. Theoretical frameworks of legal pluralism (Romano-Gierke), Maqasid al-Shariah, and Hartian legal positivism provide analytical foundations for institutional effectiveness assessment. Results: Malaysia's dual legal system creates jurisdictional tensions between Syariah and civil courts, particularly regarding immovable property administration, resulting in administrative complexity and legal uncertainty that undermines Islamic law effectiveness. Conversely, Brunei's centralized Islamic legal framework demonstrates superior institutional coherence through exclusive Syariah court jurisdiction, enabling direct faraid implementation without inter-court conflicts. The study reveals that approximately RM42 billion in Muslim inheritance remains undistributed in Malaysia due to systematic administrative failures, while Brunei's unified approach achieves greater legal certainty and administrative efficiency. Conclusions: Institutional structures fundamentally determine Islamic inheritance law implementation effectiveness in contemporary Muslim societies. Successful Islamic law implementation requires comprehensive institutional support aligning legal structures with religious objectives rather than mere constitutional recognition. Malaysia's fragmented system inadvertently undermines Islamic law's divine authority through secular intervention, while Brunei's unified approach enhances religious legitimacy and community compliance.

Advances in information technology have had a major impact on the education sector, including at the Early Childhood Education (PAUD) level. To improve the quality of education services, PAUD institutions are required to implement a more sophisticated, accurate, and efficient management system through the use of an integrated information system. This study raises various obstacles faced by PAUD KB Tsamrotul Hikmah, especially in terms of recording teacher attendance, submitting leave, and managing finances that still use manual methods. This conventional system has been shown to reduce work effectiveness, increase the possibility of errors, and weaken the transparency and accountability aspects of the institution. To overcome these problems, an information system was developed to support automated administration processes and more systematic data management. The findings of this study indicate that digitalization of administration can improve work efficiency and data accuracy, as well as build public trust in the institution. Therefore, the implementation of an integrated information system is considered a strategic step in creating more professional, open, and sustainable PAUD management.

This study aims to determine the implementation of Value Added Tax reporting procedures using the Core Tax Administration System system at PT Alam Mulya. The method used is descriptive qualitative. This research was conducted through direct observation during internship activities at the Finance & Accounting Division of PT Alam Mulya. The results showed that the Core Tax Administration System  provides convenience in the creation and reporting of digital tax invoices, can improve reporting accuracy, and minimize tax administrative errors. In addition, the Coretax system helps supervision to be tighter and easier to access. There are also some obstacles that still need to be evaluated more deeply. But overall, the implementation of the Core Tax Administration System at PT Alam Mulya has a positive impact that helps the company's efficiency and compliance strategies in the context of tax administration.

Independent internship activities are one of the educational strategies that aim to bridge theory with the practice of the world of work. This study aims to describe the implementation of independent internships for students at PT Taman Timur Regensi Surabaya and its contribution to improving students' competence and understanding of the property industry. The research method uses a qualitative descriptive approach with data collection techniques in the form of direct observation, interviews, and documentation studies. The results of the study indicate that internship activities support the improvement of students' technical skills, especially in the fields of project administration, management of legal documents, and understanding of housing development flows. In addition, students' soft skills, such as professional communication, teamwork, and time management, have also experienced significant development. In conclusion, independent internships at PT Taman Timur Regensi are an effective medium to prepare students to face the world of work in the property industry in a more prepared and competent manner.

Islam entered Malaysia through trade, especially by Arab, Indian and Chinese traders since the 7th century, but wider spread occurred in the 13th century through the Kingdoms of Samudera Pasai and Melaka. The Islamization process became stronger with the role of the Malay kingdoms in making Islam the official religion, establishing a sharia-based government system, and introducing Jawi writing as the main medium in education and administration.The development of Islamic education in Malaysia began with the Islamic boarding school and madrasa system which emphasized traditional religious teachings. In the colonial era, Islamic education underwent changes with the establishment of folk religious schools and modern madrasas which combined religious and academic curricula. After independence, the Malaysian government introduced a more formal Islamic education system through national religious schools, tahfiz institutions, and Islamic universities. This development was strengthened by the introduction of JAKIM, the Malaysian Ministry of Education, as well as an educational foundation that supports the integration of Islamic values ​​in the national education system. Today, Islamic education in Malaysia continues to develop through technology and innovation, ensuring it is relevant in the modern world while preserving Islamic scientific traditions.

Education is the primary foundation for developing competitive and high-quality human resources; therefore, the management of educational institutions such as schools and madrasahs requires a structured, efficient, and quality-oriented management system. This study aims to examine the implementation of management in the administration of schools/madrasahs, covering the basic concepts of educational management, the role of school principals, stages of implementation, and related strategies. A descriptive qualitative approach was used, with data collected through literature studies from various academic sources. The results show that effective educational management includes an integrated process of planning, organizing, implementing, and supervising all educational resources. The school principal plays a central role as a transformational leader who directs the vision and success of the institution. The implementation process includes stages of socialization, piloting, and dissemination, while the strategies involve school categorization, phased programs, and regulatory strengthening. This entire managerial process is essential in building adaptive, accountable, and high-quality educational institutions.

