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The inventory of medicinal plants involves collecting and organizing data regarding natural resources for resource management planning and serving as a database to reveal the potential of plants in a given area. This study aims to inventory the types of medicinal plants found in the home gardens of the residents of Negeri Latu, Amalatu District, West Seram Regency. The data collection methods employed were exploration and descriptive surveys. The gathered data was subsequently analyzed to identify the benefits or uses of the plants based on relevant literature. The results indicate that 57 species of medicinal plants were found in the home gardens of the residents of Negeri Latu. These plants possess various properties, including antidiabetic, antimalarial, anti-inflammatory, antioxidant, anticholesterol, anticancer, antidysentery, analgesic, antipyretic, and mosquito-repellent effects. This finding highlights the significant potential of home gardens in Negeri Latu as a rich natural resource of medicinal plants. The diversity of plant species reflects the local traditional knowledge of utilizing flora as a natural solution to various health issues.

Diabetes mellitus is a condition of elevated blood glucose levels due to impaired insulin secretion, insulin resistance, or both. This disease can lead to various serious complications that impact quality of life if not properly managed. Current diabetes management generally involves dietary modification, physical activity, and antidiabetic drug therapy. However, recent research has revealed the potential of bioactive compounds from natural sources such as curcumin in minimizing the risk of diabetes-related complications. This literature review examines and analyzes research evidence on the effects of curcumin supplementation on health parameters in patients with diabetes mellitus. The review was conducted on English-language publications in the last 10 years (2014-2024) using electronic databases. The reviewed experimental and cohort studies demonstrate the influence and beneficial effects of curcumin on glycemic control, lipid profile, weight reduction, and kidney function protection in diabetic patients. Curcumin has the potential to contribute to reducing oxidative stress and inflammation as the main triggering factors for complications of diabetes mellitus.

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia due to insulin deficiency or insulin resistance. Currently available pharmacological treatments often cause unwanted side effects, so alternative therapies that are safer and more effective are needed. This study aims to analyze the effectiveness of telang flower extract in reducing blood glucose levels and preventing complications. The potential of Clitoria ternatea as an antidiabetic agent was explored through a systematic literature review, using scientific databases such as Google Scholar, ScienceDirect, and Mendeley with the keywords “Clitoria ternatea AND diabetes AND blood glucose.” Inclusion criteria applied included experimental studies conducted on diabetes-induced mice samples, interventions with telang flower extract administration, and publications within the last 5 years (2021-2025). From a total of 1,858 articles identified, by applying the PRISMA-ScR method, 8 articles were obtained that met the inclusion criteria. The analysis showed that telang flower extract was effective in reducing blood glucose levels. This antidiabetic effect is thought to be due to the presence of flavonoids and other bioactive compounds in telang flowers that act as α-amylase enzyme inhibitors, antioxidants, and anti-inflammatories. These findings indicate the potential of Clitoria ternatea as a promising therapeutic alternative in the management of diabetes mellitus.

Background: Diabetes mellitus type 2  is a chronic metabolic disorder characterized by persistent hyperglycemia and endocrine dysfunction, including disturbances in luteinizing hormone, testosterone, and insulin levels. Moringa pterygosperma, known for its antidiabetic, antioxidant, and anti-inflammatory properties, has been explored for its therapeutic potential in mitigating diabetes-induced complications.Objective: The present study aimed to estimate the effects of Moringa pterygosperma extraction on endocrine and metabolic parameters against the diabetic rats induced by alloxan, by the mensurate the on LH, testosterone, glucose, and insulin levels.Methods: Forty adult male albino Wistar rats were used in the present study which was divided into four equal groups: Control, Negative Control, Treatment one which used 100 mg/kg extract, and Treatment two which used 200 mg/kg extract). Diabetes was induced with alloxan monohydrate (100 mg/kg). After 41 days, serum samples were analyzed for testosterone, LH, glucose, and insulin concentrations. Results: The NC group showed significant reductions in testosterone (0.0926 ± 0.0081 ng/mL) and insulin (0.560 ± 0.09274 µIU/mL) levels, with increased luteinizing hormone (0.592 ± 0.03 ng/mL) and glucose (464.6 ± 18.71 mg/dL) concentrations, indicating severe endocrine and metabolic disruptions. Treatment with Moringa pterygosperma extract significantly improved these parameters in a dose-dependent manner. The T2 group exhibited near-normal levels of testosterone (0.1769 ± 0.01 ng/mL), insulin (2.140 ± 0.1435 µIU/mL), LH (0.3163 ± 0.063 ng/mL), and glucose (105.8 ± 9.34 mg/dL).

