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The low level of public awareness regarding hand hygiene has become a contributing factor to the spread of infectious diseases transmitted through contact. This condition has sparked innovation in the development of hand sanitizer products made from natural ingredients, which are not only effective in killing germs but also safe and environmentally friendly. One promising natural ingredient is pineapple peel (Ananas comosus L.), which is generally considered organic waste. Pineapple peel contains bioactive compounds such as flavonoids, tannins, and the enzyme bromelain, all of which possess antibacterial properties. This study aims to evaluate the antibacterial effectiveness of pineapple peel extract against the growth of Escherichia coli and assess its feasibility as an active ingredient in spray hand sanitizer formulations. The research method involved preparing spray hand sanitizer with varying concentrations of pineapple peel extract: 50%, 60%, 70%, 80%, and 90%. Antibacterial activity was tested using the disk diffusion method to measure the inhibition zone against E. coli. Additional evaluations included physical quality tests such as pH, spreadability, homogeneity, organoleptic properties, skin irritation test, storage stability, and consumer preference. The results showed that the 90% concentration formulation had the highest antibacterial effectiveness, with an inhibition zone of 22 mm. This formulation was also the most preferred by respondents due to its strong and fresh aroma, appealing color, and pleasant texture on the skin. All formulations had pH values within the safe range (5.5–7), did not cause skin irritation, and demonstrated stability during storage. In conclusion, pineapple peel extract is effective as a natural active ingredient in spray hand sanitizer formulations. This product not only exhibits strong antibacterial activity against E. coli but is also safe, stable, and presents an environmentally friendly alternative to support improved public hand hygiene.

Number of vegetarians in Indonesia is rising. This increase may be attributed to improvement of people knowledge regarding health benefits of high fiber plant-based diet especially to reducing the risks of degenerative diseases. However, high fiber plant-based food especially mushroom-based food that being accepted by majority of panelists are limited to oyster and straw mushroom. Hence, the goal of this research is to get the best formula based on organoleptic and crude fiber content from Auricularia polytricha and red dragon fruit peel extract as a food for vegetarian diet. This study used experimental study with Randomized Block Design (RBC) method with two experimental factors: the concentration and volume of red dragon fruit peel extract (25 ml and 50 ml) and the proportions of wheat flour and Auricularia polytricha (30:70, 50:50, 70:30). Organoleptic test results data were analyzed using the Krusskal Wallis test and the Man-Whitney U test to test it further. The results showed that there was a significant effect of the nugget ingredient formulation on color, taste, and texture of the nuggets (p<0,05), and there was no significant effect on the aroma of the nuggets (p>0,05). The highest crude fiber content was found in nuggets with a composition of 70% Auricularia polytricha and 30% wheat flour with the addition of 50 ml red dragon fruit peel extract, which was 36.88%, and anthocyanin content of 0,99 mg/100 g. The best formula for Auricularia polytricha nuggets with the addition of red dragon fruit peel extract is J3E2 with a composition of 70% Auricularia polytricha and 30% wheat flour and the addition of 50 ml of red dragon fruit skin extract.

