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The study entitled “Cream Formulation of Methanol Extract of Tapak Kuda (Ipomoea pes-caprae (L.) R. Br.) Leaves) As an anti-inflammatory in male white mice (Mus musculus)” using laboratory experimental methods with posttest control group design, data analysis using SPSS 25.0 with One Way ANOVA test and Duncan test. The percentage of extract yield obtained was 3.12%, phytochemical screening test showed the presence of secondary metabolite compounds alkaloids, terpenoids, flavonoids, saponins, tannins and steroids. Cream preparation of methanol extract of Tapak Kuda leaves at concentrations of 2.5%, 5% and 10% showed anti-inflammatory activity and the maximum dose to reduce edema diameter was 10% concentration with a percentage inhibition of 87.97%. Data analysis with One Way ANOVA test with a significance value ≤ 0.05 which indicates the presence of anti-inflammatory activity in Ipomoea pes-caprae tread leaf methanol extract cream.

Optical Character Recognition (OCR) systems often struggle to extract text accurately from images captured at various distances, particularly under challenging conditions such as blurriness, noise, or poor lighting. These issues are common in real-world scenarios and limit the effectiveness of existing OCR technologies. This study addresses these challenges by applying Gaussian blur after the grayscale conversion. This method reduces noise for the image's clarity without sacrificing the original algorithm's key features. Results revealed that the enhanced OCR algorithm significantly outperformed existing methods in terms of accuracy and confidence levels. It demonstrated the ability to read signages with higher precision, even in difficult conditions such as intricate designs, poor lighting, and long distances. This advancement enables more reliable text recognition and translation, offering practical applications for public signage translation, cross-cultural communication, and improved accessibility in multilingual environments.

Garlic is a medicinal plant that is widely used for health and is used by people for traditional medicine. Garlic contains various secondary metabolite compounds which have antifungal activity, including tannins, flavonoids, allicin. Flavonoids are the largest group of phenolic compounds. So it is possible that flavonoids also have an effective antifungal effect. This research aims to formulate an ethanol extract of garlic (Allium sativum) ointment with a variety of bases and to determine the physical quality of the ointment. The type of research is laboratory experimental. The method used is maceration of the extract using 1000 ml of 70% ethanol, the design of the ointment formulation is to use three base variations FI (Hydrocarbon Base), FII (Absorption Base), FIII (Water Soluble Base). The results of the research conducted show that ethanol extract of garlic (Allium sativum) can be formulated into an ointment and has stable physical quality. The conclusion from this research is that ethanol extract of garlic (Allium sativum) can be formulated into an ointment and has stable physical quality.

The use of nitrogen-fixing bacteria in agriculture is an effective way to improve soil fertility and overall crop productivity. Bacteria such as Rhizobium, Azotobacter, and Azospirillum are able to extract nitrogen from the soil and convert it into a form that can be absorbed by plants, which is essential for the formation of protein, DNA, and RNA in plants. By utilizing the capabilities of these bacteria, the use of synthetic chemical fertilizers can be varied, thereby reducing the detrimental dampening effects on water quality and the environment. In addition, nitrogen-fixing bacteria improve water use efficiency and contribute to the health of aquatic ecosystems. The use of these bacteria has the potential to improve the results of a more thorough analysis with less cost and less environmental impact.

Named Entity Recognition (NER) is a crucial natural language processing task that extracts and classifies named entities from unstructured text into predefined categories. While existing NER methods have shown success in general domains, they often face significant challenges when applied to specialized contexts like Filipino cultural and historical texts. These challenges stem from the unique linguistic features, and diverse naming conventions. This research introduces an enhanced rule-based NER approach that specifically addresses these challenges. At its core, the system utilizes curated Corpus of Historical Filipino and Philippine English (COHFIE), which serves as both training and evaluation data. This research presents an enhanced rule-based approach for NER using a Corpus of Historical Filipino and Philippine English (COHFIE) building on pattern-learning methods, incorporating character and token features, and by using positive and negative example sets. To enrich the classification process, we used the International Committee for Documentation – Conceptual Reference Model (CIDOC-CRM), a cultural heritage framework, to provide a more nuanced categorization of entities based on their historical and cultural significance. Tested across existing Filipino based models (calamanCy and RoBERTa Tagalog), the enhanced model shows improvement on identifying entities related to Filipino culture (CUL) and history terms (PER, ORG, LOC).

