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Red beans (Phaseolus vulgaris L.) are a type of legumes (Leguminaceae) that have a high content of starch and fiber. The high fiber content causes red beans to prevent coronary heart disease. Red beans also have a low glycemic index so they can lower cholesterol levels in the blood and the risk of diabetes. Red beans also contain phenolic compounds that act as antioxidants in the body. Red beans are classified as food ingredients that can support the increase in nutritional value because they are classified as a relatively affordable source of vegetable protein. The purpose of this counseling is to provide knowledge and processed skills from local commodities, in this case red beans, to students majoring in Agribusiness of Agricultural Products at SMK Negeri 1 Bawen. This activity was attended by 68 students majoring in Agribusiness and Agricultural Products and 1 assistant teacher from SMK Negeri 1 Bawen, Semarang Regency. The method of this red bean processing extension activity is to increase the knowledge and skills of making processed local food products with several methods: a. The lecture method provides the theory and practice of making kidney bean cookies. b. Practice method of making red bean cut ice. c. The question and answer method, used to provide feedback to participants about the material that has been presented during the activity. d. Evaluation is given by providing pre test and post test. After the implementation, it showed that the target, namely students of SMK Negeri 1 Bawen, increased their knowledge and understood the importance of post-harvest handling and processing of red beans with the practice of making red bean cut ice. This is based on questions and answers, interviews and questionnaires shared before and after the activity. From the results of the questionnaire conducted before and after the activity, it showed that: After the implementation, there was a 50.17% increase in knowledge about kidney bean processing, Knowledge about making kidney beans into cut ice increased by 65.32% and Knowledge of other processed kidney beans such as kidney bean cookies showed that there was an increase of 67.15% after counseling. The conclusions that can be drawn from this counseling activity are (1) Processed red bean extension activities can increase the knowledge and understanding of the participants (2) The responses given by the counseling participants show a fairly satisfactory interest and there is a desire to apply the newly acquired knowledge to be socialized in the surrounding environment.

Various recent studies have shown that natural active compounds contained in traditional and fermented plants play a crucial role in supporting human health. These compounds include flavonoids, polyphenols, tannins, saponins, alkaloids, organic acids, probiotics, and other phenolic compounds. Detection of these compounds is usually carried out through specific chemical reactions that allow researchers to more precisely identify the bioactive components. Their biological activities are diverse, including antioxidant, antibacterial, anti-inflammatory, and antimicrobial properties, which work to protect the body from cell damage and infection. Natural compounds are considered promising agents for disease prevention and health promotion due to their broad biological activities. The fermentation process has been shown to increase the content of bioactive compounds while lowering the pH of the medium, creating conditions unfavorable for the growth of pathogenic bacteria. Furthermore, probiotics that develop during fermentation play a role in maintaining the balance of the gut microbiota, strengthening the immune system, and improving digestive health. Fermented products are widely recognized as functional foods because they contain beneficial probiotics and enhanced bioactive compounds. These naturally derived products, rich in secondary metabolites, have also been shown to have significant physiological effects, such as lowering cholesterol levels, controlling blood sugar, and maintaining stable blood pressure. This makes natural ingredients and fermented products not only sources of nutrition but also have great potential for development as functional foods and traditional herbal medicines. This highlights the importance of integrating traditional knowledge with modern scientific approaches in developing functional foods and herbal medicines. Therefore, research on natural bioactive compounds and the role of fermentation in enhancing their effectiveness is highly relevant to supporting sustainable public health.  

