A characteristic of students in 21st century learning is critical thinking, having the ability & willingness to digital literacy, ICT and new media, as well as adaptive and flexible initiative. However, currently, junior high school students' critical thinking abilities are still at a low level. Therefore, this research aims to develop e-book mathematics learning media based on PjBL-STEM assisted by Geometry Calculator to improve students' critical thinking skills. This type of research is research and development using the ADDIE development model which includes five stages, namely analysis, design, development, implementation and evaluation. The research subject was MTs NU Mranggen class VIII. The research instruments were material validation questionnaires, media validation questionnaires, and student critical thinking tests. The research results showed that (1) The media was declared suitable for use according to material experts, the validity level of the three material experts was 82%, 86% and 93%, while the validity level of the two media experts was 86% and 92%. (2) The average score for the experimental class was 81.04 while the control class was 64.96, so the learning media was declared effective. This research is very useful for improving students' critical thinking skills through developing a PjBL-STEM based e-book with the help of a Geometry Calculator on circle material used in learning. The unique thing about this research is that it is easier for students to learn because they use e-books which can be read anywhere and anytime. Apart from that, the e-book contains the PjBL-STEM learning method with the help of a Geometry Calculator which can make it easier for students in the learning process.
Suatu karakteristik siswa pada pembelajaran abad 21 yaitu berpikir kritis, memiliki kemampuan & kemauan literasi digital, ICT dan media baru, serta terinisiatif yang adaptif dan fleksibel. Namun saat ini, kemampuan berpikir kritis siswa SMP masih pada tingkatan rendah. Oleh karena itu, penelitian ini bertujuan untuk mengembangkan media pembelajaran matematika e-book berbasis PjBL-STEM berbantuan Geometry Calculator untuk meningkatkan kemampuan berpikir kritis siswa. Jenis penelitian ini adalah penelitian dan pengembangan dengan menggunakan model pengembangan ADDIE yang meliputi lima tahapan yaitu analisis, desain, pengembangan, implementasi dan evaluasi. Subjek penelitian adalah MTs NU Mranggen kelas VIII. Instrumen penelitian berupa validasi angket materi, validasi angket media, dan tes berpikir kritis siswa. Hasil penelitian menunjukkan bahwa (1) Media dinyatakan layak pakai menurut ahli materi, tingkat validitas ketiga ahli materi adalah 82%, 86% dan 93%, sedangkan tingkat validitas kedua ahli media adalah 86% dan 92 %. (2) Hasil nilai rata-rata kelas eksperimen 81,04 sedangkan kelas kontrol 64,96 sehingga media pembelajaran dinyatakan efektif. Penelitian ini sangat berguna untuk meningkatkan kemampuan berpikir kritis siswa melalui pengembangan e-book berbasis PjBL-STEM berbantuan Geometry Calculator terhadap materi lingkaran yang digunakan dalam pembelajaran. Hal unik dari penelitian ini yaitu siswa lebih mudah untuk belajar karena menggunakan e-book yang dapat dibaca dimanapun dan kapanpun. Selain itu, e-book tersebut di dalamnya memuat metode pembelajaran PjBL-STEM yang berbantuan Geometry Calculator yang dapat memudahkan siswa dalam proses pembelajaran.

Nursing care is a process or series of activities in nursing practice that is provided directly to clients/patients in various health service settings. In implementing nursing care based on self-transcendence theory, nurses play the role of facilitators to help individuals experience growth and development through the self-transcendence process. Self-transcendence theory was developed by Pamela G. Reed and emphasizes the spiritual and transpersonal aspects of treatment. Reed explained that nurses act as facilitators to explore positive things and build bio-psycho-social spiritual well-being. Self Transcendence Theory aims to understand a person's movement in transcending self-limitations and achieving higher well-being. This theory focuses on five concepts, namely vulnerability, self-transcendence, well-being, moderating-mediating factors, and point of intervention. This self-transcendence offers the best for living in peace and prosperity. Apart from that, this theory is also used in the context of counseling services to help individuals utilize inner resources that empower patient capacities. Thus, the aim of the Self Transcendence theory is to understand and encourage individuals to achieve higher well-being through holistic self-understanding and development.
 