Signature verification is crucial for confirming the authenticity of identities in both administrative and financial transactions, where signature forgery can lead to significant security risks. The Harris Corner Detector Algorithm is a widely used method for feature extraction in image processing; its application spans various domains, such as detection of signature forgery. While effective in identifying key features, noise significantly affects performance, especially with impulse noise like salt-and-pepper noise commonly found in signature images. To solve this problem, this study enhances the Harris Corner Detector Algorithm by applying a median filter before gradient calculation. This method removes noise without sacrificing the integrity of key features important in signature forgery detection. The study evaluates the original and the enhanced algorithm using standard image quality metrics. Peak Signal-to-Noise Ratio (PSNR) surged from an average of 13.6 dB to 43.28 dB, the Structural Similarity Index (SSIM) improved significantly from 78% to 94%, and the Mean Squared Error (MSE) dropped substantially from 16.74 to 3.84. These advancements resulted in a more reliable algorithm, exhibiting excellent resistance to noise while maintaining image structure, making the enhanced algorithm highly effective for accurate signature forgery detection.

Hemophilia is a genetic disorder resulting from impaired blood clotting. This disorder can be caused by coagulation factor abnormalities due to a deficiency of clotting factors, including vitamin K. A lack of vitamin K disrupts the coagulation process, increasing the tendency for bleeding. This article aims to determine whether there is an influence of vitamin K levels on the blood clotting factors in hemophilia patients. Searching any information needed by analyzing kinds of papers of recent research from the year of 2014 until 2024. Online databases like PubMed, ScienceDirect, Google Scholar, Scopus, and ResearchGate  are utilized by inserting relevant keywords, such as hemophilia, blood clotting factors, vitamin K deficiency and extraction. From 10 articles reviewed, a relationship was identified between vitamin K levels and blood clotting factors in hemophilia patients. Individuals with severe hemophilia experience bleeding episodes characterized by delayed onset, as well as bleeding into muscles, joints, and other internal structures, including the brain. Hemophilia is typically diagnosed through the identification of low or absent levels of FVIII:C or FIX:C. The genes encoding FVIII and FIX are located on the long arm of the X chromosome. Hemophilia A and B are the only hereditary clotting disorders inherited in a sex-linked recessive pattern. Vitamin K levels can influence the blood clotting factors in hemophilia patients, particularly those factors synthesized artificially.

Cashew leaves or also called monkey guava are known by many people, especially in Southeast Sulawesi and are believed to have a number of health benefits but are still rarely known by some people. This study aims to determine the profile of secondary metabolite content and determine the antioxidant activity of ethanol extract of cashew leaves (Anacardium occidentale Linn) using the extraction method by maceration. The extraction process of old cashew leaves is carried out by the maceration method using 96% ethanol solvent for 3 days of soaking and stirring every 24 hours, then concentration is carried out through the evaporation process. Phytochemical testing includes identification of alkaloids, flavonoids, polyphenols, tannins, steroids/triterpenoids and saponins, as well as testing antioxidant activity using the DPPH method (1,1-diphenyl-2-picrylhydrazyl). The results showed that the extract of cashew leaves (Anacardium occidentale Linn) strongly positive contains phenolic compounds, flavonoids, steroids and saponins. Based on the results of the IC50 calculation, 96% ethanol extract has the highest antioxidant activity at a concentration of 14.35 ppm (µg/mL) with a very high category. The content of secondary metabolites and very high antioxidant activity from the results obtained, explain that cashew nuts have the potential to increase body immunity and can be used in various antioxidant food products so that cashew leaves are more economically valuable for the community.

Dead skin cells can occur due to many factors, such as increasing age, sun exposure, and an unhealthy lifestyle. Signs of skin problems due to the buildup of dead skin cells are dull skin, acne, and dry skin.  Body scrub is a type of skin care that can provide many benefits for skin health and beauty. Scrub is the process of exfoliating dead skin cells using a scrub or natural ingredients. Pedada fruit scrub is a natural beauty care innovation originating from the coast of Indonesia, especially from areas rich in pedada fruit plants (Sonneratia spp.). Pedada fruit is known to have high antioxidant content which can provide benefits for the skin, such as brightening it, reducing wrinkles, and fighting the effects of free radicals. This scrub uses pedada fruit extract which is rich in flavonoids, tannins and vitamin C to care for the skin naturally. This body scrub product not only offers beauty benefits but is also environmentally friendly because the raw materials are easy to find in coastal areas and do not require complicated chemical processes. This research aims to examine the benefits of pedada fruit scrub as a natural beauty solution that is rich in antioxidants.