Dyslipidemia is a lipid metabolism disorder characterized by elevated levels of total cholesterol, triglycerides, and low-density lipoprotein (LDL) accompanied by decreased levels of high-density lipoprotein (HDL). This condition is a major risk factor for atherosclerosis, coronary heart disease, and stroke. One plant with potential as an antidyslipidemic agent is bay leaves (Syzygium polyanthum). These leaves are known to contain active compounds such as flavonoids, saponins, tannins, alkaloids, and polyphenols that have antioxidant and hypolipidemic activities. The potential of natural compounds from medicinal plants to reduce blood cholesterol levels has gained significant attention in recent years. This study aims to evaluate the effectiveness of microencapsulated ethanol extract of bay leaves in reducing total cholesterol levels in white rats (Rattus norvegicus) induced by a high-cholesterol diet. The experimental study design employed was a laboratory-based true experimental method with a post-test control group design. A total of 25 male rats were used and divided into six groups: normal control, negative control (high cholesterol diet without therapy), positive control (simvastatin), and three groups treated with bay leaf extract microencapsulates at doses of 0.25%, 0.5%, and 0.75%. The treatment was given for 14 days, then total cholesterol levels were measured using an enzymatic method. The results showed that the group with a dose of 0.75% experienced the highest decrease in total cholesterol levels, namely -70 mg/dL, greater than the simvastatin group (-49 mg/dL). Statistical analysis using One Way ANOVA showed a significant difference compared to the negative control (p < 0.001). These findings indicate that the 0.75% dose of microencapsulated Syzygium polyanthum extract demonstrated an effect equal to or greater than simvastatin. Thus, it can be concluded that bay leaf ethanol extract microencapsulates are effective in reducing total cholesterol levels in hypercholesterolemic rats. This suggests that Syzygium polyanthum microencapsulation has the potential to be developed as an alternative phytotherapy for cholesterol reduction.

This Community Service Program is entitled "Health Education Services to Prevent Hypercholesterolemia in Students at the H. Nur Abdullah Al-Qur'an Memorization Islamic Boarding School." Hypercholesterolemia is a medical condition characterized by high blood cholesterol levels, which can increase the risk of heart disease and stroke. This disease can be prevented and managed with lifestyle changes and appropriate medication. The goal of this Community Service Program is to increase students' awareness and knowledge of hypercholesterolemia and provide education on effective prevention and management methods. This Community Service Program is conducted through health counseling, health checks, and education on healthy lifestyles. The target students in this study were students from the H. Nur Abdullah Al-Qur'an Memorization Islamic Boarding School. Prior to the counseling session, 50 students were given a pre-test questionnaire regarding their knowledge of hypercholesterolemia. After the counseling session, a post-test questionnaire on hypercholesterolemia was administered, which showed an increase in knowledge, as evidenced by the post-test results. Following the counseling and health examinations, the students targeted in this study, from the Nur Abdullah Al- Quran memorization Islamic boarding school, showed increased awareness and knowledge about hypercholesterolemia. Most participants also demonstrated healthier lifestyle changes, such as increasing fruit and vegetable consumption and engaging in regular physical activity. This Community Service Program (PKM) demonstrates that health education and counseling can increase the awareness and knowledge of hypercholesterolemia among the students targeted in this study, from the Nur Abdullah Al-Quran memorization Islamic boarding school. Therefore, the students targeted in this community service session, from the Nur Abdullah Al-Quran memorization Islamic boarding school, can effectively implement prev ention and management strategies to reduce the risk of heart disease and stroke.

Elevated blood cholesterol levels are known to be a major risk factor for cardiovascular disease. Hypercholesterolemia can trigger atherosclerosis, which in turn increases the risk of coronary heart disease and stroke. One approach to managing cholesterol levels is through the use of natural ingredients with antihyperlipidemic activity. White turmeric (Curcuma zedoaria Rosc) is an herbal plant long used in traditional medicine and contains bioactive compounds such as curcuminoids and essential oils. These compounds are reported to have antioxidant and anti-inflammatory activities, as well as potential as agents for lowering blood lipid levels. Herbal-based therapies are increasingly considered as safe alternatives to synthetic drugs in managing hyperlipidemia. This study aims to evaluate the effectiveness of a microencapsulated preparation of white turmeric ethanol extract in reducing total cholesterol levels in male rats (Rattus norvegicus) induced by a high-fat diet. The study was conducted experimentally using 25 rats divided into six treatment groups. The groups consisted of normal controls, negative controls, positive controls using simvastatin, and three treatment groups given white turmeric extract microcapsules at concentrations of 0.25%, 0.50%, and 0.75%. The microencapsulation technique was applied to improve the stability and bioavailability of the turmeric extract. Cholesterol levels were measured before and after treatment. The results showed that the treatment group with the 0.25% concentration produced the most significant cholesterol reduction, from 110 mg/dL to 59 mg/dL. These findings indicate that even at a relatively low concentration, microencapsulated turmeric extract can significantly reduce cholesterol levels in vivo. Therefore, it can be concluded that white turmeric extract in microcapsule form is effective in lowering total cholesterol levels, especially at the 0.25% dose. This suggests that Curcuma zedoaria microcapsules hold promise as a natural therapeutic option for managing hypercholesterolemia and reducing cardiovascular risk.  

