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This study aimed to determine the effect of different levels of beef liver addition on the nutritional, physicochemical, and color characteristics of chicken patties. Beef liver, an underutilized animal by-product with high nutritional value, was incorporated at different levels (0%, 20%, 40%, and 60%) into chicken patty formulations. The experiment was conducted using a Completely Randomized Design with four treatments and five replications. The collected data were analyzed using analysis of variance (ANOVA) and followed by Duncan’s Multiple Range Test (DMRT). The results showed that the addition of beef liver had no significant effect (P>0.05) on protein content, water activity (aw), and b* values, but had a highly significant effect (P<0.01) on moisture content, fat content, cooking loss, texture, and color characteristics (L* and a*). Increasing beef liver levels improved the nutritional profile and modified the physical and visual characteristics of the patties. These findings demonstrate the potential of beef liver as a value-added functional ingredient for developing nutritious chicken patties while promoting the sustainable utilization of underutilized livestock by-products.

This study aims to determine the effect of triangle pass and square pass training on passing accuracy among female futsal extracurricular participants at SMA Negeri 1 Cisaat. This study employed a quantitative method with a two-group pretest–posttest experimental design. The sample was divided into two groups: one group received triangle pass training, while the other group received square pass training. Data were collected through passing accuracy tests conducted before (pretest) and after (posttest) the treatment. The data were analyzed using paired sample t-tests and independent sample t-tests. The results showed that there was an improvement in passing accuracy in both groups. The triangle pass group increased its mean score from 62.40 to 78.20, while the square pass group improved from 61.80 to 73.50. Statistical analysis indicated that both training methods had a significant effect on passing accuracy (p < 0.05). Furthermore, there was a difference in effectiveness between the two methods, with triangle pass training being more effective than square pass training. In conclusion, both triangle pass and square pass training significantly improve passing accuracy; however, triangle pass training is more recommended as the primary method in futsal training programs.

Background: Rabies is a fatal zoonotic disease that remains a serious health problem in Bali, with increase case from rabies transmiting animal bite   in 2025. Sobangan Village, area of ??the Mengwi I Public Health Center, has been identified as a high-risk area due to its largest dog population and the second-highest bite incidence in the region. Lack of understanding regarding the initial treatment of bite wounds and vaccination are major risks factor for fatalities. Aim: This community service activity aims to increase the knowledge and awareness of the Sobangan Village community regarding the prevention and initial treatment of Animal Bites. Method: The implementation method included interactive counseling and focused discussions involving 18 village cadre representatives and PKK members, evaluated using pre-tests and post-tests. Result: The results showed a significant increase in the average knowledge score of participants from 11.56 to 12.56. The most increase understanding occurred in identifying the characteristics of rabid dogs (from 55.6% to 94.4%) and the urgency of post-exposure vaccination (from 72.2% to 100%). Conclusion: Community-based health education has been shown to be effective in improving cognitive competence as a preventative measure to reduce the risk of death from rabies in endemic areas.

Background:Tuberculosis remains a serious public health challenge in Indonesia, including in Pekalongan City, which sees an annual increase in cases. The still high number of TB cases and deaths each year indicates that the program being implemented is not yet fully effective, therefore requiring active community involvement, increased capacity of health workers, and closer cross-sector integration. Aims: This activity aims to provide comprehensive community nursing care through a promotive and preventive approach, with an emphasis on identifying risky behaviors, knowledge deficits, and non-adherence to TB treatment. Method: The methods used included community assessment, establishing a community nursing diagnosis, planning education-based interventions, implementing outreach and simulation activities, and evaluating outcomes. Results: The results of the activity indicated that most people have limited knowledge about TB prevention, and that risky behaviors and non-adherence to therapy persist. Interventions, including group outreach, interactive discussions, and education on the importance of medication adherence, demonstrated increased knowledge and healthier behavior changes. Conclution: The conclusion of this activity emphasized the importance of the active role of community nurses in reducing TB transmission rates through educational approaches, active surveillance, and cross-sector collaboration. Recommendations focused on strengthening ongoing education and the involvement of families and community health workers in early detection and monitoring of TB patient therapy.