Leunca leaves are rich in bioactive compounds such as tannins, alkaloids, flavonoids, phenols and steroids, making it possible to use them as an antibacterial. This community service aims to empower the community by introducing and involving them in the production of herbal emulgel from Leunca leaf extract (Solanum nigrum), which had potential as a natural antibacterial agent, particularly for skin care. Leunca leaves, rich in bioactive compounds such as alkaloids and flavonoids, had antibacterial properties that can effectively treat skin infections. Through counseling and practical training, the community is taught how to process Leunca leaves into an emulgel formulation that is easy to use and has health benefits. The method of this community service was carried out through presentations, distribution of modules, and demonstrations of emulgel production to the community. Evaluation results showed an increase in community knowledge about the benefits of Leunca leaves as a natural antibacterial agent, with knowledge improving from 15% to 80% after the counseling. It is hoped that this initiative will raise awareness and promote the use of local herbal ingredients in skin care, as well as open up opportunities for herbal-based entrepreneurship that can improve the community's well-being

Arumanis mango rind is an organic waste that contains secondary metabolites such as flavonoids. Many flavonoids are found in the rind of the arumanis mango, which acts as a very strong antioxidant and has the potential to heal wounds, including infected wounds. This study aims to determine the effect of arumanis mango (Mangifera indica L.) rind extract ointment on healing infected wounds caused by Pseudomonas aeruginosa bacteria, determine the effective concentration for healing infected wounds, and the histopathological decripstions. This research was an experimental study using male white rats which were divided into 5 groups, namely group I (control), group II (Gentamicin), group III (5% concentration), group IV (10% concentration) and group V (15% concentration). The parameters observed were the percentage of healing of infected wounds, epithelialization time, and histopathology. Then the data were analyzed using the ANOVA test followed by Duncan's further test.The results of the study were based on the group order above, from the parameters the average percentage of infected wound healing on 3rd day  was 29.73%; 48.84%; 45.95%; 42.81%; 42.33%, on 7th day it was 70.96%; 85.79%; 83.25%; 76.95%; 73.87%, and on the 14th day it was 89.89%; 93.32%; 93.87%; 92.67%; 91.48%. Epithecization time is 9; 6; 7; 8; 9 (day), for histopathology of fibroblast cells with a score of 1; 3; 3; 2; 2; for collagen fibers 1; 3; 3; 3; 3; for re-epithelialization 2; 3; 2; 2; 2; for inflammatory cells 0; 3; 2; 2; 2. The conclusion of the research is that arumanis mango peel extract ointment (Mangifera indica L.) has an influence on the healing process of wounds infected by Pseudomonas aeruginosa bacteria in male white mice, the most effective concentration and the best histopathological descriptions at a concentration of 5%.  

Takokak fruit contains bioactive compounds that can be used as antidiabetics. This study aims to identify bioactive compounds of ethanol extract of takokak fruit and antidiabetic test of n-Hexane fraction. The method used to obtain the extract is maceration using ethanol . Antidiabetic testing is carried out through in vivo testing with the Oral Glucose Tolerance Test (OGTT) method on white rats. Secondary metabolites are compounds contained in taakokak fruit that are identified as flavonoids, saponins, tannins, steroids and terpenoids . The results of the antidiabetic test showed that the n-Hexane fraction with glibencamide as a comparator has the ability as an antidiabetic in terms of the amount of difference in blood glucose levels in the test animal group from T 30 to T 120 . The average decrease in blood glucose levels in the negative control group (Na-CMC) was 108.67 mg/dL, the positive control group ( glibencamide ) 174.67 mg/dL, the 5% concentration fraction group 35.33 mg/dL, the 10% concentration fraction group 30.67 mg/dL, the 20% concentration fraction group 47.67 mg/dL.

