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This study aims to comparatively analyze the effects of two types of inhalation anesthetics, ether and chloroform, on Wistar rats, focusing on three main parameters: induction time, duration of anesthesia, and side effects. Selecting the appropriate anesthetic method is crucial in animal studies to ensure animal welfare and the validity of the results. Twenty male Wistar rats, with an average body weight of 200–250 grams and 10–12 weeks of age, were randomly divided into two treatment groups of 10 rats each. The first group was anesthetized using ether, while the second group was anesthetized using chloroform, with doses adjusted to achieve adequate levels of anesthesia. Measurements were made of the induction time, which is the interval from the start of anesthetic exposure until the loss of the pedal reflex; the duration of anesthesia, which is the length of time until the rat regains consciousness; and clinical observations of any side effects that appear, both during and after anesthesia. The results showed that the ether group had a relatively longer induction time than the chloroform group. However, ether provided a longer and more stable duration of anesthesia, with a better recovery rate. In contrast, chloroform produced a shorter induction time but was accompanied by a shorter duration of anesthesia and a higher risk of side effects, particularly liver dysfunction and respiratory depression. These findings reinforce previous reports that chloroform has significant potential toxicity, and its use in animal research should be limited. Based on these results, ether is recommended as a relatively safe inhalation anesthetic option for laboratory procedures in Wistar rats, although its use still requires strict supervision and appropriate handling procedures to ensure the safety of both researchers and experimental animals.

Lymphoma is a type of cancer that begins in the lymphatic system, which is part of the body's immune system. The lymphatic system consists of lymph nodes (lymph nodes), lymph vessels, the spleen, bone marrow, and other organs. Lymphoma occurs when lymphocytes multiply abnormally. Lymphoma is one of the most common cancers, affecting approximately 8 million people worldwide annually. These statistics should not be underestimated, but should be taken into consideration. This study aimed to assess the level of knowledge of patients with lymphoma and to investigate the relationship between family history and risk of developing the disease.  A descriptive and analytical cross-sectional study was conducted at a final center in Wasit Governorate, Iraq, from January 2024 to March 2025. Forty patients were included in the study, who were diagnosed with lymphoma and had their lymph nodes sorted. Data were collected through a structured questionnaire covering demographics, family history, and knowledge about the disease. Data were analyzed using SPSS and Excel, with descriptive statistics and chi-square testing applied to determine statistical relationships (at a significance level of ≤ 0.05). The study was conducted using a descriptive analytical approach at the Oncology Center in Wasit Governorate, Iraq, from January 2024 to March 2025. The sample included 40 female patients diagnosed with lymphoma. Data were collected through a structured questionnaire covering demographics, family history, and knowledge about the disease. Data were analyzed using SPSS and Excel, using descriptive statistics and the chi-square test to determine statistical relationships (at a significance level of ≤ 0.05). Most of the participants (61%) had poor knowledge of lymphoma, particularly about its signs and symptoms, risk factors, and preventive measures.

This study aims to examine the implementation of the selapanan tradition among Javanese postpartum women in Limau Manis Village, and to understand the meaning and community perceptions of this practice in the context of modern life. The selapanan tradition is part of local wisdom that has been passed down from generation to generation and has important value in postpartum maternal care. This study uses a qualitative method with an ethnographic approach, which allows researchers to understand cultural practices in depth through direct interaction with the community. Data collection techniques include participant observation, in-depth interviews with mothers who practice the tradition, community leaders, and traditional birth attendants, as well as documentation and field notes. The results show that selapanan is still preserved and practiced by the people of Limau Manis Village, although it has undergone several forms of adaptation to modern developments and modern medical guidelines. In its implementation, this tradition uses various natural ingredients such as parem (traditional body scrub), pilis (forehead concoction to refresh the eyes and mind), bengkungan (cloth to wrap the stomach), gerita (a kind of stagen or body binder), and the consumption of herbal medicine as part of physical care and body recovery. In addition to its physical aspects, selapanan also has a psychological dimension, providing emotional comfort and social support to postpartum mothers, thereby helping to prevent psychological disorders such as baby blues syndrome. This tradition serves not only as a form of traditional healthcare but also as a symbol of social solidarity and respect for local cultural values. Amidst the tide of modernization, preserving selapanan is crucial as a cultural identity that remains relevant. This study concludes that despite adjustments to medical developments, the selapanan tradition continues to play a significant role in maintaining maternal well-being and strengthening Javanese cultural values in the modern era.