Dyslipidemia is a health problem characterized by impaired fat metabolism in the body, characterized by changes in blood lipid levels, either increasing or decreasing. This condition is generally seen through increased levels of total cholesterol, low-density lipoprotein (LDL), triglycerides, and decreased levels of high-density lipoprotein (HDL). This imbalance in the lipid profile, if persisted over the long term, has the potential to accelerate the formation of atherosclerotic plaque on artery walls, which can lead to cardiovascular disease. This study aims to determine the effectiveness of papaya leaf (Carica papaya L.) ethanol extract microcapsules in reducing cholesterol levels in white rats induced by a high-fat diet. The high-fat diet is formulated from a mixture of beef fat, eggs, and lard to increase cholesterol levels in a controlled manner. After the induction phase, the rats were divided into six treatment groups: a negative control group, a positive control group (simvastatin 0.36 mg), and three treatment groups with doses of papaya leaf ethanol extract microcapsules of 0.25%, 0.50%, and 0.75%. The treatment was given orally for 14 consecutive days. Total cholesterol levels were measured before and after treatment to evaluate the effectiveness of the intervention. The results showed that administration of papaya leaf extract microcapsules significantly reduced cholesterol levels. The 0.50% dose provided the most optimal effect, with a reduction reaching 77 mg/dL, greater than the simvastatin group. However, increasing the dose to 0.75% did not show a significant additional reduction effect, indicating an optimal dose-response point. Therefore, the 0.50% concentration can be considered the most effective dose and has the potential to be developed as an alternative natural cholesterol-lowering therapy. These findings also strengthen the potential use of papaya leaves as a bioactive source to support efforts to prevent and control dyslipidemia.  

Dyslipidemia is a lipid metabolism disorder characterized by an increase or decrease in blood plasma fat levels. This condition includes high levels of total cholesterol, low-density lipoprotein (LDL), and triglycerides, as well as decreased levels of high-density lipoprotein (HDL). In general, dyslipidemia is divided into two types: primary, which is influenced by genetic factors, and secondary, which is caused by other diseases or an unhealthy lifestyle. Dyslipidemia is one of the major risk factors for cardiovascular disease, making its prevention and treatment very important. In this study, male white mice were used and induced with a high-fat diet to trigger dyslipidemia. The test animals were then divided into six groups: a negative control, a positive control (given simvastatin at a dose of 0.36 mL/day), and three treatment groups with microcapsules of Chinese betel leaf herb ethanol extract (EEHSC) at concentrations of 0.25%, 0.5%, and 0.75%. The treatment was administered orally for 14 days. Cholesterol levels were measured before and after treatment using a digital cholesterol tester and laboratory analysis to ensure more accurate results. The results showed a decrease in cholesterol levels with varying percentages in each group. The negative control decreased by 24.8%, the positive control by 36.1%, the 0.25% EEHSC by 24.1%, the 0.5% EEHSC by 34.7%, and the 0.75% EEHSC by 45.5%. This indicates that the 0.5% EEHSC treatment produced cholesterol reductions almost comparable to simvastatin. Interestingly, the highest effect was observed in the 0.75% group, indicating a dose-dependent response. In contrast, the 0.25% concentration only produced a less than optimal effect. Thus, microcapsules of ethanol extract of the Chinese betel leaf herb have potential as an alternative agent for lowering cholesterol levels, particularly in dyslipidemia. These findings suggest that natural-based therapies could complement conventional treatments in managing lipid disorders.