Takokak fruit is one of the plants that can be used to lower blood sugar levels. This study aims to identify the bioactive compounds of ethanol extract of takokak fruit and test the antidiabetic ethyl acetate fraction. Antidiabetic testing was carried out by in vivo testing using the Oral Glucose Tolerance Test (OGTT) method to see the decrease in blood glucose levels using white rats as test animals. The test results showed that takokak fruit contains flavonoids, steroids, and tannins. Fractionation is the process of extracting compounds from the extract using two types of solvents that do not mix with each other. The results of the antidiabetic test showed that the ethyl acetate fraction with glibenclamide as a comparator had the ability as an antidiabetic measured by the amount of difference in the decrease in blood glucose levels in the test animal group T₃₀ to T₁₂₀. From the results obtained, the average decrease in blood glucose levels in the negative control group (Na CMC) was 5.8 mg/dL, the positive control group (Glibenclamide) 21.03 mg/dL, and the fraction group 9.86 mg/dL. Takokak fruit has antidiabetic activity. Compounds that have antidiabetic activity are flavonoids, tannins, and steroids.

Takokak fruit contains bioactive compounds that can be used as antidiabetics. This study aims to identify bioactive compounds of ethanol extract of takokak fruit and antidiabetic test of n-Hexane fraction. The method used to obtain the extract is maceration using ethanol . Antidiabetic testing is carried out through in vivo testing with the Oral Glucose Tolerance Test (OGTT) method on white rats. Secondary metabolites are compounds contained in taakokak fruit that are identified as flavonoids, saponins, tannins, steroids and terpenoids . The results of the antidiabetic test showed that the n-Hexane fraction with glibencamide as a comparator has the ability as an antidiabetic in terms of the amount of difference in blood glucose levels in the test animal group from T 30 to T 120 . The average decrease in blood glucose levels in the negative control group (Na-CMC) was 108.67 mg/dL, the positive control group ( glibencamide ) 174.67 mg/dL, the 5% concentration fraction group 35.33 mg/dL, the 10% concentration fraction group 30.67 mg/dL, the 20% concentration fraction group 47.67 mg/dL.

The Garuga floribunda (Garuga floribunda Decne) plant is one of the species known for its various medicinal properties. This research aims to investigate the inhibitory activity of α- glucosidase and α-amylase enzymes and to determine the optimum concentration of the methanol extract of Garuga floribunda leaves as an antidiabetic agent. The leaves extraction is obtained through an extraction process using methanol as the solvent and tested for itsinhibitory activity against the α-glucosidase enzyme using the p-nitrophenyl-α-D- glucopyranoside (p-NPG) substrate and the α-amylase enzyme using the DNS (3,5- dinitrosalicylic acid) substrate. The method is UV-Vis spectrophotometry. The Phytochemical tests of this plant reveal the presence of flavonoids, alkaloids, saponins, tannins, steroids, and terpenoids. The inhibition test results show that the methanol extract of Garuga floribundaleaves exhibited significant inhibitory activity against both enzymes. The highest inhibition percentage against the α-glucosidase enzyme is 91.09%, indicating very high antidiabetic activity. Meanwhile, the inhibition against the α-amylase enzyme is 7.56%, showing no significant antidiabetic activity. The optimum concentration for inhibiting both enzymes is 1000 ppm.