Pressure sensitive labels (PSLs) made of polyethylene (PE) white are widely used in the packaging industry due to their flexibility, moisture resistance, and ease of application on various substrates. This study aimed to examine the effect of glossy and matte lamination on the tensile strength and color difference (ΔE) of PE white PSLs. An experimental method was employed, with tensile testing conducted using a universal testing machine (UTM) in accordance with ASTM standards and color measurement performed using a spectrodensitometer based on the CIE Lab system. The samples were divided into three treatment groups, namely no lamination, glossy lamination, and matte lamination, with ink coverage controlled at two design conditions, full ink and minim ink. The results indicated that lamination type significantly affected both the mechanical and visual characteristics of the labels. In the tensile strength test, the highest mean value was obtained by one treatment group, indicating superior resistance to tensile loading. In terms of color stability, higher ΔE values indicated greater color change and lower lightfastness, whereas lower ΔE values reflected better color retention. Overall, the findings show that the combination of lamination type and ink coverage influences the performance of PE white PSLs in both mechanical strength and color stability.

Lead (Pb²⁺) contamination in wastewater is a major environmental concern due to its toxicity, persistence, and ability to accumulate in living organisms. Adsorption using biomass-based materials has been developed as an alternative treatment method because it is efficient, economical, and environmentally friendly. This study aimed to analyze the effect of bioadsorbent dosage and contact time on Pb²⁺ removal efficiency and evaluate Pb²⁺ mass distribution using mass balance analysis in a batch adsorption system. Ramie leaf (Boehmeria nivea) was utilized as a bioadsorbent due to its lignocellulosic content, which provides active sites for metal ion adsorption. The research was conducted experimentally through bioadsorbent preparation, chemical activation, and batch adsorption using artificial Pb²⁺ solutions with variations in bioadsorbent dosage and contact time. Pb²⁺ concentrations before and after adsorption were analyzed using Atomic Absorption Spectroscopy (AAS). The obtained data were used to determine removal efficiency and Pb²⁺ distribution between the liquid phase and bioadsorbent. The results showed that ramie leaf bioadsorbent effectively reduced Pb²⁺ concentration, with the optimum condition obtained at 4 g/L bioadsorbent dosage and 90 minutes contact time, achieving 98.46% removal efficiency. Mass balance analysis indicated that Pb²⁺ ions were successfully transferred from the solution phase onto the bioadsorbent surface. These findings demonstrate that ramie leaf bioadsorbent has potential as a sustainable alternative material for heavy metal removal in wastewater treatment.

This study aimed to determine the physical characteristics and consumer preferences of a commercial fusion dessert, durian–katuk klapertaart (Sauropus androgynus). An experimental method was employed using a Completely Randomized Design (CRD) with three different treatments. Organoleptic evaluation was conducted by 30 untrained panelists using a hedonic test. The data were analyzed using Analysis of Variance (ANOVA) followed by Duncan’s Multiple Range Test. The results showed that the substitution percentage in each treatment had a significant effect on consumer acceptance in terms of aroma, texture, color, and taste. Formulation F2 was the most preferred by the panelists. The physical characteristics of the F2 formulation were soft with a slightly fibrous texture, a moderately strong durian aroma, a fairly strong katuk aroma, a slightly dark green color, and a balanced sweet taste of durian and katuk.

Lead (Pb²⁺) is a hazardous heavy metal commonly found in industrial wastewater and poses serious risks to human health and the environment due to its toxic and non-biodegradable nature. Therefore, an effective and environmentally friendly treatment method is required to reduce Pb²⁺ concentration in wastewater. This study aimed to evaluate the effect of pH and initial Pb²⁺ concentration on the adsorption capacity of ramie leaf (Boehmeria nivea) bioadsorbent activated with NaOH. The adsorption process was conducted using a batch system with pH variations of 4, 5, and 7 and initial Pb²⁺ concentrations of 20, 25, and 30 mg/L. The residual Pb²⁺ concentration was analyzed using Atomic Absorption Spectrophotometry (AAS), and the adsorption performance was evaluated based on removal efficiency and adsorption capacity (Qe). The results showed that pH and initial Pb²⁺ concentration significantly affected the adsorption performance. The optimum adsorption condition was obtained at pH 5, with a maximum removal efficiency of 99.20% and a total adsorption capacity of 18.56 mg/g. The increase in pH from 4 to 5 enhanced adsorption performance due to reduced competition between H⁺ and Pb²⁺ ions for active sites on the adsorbent surface. Increasing the initial Pb²⁺ concentration tended to increase adsorption capacity, although removal efficiency remained relatively stable due to the limited number of active adsorption sites. The Relative Standard Deviation (RSD) values ranged from 1.56% to 3.37%, indicating good precision and repeatability of the experimental data. These findings demonstrate that NaOH-activated ramie leaves have considerable potential as an effective, low-cost, and environmentally friendly bioadsorbent for Pb²⁺ removal from wastewater.