Hypertension is a chronic clinical condition characterized by persistently elevated blood pressure above normal physiological limits and is a major global health concern due to its strong association with cardiovascular morbidity and mortality. One important contributing factor to hypertension is hypercholesterolemia, or an abnormal increase in total cholesterol levels in the blood. Elevated cholesterol concentrations may accelerate arterial stiffness and increase vascular resistance, thereby worsening blood pressure regulation. This study aimed to describe the relationship between blood pressure status and total cholesterol levels among productive-age individuals diagnosed with hypertension. The study was conducted in July 2023 using a descriptive design. A total of 30 hypertensive respondents within the productive age range were selected through accidental sampling. Data collection involved direct measurement of blood pressure using a sphygmomanometer and assessment of total cholesterol levels through standard clinical procedures. The results showed that the majority of respondents were categorized as having Stage 1 hypertension. With regard to cholesterol profiles, 16 respondents (53%) exhibited normal cholesterol levels, 9 respondents (30%) had borderline high cholesterol levels, and 5 respondents (17%) were classified as having high cholesterol levels. These findings suggest that most hypertensive individuals in the productive age category present with cholesterol levels ranging from normal to borderline high, although a smaller proportion already experience clinically high cholesterol concentrations. The study highlights the importance of regular monitoring of both blood pressure and lipid profiles in productive-age individuals to prevent progression to more severe cardiovascular complications. Lifestyle modification remains a cornerstone in hypertension management, particularly increasing physical activity, adopting a balanced diet low in saturated fats, and maintaining good sleep hygiene. Such preventive strategies can help reduce the dual burden of hypertension and hypercholesterolemia, ultimately lowering the risk of long-term cardiovascular disease.

Obesity, central obesity, and hypercholesterolemia are prevalent yet often unrecognized health conditions that significantly elevate the risk for various non-communicable diseases (NCDs) such as diabetes mellitus, hypertension, and cardiovascular disorders. These conditions, when left undiagnosed and untreated, contribute to the growing public health burden worldwide. This community service program was designed to raise awareness and provide early detection of these conditions through basic health screening measures, including body mass index (BMI), waist circumference, and blood cholesterol levels. The program was implemented in Tomang Subdistrict, West Jakarta, where 90 participants were involved. The findings from the screening revealed concerning results: 67% of the participants were classified as obese, and 58% had central obesity, both of which are major risk factors for NCDs. A deeper analysis of lifestyle factors highlighted that high-fat diets, sedentary behaviors, and night shift work were significant contributors to the high rates of obesity and metabolic abnormalities observed. The educational outreach component of the program, which included the provision of information about healthy diets, exercise, and the importance of regular health screenings, proved to be effective in raising awareness about these health issues. Moreover, the simple health screening process was well-received by the community and contributed to a greater understanding of individual health risks. This initiative is expected to serve as a sustainable model for promoting health and preventing metabolic diseases in the community. The findings underscore the importance of early detection and education as critical strategies in the fight against obesity and related NCDs, suggesting that such programs can play a key role in reducing the future burden of chronic diseases in underserved populations

Non-communicable diseases (NCDs), such as hypertension, diabetes mellitus, and obesity, pose significant health risks for the elderly in Indonesia, including those in Aneuk Paya Village, Lhoknga District, Aceh Besar. These conditions, if left unmanaged, can lead to severe complications, impacting the quality of life of older adults. This community service project aims to improve elderly individuals' understanding of NCDs, as well as their prevention and management, through educational initiatives carried out at the Integrated Health Post (Posbindu). The activities involved interactive counseling sessions, health assessments including blood pressure monitoring, and measurements of body weight, height, waist circumference, blood sugar, and cholesterol levels. The community service event, conducted on July 22, 2025, revealed a significant improvement in the elderly participants’ knowledge about NCDs. Notably, 83% of the participants gained a better understanding of the prevention of NCDs, while 70% reported improved knowledge regarding blood sugar and blood pressure management. Moreover, there was a noticeable increase in the number of elderly individuals attending regular Posbindu visits, which suggests a growing commitment to managing their health. Health education through Posbindu has proven to be an effective tool in raising awareness and changing health behaviors among the elderly, helping to prevent NCD complications. The project demonstrates the pivotal role of Posbindu not only in promoting NCD prevention but also in providing continuous support to the elderly in managing their health, ultimately enhancing their quality of life. This initiative highlights the importance of local health programs in addressing the growing prevalence of NCDs in elderly populations and emphasizes the need for further community-based health interventions.

