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Wounds are damage to body tissues caused by various factors, both external and internal, which can disrupt the normal function of these tissues. Many studies have focused on using natural ingredients as adjunctive therapy to accelerate wound healing. One plant that shows therapeutic potential is Garcinia mangostana L. This study aims to assess the therapeutic potential of Garcinia mangostana L. stem bark and fruit peel extracts in accelerating the healing of mice (Mus musculus) incision wounds. The study used a completely randomized design (CRD) with six treatments and three replicates, namely negative control mice (K-), positive control (K+), groups of mice given fruit peel and stem bark extracts of G. mangostana concentrations of 25, 50, 75 and 100%. All mice were cut with a wound diameter of 1 cm. The wounds were then left for 13 days with an interval of 3 days for measurement. The results showed that the administration of G. mangostana fruit peel and stem bark extracts had an effect in accelerating the healing of mice incision wounds. From these results, Garcinia mangostana L. has the potential as an additional therapy in accelerating wound healing in mice, which can be used as a basis for further research related to its application in humans.

Inflammation is a response to tissue damage due to various adverse stimuli, both chemical and mechanical stimuli and infections. One of the chemical compounds found in henna leaves is flavonoids that are efficacious as anti-inflammatory. The aim of the study was to determine the anti-inflammatory effectiveness of water henna leaf extract reviewed from a decrease in udem volume in the soles of the feet of male white rats induced by carrageenan 1%. The research method used was experimental on simplicia and ethanol extract of henna leaf (EEDPA) as well as testing the anti-inflammatory effectiveness of EEDPA. Testing of the anti-inflammatory effect was carried out on 30 male white mice induced with 1% carrageenan subplantarly. The test animal group was divided into five groups consisting of a positive group given Na-diclofenac, a negative control group given CMC, and a test group of water henna leaf ethanol extract at doses of 200 mg/kgBB, 400 mg/kgBB and 800 mg/kgBB. The parameters observed in this study were the volume of the leg udem of the test animal which was measured with a Plethysmometer every 6 hours. The data obtained was then calculated as the percent of inflammation and the percent of inflammation inhibition. Analyzed with One Way ANOVA with a 95% confidence rate. The results of the effectiveness test showed that EEDPA had an anti-inflammatory effect in carrageenan-induced male white rats. Optimal effectiveness indicated by the dose showed that EEDPA at a dose of 800 mg/kgBB

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia due to insulin deficiency or insulin resistance. Currently available pharmacological treatments often cause unwanted side effects, so alternative therapies that are safer and more effective are needed. This study aims to analyze the effectiveness of telang flower extract in reducing blood glucose levels and preventing complications. The potential of Clitoria ternatea as an antidiabetic agent was explored through a systematic literature review, using scientific databases such as Google Scholar, ScienceDirect, and Mendeley with the keywords “Clitoria ternatea AND diabetes AND blood glucose.” Inclusion criteria applied included experimental studies conducted on diabetes-induced mice samples, interventions with telang flower extract administration, and publications within the last 5 years (2021-2025). From a total of 1,858 articles identified, by applying the PRISMA-ScR method, 8 articles were obtained that met the inclusion criteria. The analysis showed that telang flower extract was effective in reducing blood glucose levels. This antidiabetic effect is thought to be due to the presence of flavonoids and other bioactive compounds in telang flowers that act as α-amylase enzyme inhibitors, antioxidants, and anti-inflammatories. These findings indicate the potential of Clitoria ternatea as a promising therapeutic alternative in the management of diabetes mellitus.

Indonesia, considered the country with the second-highest level of biodiversity in the world after Brazil, possesses extraordinary biological wealth that remains underutilized. The field of traditional medicine utilizes natural resources to prevent and treat physical and mental disorders. Periwinkle, or Catharanthus roseus, is one of the most widely used plants due to its abundance of bioactive phytochemicals, such as alkaloids, flavonoids, saponins, and tannins. The ethanol extract from Periwinkle leaves has the potential to act as a natural antipyretic agent that can reduce body temperature during fever. The purpose of this study is to review and analyze previous research findings on the antipyretic effects of ethanol extract from Periwinkle leaves on mice (Mus musculus). According to a literature review from various sources, the ethanol extract of Periwinkle leaves demonstrates a comparable level of effectiveness to synthetic antipyretic drugs in lowering the body temperature of fever-induced mice. Furthermore, the content of active compounds and the antipyretic performance of this plant are influenced by its variety and environmental factors. Body temperature begins to decrease one hour after extract administration and reaches its peak reduction at the third hour. Therefore, Periwinkle may serve as an alternative natural antipyretic remedy. However, further research is necessary to standardize its usage and conduct clinical trials on humans.

