Literature Review: Potensi Senyawa Bahan Alam sebagai Inhibitor HMG-CoA Reduktase untuk Terapi Kolesterol

Khansa Aliifah ; Hilma Marisa ; Indah Lestari ; Jelita Septiani ; Jihan Al Ihsani ; Muhamad Iqbal Rhamadianto
Jurnal Riset Rumpun Ilmu Kesehatan 📅 2025 Vol 4, No 2 🔗 DOI: 10.55606/jurrikes.v4i2.5991
Abstract
Hyperlipidemia is a condition in which lipid levels in the bloodstream (plasma) experience an imbalance in lipid levels, although it does not show severe symptoms but can trigger various serious diseases. Statins are used as the main therapy for antidyslipidemia, but with long-term use, statins cause various side effects such as muscle pain, muscle disorders and muscle discomfort. Indonesia has a variety of plants that have benefits for lowering blood cholesterol levels. To determine the potential of metabolite compounds contained in several plants as HMG-COA Reductase inhibitors, research can be carried out using molecular docking. The purpose of this literature study is to determine the comparison of compounds that have HMG-COA Reductase inhibitor inhibitor activity. The method used in compiling this literature study is from various national and international scientific articles published in the period 2020-2025. The natural compounds that have been studied have significant inhibitory activity against the HMG-CoA Reductase enzyme, namely from the 10 plants studied, Rhodomyrtus tomentosa has the best activity in inhibiting the HMG-CoA Reductase enzyme with an Affinity of the Binding value of -11.4 so that it has the potential to be further developed as a natural anti-cholesterol drug.
Keywords
Natural Products; HMG-COA Reductase; In Silico; Hyperlipidemia
How to Cite

Khansa Aliifah, et al. (2025). Literature Review: Potensi Senyawa Bahan Alam sebagai Inhibitor HMG-CoA Reduktase untuk Terapi Kolesterol. Jurnal Riset Rumpun Ilmu Kesehatan, 4(2). https://doi.org/10.55606/jurrikes.v4i2.5991

Khansa Aliifah; Hilma Marisa; Indah Lestari; Jelita Septiani; Jihan Al Ihsani; Muhamad Iqbal Rhamadianto, "Literature Review: Potensi Senyawa Bahan Alam sebagai Inhibitor HMG-CoA Reduktase untuk Terapi Kolesterol," Jurnal Riset Rumpun Ilmu Kesehatan, vol. 4, no. 2, 2025.

Khansa Aliifah; Hilma Marisa; Indah Lestari; Jelita Septiani; Jihan Al Ihsani; Muhamad Iqbal Rhamadianto. "Literature Review: Potensi Senyawa Bahan Alam sebagai Inhibitor HMG-CoA Reduktase untuk Terapi Kolesterol." Jurnal Riset Rumpun Ilmu Kesehatan, vol. 4, no. 2, 2025.

Khansa Aliifah; Hilma Marisa; Indah Lestari; Jelita Septiani; Jihan Al Ihsani; Muhamad Iqbal Rhamadianto. "Literature Review: Potensi Senyawa Bahan Alam sebagai Inhibitor HMG-CoA Reduktase untuk Terapi Kolesterol." Jurnal Riset Rumpun Ilmu Kesehatan 4, no. 2 (2025).

Khansa Aliifah, et al. (2025) 'Literature Review: Potensi Senyawa Bahan Alam sebagai Inhibitor HMG-CoA Reduktase untuk Terapi Kolesterol', Jurnal Riset Rumpun Ilmu Kesehatan, 4(2). doi: 10.55606/jurrikes.v4i2.5991.

Khansa Aliifah; Hilma Marisa; Indah Lestari; Jelita Septiani; Jihan Al Ihsani; Muhamad Iqbal Rhamadianto. Literature Review: Potensi Senyawa Bahan Alam sebagai Inhibitor HMG-CoA Reduktase untuk Terapi Kolesterol. Jurnal Riset Rumpun Ilmu Kesehatan. 2025;4(2).

Artikel Terkait

Inovasi Zea Coffee Tab Berbasis Robusta dan Rambut Jagung sebagai Minuman Fungsional untuk Remaja Overweight

Intan Afita Khoirun Nisa; Efina Amanda; Mulya Agustina

Tinjauan Kimia Medisinal: Hubungan Struktur-Aktivitas Senyawa Bahan Alam sebagai Kandidat Antikanker Payudara

Saeful Amin; Icha Aisah Azzahra; Natasya Zakiatul Awalia Irhan; Syifa Alifia Azzahra

The Combined Role of Immunotherapy and Radiotherapy in Muscle-Invasive Bladder Cancer: A Systematic Review

Aristya Ika Wardani

Hubungan Self-Compassion dengan Self-Objectification pada Mahasiswi Pengguna Tiktok di Kota Jambi

Salsabila Raina Fazra; Rion Nofrianda; Ayu Ulivia; Nurul Hafizah

Invisible Threat: Kajian Literatur tentang Paparan Mikroplastik dan Implikasinya terhadap Kesehatan Manusia

Rabiatul Adawiyah; Rizky Alviansyah; Khusnun Nadiah; Muhammad Yunus; Dianna Ratnawati

Hubungan antara Pengaruh Teman Sebaya, Kebiasaan Makan di Luar (Eating Out), dan Pola Konsumsi Fast Food dengan Status Gizi Lebih Remaja di SMAN 1 Surabaya

Janice Fiona Putri; Dini Ririn Andrias
Tren Sitasi Jurnal