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Nutritional problems among adolescents are increasingly associated with unhealthy dietary habits and low physical activity, contributing to the rising prevalence of overweight. According to the 2023 Indonesian Health Survey, overweight prevalence among adolescents ranges from 12% to 16.2%. This study aimed to develop Zea Coffee Tab, a functional beverage made from Robusta coffee and corn silk containing bioactive compounds, including caffeine and flavonoids, which may support metabolism and body fat oxidation. An experimental method with a Completely Randomized Design (CRD) was employed. The evaluated parameters included organoleptic tests (hedonic and hedonic quality) involving 30 semi-trained panelists, proximate analysis, and identification of bioactive compounds. Data were analyzed using the Kruskal–Wallis, Mann–Whitney, One-Way ANOVA, and Duncan’s multiple range tests. Three formulations were tested: F1 (30% Robusta coffee:70% corn silk), F2 (50%:50%), and F3 (70%:30%). The findings showed that F3 was the most preferred formulation, with an acceptance score categorized as “very much liked.” The product contained energy ranging from 319.20–324.26 kcal/100 g, protein 5.12–5.34%, fat 0.48–0.58%, carbohydrates 73.85–74.51%, moisture 9.12–9.66%, ash 2.10–2.32%, caffeine 182.45–205.86 mg/100 g, and flavonoids 4.28–6.03 mg/100 g. Zea Coffee Tab has the potential to serve as a healthy functional beverage for overweight adolescents. Further studies on shelf life and clinical effectiveness are recommended to support product commercialization.

Program Kuliah Kerja Nyata (KKN) mahasiswa Universitas 17 Agustus 1945 Semarang dilaksanakan di Kelurahan Purwosari, Kecamatan Mijen, Kota Semarang pada tanggal 3 Januari hingga 1 Februari 2026. Program ini bertujuan mengatasi permasalahan masyarakat di bidang kesehatan, literasi, keselamatan lingkungan, dan kesejahteraan sosial melalui pendekatan partisipatif yang terintegrasi. Program yang dilaksanakan meliputi pembuatan Taman TOGA, pembagian buku bacaan bergambar ke sekolah dasar, pemasangan kaca cembung di titik blind spot, penyuluhan pencegahan stunting disertai pembagian makanan bergizi, kerja bakti, serta pendampingan Posyandu, PKK, dan PAUD. Hasil program menunjukkan manfaat nyata: taman TOGA fungsional terbangun di halaman kantor kelurahan, 180 buku tersalurkan ke SDN Purwosari 1 dan 2, 3 kaca cembung terpasang di titik rawan kecelakaan, dan 25 paket makanan bergizi terdistribusi kepada anak PAUD. Program-program ini berhasil meningkatkan kesadaran dan kapasitas masyarakat di bidang kesehatan, pendidikan, dan keselamatan lingkungan.

Substance and prescription drug misuse among adolescents continues to escalate and demands targeted preventive strategies within the school setting. This community service activity aimed to enhance students’ knowledge about the hazards of drug abuse through an interactive, school-based educational intervention. The program was conducted on 11 November 2026 at SMA Negeri 7 Kota Batam, involving fifty grade-X students as participants. A pre-experimental one-group pretest–posttest design was employed. The intervention combined interactive lectures, real-case illustrations, and two-way discussion, with knowledge measured using a content-validated questionnaire covering ten indicators. The mean score improved from 55.2 (pretest) to 86.3 (posttest), a gain of 31.1 points, while the proportion of correct answers across indicators rose from 48.6-62.9% to 80.0-91.4%. The largest gains appeared on items concerning rational drug use and the importance of professional health guidance, whereas the legal-consequence indicator improved more modestly. Interactive, contextually relevant education proves effective in elevating adolescent knowledge of drug abuse hazards, with stronger gains on experience-near content than on abstract regulatory aspects.