The global halal industry is experiencing exponential growth with a market value of trillions of dollars, creating significant economic opportunities for Southeast Asian countries with large Muslim populations. The micro-livestock sector has unique characteristics that require a specialized approach in the implementation of an integrated halal assurance system, given limited resources, technical capacity and access to technology. The complexity of implementation presents multidimensional challenges covering technical, economic, social and regulatory aspects that require comprehensive analysis to understand the socio-economic impact on the sustainability of micro farms1. This study aims to analyze the socio-economic impact of implementing an integrated halal assurance system on the sustainability of micro livestock enterprises in Southeast Asia through an integrated legal and business perspective. Systematic literature review using PRISMA guidelines with searches through Google Scholar and Scopus for the period 2020-2025. Inclusion criteria included studies of halal assurance system implementation on Southeast Asian micro farms, socio-economic impact analysis, and integration of legal-business perspectives. Quality assessment using the Mixed Methods Appraisal Tool (MMAT) with systematic data extraction using Microsoft Excel 2021. Of the 321 articles identified, 7 high-quality studies were included with a selectivity rate of 2.2%. The findings show variations in implementation approaches between countries: Indonesia with Law No. 33/2014 and SEHATI program, Malaysia through JAKIM with MS 1500:2019 standard, Singapore via MUIS with strict supervision. Positive social impacts include increased social acceptance, empowerment of women and minority groups, and establishment of collaborative networks such as halal cooperatives. Significant economic impacts include increased consumer confidence, wider market access, and product competitiveness with premium prices of up to IDR 37,500/kg for certified products. Integration of legal-business perspectives creates synergy through ASEAN regulatory harmonization, blockchain technology, and multi-stakeholder collaboration. The implementation of an integrated halal assurance system has a transformative impact on the sustainability of Southeast Asian micro livestock businesses, strengthening the regional halal economy and contributing to the Sustainable Development Goals.

The maternal mortality rate (MMR) in Indonesia remains high, with many cases linked to pregnancy complications associated with iron deficiency anemia (IDA). Anemia has widespread effects on women’s reproductive health and child development, including decreased immunity, cognitive impairment, and increased risk of premature birth. One promising nutritional intervention is the consumption of mung bean extract, which is rich in iron. This community service activity aimed to improve public knowledge and skills regarding the benefits of mung bean extract for women's reproductive health and child nutrition. The program involved educational sessions and practical demonstrations delivered to residents in the target area, with active participation from local leaders and community members. The results showed increased awareness and motivation among the participants to consume mung bean extract regularly. The enthusiasm demonstrated by the community indicates the effectiveness of this outreach in raising awareness about the importance of simple nutritional interventions to prevent anemia and improve maternal and child health. It is hoped that this activity can be sustained as a promotive and preventive public health effort.

Pharmacology is the study of drug interactions with living organisms. This study aims to evaluate the anti-inflammatory effects of several drug preparations, including Hemilon (methylprednisolone), Lupred (prednisolone), Kamathasone (dexamethasone), neem leaf infusion, and snakehead fish extract, on mice (Mus musculus) induced with inflammation using carrageenan solution via intraplantar injection. Edema volume was observed using a plethysmometer at 15, 30, 45, and 60 minutes post-induction. Data were analyzed using normality, homogeneity, ANOVA, and Tukey tests via SPSS. Results showed that Hemilon had the highest anti-inflammatory effect, followed by Kamathasone and Lupred, while neem leaf and fish extract showed weaker activity. Statistical tests revealed normal distribution (sig. 0.197 > 0.05), non-homogeneous data (sig. 0.022 < 0.05), and no significant difference between groups (ANOVA sig. 0.366 > 0.05). Despite this, descriptive results confirmed strong anti-inflammatory potential of synthetic drugs. This practicum provides valuable insights into drug mechanisms and emphasizes methodological accuracy in pharmacological testing.

The Indonesian manufacturing industry is currently facing intense pressure due to global economic fluctuations and domestic volatility, prompting a strategic reassessment of sustainability practices to maintain competitiveness. While firm value reflects investor confidence, discrepancies remain between operational performance and market valuation, particularly in highly profitable firms. This study aims to systematically investigate how internal corporate factors namely dividend policy, firm size, and green accounting influence firm value. Using a Systematic Literature Review (SLR) method, ten journal articles published between 2023 and 2025 were selected based on indexation (SINTA, Scopus, Copernicus), methodological clarity, and variable alignment. The articles were screened and analyzed using content analysis techniques, supported by Microsoft Excel and Mendeley for structured data extraction. The findings reveal that a stable dividend policy serves as a strong signal of financial stability, firm size reinforces strategic positioning and resource capacity, and green accounting strengthens legitimacy through sustainability disclosure. These factors jointly shape market perceptions and ultimately influence firm valuation. The synthesis supports both signal theory and legitimacy theory in explaining the transmission of value through internal policies. This study contributes theoretically by integrating financial and sustainability variables into a unified value framework and offers practical insights for corporate decision-makers seeking to align internal strategies with investor expectations. Limitations include reliance on secondary data and scope restricted to the manufacturing sector. Future studies should explore empirical validation through cross-sectoral analysis and primary data to enrich the findings.