This study aims to analyze the forms and structure of social stratification portrayed in the animated film Zootopia, produced by Walt Disney Pictures. The film was chosen because it represents societal structures with various social layers through animal characters that reflect human social realities. The type of research used is descriptive qualitative research, with data collection techniques involving observation and note-taking of scenes, dialogues, and narratives that illustrate social class divisions in the film. The study was conducted objectively without comparing it to the real-life society where the film was produced. The theoretical framework used in this study is based on Sorokin's theory, which divides society into three social classes: upper class, middle class, and lower class. Additionally, Soekanto's theory is applied, which classifies social stratification into closed, open, and mixed classes.The results of the study show that Zootopia presents a clear picture of social stratification. The upper class is represented by predators, such as lions and wolves, who hold power and have influential roles in the government. The middle class is symbolized by wealthy mice involved in mafia activities. The lower class consists of herbivores, who are perceived as weak, often discriminated against, and have limited access to power and resources. The film also illustrates an open class system, where certain characters from the lower class—such as Judy Hopps—are able to transcend social boundaries and achieve higher status through effort and merit.

Pain is the body's response to tissue damage that is often addressed using analgesic compounds. Purslane plants (Portulaca oleracea L) are known to contain flavonoids, saponins, tannins, and alkaloids that have potential as analgesics. This study aims to test the analgesic effectiveness of purslane ethanol extract by writhing test method using white mice (Mus musculus) induced by 1% acetic acid. A total of 15 mice were divided into 5 treatment groups, namely negative control, positive control (paracetamol), and three groups with doses of purslane extract 200 mg/kgBB, 400 mg/kgBB, and 800 mg/kgBB. The number of writhes was observed every 15 minutes for 1 hour, and the percentage of protective power was calculated. The results showed that the dose of 800 mg/kgBB gave the highest analgesic effect with a percent protection power of 65.28%, followed by doses of 400 mg/kgBB (52.4%) and 200 mg/kgBB (30.6%). The highest analgesic effect was achieved at a dose of 800 mg/kgBB, almost equivalent to the positive control. This shows the significant potential of purslane ethanol extract as an analgesic agent.

This quantitative study uses SmartPLS3 to analyze the main issues related to the impact of the COVID-19 pandemic on MICE (Meeting, Incentive, Convention, and Exhibition) business actors, as well as the role of the hybrid model in maintaining the sustainability of MICE activities in Indonesia. This study focuses on five representative cities that are the main targets of MICE activities according to the government's strategic plan, namely Jakarta, Bogor, Bali, Yogyakarta, and Malang. The COVID-19 pandemic that has hit various countries, including Indonesia, for more than a year, has brought major challenges. The tourism and MICE sectors are among the most affected, with many business actors forced to stop their operations and switch to alternative sectors such as culinary, agriculture, and plantations as a means of survival. However, the emergence of the hybrid model has become an important solution for the MICE sector. Some alternative solutions adopted during the pandemic include organizing virtual MICE events, virtual tourism, webinars, and meetings through platforms such as Google Meet and Zoom. Teleconferencing has also become an important tool to maintain engagement. These adaptations highlight the increasing reliance on advanced technology to ensure the sustainability of the MICE industry. The implementation of these activities requires high creativity and quality in order to run well. This change emphasizes the importance of continuous innovation and utilization of technology by MICE industry players to navigate the ever-evolving landscape.

The study entitled “Cream Formulation of Methanol Extract of Tapak Kuda (Ipomoea pes-caprae (L.) R. Br.) Leaves) As an anti-inflammatory in male white mice (Mus musculus)” using laboratory experimental methods with posttest control group design, data analysis using SPSS 25.0 with One Way ANOVA test and Duncan test. The percentage of extract yield obtained was 3.12%, phytochemical screening test showed the presence of secondary metabolite compounds alkaloids, terpenoids, flavonoids, saponins, tannins and steroids. Cream preparation of methanol extract of Tapak Kuda leaves at concentrations of 2.5%, 5% and 10% showed anti-inflammatory activity and the maximum dose to reduce edema diameter was 10% concentration with a percentage inhibition of 87.97%. Data analysis with One Way ANOVA test with a significance value ≤ 0.05 which indicates the presence of anti-inflammatory activity in Ipomoea pes-caprae tread leaf methanol extract cream.