Excessive fat consumption can lead to increased cholesterol levels in the body, which in turn can trigger various serious health problems, including heart disease, blood vessel blockage, and even stroke. Blood cholesterol consists of two main types: LDL (Low-Density Lipoprotein) cholesterol, often referred to as bad cholesterol, and HDL (High-Density Lipoprotein) cholesterol, which plays a role in transporting cholesterol from the blood vessels to the liver for excretion. Elevated LDL cholesterol levels can cause plaque buildup on blood vessel walls, which narrows blood flow and increases the risk of various cardiovascular diseases. One method considered effective for lowering LDL cholesterol levels in the blood is by consuming phytosterols, compounds found naturally in various types of plants. Phytosterols have a structure similar to cholesterol and can compete with cholesterol for absorption in the intestine. This results in a decrease in the amount of cholesterol entering the body, thereby reducing total cholesterol levels and especially LDL cholesterol in the blood. Research shows that giving food or supplements containing about 3 grams of phytosterols per day to human subjects can reduce LDL cholesterol levels by up to 15%. Furthermore, phytosterols directly isolated from plants, such as green beans, have also been shown to significantly lower LDL cholesterol levels. Studies in mice fed phytosterols isolated from green beans showed a reduction in blood LDL cholesterol levels of more than 30%. This demonstrates the potential of phytosterols as a natural ingredient that can be used to support cholesterol management in the body. Although phytosterols have significant potential in lowering cholesterol levels, it is important to remember that consuming supplements or foods containing phytosterols should be done under the supervision and recommendation of a medical professional, especially for individuals with certain medical conditions or who are taking medications.  

This study aims to determine the effect of adding EM4 probiotics in various doses to commercial feed on the growth of jatimbulan tilapia (Oreochromis niloticus L). Probiotics are known to play a role in increasing digestive efficiency, nutrient absorption, and maintaining the health of the fish's digestive tract, so they are expected to support optimal growth. The research method used was a Completely Randomized Design (CRD) with four treatments, namely: P0 (control/without probiotics), P1 (5 ml EM4/kg feed), P2 (7 ml EM4/kg feed), and P3 (11 ml EM4/kg feed), each with four replications. The parameters observed were the growth in length and weight of jatimbulan tilapia during the maintenance period. The results showed that the administration of EM4 probiotics at certain doses was able to provide a significant effect on the growth of tilapia compared to the control treatment. Treatment P2 (7 ml/kg feed) provided the best growth results compared to other doses, both in terms of increasing length and body weight. Meanwhile, administering probiotic doses that are too low (P1) or too high (P3) tends to be less effective in supporting optimal growth. This is thought to be due to the disruption of the microbial balance in the digestive tract when the probiotic dosage is incorrect. This research provides useful information for Jatimbulan tilapia cultivation practices, particularly regarding the use of probiotics to increase growth efficiency. Using the correct probiotic dosage can be a strategy to increase the productivity and sustainability of freshwater fish farming.  