Health is a condition where the body system and organs in the body can carry out their respective functions. However, in some cases that occur in Indonesian society, health problems have begun to appear, such as diabetes, malaria, and so on. According to the analysis, the incidence of diabetes continues to increase every year. Furthermore, the plant extract that is used as a source of antioxidants is bamboo shoots. The incidence of malaria resistance has reached >25% so that several drugs such as chloroquine are no longer used as the main drug in cases of malaria. The purpose of writing is to analyze the results of a review of the pharmacological potential of plant extracts that are effective as antidiabetic, antioxidant, and antimalarial supplements. The writing method used in writing this journal is to use a qualitative type. The results of the study are that bamboo leaf extract provides effectiveness as an antioxidant. Furthermore, antidiabetic can be found in the extract of the butterfly pea flower. Then the extract of the moon flower leaf has effectiveness as an antimalarial. The conclusion drawn is that the use of natural plant extracts can be used as antidiabetic, antioxidant, and antimalariall.

Diabetes mellitus (DM) is a global public health threat, and around 90% of all patients suffering from DM throughout the world are type 2 DM. Non-compliance related to Diabetes Mellitus is something that is a problem that should be avoided. This study aims to determine the level of patient compliance with the use of antidiabetic drugs at the Cidemp Indramayu Community Health Center, and to determine the relationship between the level of compliance of Diabetes Mellitus patients with blood glucose levels (fasting and while) at the Cidemp Indramayu Community Health Center. This research is a type of analytical observational research with a research design. cross-sectional. Data analysis in this study used SPSS version 23 software. The results showed that the majority of respondents fell into the "compliant" category, 20 respondents (62.5%) compared to "non-compliant" 12 respondents (37.5%). In addition, when checking blood glucose levels it was found that 62.5% of "compliant" patients had controlled fasting blood glucose levels, while only 28.1% of "compliant" patients had uncontrolled fasting blood glucose levels. Regarding the relationship between the level of absolute compliance with fasting blood glucose levels (P= 0.005), the results of compliance with glucose levels when controlled were (0.003). Keywords: diabetes mellitus, patient compliance, blood glucose levels.    

Longevity spinach leaf (Gynura procumbens (Lour) Merr.) is a traditional plant that contains various secondary metabolite compounds such as alkaloids, flavonoids, tannins and saponins, where flavonoids have various properties, including in the treatment of degenerative diseases such as diabetes mellitus. The purpose, of the research was to determine the effectiveness of the ethanol extract of Longevity spinach (Gynura procumbens (Lour) Merr.) leaf on reducing blood sugar levels in male white rats (rattus norvegicus) induced by alloxan. In this study, 5 test groups were used, namely negative control group, positive control group (metformin 9 mg), first dose 7.2 mg, second dose 14.4 mg, and third dose 21.6 mg. The rats were acclimatized and fasted before being given treatment, then their blood sugar was checked, before and after being induced by alloxan, then they were given treatment for 5 consecutive days and their blood sugar levels were checked once a day. The results of research from testing the ethanol extract of Longevity spinach leaf on male white rats proved effective in reducing blood sugar levels with the best dose, namely the 3rd dose (21.6 mg) on ​​the 6th day. 

Medicinal plants are plants that are used by the community to improve the ability to live a healthy life. This public belief that has been carried out from generation to generation has been scientifically proven. Rural communities generally plant various types of plants, both seasonal and perennials, in their yards, which are commonly referred to as living barns, living stalls and living pharmacies. This research was conducted in one of the house yards in Pataruman village, Cihampelas sub-district, Bandung Regency. By identifying medicinal plants based on their morphology and literature studies. The results of this research obtained 6 plant species, namely Katuk, Betel, Bandotan, Honje, Ki Edi, and Aloe Vera. The substances contained in these plants are very beneficial for health, such as flavonoids, alkaloids, tannins, vitamins A, B, C and others. These benefits include antidiabetic, anti-inflammatory, analgesic, antioxidant, and can increase breast milk production.   

Chinese Betel Plant (Paperomia pellucida) is an herbal plant that has benefits for treating diseases such as acne, ulcers, antidiabetic, antioxidant, anti-inflammatory, antimicrobial, and antibacterial. The content of bioactive compounds from Chinese betel include alkaloids, flavonoids, steroids, saponins, tannins, triterpenoids, and carbohydrates. The aim The purpose of this study was to determine the effect of steeping Chinese betel and  on reducing blood glucose levels in male mice. This method used is an experimental method at the Pharmacology Laboratory D3 Pharmacy FMIPA Bengkulu University. The test animals used were three groups, namely the positive control treatment group that received glibenclamide, the negative control treatment group received aquadest, and the 2% Chinese betel steeping treatment group. The results showed that Chinese betel curd was reduced from 125 mg/dl to 93 mg/dl and there was no hypoglycemic decrease in blood glucose due to glibenclamide. From the results of the study it can be concluded that the administration of Chinese betel and glibenclamide steeping is effective in lowering blood glucose levels in male mice.