Joint pain is one of the most common health problems among older adults and may reduce mobility and quality of life. Community self-survey data in Cepoko Village indicated that 55% of residents, particularly older adults, experienced joint pain complaints. One non-pharmacological intervention that can be applied is warm lemongrass foot soaking therapy known as SEHATI (Serai Hangat untuk Kaki). This community service activity aimed to improve elderly knowledge regarding self-management of joint pain and demonstrate warm lemongrass foot soaking therapy as a complementary treatment. The methods included health education, demonstration of warm lemongrass preparation, direct practice by participants, and evaluation through discussion and question-answer sessions. The participants were elderly individuals experiencing joint pain in Cepoko Village, Panekan District, Magetan Regency. The results showed that participants actively engaged in all activities, were able to explain the preparation steps of SEHATI, and understood the benefits of warm lemongrass foot soaking therapy for reducing joint pain. This program provides an easy, affordable, safe, and home-based complementary therapy alternative for elderly people.

Background: Chronic Kidney Disease (CKD) patients undergoing long-term hemodialysis often experience anxiety due to therapy dependency, changes in health conditions, and uncertainty regarding the disease. Unresolved anxiety can reduce quality of life, comfort, and patient adherence to treatment. Therefore, non-pharmacological interventions are needed that are safe, easy to implement, and aligned with the patient's spiritual values. Mantram Tri Sandya has the potential to provide relaxation and psychological calm, thus helping to reduce anxiety. However, scientific evidence regarding the effectiveness of this therapy in hemodialysis patients is still limited, making this research crucial.  Purpose: The aim of this research is to determine the effect of the Tri Sandya mantra on reducing anxiety levels in CKD patients who are undergoing hemodialysis at the Buleleng Regency Regional Hospital. Methods: Pre-Experimental One Group Pre-Test & Post-Test research design with the Wilcoxon Signed Rank Test conducted at the Buleleng Regency Regional General Hospital. Data were collected using the HARS (Hamilton Anxiety Rating Scale) questionnaire sheet with Purposive Sampling technique with a sample size of 88 people. Results: The results obtained from this study were that there was a decrease in anxiety levels when given Mantra Tri Sandya therapy to CKD patients who were undergoing hemodialysis with a P value <0.001 (p<0.05). Conclusion: There is a significant effect of administering the Tri Sandy mantra on reducing anxiety levels in CKD patients who are undergoing hemodialysis at the Buleleng Regency Regional Hospital.

Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that may persist into adulthood and affect academic, social, and occupational functioning. In adult patients, ADHD is frequently associated with an increased risk of Substance Use Disorder (SUD), raising concerns regarding the potential for misuse and dependence related to stimulant medications used in ADHD therapy. This study aimed to evaluate the effectiveness of pharmacotherapy for adult ADHD and to review the risk of stimulant misuse and dependence based on current scientific evidence. The method employed in this study was a literature review using data obtained from national and international journals indexed in Scopus, PubMed, and Google Scholar published between 2017 and 2026. The findings indicated that stimulant medications, such as methylphenidate and amphetamine, were effective in reducing the core symptoms of ADHD by increasing dopamine and norepinephrine activity in the central nervous system. Most studies reported that the use of stimulant medications at therapeutic doses and under medical supervision was not significantly associated with an increased risk of substance misuse or dependence. The risk of misuse was more commonly observed in cases involving non-medical use and inadequate clinical monitoring. In addition to pharmacological therapy, non-pharmacological approaches such as cognitive behavioral therapy (CBT) also contributed to improving treatment outcomes and patients’ quality of life. Therefore, the use of stimulant medications in adult ADHD patients may be considered relatively safe and effective when administered rationally, individually, and under appropriate medical supervision.