Working memory capacity is a crucial aspect of cognitive function that plays a significant role in supporting students' learning processes. Working memory functions as a temporary storage system that allows individuals to store and manipulate information quickly. In an educational context, optimal working memory capacity can improve students' ability to understand, process, and remember information presented during the teaching and learning process. Several factors known to influence working memory capacity include breakfast habits, nutritional status, body fat percentage, and hemoglobin (Hb) levels. These factors are closely related to students' daily nutritional intake and healthy lifestyle. This Community Service (PkM) activity, with the topic "Healthy Food and Lifestyle to Increase Working Memory Capacity," aimed to increase students' understanding and awareness of the importance of a healthy diet and an active lifestyle in supporting cognitive function, particularly working memory. This activity was held in July 2024 at MTs (Madrasah Tsanawiyah) Al Fatah, Natar District, Lampung Regency. The implementation method was interactive nutrition education, covering the importance of a nutritious breakfast, consuming a balanced diet, physical activity, and general health care. Based on the results of evaluations conducted before and after the activity, there was an increase in the average knowledge scores of female students, as well as a significant difference in their understanding of the concepts of healthy eating and a lifestyle that supports working memory function. These findings indicate that nutrition education interventions have significant potential to improve the quality of learning by enhancing students' cognitive aspects. This activity is expected to become a model that can be implemented sustainably in other school settings.

Thalassemia is a genetic disorder characterized by impaired hemoglobin synthesis. This disease is caused by mutations in the globin gene, leading to disrupted production of globin chains. As a result, the red blood cells produced are dysfunctional and have a shorter lifespan, causing anemia. This condition requires proper medical management, including blood transfusions and other treatments. One way to detect and monitor the progression of thalassemia is by using biochemical markers that can identify changes in the patient’s body. Therefore, the aim of this systematic literature review is to identify biochemical markers that can be used for the diagnosis and monitoring of thalassemia. The literature used in this study includes articles on human thalassemia research published in the last 10 years. Literature searches were conducted in several academic databases using relevant keywords such as “biochemical markers for thalassemia,” “diagnosis of thalassemia,” and “thalassemia monitoring.” Based on the search results, several biochemical markers related to thalassemia were identified, including hepcidin, ferritin, and lipid profile. Ferritin plays a role in monitoring iron levels, which are often elevated in thalassemia patients, while hepcidin regulates iron homeostasis in the body. Additionally, other components involved in thalassemia diagnosis and monitoring include Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), and hemoglobin levels. The findings of this systematic literature review are expected to provide a comprehensive overview of biochemical markers that can be used in the diagnosis and monitoring of thalassemia. By identifying relevant markers, it is hoped that more accurate and effective diagnostic methods will be developed in the future, leading to better monitoring of thalassemia patients.

Involvement across generations in church worship remains a significant challenge in building a solid and inclusive congregation community. At GKSI Sui Deras Estate, worship tends to be divided according to age groups, which limits spiritual interaction between generations. This creates a gap between younger and older congregation members, ultimately affecting the harmony and cohesion of the community. This community service program aims to optimize intergenerational worship as an effort to strengthen social and spiritual cohesion among the congregation by fostering mutual respect and enhancing relationships between generations. The activities began with an initial observation to identify the issues and needs of the congregation concerning worship. Based on the observation findings, a worship design was created involving representatives from various age groups, ensuring that each generation could feel included in the worship experience. This design process also took into account aspects that could bridge generational differences, such as the selection of hymns, liturgical readings, and approaches that were appropriate for different age groups. In addition, intergenerational liturgy training was conducted to ensure that worship could proceed harmoniously, with active participation from all age groups, from children to the elderly. Intergenerational worship was conducted periodically, providing opportunities for the entire congregation to interact and experience unity in worship. The results of these activities showed a significant increase in participation from congregation members of various ages. A sense of mutual respect between generations grew, something that had previously been lacking. This intergenerational worship also contributed to the strengthening of the community's identity as one body in Christ, where every member, regardless of age, felt valued and involved. Overall, intergenerational worship has proven to be a relevant and practical approach to strengthening the congregation community in a sustainable way, creating a more inclusive and loving atmosphere among fellow congregation members.

