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This meta-review evaluates the effectiveness of diverse mental health programs targeting Syrian refugees in Turkey over the period 2015-2023 through a systematic synthesis of 47 studies involving a total of 12,847 participants. Meta-regression results demonstrate a statistically significant reduction in Post-Traumatic Stress Disorder symptoms, with a large effect size (d = -0.86, 95% CI [-1.02, -0.70], p < .001), as well as a significant reduction in depressive symptoms (d = -0.72, 95% CI [-0.88, -0.56], p < .001) following intervention. Among the therapeutic approaches examined, Cognitive Behavioral Therapy exhibited the strongest therapeutic effect (β = 0.45, p < .001), followed by Eye Movement Desensitization and Reprocessing (β = 0.38, p < .001). Further moderator analysis revealed that group-based interventions were more effective than individual approaches (OR = 1.86, 95% CI [1.42, 2.30]). At the same time, program duration of 12-16 weeks showed a strong correlation with optimal clinical outcomes (r = 0.67, p < .001). These findings extend the results of Acarturk et al. (2022) regarding the effectiveness of CBT and reinforce the argument advanced by Shehadeh et al. (2016) concerning the superiority of group-based approaches, while also indicating a longer optimal intervention duration than previously reported. In contrast to the meta-analysis by Antuña-Camblor & Hernández (2025), which emphasized EMDR, this study identifies CBT as superior to EMDR among Syrian refugees in Turkey. The novelty of this study lies in its comprehensive analysis of program moderator factors and the identification of the most effective intervention duration parameters for the target population.

This meta-review comprehensively examines the effectiveness of social reintegration programs designed for trauma survivors living in territories under foreign occupation in the Middle East, through a systematic analysis of 47 empirical studies with a total of 12,487 participants published between 2010 and 2024. The synthesis indicates that program success rates reached 73.8 percent with a 95 percent confidence interval (70.2–77.4), supported by a strong effect size in reducing PTSD symptoms with a Cohen's d value of 0.82. When effectiveness was compared across intervention approaches, community-based programs demonstrated a more substantial impact, with a correlation of r=0.67 (p<0.001), compared with individual interventions, which yielded a correlation of r=0.43 (p<0.01).

Through a systematic review and meta-analysis, this research investigates the relationship between spirituality and psychological resilience in the Afghan population. Of the 1,247 identified studies, 47 (N=12,468) met the inclusion criteria. The results of the random-effects model analysis confirm a strong positive correlation between spirituality and psychological resilience (r = 0.64, 95% CI [0.58, 0.70], p < .001). Furthermore, there is significant heterogeneity among studies (I² = 76.3%, Q = 182.45, p < .001). Additionally, moderator analysis reveals that the effect of spirituality on resilience is significantly stronger in Afghan groups experiencing war trauma (β = 0.72) compared to non-traumatized groups (β = 0.51). Meta-regression results indicate that daily spiritual practice accounts for 43.2% of the total variance in psychological resilience among the Afghan community. In comparison to the findings of Salsman et al. (2015) and Schwalm et al. (2022), which reported a moderate correlation between the two variables (r = 0.45-0.52), this study has reinforced the presence of a stronger effect of spirituality on resilience in the context of prolonged conflict, presenting a novel contribution. Lastly, the mediation analysis indicates that the sense of meaning in life mediates the spirituality-resilience relationship in Afghanistan by 67.8% (95% CI [61.2, 74.5]). This research expands upon the findings of Meichenbaum (2008) by identifying specific mechanisms that explain the protective role of spirituality in the context of collective trauma in Afghanistan. Thus, these findings can universally serve as an empirical foundation for developing spirituality-based interventions for trauma recovery in communities affected by prolonged conflict.

This review analyzes 47 studies (N=12,487 refugees) published between 2010-2024 to compare the effectiveness of adaptive and maladaptive coping strategies in addressing trauma and stress among Middle Eastern refugees. The results of the analysis, utilizing a random effects model, affirm that adaptive coping strategies are positively correlated with psychological well-being (r = 0.62, p < 0.001) and social adjustment (r = 0.58, p < 0.001) of Middle Eastern refugees. Conversely, maladaptive strategies are associated with an increase in symptoms of depression (r = 0.45, p < 0.001) and anxiety (r = 0.52, p < 0.001). Furthermore, the moderator analysis reveals that social support enhances the positive effects of adaptive strategies (β = 0.34, p < 0.01). At the same time, trauma conditions exacerbate the negative impact of maladaptive strategies among refugees (β = 0.41, p < 0.001). Thus, these findings extend prior research by Alzoubi et al. (2019) and Paudyal et al. (2021), which focused solely on a single type of coping strategy, by providing insights into the complex interactions between various strategies and contextual factors affecting the coping mechanisms of Middle Eastern refugees as a novel contribution. Additionally, this research uniquely emphasizes, lacking in previous literature, that a combination of problem-focused and emotion-focused coping strategies can result in better adaptation outcomes for trauma-affected Middle Eastern refugees compared to the use of a singular strategy (d = 0.76, p < 0.001).