Excessive fat consumption can lead to increased cholesterol levels in the body, which in turn can trigger various serious health problems, including heart disease, blood vessel blockage, and even stroke. Blood cholesterol consists of two main types: LDL (Low-Density Lipoprotein) cholesterol, often referred to as bad cholesterol, and HDL (High-Density Lipoprotein) cholesterol, which plays a role in transporting cholesterol from the blood vessels to the liver for excretion. Elevated LDL cholesterol levels can cause plaque buildup on blood vessel walls, which narrows blood flow and increases the risk of various cardiovascular diseases. One method considered effective for lowering LDL cholesterol levels in the blood is by consuming phytosterols, compounds found naturally in various types of plants. Phytosterols have a structure similar to cholesterol and can compete with cholesterol for absorption in the intestine. This results in a decrease in the amount of cholesterol entering the body, thereby reducing total cholesterol levels and especially LDL cholesterol in the blood. Research shows that giving food or supplements containing about 3 grams of phytosterols per day to human subjects can reduce LDL cholesterol levels by up to 15%. Furthermore, phytosterols directly isolated from plants, such as green beans, have also been shown to significantly lower LDL cholesterol levels. Studies in mice fed phytosterols isolated from green beans showed a reduction in blood LDL cholesterol levels of more than 30%. This demonstrates the potential of phytosterols as a natural ingredient that can be used to support cholesterol management in the body. Although phytosterols have significant potential in lowering cholesterol levels, it is important to remember that consuming supplements or foods containing phytosterols should be done under the supervision and recommendation of a medical professional, especially for individuals with certain medical conditions or who are taking medications.  

Virgin Coconut Oil (VCO) is a high-quality coconut oil that is extracted from fresh coconut meat without the use of high heat or chemicals, preserving its natural nutrients and beneficial properties. The demand for VCO has increased in recent years due to its various health benefits, such as boosting the immune system, improving digestion, and providing antimicrobial effects. The oil is rich in medium-chain fatty acids, particularly lauric acid, which is known for its positive effects on cholesterol levels and cardiovascular health. This study focuses on the production of VCO using a natural fermentation method, a traditional technique that is gaining attention for its simplicity and environmental friendliness. In this method, mature coconut meat is grated and squeezed to extract the coconut milk, which is then fermented at room temperature for 24–48 hours. The fermentation process allows the separation of the oil from the milk, forming a clear oil layer on top, which retains the characteristic aroma of coconut. The quality of the produced VCO was analyzed by determining its acid value and saponification number. The saponification value, which indicates the amount of alkali required to saponify the fat, was found to be 50.49. The acid value, which reflects the free fatty acid content, was measured at 5.61. These results suggest that the VCO produced through natural fermentation is of relatively good quality, with a favorable acid value indicating lower rancidity. Overall, the study demonstrates that natural fermentation is an efficient, eco-friendly, and cost-effective alternative for VCO production. This method not only preserves the natural properties of the coconut oil but also offers a sustainable approach to producing high-quality oil for various health and cosmetic applications.

Black sticky rice tapai is a traditional Indonesian fermented food that has long been consumed by the public for its distinctive taste and high cultural value. However, with the increasing demand for functional foods and natural-based products that can support health, attention for black sticky rice tapai has shifted from being simply a traditional food to an object of scientific study in the nutraceutical field. Black sticky rice, the basic ingredient for tapai, contains important bioactive compounds such as anthocyanins, flavonoids, B-complex vitamins, and soluble fiber, which have been shown to play a role in lowering cholesterol levels, inhibiting LDL cholesterol oxidation, and increasing HDL cholesterol levels in the blood. The fermentation process further enhances the biological activity of these compounds, making black sticky rice tapai have a higher therapeutic value than ordinary black sticky rice. The purpose of this study was to examine the potential of black sticky rice tapai as a natural, tradition-based solution for lowering cholesterol levels, while also supporting the development of local foods into modern health products that are safe, effective, and affordable. The study was conducted using a descriptive literature review method of various scientific articles, textbooks, and relevant research results that discuss the nutritional content of black sticky rice, the benefits of fermentation, and the effect of active components on lipid metabolism. The study results show that regular consumption of black glutinous rice tapai has the potential to lower total and LDL cholesterol levels and increase HDL through a combination of antioxidant effects, cholesterol binding by fiber, and increased fat excretion. In addition, the potential of black glutinous rice tapai as a nutraceutical is also relevant in supporting the preservation of local-based culture and food independence.