Dental caries is an oral health problem associated with the activity of Streptococcus mutans. Water hyacinth (Eichhornia crassipes) contains bioactive compounds such as flavonoids, tannins, and alkaloids with antibacterial potential. This study aimed to evaluate the effectiveness of water hyacinth extract against the growth of Streptococcus mutans. The research method used was an in vitro experimental study with a post test only group design. A total of 24 samples were divided into four treatment groups with extract concentrations of 6.25%, 12.5%, 25%, and 50%. Antibacterial activity was tested using the disc diffusion method on Mueller Hinton Agar media. Data were analyzed using the Kruskal-Wallis and Mann-Whitney tests. The results showed that water hyacinth extract inhibited the growth of Streptococcus mutans. The largest inhibition zone was observed at 50% concentration, while the smallest was found at 6.25% concentration. Kruskal-Wallis analysis showed significant differences among groups (p<0.05). In conclusion, water hyacinth (Eichhornia crassipes) extract has antibacterial activity against Streptococcus mutans.

This community service activity aims to improve lecturers' competence in supervising master's student thesis proposals through interactive workshops and intensive mentoring at the Adias Institute of Technology and Business, Pemalang. The activity was carried out in two online sessions via Zoom Meeting on April 11 and May 21, 2026, involving 24 participants consisting of 12 active supervisors and 12 master's students. The approach used refers to Kolb's experiential learning model, including socialization of needs, workshops on academic standards and feedback techniques, mentoring simulations, and formative evaluations based on competency rubrics. The results of the activity showed a significant increase in all indicators of mentoring competence with an average increase of 51.7 percent. All 12 lecturers successfully developed structured mentoring plans, and 24 student proposals reached the seminar-ready stage. Theoretically, these findings strengthen the relevance of the experiential learning approach in developing lecturers' academic competence. Practically, this program provides a replicable intervention model for private universities in standardizing the quality of thesis supervision at the master's level.

Non-Communicable Diseases (NCDs) such as Diabetes Mellitus and Gout pose a serious threat to the health of the elderly due to their often asymptomatic nature. Cost barriers hinder the elderly community from accessing laboratory services. This community service activity aims to improve health standards and early detection of NCDs through monitoring blood glucose and uric acid levels in the Generasi Kaleb community of the JKI Injil Kerajaan Church, Semarang. The Participatory Health Screening and Education method used includes health education, screening using the Point of Care Testing (POCT) tool, and personal consultation on the results. The service subjects were 50 elderly respondents. The examination results showed a prevalence of abnormal random blood glucose (GDS) of 8%, 32%, had high uric acid levels with a maximum value of 10.3 mg/dL. This activity successfully transformed the elderly's awareness from subjective perception to awareness based on objective data, and encouraged community independence in managing a healthy lifestyle to prevent further NCD complications. .

Anak merupakan amanah dan generasi penerus bangsa yang harus memperoleh perlindungan secara optimal dari segala bentuk eksploitasi, termasuk eksploitasi ekonomi melalui pekerjaan yang dapat mengganggu tumbuh kembangnya. Meskipun hukum Indonesia telah mengatur perlindungan anak melalui Undang-Undang Nomor 35 Tahun 2014 tentang Perubahan atas Undang-Undang Nomor 23 Tahun 2002 tentang Perlindungan Anak dan Undang-Undang Nomor 13 Tahun 2003 tentang Ketenagakerjaan, masih ditemukan rendahnya pemahaman anak dan masyarakat mengenai hak-hak anak dalam dunia kerja. Kegiatan penyuluhan hukum ini bertujuan meningkatkan pengetahuan dan kesadaran hukum anak-anak di Panti Sosial Anak Tawangmangu mengenai hak anak, batasan pekerjaan yang diperbolehkan bagi anak, serta perlindungan hukum terhadap praktik eksploitasi anak. Metode yang digunakan berupa ceramah, diskusi interaktif, studi kasus, dan evaluasi melalui pre-test dan post-test. Hasil penyuluhan menunjukkan adanya peningkatan pemahaman peserta mengenai hak-hak anak, ketentuan pekerja anak, dan mekanisme perlindungan hukum apabila terjadi pelanggaran hak anak. Penyuluhan hukum ini diharapkan mampu membangun kesadaran hukum sejak dini sehingga anak-anak dapat memahami hak dan kewajibannya serta terhindar dari berbagai bentuk eksploitasi ekonomi dan pelanggaran hak anak.