A good administrative system in admitting new students not only makes things easier for prospective students, but also increases the efficiency and effectiveness of the registration process. With a structured system, prospective students can register directly at the counter or via an online platform, which makes access easier and reduces waiting time1. This is in line with the need for institutions to adapt to the digital era and improve services to prospective students. However, this often happens in the process of accessing information and inputting data. Because some students are still searching for registration information at Pancasakti University manually, this will take time and energy. When Pancasakti University Tegal opened student registration, thousands of prospective Pancasakti University Tegal students and their parents contacted the administration of Pancasakti University Tegal with various questions about the registration process and requirements. Chatbots, as a technological innovation based on artificial intelligence, offer an efficient solution to this problem. Chatbot is AI software that can interact with humans via text or voice, simulate human conversation, and provide relevant responses..

This study aims to evaluate the performance of administrative services in Mojoroto District, Kediri City based on the 2024 Public Satisfaction Index (IKM) Survey. Based on the survey results, all performance indicators showed very good results, with an aggregate IKM score reaching 93.12. The assessment of service quality includes employee competence, infrastructure, and service innovations such as online systems and mobile services. In addition, the timeliness of administrative processing, service effectiveness, and employee independence and work commitment were also recorded as optimal. The public gave a positive assessment of administrative services, exceeding their expectations according to the Expectancy Disconfirmation Theory (Oliver, 1980). However, there are obstacles such as disruptions to the information system, fluctuations in requests, and lack of document readiness from the public. This study contributes to improving the quality of public services, with recommendations for strengthening the IT system, managing fluctuations in requests, and increasing public awareness of the required documents. These findings are expected to be a model for effective and responsive public administration services for other sub-districts in Kediri City.

This research seeks to develop a web-based tuition payment system to improve the efficiency of financial administration at SMK Techno Media.The Agile development method was employed, with data collected through observation, interviews, literature review, and documentation. Several challenges were identified, such as delays in processing, inaccuracies in payment information, and inefficiencies in financial reporting. The developed system includes functionalities for generating bills, tracking payment status, sending notifications, and producing financial reports. These features are designed to be utilized by six user roles: administrators, teachers, students, parents, finance staff, and the school principal. The implementation results show notable improvements in data accuracy, information transparency, and administrative efficiency. Furthermore, the system supports digital transformation in the school’s financial management processes.

 In today's digital era, efficient and accurate inventory management is crucial to support operational effectiveness in business sectors, including retail optics stores. Optik Retna, a retail optical business, previously utilized Microsoft Excel for stock management, which led to various limitations such as restricted multi-user access, risk of data loss, and lack of real-time reporting. To address these challenges, a web-based inventory system was designed and implemented using the Agile methodology. The system was developed using HTML, CSS, JavaScript, PHP, and MySQL, and includes key features such as inventory tracking, expense and return management, transaction recording, sales reporting, and user administration. The implementation results demonstrate that the system enhances work efficiency, simplifies the recording of incoming and outgoing goods, and supports faster and more accurate decision-making at Optik Retna. Therefore, this system provides a practical contribution to the digital transformation of small and medium-sized enterprises in the optical sector.

This Study explore the study of The Bugis people’s migration from south sulawesi to East Kalimantan on their sattlement in Kutai dan Pasir from the 18th through 19th centuries. It looks at how the Buginese diaspora established independent groups, traded and developed political clouth through smart partnerships like marriages with local elites, all motivated by marine culture and economic aspirations. Internal disputes among Bugis factions, particularly over taxation and port countrol, and tentions with local authorities were frequently the results of these developments. In oder to increase their power in the area, the Dutch Colonial authorities kept an eye on these conflicts and accosianally got involved. This study emhasises how the Bugis significantly influenced power dynamics and coastal administration in East Kalimantan throughout both indigenous and colonial regimes, drawing on historical documents, open access academic sources and Buginese manuscripts.

MSMEs are the backbone of the Indonesian economy. To maintain the continuity of their business, MSMEs must have good and correct financial report management. MSME financial reports tend to be simple and ignore financial administration rules. This research aims to create and compile financial reports in accordance with the Financial Accounting Standards for Micro, Small and Medium Entities (SAK EMKM) for the Berkah Laris Frozen Food UMKM in Malang. The method used in this research is a descriptive qualitative method. The data sources used are primary data in the form of interviews and secondary data in the form of documentation. The results of the research are the presentation of an income statement showing operating profit, a change in capital report showing capital at the end of 2024, a financial position report showing the amount of assets owned equal to the total of liabilities and capital, and notes to the financial report which presents a general overview, an overview of important accounting policies, retained earnings and sales revenue for the period 31 December 2024.