This study explores the use of psychotropic substances, which affect the central nervous system and can alter mental functions, behavior, and individual perception. In the medical context, psychotropics have been widely utilized for treating mental disorders such as depression, anxiety, and schizophrenia. The research emphasizes the importance of understanding the mechanisms of psychotropics to optimize their therapeutic benefits while minimizing the risk of adverse effects. The study employed animal models, specifically rats, using the forced swimming test (FST) to assess the antidepressant and sedative effects of various substances, including Esilgan, Xanax, Zolmia, Syzygium malaccense leaf extract, and lelap (herbal), with NaCMC as a negative control. The results demonstrated varying sedative and antidepressant effects among the substances, with Xanax exhibiting the most significant antidepressant effect, while Syzygium malaccense leaf extract showed potential as a natural sedative agent. The study also underscores the importance of applying the 3R ethical principles (Replacement, Reduction, Refinement) in animal research and highlights the need for alternative methods to reduce reliance on animal testing. These findings are expected to serve as a foundation for developing safer, more effective, and ethical psychotropic therapies for mental disorders in the future.

Abstract. Background: Slimming drugs, such as phentermine, are widely used for weight reduction but are known to induce oxidative stress, particularly affecting hepatic and renal tissues. Selenium nanoparticles (SeNPs), especially those biosynthesized using natural sources like spirulina platensis, have demonstrated promising antioxidant and protective activities in biological systems. Objective: This study aimed to assess the protective effects of selenium nanoparticles synthesized from spirulina platensis extract on renal and hepatic functions in male rats exposed to phentermine induced oxidative stress. Methods: Twenty-six adult male wistar rats were divided into five experimental groups: control group (dosed with water n=5), SeNPs group (dosed with SeNPs n=5), phentermine group (dosed with phentermine n=5), SeNPs then phentermine group (dosed with SeNPs then phentermine n=5), phentermine then SeNPs group (dosed with phentermine then SeNPs n=5). The experiment lasted for 45 days, the measurement of cytokines IL-6, IL-12, TOS and TO-AC. Results: Phentermine administration significantly increased cytokines IL-6, IL-12 indicating marked oxidative stress and immune activation. Treatment with SeNPs alone or in combination with phentermine notably improved these parameters. The group dosed with SeNPs prior to phentermine (SeNPs then phentermine) showed the most prominent protective effects with values approaching those of the control. Conclusions: Selenium nanoparticles from spirulina platensis demonstrated significant protective, antioxidant, and immunomodulatory effects against phentermine induced immune disturbances. These findings support their potential

This study analyzes Gopay user satisfaction in DKI Jakarta area. Amidst Indonesia's booming digital economy and the shift to cashless transactions, Gopay's role as a leading e-wallet is crucial, making user satisfaction vital for business sustainability. Employing a quantitative descriptive approach, data was collected via surveys from 170 Gopay users in DKI Jakarta, primarily young adults (18-29) and students. Data were analyzed using descriptive and exploratory factor analysis with SPSS version 25. Descriptive analysis showed respondents hold a highly positive perception across all five satisfaction dimensions: Content, Accuracy, Format, Ease of Use, and Timeliness. Factor analysis extracted five key factors—Completeness, Accurate, Appearance, Easy to Understand, and Information Availability—collectively explaining 68.601% of the total variance. These factors significantly contribute to overall user satisfaction. The findings offer valuable insights for Gopay to enhance services and foster user loyalty by focusing on these critical aspects of application quality.