Artikel pengabdian ini menyajikan program partisipatif yang mengintegrasikan pengelolaan sampah rumah tangga dan kebun hidroponik untuk meningkatkan kesadaran lingkungan di Desa Betro. Program dirancang berdasarkan kondisi awal berupa kebiasaan membuang sampah campur, belum optimalnya pemanfaatan sampah organik, serta masih terbatasnya pemanfaatan pekarangan rumah. Kegiatan dilaksanakan melalui analisis situasi, sosialisasi 3R, pelatihan pemilahan sampah dan pengomposan sederhana, pembuatan demplot hidroponik, serta pendampingan kader. Pendekatan yang digunakan ialah participatory action dan edukasi berbasis komunitas dengan melibatkan unsur PKK, karang taruna, dan perangkat desa. Hasil program menunjukkan peningkatan pemahaman warga tentang pengelolaan sampah, munculnya kebiasaan memilah sampah dari rumah, terbentuknya titik kumpul sampah anorganik yang bernilai jual, serta pemanfaatan kebun hidroponik sebagai media belajar lingkungan dan sumber sayur rumah tangga. Integrasi kedua program mendorong perubahan perilaku yang lebih nyata, terukur, dan berkelanjutan.

Adolescents face significant barriers in accessing reproductive health services due to fears of privacy breaches and social stigma. In primary healthcare facilities, healthcare professionals are often trapped in a dilemma between the obligation to maintain medical confidentiality based on professional ethics and national regulatory demands requiring parental involvement for underage patients. This study aims to analyze the practice of protecting adolescent patient data privacy at Mardi Saras Primary Clinic and identify the gap between practical implementation and the norms of medical ethics and applicable legal regulations. This study employs a socio-legal research method with a qualitative approach. Data were collected through in-depth interviews with doctors and nurses, observation of service procedures, and study of the clinic's Standard Operating Procedures. The results indicate that although Mardi Saras Primary Clinic has implemented basic confidentiality protocols such as closed consultation rooms, there are substantial weaknesses in informed consent management, which still heavily relies on parental presence for all adolescent cases. This practice is driven by healthcare professionals' fear of legal risks, thereby ignoring the principle of developing autonomy in adolescents. These findings indicate a disparity between rigid administrative compliance and the spirit of protecting adolescent health rights within national regulations. The implication of this study underscores the urgency of developing specific SOPs that are sensitive to adolescent rights, as well as the need for continuous training for healthcare professionals regarding the legal and ethical boundaries of maintaining confidentiality for underage patients without compromising legal safety aspects.

Breast cancer remains a major global health challenge, with treatment effectiveness often limited by drug resistance and the toxic side effects of chemotherapy on normal cells. The exploration of bioactive compounds from natural sources through a medicinal chemistry approach offers a promising alternative strategy. This study aims to examine the molecular mechanisms of action and Structure-Activity Relationships (SAR) of various natural compound scaffolds as potential breast anticancer agents. The method employed was a systematic narrative literature review of 15 recent scientific articles evaluating computational parameters, including molecular docking, as well as in vitro and in vivo activities. The results indicate that polyphenols, flavonoids such as quercetin and EGCG, and curcumin possess strong cytotoxic activity and high binding affinity toward cancer-related target macromolecules. SAR analysis demonstrates that key structural features, including the number and position of free phenolic hydroxyl groups, the presence of gallate ester groups, and conjugated diketone systems, play a crucial role in determining ligand receptor complex stability. These interactions are supported by hydrogen bonding, hydrophobic interactions, and favorable steric compatibility within receptor binding sites. Computational findings further suggest that structural optimization can enhance ligand selectivity and improve pharmacokinetic properties. This study concludes that natural phytochemical scaffolds have significant potential as lead compounds and provide a rational basis for Computer-Aided Drug Design in developing more potent, selective, multi-target, and safer breast anticancer therapies.