Takokak fruit is one of the plants that can be used to lower blood sugar levels. This study aims to identify the bioactive compounds of ethanol extract of takokak fruit and test the antidiabetic ethyl acetate fraction. Antidiabetic testing was carried out by in vivo testing using the Oral Glucose Tolerance Test (OGTT) method to see the decrease in blood glucose levels using white rats as test animals. The test results showed that takokak fruit contains flavonoids, steroids, and tannins. Fractionation is the process of extracting compounds from the extract using two types of solvents that do not mix with each other. The results of the antidiabetic test showed that the ethyl acetate fraction with glibenclamide as a comparator had the ability as an antidiabetic measured by the amount of difference in the decrease in blood glucose levels in the test animal group T₃₀ to T₁₂₀. From the results obtained, the average decrease in blood glucose levels in the negative control group (Na CMC) was 5.8 mg/dL, the positive control group (Glibenclamide) 21.03 mg/dL, and the fraction group 9.86 mg/dL. Takokak fruit has antidiabetic activity. Compounds that have antidiabetic activity are flavonoids, tannins, and steroids.

Indonesia is an archipelagic country that has abundant mineral wealth, both metal minerals and other minerals. Metal minerals, including gold, tend to have a higher economic value. Based on data from the Ministry of Energy and Mineral Resources, the world's gold reserves in 2020 were 50,300 tons of Au. Indonesia is among the 5 largest in the world with 5% of the total gold reserves, which is 2,600 tons of Au. Therefore, it is necessary to develop technology and science in the mining industry, especially gold and silver, to improve the optimization of the process and increase the added value of the mining products themselves. One of the gold extraction processes can be done hydrometallurgically with the cyanidation method using a intensive leach test. The results of this experiment show that factors such as cyanide usage and ultra fine particle size will greatly affect the recovery of gold and silver metals.

Gold (Au) as a precious metal has played significant role throughout human history. Most gold ores subjected to leaching using the sodium cyanide (NaCN) contain high levels of base metals. High base metal content can influence the recovery of pregnant leach solution (PLS), as it affects the consumption of sodium cyanide (NaCN) and lime used to optimize the gold ore leaching process. Pre treatment leaching process is required for gold ores before the leaching process is carried out. In this study, a pre treatment leaching process was carried out using the Aachen High Shear and Filblast Low Shear Reactors with variations in feed solids percentage for each reactor, utilizing NaCN concentrations of 1000 ppm for the Aachen with bottle roll test (BRT) and 500 ppm for the Filblast with agitations leach test (ALT). Based on this study, each pre-treatment leaching reactor, the extraction percentages were 54.30% Au, 63,40%  Ag for the Aachen and 52.19% Au and 68,10% Ag at Filblast. Lime consumption in the Aachen was highest at 3.47 kg/t (PreOx 3 and AAL), while in Filblast at 1.71 kg/t. Meanwhile, NaCN consumption in the Aachen was highest at 0.64 kg/t (PreOx 2), compared to 0.80 kg/t in Filblast.

The seismic and magnetic data are well known for the investigation of tectonic structures and their directions on surface and subsurface, a methodological approach integrated the seismic and magnetic data interpretation combined with field measurement on cracked building and its underlying substratum, represented by Agadez sandstones and basement. The extraction of seismic lineaments from West African seismic map showed the seismic directions oriented NW-SE (N135 to N160°), passing through the studied area. The structural interpretation of magnetic map show that the Agadez region is also affected by the subsurface lineaments mainly oriented in NW-SE (N135°) directions, which are similar to the identified seismic lineaments in the same zone. A structural study carried out on the Agadez sandstones and the underlying basement, showed that faults and fractures oriented N120° to N165°, affect both the basement of the Aïr Mountains and the sandstone for­mations on which the city of Agadez is built. These observations showed that building cracking in Agadez region has a higher propagation tendency according to the directions rang­ing from NW-SE (N135°) to NNW-SSE (N165°). Therefore, the buildings cracking has a stronger propagation component according to these mean directions those are not recommended for building. To prevent and reduce the risks related to building cracking in Agadez region, it is highly recommended to build in the minor directions of cracking propagation which correspond to NE and SW directions.

The Garuga floribunda (Garuga floribunda Decne) plant is one of the species known for its various medicinal properties. This research aims to investigate the inhibitory activity of α- glucosidase and α-amylase enzymes and to determine the optimum concentration of the methanol extract of Garuga floribunda leaves as an antidiabetic agent. The leaves extraction is obtained through an extraction process using methanol as the solvent and tested for itsinhibitory activity against the α-glucosidase enzyme using the p-nitrophenyl-α-D- glucopyranoside (p-NPG) substrate and the α-amylase enzyme using the DNS (3,5- dinitrosalicylic acid) substrate. The method is UV-Vis spectrophotometry. The Phytochemical tests of this plant reveal the presence of flavonoids, alkaloids, saponins, tannins, steroids, and terpenoids. The inhibition test results show that the methanol extract of Garuga floribundaleaves exhibited significant inhibitory activity against both enzymes. The highest inhibition percentage against the α-glucosidase enzyme is 91.09%, indicating very high antidiabetic activity. Meanwhile, the inhibition against the α-amylase enzyme is 7.56%, showing no significant antidiabetic activity. The optimum concentration for inhibiting both enzymes is 1000 ppm.