This study proposes a hybrid approach combining Frequent Itemset Mining (FIM) and Algorithms and Genetic Algorithm for product layout optimization with a case study at PT. MPI Pharmacy. The FIM Algorithms is employed to extract association rules from 1,000 beauty product sales transactions, while the Genetic Algorithm is utilized to perform product placement based on these rules generated, with storage space constraints. Implementation results demonstrate that this hybrid approach successfully identifies 18 key association rules (support >15, confidence >80%) and proposes an optimal layout configuration model that reduces customer travel distance by 25 compared to conventional layouts used by MPI Pharmacy. The Genetic Algorithm solves complex rule-based optimization problems for product placement, which are limited by traditional market basket analysis (MBA) approaches that rely solely on association rules. This hybrid sistem not only improves pharmacy operational efficiency at PT MPI (reducing service time by 18) but also increases cross-selling opportunities by 22. Hence, inventory operations management impproved efficiently. The research findings contribute to the field of retail space optimization by effectively integrating association rule mining and evolutionary computation.  

This study aimed to evaluate the antioxidant activity and total phenolic content of methanolic extract and column chromatography fractions of Lantana camara L. leaves. Antioxidant activity was assessed using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging method, while total phenolic content was determined by the Folin–Ciocalteu assay. The methanolic extract exhibited strong antioxidant activity (IC₅₀ = 23.25 mg/L) and a total phenolic content of 2927.4 mg/L gallic acid equivalents (GAE). Fractionation yielded nine fractions (A–I), among which Fraction E demonstrated the highest antioxidant activity (IC₅₀ = 11.58 mg/L) and the greatest phenolic content (5200 mg/L GAE). A strong negative correlation (R² = 0.9485) was observed between phenolic content and IC₅₀ values, indicating that phenolic compounds are the major contributors to the antioxidant activity. These findings highlight L. camara leaves as a promising natural source of antioxidants and support their potential application in the development of functional foods and plant-based pharmaceutical formulations.

Burn injuries are complex tissue damage often accompanied by serious complications such as infection, systemic inflammation, and organ dysfunction. Effective burn management requires a comprehensive multidisciplinary approach, including infection control, local wound care, nutritional support, and regenerative therapy. Along with advances in science and technology, various novel treatment modalities have been developed to accelerate healing, reduce scarring, and improve patients’ quality of life. This study aims to evaluate the effectiveness and clinical prospects of the latest burn treatment modalities through a review of relevant literature from 2021 to 2025. This research employed a descriptive qualitative literature review method, analyzing 10 relevant scientific articles obtained from academic databases such as PubMed, ScienceDirect, and Google Scholar. The reviewed modalities include stem cell therapy, Platelet Rich Plasma (PRP), silver nanoparticles, nanofiber and hydrogel-based dressings, natural extracts such as aloe vera and binahong, as well as advanced technologies like smart dressings and low-level laser therapy. The results indicate that regenerative and smart technology-based approaches significantly enhance epithelialization, reduce infection, and improve tissue repair. Natural therapies also show promising potential as safe, affordable, and effective treatment alternatives. In conclusion, the integration of biological therapy, phytotherapy, and modern technology represents a promising direction in contemporary burn care. Further large-scale clinical research is needed to confirm the long-term safety and effectiveness of each modality.

Breast cancer is the second leading cause of cancer-related deaths in women, after cervical cancer. To date, breast cancer treatment still faces various challenges, particularly in terms of effectiveness and therapy-related side effects. Therefore, alternative treatments that are safer and more effective are needed, one of which is through the use of natural ingredients such as soursop leaves (Annona muricata). This review article aims to examine the potential of soursop leaf extract in slowing the growth of breast cancer cells. Several studies have shown that soursop leaf extract contains active compounds such as acetogenin, which are known to inhibit cancer cell proliferation, induce apoptosis, and block the formation of new blood vessels (anti-angiogenesis) in cancer tissues. These bioactive compounds make soursop leaves a promising candidate for natural anticancer agents. Thus, soursop leaf extract may be considered as a complementary therapy in the management of breast cancer.