Muscle-invasive bladder cancer (MIBC) is an aggressive malignancy associated with high morbidity, reduced survival, and impaired quality of life. Radiotherapy (RT) has been widely used as a bladder-preserving strategy, particularly for patients unsuitable for surgery or systemic chemotherapy. RT may also enhance tumor immunogenicity through programmed death-ligand 1 (PD-L1) upregulation, providing a rationale for combination therapy with immunotherapy. This study aimed to evaluate the effectiveness of combining immunotherapy and radiotherapy in MIBC treatment. A systematic review was conducted following PRISMA 2020 guidelines using the PICO framework. Literature searches were performed in PubMed, Embase, Cochrane, ClinicalTrials.gov, Web of Science, and Scopus databases for studies published between 2016 and 2025. Risk of bias was assessed using the Cochrane Risk of Bias Tool and ROBINS-I. Of 105 identified studies, five met the inclusion criteria and were included in the final analysis. Only one Phase II randomized controlled trial demonstrated low risk of bias in randomization and allocation concealment. ROBINS-I assessment indicated moderate to serious risk in confounding and participant selection domains. Clinical findings showed promising outcomes, with complete response rates ranging from 35%–50% and partial response rates from 25%–40%. Median overall survival ranged from 24–30 months, with favorable disease-free and progression-free survival outcomes. Combined immunotherapy and radiotherapy demonstrate potential to improve survival and disease control in MIBC; however, further rigorous clinical studies are needed to optimize patient-centered treatment strategies.  

Kurangnya pemahaman masyarakat mengenai hukum waris sering kali menjadi pemicu konflik dalam keluarga, terutama terkait pembagian harta peninggalan yang tidak sesuai dengan ketentuan hukum yang berlaku. Pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pemahaman dan kesadaran hukum masyarakat mengenai hak dan kewajiban para ahli waris guna mencegah terjadinya sengketa keluarga. Kegiatan dilaksanakan di Kelurahan Peterongan, Kecamatan Semarang Selatan, dengan menggunakan metode penyuluhan hukum melalui ceramah, diskusi interaktif, dan sesi tanya jawab. Pendekatan partisipatif diterapkan untuk mendorong keterlibatan aktif peserta dalam memahami permasalahan hukum waris yang sering muncul di lingkungan masyarakat. Hasil kegiatan menunjukkan adanya peningkatan pengetahuan peserta mengenai prinsip-prinsip dasar hukum waris, prosedur pembagian warisan, serta pentingnya penyelesaian masalah waris secara musyawarah dan sesuai ketentuan hukum. Penyuluhan ini berkontribusi dalam meningkatkan kesadaran hukum masyarakat sebagai langkah preventif untuk mengurangi potensi konflik keluarga terkait warisan.

Kegiatan pengabdian masyarakat ini bertujuan untuk membekali siswa SMK Negeri 11 Semarang dengan pengetahuan, sikap, dan keterampilan yang dibutuhkan untuk bekerja di Jepang. Kegiatan dilaksanakan melalui metode penyuluhan dan workshop yang melibatkan 50 siswa kelas XII jurusan Teknik Grafika, Animasi, dan Pengembangan Game. Materi mencakup tiga pilar utama: kemampuan bahasa Jepang (minimal N5/JLPT), sikap kerja (disiplin, tanggung jawab, sopan santun, dan pantang menyerah), serta keterampilan teknis (hard skill, soft skill, dan survival skill). Tiga jalur ke Jepang diperkenalkan yaitu magang teknis (Ginou Jisshuu), Specified Skilled Worker (SSW), dan sekolah sambil bekerja (Ryuugakusei). Hasil evaluasi menunjukkan peningkatan pemahaman dan motivasi siswa untuk mengejar peluang karier di Jepang. Kegiatan ini diharapkan menjadi langkah konkret dalam meningkatkan kualitas dan daya saing lulusan SMK di pasar kerja internasional.