Type 2 diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia due to impaired insulin secretion, insulin resistance, or a combination of both. HbA1c levels are used as an indicator of long-term glycemic control in patients with type 2 diabetes mellitus. Insulin therapy is one of the treatment options given to help achieve glycemic control targets. The purpose of this study was to determine the difference in HbA1c levels of type 2 diabetes mellitus patients with insulin and non-insulin therapy at PKU Muhammadiyah Gamping Hospital. This research method used a descriptive study with a cross-sectional approach. The subjects in this study were 80 type 2 diabetes mellitus patients who had used insulin and non-insulin therapy for less than 1 year, using Purposive Sampling techniques and data analysis using SPSS with Chi-Square and Mann-Whitney tests. This study has obtained ethical approval from PKU Muhammadiyah Gamping Hospital. This study shows that the characteristics of gender and age of type 2 DM patients with insulin and non-insulin therapy are dominated by women at 60.0% and 43.3%, while elderly patients at 60.0% and 53.3%. Of the 50 patients using insulin, 45 patients (90.0%) had controlled HbA1c and 5 patients (10.0%) were uncontrolled. Meanwhile, all non-insulin patients, 30 patients (100%), had uncontrolled HbA1c. Based on this study, there is a significant difference in HbA1c levels between type 2 diabetes mellitus patients with insulin and non-insulin therapy with a p-value <0.001. Patients using insulin therapy tend to have better glycemic control than patients not using insulin therapy.

Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that may persist into adulthood and affect academic, social, and occupational functioning. In adult patients, ADHD is frequently associated with an increased risk of Substance Use Disorder (SUD), raising concerns regarding the potential for misuse and dependence related to stimulant medications used in ADHD therapy. This study aimed to evaluate the effectiveness of pharmacotherapy for adult ADHD and to review the risk of stimulant misuse and dependence based on current scientific evidence. The method employed in this study was a literature review using data obtained from national and international journals indexed in Scopus, PubMed, and Google Scholar published between 2017 and 2026. The findings indicated that stimulant medications, such as methylphenidate and amphetamine, were effective in reducing the core symptoms of ADHD by increasing dopamine and norepinephrine activity in the central nervous system. Most studies reported that the use of stimulant medications at therapeutic doses and under medical supervision was not significantly associated with an increased risk of substance misuse or dependence. The risk of misuse was more commonly observed in cases involving non-medical use and inadequate clinical monitoring. In addition to pharmacological therapy, non-pharmacological approaches such as cognitive behavioral therapy (CBT) also contributed to improving treatment outcomes and patients’ quality of life. Therefore, the use of stimulant medications in adult ADHD patients may be considered relatively safe and effective when administered rationally, individually, and under appropriate medical supervision.

Wastewater Treatment Plant (WWTP) pada kawasan industri konvensional umumnya masih mengandalkan strategi pemeliharaan berbasis interval waktu yang tetap. Pendekatan tersebut berisiko menyebabkan penurunan performa pompa yang tidak teridentifikasi secara dini serta meningkatkan potensi pemborosan energi operasional. Penelitian ini mengembangkan Green Maintenance Framework berbasis machine learning untuk meningkatkan reliabilitas pompa sirkulasi pada sistem Moving Bed Biofilm Reactor (MBBR). Analisis dilakukan menggunakan dataset telemetri multi-sensor yang mencakup parameter getaran, temperatur, tekanan, debit aliran, dan rotasi per menit (RPM). Proses rekayasa fitur diterapkan melalui pembentukan System Efficiency Index untuk meningkatkan sensitivitas model terhadap indikator degradasi kinerja pompa. Model prediktif dibangun menggunakan algoritma Random Forest Classifier dengan skema pembagian data 80:20 secara stratified. Hasil pengujian menunjukkan bahwa model menghasilkan tingkat akurasi klasifikasi sebesar 100%, dengan variabel Vibration dan Temperature menjadi parameter yang paling dominan dalam proses prediksi. Analisis operasional memperlihatkan bahwa degradasi pompa menyebabkan penurunan flow rate meskipun nilai rotasi per menit (RPM) mengalami peningkatan, sehingga memicu kenaikan konsumsi energi dan meningkatkan risiko gangguan pada proses biologis Moving Bed Biofilm Reactor (MBBR). Dari aspek ekonomi, kondisi tersebut menyebabkan pemborosan energi sebesar 5.623 kWh atau setara Rp6.271.236, - per bulan untuk setiap unit pompa. Penelitian ini berkontribusi pada pengembangan sistem predictive maintenance berbasis kecerdasan buatan untuk mendukung efisiensi energi serta implementasi green manufacturing di kawasan industri.