Dengue Hemorrhagic Fever (DHF) is an infectious disease caused by the dengue virus (DENV), which is transmitted through the bite of Aedes aegypti mosquitoes. These mosquitoes act as the primary vectors carrying the dengue virus. The spread of DHF primarily occurs in tropical and subtropical regions. Mosquito control can be carried out using various methods, one of which is chemical control. However, the long-term use of chemical insecticides may lead to mosquito resistance, highlighting the need for safer alternatives to synthetic insecticides. One such alternative is the use of plant-based extracts. The butterfly pea plant (Clitoria ternatea) has shown potential as a natural larvicide due to its content of flavonoids, tannins, and anthocyanins, which function as antioxidants and are toxic to mosquito larvae. This study aims to determine the potential of Clitoria ternatea flower extract as a natural larvicide against Aedes aegypti larvae. The results of the effectiveness test showed that Clitoria ternatea flower extract has significant larvicidal potential against Aedes aegypti larvae. Observed larval mortality at 24 hours was 22 larvae at 10% concentration, 23 larvae at 50%, and 25 larvae (100%) at 100% concentration. The LC₅₀ value obtained from the test was 36.78%, indicating the extract's potency as a natural larvicide.

The present study aims to prepare the aqueous extract of the frankincense plant and then identify the most important biologically active substances in it, and study the effect of these substances against free radicals (2,2-diphenylpicrylhydrazyl (DPPH)) and Total Antioxidant Capacity. Then the effect of extract was tested on the blood serum of Alzheimer's patients in the nursing home in Diwaniyah Governorate, where 30 people were taken. 10 of them were healthy and were considered a positive control groupG1, and 20 of them were Alzheimer's patients, where 10 of them were considered a negative control groupG2, and the other 10 Alzheimer's patients had their serum treated with the extract of frankincenseG3. The effect of the extract on malondialdehyde and acetylcholinesterase enzyme was tested. The current study showed that extract contains biologically active substances such as (Flavonoids, Phenols, Tannins Triterpenoids, Steroids and Saponins) and these substances had an effective effect in inhibiting the radical (DPPH) where the inhibition rate reached 88% at (250mg/ml) and Total Antioxidant Capacity was (8.8*103 µmol/L) at the same concentration. That results also showed the significant rise in the concentration malonaldehyde in Alzheimer’s patients (G2, G3) when compared with G1. When the G3 was treated with the aqueous extract, a decrease in the concentration of malonaldehyde (3.23µml/l) was observed. The significant reduction in the Activity of the Acetylcholinesterase enzyme (3.97U/ml) was also observed in the (G3) as compared with(G2) (12.297U/ml). This is due to the biologically active substances in the extract, which indicates the possibility of using this extract to treat Alzheimer's patients in the future.

Flying fish (Hirundichthys oxycephlus) roe filaments, which are often considered as by-products, have high protein content and various essential nutrients, thus potentially increasing the nutritional value of food products. With innovation and in-depth research, this waste can be transformed into products with economic value while supporting the implementation of sustainability principles in the fisheries industry, in this case sauce as a flavoring that has become an important part of the food industry. This study aims to determine the quality of the texture and taste of chili sauce fortified with fly fish (Hirundichthys oxycephlus) roe filament extract and to determine the protein content and water content of chili sauce enriched with fly fish (Hirundichthys oxycephlus) roe filament extract. The methodology used in this study was Complete Random Design (CRD) with variations in filament powder concentration (0%, 0.5%, 1%, and 1.5%) on the sensory characteristics of chili sauce, which include aroma, color, taste, and texture. The results of organoleptic tests showed that the addition of fly fish (Hirundichthys oxycephlus) egg filament extract had a significant positive impact on all sensory parameters tested. The average aroma score increased from 2.88 in the non-enriched treatment to 3.90 at the highest filament powder concentration (1.5%). In addition, the taste score also showed the most striking increase, from 2.80 to 4.33. Analysis of the water content of the chili sauce product was recorded at 79.93% according to (SNI 01-2976-2006), while the protein content reached 10.53%, indicating the potential of this product as an additional source of protein in daily consumption patterns.