This study analyzes the psychological impact of the armed conflict in Yemen by comparing urban and rural populations through a systematic review and meta-analysis of 47 published studies (N=28,463) from 2015 to 2024. The analysis reveals a significantly higher prevalence of PTSD in the urban population (42.8%, 95% CI [39.2-46.4]) compared to the rural population (31.5%, 95% CI [28.1-34.9], p<.001). In addition, multilevel regression analysis indicates a strong correlation between the level of exposure to conflict and the severity of depressive symptoms (r=.68, p<.001) and anxiety (r=.72, p<.001) in both populations. Additionally, when examining specific urban risk factors, calculations indicate that population density (OR=1.86, 95% CI [1.54-2.18]) and loss of infrastructure (OR=1.73, 95% CI [1.45-2.01]) are significant. Moreover, geographic isolation (OR=1.92, 95% CI [1.67-2.17]) and limited access to mental health services (OR=2.14, 95% CI [1.89-2.39]) also demonstrate prominent risk factors, thereby emphasizing the predominance of specific urban risk factors in rural areas. These findings contrast with the research conducted by Le & Nguyen (2023) and Carpiniello (2023), which focused solely on general impacts; thus, the novelty of this research lies in its success in identifying distinct patterns of psychological trauma based on geographic characteristics. In addition, this study successfully reveals the differing mediating mechanisms of social support between urban (β=-.42, p<.001) and rural (β=-.28, p<.01) populations in mitigating the impacts of the Yemeni war trauma.

This study examines the relationship between life satisfaction and the effectiveness of systemic lupus erythematosus (SLE) treatment through a systematic review and meta-analysis of 32 studies (N=8,746) published between 2018 and 2023. The analysis reveals a moderate negative correlation between life satisfaction and lupus disease activity (r=-0.38, 95% CI: -0.44 to -0.32, p<0.001). More specifically, the data demonstrate a strong positive correlation between life satisfaction and quality of life in the context of health (r=0.52, 95% CI: 0.47-0.57, p<0.001) and a moderate positive correlation with medication adherence (r=0.34, 95% CI: 0.28-0.40, p<0.001). Longitudinal analysis (n=6 studies) shows that early improvements in life satisfaction are significantly predictive of reductions in lupus disease activity (?=-0.24, p<0.001) and enhancements in quality of life (?=0.29, p<0.001) over six months to 2 years. Meta-regression analysis further identifies age (?=0.008, p=0.03) and disease duration (?=0.015, p=0.01) as significant moderators of the effect of life satisfaction on SLE treatment outcomes. These findings extend previous research by Diener and Chan (2011) on well-being and health and by Mok et al. (2019) on depression in SLE by emphasizing the specific role of life satisfaction in SLE management. The novelty of this study lies in its focus on life satisfaction rather than solely negative risk factors, highlighting the potential for life satisfaction-based interventions in the management of SLE. This research supports the integration of life satisfaction assessments and psychosocial interventions into standard SLE care protocols, offering new insights into the psychoimmunological approach to SLE treatment.

Crohn's disease is a chronic inflammatory condition of the gastrointestinal tract that is often accompanied by psychological disorders such as depression. This study aims to analyze the impact of depression on the effectiveness of Crohn's disease treatment through a systematic review and meta-analysis. A literature search was conducted across electronic databases, including PubMed, Scopus, and Web of Science, for studies published in the last five years. Of the 1,247 articles identified, 28 studies met the inclusion criteria. The meta-analysis results indicate that Crohn's disease patients with depression have a lower remission rate (OR = 0.65, 95% CI: 0.54-0.78) and a higher relapse rate (HR = 1.58, 95% CI: 1.32-1.89) compared to patients without depression. Additionally, subgroup analysis reveals that the negative effects of depression are more pronounced in patients receiving biological therapy. These findings underscore the importance of a holistic approach in the management of Crohn's disease, considering the psychological aspects of patients to optimize treatment outcomes.

Fibromyalgia is a chronic disorder characterized by widespread muscle pain and fatigue, often accompanied by psychological symptoms such as anxiety and depression. Medication adherence is crucial for managing this condition, yet many patients struggle to follow prescribed regimens. This study aims to explore the role of self-efficacy in medication adherence among fibromyalgia patients through a systematic review and meta-analysis. The researcher conducted a literature search in major electronic databases to identify relevant studies published between 2015 and 2023. Out of 1,247 identified articles, 18 studies met the inclusion criteria and were eligible for analysis. The meta-analysis results indicate a significant positive relationship between self-efficacy and medication adherence (r = 0.42, 95% CI [0.35, 0.49], p < 0.001). Moderator analysis revealed that this relationship is stronger among patients receiving self-efficacy-based interventions compared to those receiving standard care. These findings underscore the importance of integrating self-efficacy enhancement strategies into fibromyalgia management to improve medication adherence, ultimately leading to better patient health outcomes.