Bekasam is a traditional fermented fish-based food popular in various regions in Indonesia, including Batanghari, Jambi. This product is produced through a spontaneous fermentation process that utilizes the activity of microorganisms, particularly lactic acid bacteria (LAB), which play an important role in the formation of distinctive flavors, food safety, and potential health benefits. One type of fish used is lambak fish (Labiobarbus ocellatus), which is commonly found in local waters. Given the high prevalence of cardiovascular disease associated with cholesterol levels, exploring the probiotic potential of local fermented foods presents a strategic opportunity to support public health. This study aims to isolate and identify LAB from bekasam lambak fish from Mersam, Batanghari, and evaluate its initial potential as a candidate for cholesterol-lowering probiotics. The research method was carried out in the laboratory through a series of dilutions (10⁻¹–10⁻⁶) of bekasam samples, followed by cultivation on Nutrient Agar (NA) media using the pour and streak method. Incubation was carried out at 37°C for 24–48 hours. The growing colonies were then observed morphologically and tested using Gram staining. Observations revealed spherical, milky-white colonies with Gram-positive rod-shaped characteristics, indicating they likely belonged to the Lactobacillus genus. This genus is known to lower cholesterol through bile acid binding and free cholesterol assimilation mechanisms in the digestive tract. These findings reinforce the notion that bekasam lambak fish contains local LAB isolates that have the potential to be developed as a natural probiotic raw material. This potential can be utilized in the development of functional fermented food products or nutraceuticals that not only maintain the traditional value of bekasam but also provide preventative health benefits, particularly in controlling cholesterol levels.

Successful development encompasses various aspects of community life and cannot be separated from progress in the health sector. Health is one of the key indicators in determining the quality of life of a population. Therefore, attention to health—especially for vulnerable groups such as the elderly—is of great importance. Regular health check-ups serve as a preventive measure to help the community detect illnesses early and encourage individuals to take an active role in maintaining their own health. Several types of examinations are commonly provided free of charge during community service activities, including blood pressure checks, random blood glucose tests, uric acid level tests, and cholesterol level screenings. These health checks are especially beneficial for the elderly, as they help monitor overall health conditions and enable early management of diseases to prevent further complications. In this activity, a total of 40 elderly individuals voluntarily participated in the health screening. The methods used included health education sessions and direct examinations of blood pressure, uric acid levels, and random blood glucose levels. The counseling was delivered using simple and clear language, and it included a question-and-answer session to help participants better understand the information provided. The results of the examinations showed that some of the elderly participants had high blood pressure and elevated blood glucose levels, which led to recommendations for follow-up visits to nearby healthcare facilities. Through this health screening initiative, the overall health quality of the elderly participants improved, and their awareness of the importance of early detection increased. This activity is expected to motivate the broader community to pay more attention to their health and to undergo regular health check-ups. By taking a proactive role in managing their well-being, individuals can reduce the risk of serious complications in the future and contribute to the creation of a healthier society overall.

Diabetic foot ulcers represent one of the most serious long-term complications associated with type 2 diabetes mellitus, often contributing to increased rates of morbidity and mortality, while significantly impairing patients' quality of life. Among the various underlying causes, peripheral neuropathy and vascular disorders (vasculopathy) are frequently linked to dyslipidemia. This study aimed to examine the characteristics of total cholesterol and triglyceride levels, along with the prevalence of diabetic foot ulcers in patients with type 2 diabetes mellitus. A descriptive retrospective approach was used by analyzing medical record data collected from Dr. H. Chasan Boesoirie General Hospital in Ternate. The findings indicated that the majority of patients with type 2 diabetes were aged 45 years or older (80%) and were predominantly female (60%). In terms of lipid profiles, most patients exhibited normal total cholesterol levels (82.2%) and normal triglyceride levels (51.1%). Despite these normal lipid values, a significant portion of the patients (53.3%) were identified as being at risk of developing diabetic foot ulcers. These results suggest that while dyslipidemia is commonly implicated in the development of diabetic foot complications, normal lipid levels do not necessarily eliminate the risk. The study concludes that the typical profile of type 2 DM patients includes those aged ≥ 45 years, females, and individuals with normal cholesterol and triglyceride levels who are still susceptible to diabetic foot ulcers. This highlights the multifactorial nature of diabetic foot ulcer development and underscores the importance of comprehensive risk assessments beyond lipid profile evaluation alone in diabetic patient care.