Significant physical and psychological changes occur throughout pregnancy, especially in the third trimester (weeks 27–40).  Lower back pain, frequently caused by poor posture, changes in the curvature of the spine, and increasing body weight that shifts the center of gravity forward, is a common issue during this time.  Between 30% and 78% of pregnant women report experiencing lower back discomfort.  Maintaining physical health, endurance, and mental preparedness for childbirth are key objectives of prenatal exercise.  This study aimed to examine the effect of pregnancy exercise on lower back discomfort in third-trimester pregnant women at the Likupang Community Health Center.  The study used a one-group pretest-posttest design and was pre-experimental in nature, with the Likupang Community Health Center serving as the research site.  Fifteen pregnant women from the Likupang Community Health Center were chosen as the study sample.  The results indicated that pregnancy exercise had a significant impact on reducing back pain (p-value 0. 000), showing a clear effect between pregnancy exercise and the reduction of lower back pain (p-value 0. 000), as confirmed by the bivariate statistical test.  The findings suggest that pregnancy exercise can effectively alleviate lower back discomfort in third-trimester pregnant women.

The lips are one of the most sensitive parts of the body and are highly vulnerable to damage from ultraviolet (UV) radiation from sunlight. Unlike other parts of the skin, the lips lack oil glands, making them more prone to dryness, chapping, and inflammation when not properly protected. One common method to maintain lip moisture and health is the use of lip balm. Natural lip balms made from ingredients such as beeswax and coconut oil are widely used due to their excellent emollient properties, which help moisturize and provide a protective layer on the surface of the lips. However, using natural lip balm alone may not be sufficient to offer complete protection, particularly against the harmful effects of UV rays. Therefore, innovation is needed by incorporating Sun Protection Factor (SPF) into natural lip balm formulations to enhance protection from sun exposure. This study aims to evaluate the effect of adding SPF to lip balm formulations based on beeswax and coconut oil, focusing on UV protection effectiveness, product stability, and moisturizing ability. The method involved formulating two types of lip balm—one with SPF and one without. UV protection effectiveness was tested using in vitro spectrophotometry, while moisturizing ability was assessed by measuring skin moisture content on the lips. In addition, physical characteristics such as texture, color, and stability under various storage conditions were analyzed. The results showed that the lip balm with added SPF provided significantly higher UV protection compared to the formulation without SPF. Furthermore, the addition of SPF did not reduce the moisturizing performance of beeswax and coconut oil and did not interfere with the overall product stability. In conclusion, integrating SPF into natural lip balm formulations is an effective innovation to enhance the protective function of lip care products without compromising their moisturizing benefits or user comfort. This combination provides a holistic solution for maintaining lip health while preventing UV-induced damage.

the liberation of the Israelites from slavery in Egypt, marking God's intervention in the history of His people and the beginning of a new grain harvest. On the other hand, Easter marks the resurrection of Jesus Christ, a symbol of victory over sin and death, and the culmination of salvation provided through His sacrifice on the cross. In this context, the Eucharist becomes an important sacrament symbolizing the body and Passover and Easter have deep meanings in their respective religious traditions. Passover (Pesach) celebrates blood of Christ. The bread, as a symbol of His broken body, and the cup, as a symbol of His shed blood, remind Christians of God's infinite sacrifice and love. However, in the early days of Christianity, the practice of the Eucharist was often misunderstood, leading to accusations of cannibalism against Christians. This misunderstanding arose because the terms "body" and "blood" were interpreted literally by outsiders. To counter these accusations, Christian apologists, such as Justin Martyr and Tertullian, attempted to provide a theological explanation for the symbolism, emphasizing that the Eucharist was a spiritual and not a physical act. Thus, both Easter and the Eucharist reflect the profound themes of liberation and hope, as well as the importance of a correct understanding of the symbolism of Christian teaching to avoid harmful misunderstandings. This shows that a proper understanding of religious traditions can strengthen faith and strengthen relationships among believers.