Allergic rhinitis (AR) is a chronic inflammatory disorder of the nasal mucosa mediated by immunoglobulin E (IgE) in response to allergen exposure. This condition has become a significant global health concern because of its increasing prevalence and substantial impact on quality of life, sleep, cognitive function, and work productivity. AR is also commonly associated with other atopic diseases, including asthma and atopic dermatitis. This article aims to review the current understanding of allergic rhinitis, focusing on epidemiology, pathophysiology, clinical manifestations, diagnostic approaches, and evidence-based management strategies. This study used a narrative literature review method by analyzing scientific articles, clinical guidelines, and peer-reviewed journals published between 2015 and 2025. Literature sources were obtained from PubMed, Google Scholar, and relevant medical databases using keywords related to allergic rhinitis, IgE, diagnosis, and immunotherapy. The findings indicate that allergic rhinitis involves complex immune mechanisms characterized by Th2 lymphocyte activation, IgE production, and inflammatory mediator release. Diagnosis is primarily established clinically and supported by allergy testing such as skin prick tests or serum-specific IgE measurement. Intranasal corticosteroids remain the first-line therapy for moderate to severe cases, while antihistamines and leukotriene receptor antagonists are used as adjunctive therapies. Allergen immunotherapy has shown effectiveness in modifying disease progression and improving long-term outcomes. In conclusion, allergic rhinitis is a manageable chronic disease that requires a comprehensive and individualized treatment approach involving environmental control, pharmacotherapy, and immunotherapy.

Geographic tongue or benign migratory glossitis is a benign disorder of the oral mucosa that is relatively common in dental practice. This condition is characterized by erythematous areas caused by the loss of filiform papillae surrounded by irregular white borders. To understand the clinical characteristics of geographic tongue and the contributing factors involved in the development of the lesion in order to establish an appropriate diagnosis and provide adequate patient education. A 25-year-old female patient presented with complaints of patches on the tongue for approximately two months. The patient had been following an OMAD (One Meal A Day) diet for one year and reported an allergy to white rice. The patient also had a history of psoriasis. Nutritional deficiencies such as vitamin B complex, vitamin B12, folic acid, iron, and zinc may affect the integrity of the oral mucosa and disrupt the regeneration of the lingual epithelium. These conditions may lead to atrophy of the filiform papillae, resulting in the characteristic erythematous appearance of geographic tongue. In addition, immunological and inflammatory factors associated with psoriasis are also suspected to contribute to lesion development. Geographic tongue is a benign inflammatory condition with a multifactorial etiology, including nutritional deficiencies and immunological factors such as psoriasis. Evaluation of systemic conditions and nutritional status is important to support accurate diagnosis and proper patient management.

Clean and healthy living habits (PHBS) is the essence and human right to maintain the continuity of life. Clean and healthy living habits is a set of behaviors that are practiced on the basis of awareness as a result of learning, which makes a person, family, group or community able to help themselves (independently) in the health sector and play an active role in realizing public health. The impacts of families who do not practice PHBS are numerous, this problem comes from unhealthy behavior and environments. Clean and Healthy Living Behavior in Cemparam Lama Village, Bener Meriah Regency, based on the results of observations made by the Mesidah District Health Center, Bener Meriah Regency, in 2022 is 1.8%. The aim of this research is to see the description of clean and healthy living behavior in the household structure in Cemparam Lama Village, Mesidah District, Bener Meriah Regency. This type of research is purely descriptive which aims to see the description of clean and healthy living habits in the family structure in Cemparam Lama Village, Bener Meriah Regency. Results of this research were good knowledge of respondents with a percentage of 93.9%, positive attitudes of respondents with a percentage of 95.6%, and good actions of respondents with a percentage of 94. 7%. Conclusion of this research is that the majority of families in Cemparam Lama Village, Mesidah District, Bener Meriah Regency have a good description of characteristics, knowledge, attitudes and actions regarding Clean and Healthy Living Habits.  