Virgin Coconut Oil (VCO) is derived from fresh coconut meat and can be produced through various methods, including enzymatic processes. This study investigates the effect of adding papain enzyme on the antioxidant activity of VCO. The enzymatic method involves extracting coconut milk with the addition of papain obtained from young papaya. The antioxidant activity was measured using the DPPH method, while other parameters such as moisture content and free fatty acids were also evaluated.The research highlights that VCO is recognized for its health benefits and versatility in various applications. The enzymatic extraction method offers an efficient means of producing VCO while enhancing its properties. This study specifically focuses on how the incorporation of papain influences both the quality of VCO and its antioxidant capacity.In terms of methodology, the study utilized an enzymatic approach for VCO production by incorporating papain into the extraction process. The antioxidant activity was assessed using the DPPH assay, and the resulting VCO was analyzed for moisture content and free fatty acids.The results indicated that VCO produced with papain had a moisture content of 0.22% and free fatty acids of 0.76%, while VCO without enzyme addition showed a moisture content of 0.16%. The antioxidant activity was measured at 18.35 ppm for VCO with papain, compared to 13.51 ppm for pure VCO.In conclusion, the addition of papain enzyme not only accelerated the production of VCO but also enhanced its antioxidant activity, classifying both types of VCO as having strong antioxidant properties. However, it is important to note that the moisture content and free fatty acids in VCO with enzyme addition did not meet the Indonesian National Standard (SNI 7381:2008), likely due to residual water from the papaya fruit.

Background. The paradigm of treatment using herbal plants is still attached to the Indonesian people for wound healing. One of the plants that is often used for treatment and has the effect of accelerating wound, is the binahong plant (Anredera cordifolia). The aim of this study is to determine the effect of hydrogel of binahong leaf extract (Anredera Cordifolia(Ten.) Stennis) on the healing of incisional wounds in wistar rats. Method. This study uses a True Experimental research design with the Post Test Only Control Group Design method. The samples were 30 wistar Rattus norvegicus rats, divided into 5 groups, namely: K (control group), P1 (was given 10% puvidone iodine ointment), P2 (was given 5% binahong leaf extract hydrogel), P3 (was given 10% binahong leaf extract hydrogel), P4 (was given 20% binahong leaf extract hydrogel). The treatment was carried out for 14 days. Wound examination was carried out on days 1,3,6,9,12,14. The REEDA score parameter were used to assess wound healing. Result. The bivariate analysis using the Wilcoxon paired difference test in each experimental group showed a significant difference only in group P2 (was given 5% binahong leaf extract hydrogel) with group K (control group), group P1 (was given 10% puvidone iodine ointment) and group P2 (was given 5% binahong leaf extract hydrogel) during days 12 and 14. incision wound compared to groups P3 and P4 on the same day. The average score of the REEDA scale on days 1,3,6,9,12, and 14, the most significant incisional wound healing in wistar rats was given hydrogel binahong leaf extract with a concentration of 5%. Conclusion. There is an effectiveness of healing incision wounds in wistar rats by giving hydrogel binahong leaf extract. The hydrogel binahong leaf extract 5% is the most significant concentration assessed from the average REEDA scale score.

Objective: This scoping literature review is intended to identify factors that influence Psychological well-being and see the gap synthesis of previous studies. Introduction: Students as the next generation of the nation often face various challenges, both in academic, social, and personal fields. These challenges can affect their psychological well-being, which is an important aspect in supporting the success of studies and life as a whole. Methods and analysis: This study uses 5 main stages, namely the stage of identifying questions, identifying relevant studies, selecting study results, data extraction, data synthesis. Specifically using the PCC framework and paying attention to inclusion and exclusion criteria so that the final results are obtained. Results: The results found from the data selection found a total of 8,401 articles from 1 database and duplication was done twice (in the first check using Rayyan.ai the second work during data selection with Rayyan.ai n = 807 After duplication of data selection based on inclusion exclusion criteria, 63 relevant articles were found. After manual re-detection, the final results were 13 articles that were most relevant to the research topic.