Type 2 diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia due to impaired insulin secretion, insulin resistance, or a combination of both. HbA1c levels are used as an indicator of long-term glycemic control in patients with type 2 diabetes mellitus. Insulin therapy is one of the treatment options given to help achieve glycemic control targets. The purpose of this study was to determine the difference in HbA1c levels of type 2 diabetes mellitus patients with insulin and non-insulin therapy at PKU Muhammadiyah Gamping Hospital. This research method used a descriptive study with a cross-sectional approach. The subjects in this study were 80 type 2 diabetes mellitus patients who had used insulin and non-insulin therapy for less than 1 year, using Purposive Sampling techniques and data analysis using SPSS with Chi-Square and Mann-Whitney tests. This study has obtained ethical approval from PKU Muhammadiyah Gamping Hospital. This study shows that the characteristics of gender and age of type 2 DM patients with insulin and non-insulin therapy are dominated by women at 60.0% and 43.3%, while elderly patients at 60.0% and 53.3%. Of the 50 patients using insulin, 45 patients (90.0%) had controlled HbA1c and 5 patients (10.0%) were uncontrolled. Meanwhile, all non-insulin patients, 30 patients (100%), had uncontrolled HbA1c. Based on this study, there is a significant difference in HbA1c levels between type 2 diabetes mellitus patients with insulin and non-insulin therapy with a p-value <0.001. Patients using insulin therapy tend to have better glycemic control than patients not using insulin therapy.

ASTM A36 steel has relatively low hardness and corrosion resistance, making surface treatment necessary to improve its material properties. This study aims to determine the effect of temperature and holding time variations in the pack carburizing process on the hardness, corrosion rate, and microstructure of ASTM A36 steel. The pack carburizing process was carried out using coconut shell charcoal as the carburizing medium with temperature variations of 850°C, 900°C, and 950°C and holding times of 20, 40, and 60 minutes, followed by quenching in distilled water. Hardness testing was conducted using the Rockwell B scale (HRB) method, corrosion rate testing was performed according to the ASTM G31 method, and microstructural observations were carried out using Scanning Electron Microscopy (SEM). The results showed that increasing the temperature and holding time improved the hardness and corrosion resistance of ASTM A36 steel. The highest hardness value was obtained at a temperature of 950°C with a holding time of 60 minutes, reaching 114.1 HRB. Microstructural analysis revealed the formation of a martensitic phase on the specimen surface after the carburizing process.

Dental caries is an oral health problem associated with the activity of Streptococcus mutans. Water hyacinth (Eichhornia crassipes) contains bioactive compounds such as flavonoids, tannins, and alkaloids with antibacterial potential. This study aimed to evaluate the effectiveness of water hyacinth extract against the growth of Streptococcus mutans. The research method used was an in vitro experimental study with a post test only group design. A total of 24 samples were divided into four treatment groups with extract concentrations of 6.25%, 12.5%, 25%, and 50%. Antibacterial activity was tested using the disc diffusion method on Mueller Hinton Agar media. Data were analyzed using the Kruskal-Wallis and Mann-Whitney tests. The results showed that water hyacinth extract inhibited the growth of Streptococcus mutans. The largest inhibition zone was observed at 50% concentration, while the smallest was found at 6.25% concentration. Kruskal-Wallis analysis showed significant differences among groups (p<0.05). In conclusion, water hyacinth (Eichhornia crassipes) extract has antibacterial activity against Streptococcus mutans.