Arumanis mango rind is an organic waste that contains secondary metabolites such as flavonoids. Many flavonoids are found in the rind of the arumanis mango, which acts as a very strong antioxidant and has the potential to heal wounds, including infected wounds. This study aims to determine the effect of arumanis mango (Mangifera indica L.) rind extract ointment on healing infected wounds caused by Pseudomonas aeruginosa bacteria, determine the effective concentration for healing infected wounds, and the histopathological decripstions. This research was an experimental study using male white rats which were divided into 5 groups, namely group I (control), group II (Gentamicin), group III (5% concentration), group IV (10% concentration) and group V (15% concentration). The parameters observed were the percentage of healing of infected wounds, epithelialization time, and histopathology. Then the data were analyzed using the ANOVA test followed by Duncan's further test.The results of the study were based on the group order above, from the parameters the average percentage of infected wound healing on 3rd day  was 29.73%; 48.84%; 45.95%; 42.81%; 42.33%, on 7th day it was 70.96%; 85.79%; 83.25%; 76.95%; 73.87%, and on the 14th day it was 89.89%; 93.32%; 93.87%; 92.67%; 91.48%. Epithecization time is 9; 6; 7; 8; 9 (day), for histopathology of fibroblast cells with a score of 1; 3; 3; 2; 2; for collagen fibers 1; 3; 3; 3; 3; for re-epithelialization 2; 3; 2; 2; 2; for inflammatory cells 0; 3; 2; 2; 2. The conclusion of the research is that arumanis mango peel extract ointment (Mangifera indica L.) has an influence on the healing process of wounds infected by Pseudomonas aeruginosa bacteria in male white mice, the most effective concentration and the best histopathological descriptions at a concentration of 5%.  

Bacterial growth is one processes carried out through binary fission for its reproduction process. Bad bacteria in their growth process must course be inhibited in several ways, one which is through the consumption several herbal or traditional plants, such as torch ginger and kalanduyung extracts. The dangers cigarette smoke can reduce the health individuals. Cigarette smoke can have an impact on reducing the number of spermatozoa caused by decrease in the diameter seminiferous tubules for 45 days. The purpose writing journal is to analyze antibacterial activity of torch ginger and kalanduyung extracts on bacterial growth and the effect of cigarettes on the quality male mouse sperm. The writing method uses qualitative type. The results and conclusions that bacterial growth can be inhibited by consuming several traditional plants such as torch ginger extract and kalanduyung leaf extract. In inhibiting growth of antibacterial activity, torch ginger extract has quite good effectiveness with concentration value 20%. The value inhibition zone formed is 17.22. The use largest concentration, namely 80%, has an effective inhibition of bacterial growth which is known to have an average inhibition zone value of 14.9 mm. Furthermore, the quality male mouse sperm does not have specific effect on the provision control treatment related to provision amount of cigarette smoke.

Clove leaves have the property of overcoming hair growth problems, where the eugenol compound contained in clove leaves is efficacious as a hair growth agent. This research was conducted to formulate a clove leaf extract shampoo preparation. The research method used was the experimental method. Tests were carried out on experimental animals, namely male white mice in various groups. The first group (without treatment), the second group (negative control), the third group (5% clove leaf extract shampoo), the fourth group (10% clove leaf ethanol extract shampoo), the fifth group (15% clove leaf ethanol extract shampoo) and groups sixth (positive control). The shampoo preparations were tested and evaluated, the results of the preparation evaluation test showed that the four shampoo preparations were homogeneous and had a pH ranging from 5.1-5.7, with a viscosity of 1700-3000 cps and a foam height of 9-11 cm. This shampoo preparation also does not irritate the skin. The results of the data analysis obtained showed that all data were normally distributed (p> 0.005) and homogeneous (p> 0.005). The results of the one way ANOVA test show that F1 (5% formula), F2 (10% formula) and F3 (15% formula) have significant differences. This research shows that clove leaf ethanol extract shampoo with a concentration of 15% is the most effective formulation in hair growth in male white rats. However, the ethanol extract of clove leaves shampoo is less effective than minoxidil 5% for hair growth.