Penelitian ini bertitik tolak dari gagasan bahwa hukum merupakan sebuah sistem, yang berarti tidak ada satu peraturan perundang-undangan pun yang berdiri lepas tanpa memiliki keterhubungan dengan peraturan perundangan yang lain. Konsistensi dan koherensi antar peraturan perundang-undangan menjadi tolok ukur untuk menilai apakah suatu sistem hukum telah berjalan baik. Pada penelitian ini, pembahasan akan difokuskan pada tiga permasalahan, yaitu Pengaturan BPHTB dalam peraturan perundang-undangan Indonesia, Penyebab inkonsistensi pengaturan BPHTB dalam Peraturan Pemerintah Nomor 35 Tahun 2023 tentang Ketentuan Umum Pajak Daerah dan Retribusi Daerah, dan Pengaturan ideal BPHTB dalam tinjauan sistem hukum. Metode pendekatan dalam penelitian ini adalah metode pendekatan yuridis normatif, yang mengkaji norma hukum tertulis dari aspek sistem hukum. Spesifikasi penelitian yang digunakan adalah deskriptif analitis. Data yang digunakan dalam penelitian ini adalah data sekunder, dengan metode pengumpulan data berupa studi kepustakaan. Analisis data penelitian ini menggunakan analisis data kualitatif normatif. Hasil penelitian ini menunjukkan: 1). Pengaturan BPHTB dalam perundang-undangan Indonesia dimulai dengan Undang-Undang Nomor 21 Tahun 1997 tentang BPHTB hingga Peraturan Pemerintah Nomor 35 Tahun 2023, yang menjadi fokus bahasan penelitian ini. 2). Ketentuan Pasal 18 ayat (2) Peraturan Pemerintah Nomor 35 Tahun 2023 tidak konsisten dengan UUPA, Undang-Undang Hak Tanggungan, Peraturan Pemerintah tentang Pendataran Tanah, dan Peraturan Jabatan PPAT. 3). Pengaturan ideal BPHTB merupakan sintesis dari tiga aspek sebagaimana dicetuskan R.Mansury, yaitu Revenue Productivity, Equality/Equity, Ease of Administration. Maka, BPHTB untuk jual beli idealnya ditetapkan pada saat pembuatan PPJB Lunas di hadapan PPAT.

This research aims to describe the use of WhatsApp social media as a means of population administration services at the Tebel Village Hall, Bareng District. The problem raised in this research is the process of using WhatsApp in services and how the public responds to this service. This research uses a qualitative descriptive approach with data collection techniques in the form of in-depth interviews and observations of officers and service users. The research results show that using WhatsApp helps speed up communication, makes sending required documents easier, and provides more practical access to information for village communities. Village officials are also able to provide more responsive service assistance. However, several obstacles were also found, such as limited number of officers and technical problems with the system. The results show that digital media such as WhatsApp can help make public services more accessible, especially in rural areas. This study found that WhatsApp was well received by the public and helped administration.

Law constitutes a set of rules that must be obeyed and implemented by every individual. The concept of law-making forms part of the broader meaning of legal politics, serving as a guideline for the governance of the state and the life of society. Law is a necessity for all components of the nation and the state to create security and order, thereby providing a sense of justice. General elections (Pemilu) conducted directly by the people, from the people, and for the people serve as a means of manifesting sovereignty for the state to produce a democratic government based on Pancasila and the 1945 Constitution. The administration of general elections direct, free, universal, and secret must be carried out honestly and fairly, capable of realizing national integration, professionalism, and accountability in order to position the people as the primary holder of sovereignty. This study employs a normative juridical legal research method with a statutory approach and a conceptual approach. The results of this research indicate that the legal concept concerning general elections depends on legal politics, which acts as a determining activity in the pattern and formation of election legislation designed to oversee and renew that law as a determination of politics related to democracy in the country. This study aims to ascertain the impact of the implementation of legal politics in the post-reform general election system and represents an existence of legal politics within Indonesia’s legal enforcement system.

The SEBLAK program (Birth Certificate, Birth Registration, and Family Card) initiated by RS dr. Mohammad Zyn represents an innovation in digital-based civil registration services, aimed at improving efficiency, effectiveness, and transparency in public services related to population administration. This innovation integrates the processes of data collection, verification, and the issuance of administrative documents automatically through a digital system directly connected to the Department of Population and Civil Registration (Disdukcapil). Consequently, procedures for obtaining documents such as birth certificates and family cards can be carried out more quickly, easily, and without bureaucratic obstacles, while also providing more accurate and reliable data. The overall success of this program is supported by several key factors, including adequate technological infrastructure, continuous training for officers and the community, and effective socialization through various media and community forums. A qualitative approach was used to evaluate the implementation process and its impact on the community and hospital staff. Data were collected through in-depth interviews, observations, and documentation, then analyzed using the Miles and Huberman (1994) model. The results indicate that the implementation of this digital system can significantly reduce the time and costs associated with document processing, improve data accuracy, and strengthen public trust in government services. Beyond operational aspects, the SEBLAK program also positively impacts increasing access to administrative services for communities in remote and hard-to-reach areas. This aligns with the goal of expanding digital services inclusively and reinforcing the role of hospitals as the initial point and center for civil registration services while enhancing community participation in fulfilling their administrative rights. However, challenges remain, including technical infrastructure limitations, a lack of sufficient training for human resources, and the need to improve data security capacity. Therefore, continuous capacity building for human resources and infrastructure development are crucial to ensure the sustainability and success of this program, which can serve as a model for innovative public services that other institutions in Indonesia can adopt.