Blood sugar levels, or blood glucose levels, are crucial for overall health and are regulated by the pancreas through insulin. Normal blood sugar levels range between 70-99 mg/dL when fasting and up to 140 mg/dL two hours after eating. Abnormal blood sugar levels can suggest a variety of health issues, including hypoglycemia (low blood sugar levels caused by excess insulin, certain drugs, or illnesses such as diabetes) and hyperglycemia (high blood sugar levels associated with diabetes). Regular blood sugar monitoring is necessary, especially for diabetics. Guava, a tropical fruit, includes a variety of phytochemicals that have been linked to pharmacological benefits such as antibacterial capabilities. This research uses an extraction process involving solid-liquid extraction or maceration, with methanol being the optimal solvent. The extract yields 9.51%. Wistar rats are used to investigate its antidiabetic efficacy. The rats are divided into three groups: positive control, negative control, and extract treatment. Diabetes is induced by subcutaneous injection of Alloxan, followed by oral administration of the methanol extract. Blood glucose levels are assessed after fasting for 6-8 hours. The extract from dried Guava leaf powder yields a concentrated extract with a 9.51% yield. In vivo assessments showed a significant reduction in blood glucose levels in rats treated with guava leaf extract, suggesting potential anti-hyperglycemic effects. The phenolic compounds in guava leaves contribute to antioxidant and anti-hyperglycemic effects. The study highlights the potential therapeutic effects of guava mint leaves and their extract components for diabetes management and antioxidant health benefits.

In previous research, mango rind extract has been studied as an antioxidant, antihypertensive, and antidiabetic, because it contains flavonoids and 17% mangiferin compounds. In this research, the effect of arumanis mango rind extract gel (Mangifera indica L.) as an anti-inflammatory was tested in male white mice induced by carrageenan using the granuloma pouch method. This experimental study used experimental white male mice which were grouped into 5 groups: the control group, the group with 2% mango rinf extract, the group with 4% mango rind extract, the group with 8% mango rind extract, and the comparison group. The parameters that were analyzed were exudate volume, total leukocytes, and type of leukocytes on days 3, 5, 7. The results showed that mango arumanis (Mangifera indica L.) rind extract had anti-inflammatory effectiveness topically as indicated by a decrease in the average exudate volume, total leukocytes, and leukocyte cell types (segmented neutrophil cells and lymphocyte cells) in each concentration group of mango rind extract, based on two-way ANOVA test and Duncan's test showed significant differences with respect to concentration and time (p<0.05). It can be concluded that all gel concentrations of arumanis mango rind extract (Mangifera indica L.) 2%, 4%, and 8% have anti-inflammatory effects.

Diabetes Mellitus is a group of chronic metabolic disorders due to abnormal metabolism of carbohydrates, fats, and proteins, characterized by hyperglycemia which is results in long-term microvascular, macrovascular and neuropathic complications. Oral antidiabetic therapy is the main pharmacological therapy to treat type II diabetes mellitus. This therapy can be oral antidiabetic therapy. Thus, to find out the effectiveness of either combination or single of antidiabetics on diabetes mellitus patients, researchers conducted a studies of inpatients at RSUD Madiun.             This study included as non-experimental observational study with a cross-sectional study design at RSUD Caruban. Data were collected from Medical Records in October 2018. The sampling method that used in this study was non probability with purposive sampling technique, so there are 58 patients as a total sample.             The results showed that the effectiveness of controlling blood sugar levels when using an effective single ADO was Metformin, because Metfomin was able to reduce blood sugar levels with an average length of stay of 6.17 and the effectiveness of controlling blood sugar levels when using an effective combination of ADO was Metformin and acarbosa, because Metfomin and acarbosa are able to reduce blood sugar  average length of stay 7 days inpatient.