Indonesia is undergoing a transformative era in vocational education, pushed by the integration of technology-driven, project-based learning (PJBL) methodologies and Learning Management Systems (LMS). This comprehensive study examines the implementation and effectiveness of technology-driven project-based learning at SMK Cut Nya' Dien, utilizing a quasi-experimental design with 35 students divided into experimental and control groups. Using SPSS statistical analysis, the research demonstrates significant improvements in student learning outcomes, creativity measures, and engagement levels in the experimental group that utilized Google Classroom LMS with project-based learning approaches. This study is contributing to the growing body of literature supporting the efficacy of technology-integrated pedagogical methods in vocational education settings, providing empirical evidence for policy makers and educational practitioners seeking to enhance graduate employability and industry alignment. Results revealed statistically significant differences between groups (t (33) = 4.852, p = 0.0003) with a very large effect size (Cohen's d = 1.67), indicating substantial practical significance for educational implementation.

This qualitative descriptive research explores the principal’s efforts to enhance teacher performance through the implementation of educational supervision at SDI Puudhombo, East Nusa Tenggara. The study aims to understand the strategies, processes, and impacts of educational supervision in improving teaching quality. Purposive sampling was used to select three informants consisting of one school principal and two classroom teachers. Data were gathered through structured interviews, allowing for in-depth exploration of participants’ experiences and perceptions. Analysis was conducted using the Miles and Huberman interactive model, involving data reduction, data display, and conclusion drawing to ensure the credibility and reliability of the findings.The results reveal that educational supervision is systematically implemented twice a year, guided by a well-structured plan that outlines objectives, schedules, and targeted competencies. The principal applies a collaborative supervision approach, using classroom visitation techniques to observe teaching practices in real contexts. Post-observation, constructive feedback sessions are conducted to highlight strengths, identify areas for improvement, and provide practical recommendations for pedagogical development. Teachers demonstrate notable progress in preparing lesson plans, delivering interactive learning activities, and applying effective evaluation methods. However, certain aspects such as the integration of technology in teaching and differentiation strategies still require further enhancement. The findings indicate that educational supervision not only improves technical teaching skills but also fosters teacher professionalism, boosts work motivation, and promotes a culture of continuous improvement within the school. The study underscores the importance of consistent, supportive, and developmental supervision in elevating instructional quality. It concludes that systematic and ongoing educational supervision represents a highly effective strategy for advancing teacher performance in elementary education. This research enriches the body of literature in educational management and provides practical implications for strengthening school leadership, particularly in rural and resource-limited contexts such as East Nusa Tenggara.

Type 2 diabetes mellitus is a long-term or chronic disease that needs to be managed properly. One of the biggest challenges for people with type 2 diabetes mellitus is their ability to control their weight. This cross-sectional study aims to determine the ability to control their weight in people with type 2 diabetes mellitus and the factors that influence it. Respondents in this study were 96 respondents using a purposive sampling technique. The independent variables were factors related to the ability to control their weight, while the dependent variable was the ability to control their weight. Data collection used a questionnaire, and statistical testing was carried out using Spearman's rho with a significance level of 0.05. The results of the study showed that most respondents (71.9%) used oral diabetes medication, almost all respondents (37.5%) used insulin diabetes medication, most respondents (59.4%) had suffered from diabetes for 1-2 years, most respondents (52%) were committed to maintaining their weight in the sufficient category, and most respondents (62.5%) had the ability to control their weight in the fairly good category. The Spearman rho statistical test results showed a relationship between the duration of diabetes (p-value: 0.027) and commitment (p-value: 0.039) with the ability to control weight, while there was no relationship with other factors. The relatively good ability to control weight in patients newly diagnosed with type 2 diabetes mellitus may be due to the patient's awareness and motivation that creates a commitment to control their health condition to prevent worsening conditions. It is hoped that patients with type 2 diabetes mellitus can maintain the ability to control their weight so that glucose levels remain under control.