California papaya leaves (Carica papaya L.) are known to contain various active compounds that have the potential to stimulate appetite and boost metabolism, making them a promising candidate for development as a pharmaceutical formulation. This study aims to design a capsule formulation of California papaya leaf extract with appropriate excipients and to evaluate its ability to increase body weight through preclinical testing using a zebrafish (Danio rerio). The extract was obtained via maceration with 96% ethanol and formulated into capsules using the wet granulation method in four variations (F0–F3). Physical evaluations included organoleptic properties, flowability, angle of repose, loss on drying, disintegration time, weight uniformity, and stability testing using the cycling test method. The results indicated that all formulas met the physical requirements, with disintegration times of 3–4 minutes and loss on drying <15%. Formula F2 exhibited the most optimal physical characteristics; however, stability testing revealed a decline in physical properties after extreme temperature treatment. Efficacy tests showed a significant increase in zebrafish weight (p < 0.05), with F3 yielding the best results. A high survival rate (≥80%) suggests the formulation is relatively safe. In conclusion, California papaya leaf extract capsules demonstrate significant potential as an agent to promote weight gain.

Muscle-invasive bladder cancer (MIBC) is an aggressive malignancy associated with high morbidity, reduced survival, and impaired quality of life. Radiotherapy (RT) has been widely used as a bladder-preserving strategy, particularly for patients unsuitable for surgery or systemic chemotherapy. RT may also enhance tumor immunogenicity through programmed death-ligand 1 (PD-L1) upregulation, providing a rationale for combination therapy with immunotherapy. This study aimed to evaluate the effectiveness of combining immunotherapy and radiotherapy in MIBC treatment. A systematic review was conducted following PRISMA 2020 guidelines using the PICO framework. Literature searches were performed in PubMed, Embase, Cochrane, ClinicalTrials.gov, Web of Science, and Scopus databases for studies published between 2016 and 2025. Risk of bias was assessed using the Cochrane Risk of Bias Tool and ROBINS-I. Of 105 identified studies, five met the inclusion criteria and were included in the final analysis. Only one Phase II randomized controlled trial demonstrated low risk of bias in randomization and allocation concealment. ROBINS-I assessment indicated moderate to serious risk in confounding and participant selection domains. Clinical findings showed promising outcomes, with complete response rates ranging from 35%–50% and partial response rates from 25%–40%. Median overall survival ranged from 24–30 months, with favorable disease-free and progression-free survival outcomes. Combined immunotherapy and radiotherapy demonstrate potential to improve survival and disease control in MIBC; however, further rigorous clinical studies are needed to optimize patient-centered treatment strategies.  

Human Papillomavirus (HPV) infection is typically the cause of cervical cancer, one of the cancers with a high death rate among women. Despite their widespread use, conventional therapeutic approaches still have drawbacks, such as the emergence of cancer cell resistance and severe side effects. Natural compounds are now used as safer alternative treatments as a result. Soursop leaves (Annona muricata L.) are one plant that has been shown to have anticancer potential. Through phytochemical screening, compound identification using GC-MS, cell viability testing using the MTT Assay, and BCL2 gene expression analysis using qPCR, this study attempts to examine the potential of soursop leaf extract as an anticancer agent against cervical cancer cells (HeLa cells). The results of the phytochemical examination showed that steroids, phenolics, and alkaloids were present. Ostole, bisacumol, and ricinoleic acid were found to be the predominant components when the active chemicals were identified by GC-MS. With an IC²₀ value of 5.01 μg/mL, the MTT experiment demonstrated that soursop leaf extract could decrease cell viability as the concentration rose. Furthermore, BCL2 gene expression was significantly reduced, especially in treatments with doses of 500 and 1000 μg/mL, according to the results of qPCR gene expression analysis. The overall findings suggest that soursop leaf extract may be used as a natural anticancer treatment against HeLa cells by lowering the expression of the BCL2 gene.