Human nature, social life, requires humans to socialize with and interact with other humans for survival. There are the five important elements of socialization: social, cultural, social institutions, social stratification or the final grouping of society: power and authority. The study was done to identify social differences and factors that contributed to social differences. The study used qualitative descriptive methods with an objective approach to literature. Well-illustrated social differences in the background of both mice (country mouse) and (city mouse), they had conflicting backgrounds. The cause of these differences is that they live in different neighborhoods.    

Human nature, social life, requires humans to socialize with and interact with other humans for survival. There are the five important elements of socialization: social, cultural, social institutions, social stratification or the final grouping of society: power and authority. The study was done to identify social differences and factors that contributed to social differences. The study used qualitative descriptive methods with an objective approach to literature. Well-illustrated social differences in the background of both mice (country mouse) and (city mouse), they had conflicting backgrounds. The cause of these differences is that they live in different neighborhoods.    

Analgesics are compounds that in therapeutic doses relieve or suppress pain, without having general anesthetic action. Traditionally, the herb bamboo grass (Lophatherum gracile Brongn.) has been used and proven empirically to reduce pain, so it may have an analgesic effect. This can be caused by the content of secondary metabolite compounds, flavonoids, tannins, alkaloids, steroids/triterpenoids, saponins and glycosides, but this has not been scientifically proven. This research aims to determine the secondary metabolite compounds contained in fresh bamboo grass herbs, simplicia and dekokta and the effectiveness as an analgesic of the bamboo grass herb dekokta in mice.This research was carried out experimentally, including making simplicia and decoction, phytochemical screening and analgesic effectiveness testing. bamboo grass herb dekokta in male mice induced with 0.5% acetic acid intraperitoneally under the stomach, orally administered bamboo grass herb dekokta at a dose of 100 mg/kgBW, 200 mg/kgBW, 300 mg/kgBW, CMC 0.5% (blank), methampirone 65 mg/kgBB. Count the number of animal movements every 5 minutes for 1 hour. From the number of writhes obtained, the percentage of analgesic power and analgesic effectiveness were calculated. Next, the data obtained was analyzed statistically using SPSS ver.20 One Way ANOVA followed by the Tukey test. The results of the phytochemical screening of fresh bamboo grass, simplicia and dekokta contain alkaloids, flavonoids, tannins, saponins, steroids and glycosides. The greater the dose of bamboo grass herb dekokta given, the greater the percentage of reduction in writhing, so that the analgesic power and analgesic effectiveness are greater. . The results of the One Way ANOVA test and the Tukey test showed that the dose of 300 mg/kgBB had the best analgesic power at 50 minutes, not significantly different from administering 65 mg/kgBB of methampirone.

Wounds are a condition where the integrity of the skin is disrupted, often requiring a fast and accurate healing process to prevent infection. Bitter melon (Momordica charantia L) is known to have chemical components that potentially accelerate the wound healing process. This study aims to test the effectiveness of bitter melon extract in accelerating wound healing in mice (Mus musculus). The research method used is an experimental method with a post-test only control group design. This study involved 30 mice divided into five treatment groups: negative control, positive control, and three treatment groups with different concentrations of bitter melon extract. The results showed that bitter melon extract could accelerate wound healing in mice, indicated by a significant decrease in wound length in the treatment groups compared to the control groups. Therefore, bitter melon extract has the potential to be used as an alternative treatment to accelerate the wound healing process.

Dyandra Promosindo is a subsidiary of PT Digital Inisiatif, part of Kompas Gramedia, operating in the MICE (Meetings, Incentives, Conference, and Exhibitions) sector. The event organizer is responsible for determining the theme and overall concept of the event, which serves as the foundation for all event-related aspects. This study aims to understand the role of Dyandra Promosindo Surabaya as an event organizer in organizing an event, namely the Indonesia International Motor Show (IIMS) 2024 in Surabaya. The findings show that Dyandra Promosindo plays a crucial role in promoting products or company brands through various types of events such as expos or exhibitions. The implications of this study highlight the importance of the role of event organizers in the success of events and the satisfaction of all involved parties.