Background: Diabetes mellitus (DM) is a degenerative disease caused by damage to the pancreas in production or insulin cannot work effectively. Purslane Leaf Extract (Portulaca Oleracea) can help lower blood sugar levels. The purpose of this study was to analyze the effect of purslane leaf extract (Portulaca Oleracea) on blood sugar levels in alloxan-induced rats as a diabetes model.Methods: The rats in this study were 30 rats divided into 5 groups, each group consisting of 6 rats. The negative control group was only given aquadest and standard rat feed, while the other group was induced with 35 mg/200gBW of alloxan. The positive group was treated with standard rat diet, treatment group 1 was given purslane leaf extract at a dose of 60 mg/200grBB, treatment group 2 was given purslane leaf extract at a dose of 90 mg/200grBB and treatment group 3 was given purslane leaf extract at a dose of 110 mg/200grBW rats. Analysis of the results used the Kruskall Wallis test followed by Post Hoc Mann Whitney analysis. Results: The results of the Kruskal Wallis test on blood sugar levels showed that there was an effect after administration of purslane leaf extract among the five treatment groups p= 0.000 (p<0.05). The results of the Mann Whitney test showed that purslane leaf extract had effective antidiabetic at a dose 60 mg/200grBB p= 0.011 (p<0.05).Conclusion: Based on the results of this study, it can be concluded that purslane leaf extract can reduce blood sugar levels.    

Indonesia has a variety of plants that have potential as medicinal ingredients. One of the plants that can be used as medicine for various diseases is the parijoto plant. Parijoto is a plant that belongs to the Melastomataceae family. Parijoto plants contain flavonoid compounds, saponins, tannins and terpenoids. The content of compounds contained in the parijoto plant has various pharmacological activities. This study aims to determine the pharmacological activity of the parijoto plant (Medinilla speciosa). The method used in this study is to use the literacy review method. Reference search is done by searching Google search, Google Scholar, PubMed according to the topic. Based on a review of several literatures, it is shown that the parijoto plant (Medinilla speciosa) has pharmacological activity as antibacterial, antibiofilm, antidiabetic, antifungal, antioxidant, anticholesterol, and cytotoxic.  

Diabetes Mellitus is a group of chronic metabolic disorders due to abnormal metabolism of carbohydrates, fats, and proteins, characterized by hyperglycemia which is results in long-term microvascular, macrovascular and neuropathic complications. Oral antidiabetic therapy is the main pharmacological therapy to treat type II diabetes mellitus. This therapy can be oral antidiabetic therapy. Thus, to find out the effectiveness of either combination or single of antidiabetics on diabetes mellitus patients, researchers conducted a studies of inpatients at RSUD Madiun. This study included as non-experimental observational study with a cross-sectional study design at RSUD Madiun. Data were collected from Medical Records in October 2018. The sampling method that used in this study was non probability with purposive sampling technique, so there are 58 patients as a total sample. The results showed that the effectiveness of controlling blood sugar levels when using an effective single ADO was Metformin, because Metfomin was able to reduce blood sugar levels with an average length of stay of 6.17 and the effectiveness of controlling blood sugar levels when using an effective combination of ADO was Metformin and acarbosa, because Metfomin and acarbosa are able to reduce blood sugar  average length of stay 7 days inpatient.

Nutmeg is known as a spice plant that has economic value and multipurpose because every part of the plant can be used in various industries. Compounds contained in nutmeg seeds include essential oils, a-pinene, b-pinene, limonene, myristicin, safrole, and methyl eugenol. Nutmeg plant nutritious as antidiarrheal, antidiabetic, antimicrobial. The purpose of this study was to make a formulation of rubbing oil and to determine the bacteriostatic activity of nutmeg seed oil on staphylococcus aureus bacteria. This study used three formulations, namely the provision of distilled water as a negative control, chloramphenicol as a positive control. The method used in this research is the well method. Bacteria that were incubated for 24 hours in the fastest concentration inhibition research were at 50% concentration because of bacterial growth which showed that the higher the concentration, the higher the inhibitory power and at 20% concentration the results were resistant, because the amount of solvent used was higher. low and can not inhibit the growth of microorganisms.