Drinking water is a basic human need that must meet health requirements to be suitable for direct consumption without causing health risks. Drinkable water must be free from various contaminants, both physical, chemical, and microbiological that can harm the human body. One of the sources of drinking water that is widely used by the community is refillable drinking water (DAMIU), which is now growing due to its affordable price and ease of access. However, the water quality from DAMIU is often a concern due to potential contamination due to sanitation that does not meet standards. This study aims to analyze the sanitary conditions of the refillable drinking water depot (DAMIU) and assess the quality of drinking water based on physical, chemical, and microbiological parameters in the working area of the Punti Kayu Health Center, Palembang. A total of 15 DAMIU are the object of research that are examined through laboratory tests and direct observation of the sanitary conditions and equipment of the depot. The results showed that all DAMIU (100%) had met the general sanitation requirements, such as room cleanliness, equipment, and workers. However, microbiological testing found that 33.4% of the water samples contained E. coli and Coliform bacteria, indicating the presence of contamination. In addition, all samples (100%) did not meet the ideal drinking water pH requirements, and as many as 40% of the samples had aluminum content that exceeded the threshold set by the Indonesian Minister of Health. From these findings, it can be concluded that although the sanitary conditions of DAMIU are relatively good, the quality of the drinking water produced still requires serious attention.

This research is motivated by the importance of understanding the niqab (face veil) as a religious symbol and an identity marker for Muslim women, which continues to spark public debate in Indonesia. The niqab is often viewed from various perspectives—religious, cultural, social, and political—making it a controversial topic. These differing viewpoints highlight the need for a deeper exploration of the meaning and practice of wearing the niqab, especially within Islamic higher education institutions. The study aims to examine both the normative and sociological aspects of niqab use among female students at Ma’had Al-Birr, Muhammadiyah University (Unismuh) Makassar. This institution is known for having a significant number of students who wear the niqab, each with different backgrounds and motivations, ranging from theological beliefs to personal convictions and environmental influences. The research employs a descriptive qualitative method with a field-based approach. It combines normative Islamic theological perspectives with sociological analysis, using data collection techniques such as observation, in-depth interviews, and documentation. The findings reveal that students perceive the niqab not merely as a religious obligation to cover one's aurat (parts of the body that should be concealed), but also as a symbol of piety, honor, obedience, and personal ijtihad (independent reasoning) in practicing Islamic teachings. An inclusive campus environment supports these students in engaging freely in both academic and social activities. However, challenges still arise, particularly in the form of stereotypes and perceptions of exclusivity that some individuals associate with niqab wearers. These misconceptions underscore the importance of cross-perspective understanding in addressing this phenomenon. This study is expected to contribute to the development of campus policies that support freedom of expression, uphold mutual respect, and promote a more inclusive, open, and tolerant atmosphere within Islamic higher education institutions—one that embraces the diversity of religious practices and encourages respectful coexistence.

Tempoyak is a traditional fermented product made from durian and widely consumed in Sumatra. Tempoyak fermentation involves lactic acid bacteria (LAB), which are known to have potential as probiotics and as producers of antioxidant compounds. The tempoyak fermentation process plays an important role in increasing nutritional value and health benefits, primarily due to its ability to produce bioactive compounds such as lactic acid and antioxidants that are beneficial for the human body. This study aims to isolate lactic acid bacteria from local fermented tempoyak from Sumatra and evaluate their potential antioxidant activity. Isolation was carried out using the spread method on MRS agar media, which is specifically designed to support the growth of lactic acid bacteria. Next, the obtained isolates were analyzed based on colony morphology, Gram staining, and catalase test for initial identification of the types of bacteria present in tempoyak. After isolation, selected isolates were tested for antioxidant activity using the DPPH test, which is one method to measure the ability of a compound to neutralize free radicals. Vitamin C was used as a positive control in this test. The results showed that several LAB isolates from tempoyak had varying antioxidant activity, with some isolates showing significant potential. The detected antioxidant activity indicates that LAB isolates from tempoyak have the potential to be applied as probiotics with health benefits and as functional food ingredients that can help prevent cell damage caused by free radicals. This study provides evidence that tempoyak, besides being a traditional food, also has the potential to be further developed in the functional food and probiotic industries. These findings add insight into the potential of traditional fermented products, such as tempoyak, which provide not only culinary benefits but also health benefits.