Background: Burns with diabetes mellitus conditions can interfere with the wound healing process. Mesenchymal stem cells have been studied to heal burns, one of which originates from the bone marrow Objective: Determine the effect of human bone marrow mesenchymal stem cells on burn wound healing in the formation of granulation tissue DM rats. Methods: Research is experimental research with post-test only control group design. The research subjects were 30 rats divided into two groups, the control group was given NaCl and the treatment group was given hBM-MSCs. Mice were induced by alloxan to cause hyperglycemia, burns were made using a heated plate. Tissue collection was carried out after termination of the experimental animals on the 3rd, 7th, 14th days and then made histological preparations to assess the formation of granulation tissue. Data were analyzed using Two Way Anova Test. Results: Increase in the number of macrophages, fibroblasts and new blood vessels after hBM-MSCs were given. There were no increase on the 14th day neutrophils and 3rd day lymphocytes. Statistical analysis showed a significant increase in the number of lymphocytes, macrophages, fibroblasts and new blood vessels. Conclusion: The is study concludes that human bone marrow mesenchymal stem cells can increase the formation of granulation tissue by increasing macrophages, fibroblasts and new blood vessels in DM rats.

Advertising is a crucial element in marketing strategies aimed at attracting consumer attention and influencing purchasing decisions. The rapid development of Indonesia's advertising industry, driven by increasing media consumption, has brought about ethical and regulatory challenges. This study examines the ethical violations in the Garnier Micellar Water television advertisement in 2023, which claimed to be the "No 1 Micellar Water in Indonesia" without sufficient evidence, violating the Indonesian Advertising Code of Ethics (EPI). Using a qualitative descriptive method, the research analyzes the content of the advertisement and interviews with advertising experts. Findings reveal that the claim was misleading, lacking valid data support, and driven by commercial pressures and insufficient ethical awareness. Recommendations include stricter enforcement of advertising ethics, enhanced awareness programs, and collaborative efforts among advertising industry stakeholders to uphold honesty and responsibility in advertising practices.

Introduction: Banana peel is an organic waste which is known to have various benefits, especially as an antidepressant for mental health. It inspired to conduct a research on various type of banana peels in Indonesia, particularly on Kepok banana which has been widely studied. This research aimed to prove the effect of Kepok banana peel extract (Musa paradisiaca L.) as an antidepressant in mice (Mus musculus) with acute restraint stress.Method: This research used a laboratory experimental design. The male mice were acclimatized for 3 days. Twenty-four mice were then divided evenly into 4 groups. The first group was given banana peel extract (Musa paradisiaca L.) at a dose of 200 mg / kgBW, the second group was given a dose of 400 mg / kgBB, the third group was given a dose of 800 mg / kgBW and the fourth group was given water as control. Each group was given a dose orally for 14 days and ARS depressed induction for 7 hours. Subsequently, mice were treated to assess depression behavior using the tail suspension test (TST) and forced-swim test (FST) to determine the duration of immobility.Result: The result showed that there was a significant difference (p<0.01) between the control group and the experimental group, at TST there was a significant difference (p<0.01) between two doses of 400 mg / kgBW and 800 mg / kgBW, as well as on the forced-swim test (FST). In addition, there was a significant difference (p<0.01) between two doses of 200 mg / kgBW and 800 mg / kgBW, and between two doses of 400 mg / kgBW and 800 mg / kgBW. Conclusion: These result confirmed that Kepok banana peel extract (Musa paradisiaca L.) was an effective antidepressant in reducing immobility duration with acute restraint stress.

Chinese Betel Plant (Paperomia pellucida) is an herbal plant that has benefits for treating diseases such as acne, ulcers, antidiabetic, antioxidant, anti-inflammatory, antimicrobial, and antibacterial. The content of bioactive compounds from Chinese betel include alkaloids, flavonoids, steroids, saponins, tannins, triterpenoids, and carbohydrates. The aim The purpose of this study was to determine the effect of steeping Chinese betel and  on reducing blood glucose levels in male mice. This method used is an experimental method at the Pharmacology Laboratory D3 Pharmacy FMIPA Bengkulu University. The test animals used were three groups, namely the positive control treatment group that received glibenclamide, the negative control treatment group received aquadest, and the 2% Chinese betel steeping treatment group. The results showed that Chinese betel curd was reduced from 125 mg/dl to 93 mg/dl and there was no hypoglycemic decrease in blood glucose due to glibenclamide. From the results of the study it can be concluded that the administration of Chinese betel and glibenclamide steeping is effective in lowering blood glucose levels in male mice.