Orthosiphon aristatus is a medicinal plant that has the potential as a natural antibacterial agent. This study aims to evaluate the effect of cat's whiskers leaf extract on microbial growth using Nutrient Agar (NA) media with variations in extract concentrations of 100 gr, 50 gr, and 25 gr. Antibacterial activity tests were carried out using the well diffusion paper disk method, and observations of microbial growth inhibition zones were carried out after incubation for 24 hours at 37°C. The test results showed that there was inhibition of microbial growth that varied according to the concentration of the extract used; a concentration of 100 gr gave the largest inhibition zone compared to 50 gr and 25 gr. Data analysis showed that increasing extract concentration was directly proportional to increasing antibacterial effectiveness. These findings indicate that Orthosiphon aristatus leaf extract has the potential as a natural antibacterial that is effective in inhibiting microbial growth in NA media, so it has the potential to be developed as an active ingredient in pharmaceutical formulations.

Shrimp petis is a traditional Indonesian fermented product that is susceptible to contamination by pathogenic bacteria such as Staphylococcus aureus, Escherichia coli, and Pseudomonas spp. Preservation is generally carried out with chemical antibiotics, but their use can cause side effects and microbial resistance. This study aims to examine the effectiveness of ginger extract (Zingiber officinale) as a natural antibiotic against bacteria in shrimp petis. Ginger extract is known to contain active compounds such as gingerol and shogaol which have antibacterial activity. Through literature studies and disc diffusion method analysis, it was found that ginger extract was able to produce an inhibition zone of 12–22 mm against test bacteria. These results indicate that ginger extract is effective in inhibiting the growth of pathogenic bacteria and has the potential to be used as a natural preservative. In addition, a combination of biological, chemical, and natural preservation approaches is recommended to maintain the quality and safety of shrimp petis. The use of ginger extract is in line with the trend of healthy and environmentally friendly food.

Skin damage can adversely affect a person's health and physical appearance. One of the factors causing is exposure to free radicals that can trigger various skin problems such as premature aging, hyperpigmentation, to skin cancer. The combination of astaxanthin and carrot extract (Daucus carota L.) can be a natural approach that is promising for skin care because it contains antioxidant carotenoids. Astaxanthin and carrot extract are formulated in the form of emulgel preparations to optimize their effectiveness when used on the surface of the skin. The success of an emulgel preparation is not only determined by its active ingredient, but also by the physical characteristics of the preparation. This study aims to determine the optimum formulation of the combination of carbopol 940, triethanolamine, and aquadest in making emulgel preparations with active substances Astaxanthin and carrot extract in order to obtain physical properties that meet the standards. Optimization is carried out using the D-Optimal Mixture Design method through the Design Expert® software version 13.0.0. The evaluated parameters include pH, viscosity, scattering power, and adhesion. This study produced an optimum formulation of emulgel with a composition of 940 1.5% carbopol as much as 40.697 grams, TEA as much as 0.5 grams, and aquadest amounted to 15,188 grams. This formula shows a pH of 5,783 ± 0.0249, viscosity 24,856.7 ± 2,829.61 cps, 5,113 ± 0.4216 cm spread power, as well as the adhesion of 1,873 ± 0.1641 seconds. Based on the analysis using the D-optimal method, Tea is known as the most influential component of the physical characteristics of the Astaxanthin combination emulgel and carrot extract.

This study aims to evaluate the antibacterial activity of shrimp paste extract against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) using the paper disk method. The shrimp paste was extracted using ethanol as a solvent and tested for its inhibitory effect on bacterial growth through paper disks infused with various concentrations of the extract. The results showed that the shrimp paste extract exhibited antibacterial activity against both bacterial species, with varying inhibition zone diameters depending on the concentration used. Higher antibacterial activity was observed against Staphylococcus aureus compared to Escherichia coli, indicating that shrimp paste has potential as a natural antibacterial agent, particularly against Gram-positive bacteria. These findings support the utilization of fishery by-products such as shrimp paste as an eco-friendly alternative source of natural antibacterial agents.