Daun kelor (Moringa oleifera) merupakan tanaman lokal yang kaya protein, vitamin, dan mineral, serta berpotensi mendukung pemenuhan gizi anak apabila diolah dalam bentuk yang lebih diterima. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberdayakan masyarakat melalui inovasi pemanfaatan daun kelor (Moringa oleifera) berbasis data empiris masyarakat sebagai permen pendukung gizi anak. Kegiatan dilaksanakan di Desa Tinelo, Kabupaten Bone Bolango, Provinsi Gorontalo, dengan sasaran ibu yang memiliki anak usia 5–12 tahun. Tahap awal dilakukan pengumpulan data empiris melalui wawancara semi-terstruktur untuk mengidentifikasi pola pemanfaatan daun kelor dan tingkat penerimaan anak. Selanjutnya dilakukan kegiatan edukasi mengenai manfaat gizi daun kelor serta pendampingan pembuatan permen herbal kelor sebagai inovasi pengolahan pangan berbasis kearifan lokal. Evaluasi kegiatan dilakukan secara deskriptif dengan membandingkan kondisi pra dan pasca kegiatan terhadap perubahan pengetahuan, sikap, dan penerimaan masyarakat. Hasil kegiatan menunjukkan adanya peningkatan pemahaman ibu terhadap manfaat gizi daun kelor, dukungan terhadap inovasi pengolahan, penerimaan anak terhadap konsumsi kelor, partisipasi aktif masyarakat, serta minat untuk mengolah daun kelor secara mandiri. Kegiatan ini menunjukkan bahwa pendekatan pemberdayaan berbasis data empiris dan inovasi pangan lokal efektif dalam meningkatkan pemanfaatan daun kelor sebagai pendukung gizi anak.

Program Pengabdian kepada Masyarakat ini bertujuan meningkatkan kualitas pelayanan pelanggan pada usaha jasa pengetikan Metronet di Kecamatan Ambulu, Kabupaten Jember, melalui optimalisasi tiga fitur produktivitas Microsoft Office: autocorrect, autoformat, dan template dokumen. Tim pelaksana memakai metode riset tindakan partisipatif dengan menggabungkan metode ini dengan pelatihan dan bimbingan. Pelaksanaan program menunjukkan hasil yang jelas pada semua parameter evaluasi. Kemampuan karyawan meningkat sekitar 93,2%. Waktu penyelesaian dokumen berkurang rata-rata 58%. Tingkat kesalahan juga turun menjadi 1,2%. Kapasitas layanan bertambah 40%, dan adanya pelanggan baru dari kecamatan lain yang dapat dilayani. Ditemukan bahwa perbaikan kecil ini dengan tetap terfokus pada perangkat lunak perkantoran sehari-hari mampu mempertajam kualitas pelayanan usaha mikro dan memperluas jangkauan pasarnya dalam waktu relatif singkat.

In the planning of removable partial dentures (RPD), design is a crucial factor that must be tailored to each patient’s clinical condition, while one of the main challenges in RPD design is anatomical variation in the oral cavity such as torus palatinus, which may affect retention, stability, and patient comfort. This report aims to discuss the design considerations of acrylic resin RPD in patients with torus palatinus, particularly in determining optimal design modifications. A 42-year-old female patient presented with complaints of difficulty chewing due to the loss of several teeth in both the maxilla and mandible. Intraoral examination revealed missing teeth 15, 11, and 25, with healthy mucosal and periodontal conditions, and a nodular torus palatinus measuring approximately 2.5 × 2 cm was identified along the midline of the palate. RPD design planning in this case requires an individualized approach, particularly in the selection of the major connector and base adaptation to avoid pressure on the torus area, and design modifications were implemented to improve load distribution and patient comfort. The use of a U-shaped major connector with relief over the torus area effectively avoids direct contact, thereby enhancing comfort, preventing mucosal irritation, and supporting masticatory function.

Geometry learning at the Junior High School (SMP) level frequently faces challenges due to the abstract nature of the objects, which impacts students' low spatial literacy. This issue is exacerbated by the dominance of conventional teaching methods that lack interactive digital media. This community service activity aims to enhance students' spatial literacy at SMP IT Qoshrul Muhajirin through learning assistance using ethnomathematics-based digibooks. The method employed consists of four stages: Planning, Acting, Observing, and Reflecting. Data were collected through observation, student response questionnaires, as well as pre-test and post-test instruments. The results indicate a significant improvement in students' spatial literacy by 22.70%, with the average score increasing from 43% in the initial stage to 65.70% following the assistance. Furthermore, 91.3% of students provided positive responses regarding the ease of use of the media, and 90.4% felt more motivated in learning. It can be concluded that the use of ethnomathematics-based digibooks is effective as an innovative learning solution capable of integrating digital technology with local cultural values to optimize students' spatial abilities.