Moringa leaves (Moringa oleifera) are known to contain flavonoids that function as natural antioxidants, playing an important role in preventing the oxidation of body cells and maintaining health. However, the results of observations and interviews show that the people of Baet Village still do not understand the health benefits of moringa leaves and how they are processed into food with nutritional value. This community service activity aims to increase public understanding of the health benefits of moringa leaves and skills in processing them into food, vegetables, and various cakes. Partners in this activity are the Kaju Health Center and the people of Baet Village, with a total of 15 participants. The methods used include counseling on the nutritional content and benefits of moringa leaves, as well as the direct practice of processing moringa leaves into food products such as sponge cakes and puddings. The results of the activities showed success which was marked by the enthusiasm and active participation of the community in the evaluation sessions and processing demonstrations. The community is able to answer evaluative questions well and show skills in processing moringa leaves independently. In addition to increasing knowledge, the community also shows a commitment to implementing the results of counseling in daily life, including in efforts to reduce high blood pressure through the consumption of processed moringa leaves. This activity ran smoothly and had a positive impact on improving nutrition literacy and public health. It is hoped that this activity can be a model of sustainable community empowerment based on local potential.

Human skin undergoes aging and degenerative processes, like other body tissues. Skin aging is characterized by various structural and functional changes, such as decreased skin elasticity, degradation of elastic fibers, thinning of the epidermis, reduced collagen content, the appearance of wrinkles, and increased skin dryness. One effort to inhibit this process is the use of natural phytochemical compounds with antioxidant and skin-protective activity, such as ferulic acid. Ferulic acid is known to scavenge free radicals and absorb ultraviolet (UV) light. Furthermore, this compound can protect the structure of collagen, elastin, and fibroblast cells from damage, and inhibit the enzymes collagenase and tyrosinase, which play a role in collagen degradation and the formation of hyperpigmentation. This literature review aims to examine the anti-aging activity of ferulic acid based on the results of in vitro and in vivo studies published in the past ten years. The search was conducted through a systematic literature review of relevant scientific articles. The results indicate that ferulic acid has a promising mechanism of action in preventing and slowing skin aging. This compound can improve skin elasticity, suppress melanin production, reduce dark spots, and exhibit anti-inflammatory properties that help reduce redness and inflammation caused by acne. Its antioxidant effects also contribute to slowing the appearance of wrinkles, thus helping maintain a more youthful appearance. Despite its significant potential, further research is needed to better understand its mechanism of action and long-term safety for use on human skin.

Giving breast milk (ASI) exclusively during the first six months of a baby's life is very important in supporting the baby's growth and development and body resilience. However, the practice of giving formula milk is still quite high and is a challenge in fulfilling exclusive breastfeeding. This study aims to determine the determining factors for giving formula milk to babies aged 0-6 months in the work environment UPT Primary Health Care Pujon. This research design uses a descriptive analytical approach with a cross-sectional method to identify factors associated with exclusive breastfeeding. The research population was all mothers who had babies with a sample of 52 respondents obtained through total sampling. Data analysis was carried out using the Chi-Square test and logistic regression to determine the most dominant factors. The research results showed that all variables had a p value > 0.05, namely age (p=0.274), education (p=0.156), occupation (p=0.384), parity (p=0.280) and socio-culture (p=0.711), so there was no significant relationship between these variables and exclusive breastfeeding. The logistic regression model was also not significant (p=0.308), indicating that there were no dominant factors influencing the practice of exclusive breastfeeding among respondents. Thus, the low coverage of exclusive breastfeeding in this study may be influenced by other factors outside the variables studied.