This study was conducted to evaluate the impact of adding binahong flour in concentrate on the blood biochemical parameters of fat-tailed sheep. The study used a Completely Randomized Design with 16 experimental units divided into 4 treatments and 4 replications. The treatments given were: R0 (control feed), R1 (10% binahong flour), R2 (20%), and R3 (30%). The average results of blood plasma glucose analysis (mg/dl): R0 83.08±4.85, R1 85.62±,4.47 R2 88.46±1.69, R3 88.92±2.26. For Blood Plasma urea (mg/dl) R0 43.55±2.96, R1 46.69±1.28, R2 46.87±3.35, R3 47.36±3.10. Meanwhile, for blood cholesterol (mg/dl) R0 200.50±2.13, R1 192.18±17.44, R2 190.51±19.68, R3 190.43±2.36. The results of statistical tests showed that the treatment had a very significant impact (P<0.01) on blood glucose, blood plasma urea and blood cholesterol in sheep. The conclusion is that the use of binahong flour up to 30% in the concentrate has the potential to increase glucose levels, blood plasma urea, and reduce cholesterol levels in fat-tailed sheep.

Dyslipidemia is a major public health risk factor for cardiovascular disease. This condition is characterized by abnormal blood lipid levels, including LDL cholesterol, HDL cholesterol, and triglycerides. Hypercholesterolemia is often asymptomatic, resulting in many undiagnosed cases until cardiovascular complications occur. The rising prevalence of dyslipidemia, especially in low- and middle-income countries, underscores the importance of screening and prevention to reduce the risk of long-term complications. This community service activity involved 49 adult participants in Danau Sunter, North Jakarta, with cholesterol and HDL level screening conducted through blood tests by trained health workers. The results showed that 29 participants (59.18%) had abnormal cholesterol levels, and 22 participants (44.9%) had low to very low HDL levels. Adopting a healthy lifestyle, including a balanced diet, increased physical activity, and controlling other risk factors such as smoking and alcohol consumption, can help lower cholesterol levels. Routine cholesterol screening is highly effective for early detection of dyslipidemia risk, enabling timely preventive interventions to reduce cardiovascular morbidity and mortality.

Hyperlipidemia is a condition in which lipid levels in the bloodstream (plasma) experience an imbalance in lipid levels, although it does not show severe symptoms but can trigger various serious diseases. Statins are used as the main therapy for antidyslipidemia, but with long-term use, statins cause various side effects such as muscle pain, muscle disorders and muscle discomfort. Indonesia has a variety of plants that have benefits for lowering blood cholesterol levels. To determine the potential of metabolite compounds contained in several plants as HMG-COA Reductase inhibitors, research can be carried out using molecular docking. The purpose of this literature study is to determine the comparison of compounds that have HMG-COA Reductase inhibitor inhibitor activity. The method used in compiling this literature study is from various national and international scientific articles published in the period 2020-2025. The natural compounds that have been studied have significant inhibitory activity against the HMG-CoA Reductase enzyme, namely from the 10 plants studied, Rhodomyrtus tomentosa has the best activity in inhibiting the HMG-CoA Reductase enzyme with an Affinity of the Binding value of -11.4 so that it has the potential to be further developed as a natural anti-cholesterol drug.

Imbalance of body lipid levels, especially total cholesterol and HDL, is a major risk factor for cardiovascular disorders. A simple lipid profile examination can be used to detect potential atherogenic dyslipidemia that has not shown clinical symptoms. Total cholesterol and HDL levels were examined in 104 participants using the Point-of-Care Testing (POCT) technique. Education was provided individually using leaflets, which contained information on the effects of saturated fat and trans fat consumption, and the importance of unsaturated fat and fiber intake on lipid profiles. Most participants had total cholesterol levels within normal limits. However, more than half of the population showed low to very low HDL levels, indicating hidden metabolic risks. Dietary education was provided in a targeted manner according to the results of each participant's examination. Total cholesterol and HDL examinations were used to assess the risk of lipid disorders early on. Nutrition education based on examination results is useful in raising awareness of the importance of regulating diet to reduce the risk of atherosclerosis and cardiovascular complications.