This study explores the utilization of LightGBM, a gradient-boosting framework, to classify the inhibitory activity of beta-secretase 1 inhibitors, addressing the challenges of Alzheimer's disease drug discovery. The study aims to enhance classification performance by focusing on overcoming the limitations of traditional statistical models and conventional machine-learning techniques in handling complex molecular datasets. By sourcing a dataset of 7298 compounds from the ChEMBL database and calculating molecular descriptors for each compound as features, we employed LightGBM in conjunction with a set of carefully selected molecular descriptors to achieve a nuanced analysis of compound activities. The model's efficiency was benchmarked against traditional machine-learning algorithms, revealing LightGBM's superior accuracy (84.93%), precision (87.14%), sensitivity (89.93%), specificity (77.63%), and F1-score (88.17%) in classifying beta-secretase 1 inhibitor activity. The study underscores the critical role of molecular descriptors in understanding drug efficacy, highlighting LightGBM's potential in streamlining the virtual screening process. Conclusively, the findings advocate for LightGBM's adoption in computational drug discovery, offering a promising avenue for advancing Alzheimer's disease therapeutic development by facilitating the identification of potential drug candidates with enhanced precision and reliability.

This journal discusses the concept and implementation of state defense in the context of student life. State defense is an important concept to strengthen and protect the country's sovereignty, as well as build awareness and a sense of national responsibility towards their country. This journal focuses on the conceptual framework of state defense, including the values contained in the concept. Values such as patriotism, loyalty to the country, concern for the environment, and a sense of social responsibility are crucial in building a strong sense of state defense in university students. Furthermore, this journal analyzes how state defense can be implemented in everyday life as a student. The research method used is qualitative description, while the type of research is library research, the activity is carried out by collecting data related to the title which is literature. Through good civic education, active participation in social and political activities, and real contributions to state development. In addition, this journal also discusses how improving integrity as a student is an implementation of state defense and also the reasons why improving integrity and state defense are very important. The author suggests several ways that can be done to improve integrity as a student to realize state defense and citizenship in universities, expand community participation programs, and build awareness of the importance of state defense through mass media and social campaigns. This journal summarizes the importance of state defense in building and protecting state defense, and provides a framework that can be used by educational institutions in implementing the concept of state defense. It is hoped that readers of this journal will gain a better understanding of state defense and the importance of building state defense awareness.

This study aims to determine the criminal responsibility of intellectual disabilities in the legal system in Indonesia and examine how the accountability of drug dealers by people with intellectual disabilities in Decision Number 290 / Pid.Sus / 2019 / PN.Tng which decided the defendant to release and Decision Number 1364k / Pid.Sus / 2017 which decided the defendant to be imprisoned, whether the judge's consideration in deciding the two cases was in accordance with Law Number 35 of 2009 on Narcotics and Article 44 of the Criminal Code. This research is a type of normative legal research that is prescriptive and applied. This legal writing uses a statutory approach and a case approach. The technique of collecting legal materials carried out is by literature study.

Sharia people's credit bank (BPRS) is an institution that carries out business activities based on sharia principles and in its activities does not provide services in payment traffic. The level of interest in PT. Many BPRS Al Washliyah choose murabahah financing. This high level of murabahah financing activity can cause high risks faced by the entity providing the financing. Risk management is an effort that must be made to minimize the possibility of loss risks that may occur as a result of problematic murabahah financing transactions. The conclusion from these results is that murabahah financing risk management faced by PT. BPRS AL-Washliyah Medan, namely by persuasive means, if this method cannot be a solution to the existing problems, then PT. BPRS Al-Washliyah Medan resolved this by means of collateral, namely the confiscation/sale of collateral

The Supan Supan Laki plant (N. plena Lour) has been used traditionally by a group of people in Pal Batu Village, Paminggir District, North Hulu Sungai Regency as a herbal medicine to increase male sexual activity. Based on previous research, this plant has been proven to have a positive effect in increasing fertility in test animals. However, until now, there is no certainty regarding the safety of using this plant. This study aims to examine the effects and safety of consuming Supan Supan Laki extract on the macroscopic appearance of the liver and kidneys in mice. This research was carried out, there were four treatment groups in this study, namely Na-CMC 0.5%; 87.5mg/KgBW; 175mg/KgBW; and 350mg/KgBW, given for 28 days using a Completely Randomized Design (CRD) trial design. On the 29th day, surgery was performed to observe the liver and kidney macroscopically. Measurement of color, surface and relative organ weight parameters of the kidneys and liver of mice. The results of the study showed that administration of Supan Supan Laki leaf extract caused significant changes in the macroscopic appearance of the liver and kidney organs. In the research analysis using the One Way Anova test, the results of the test showed that the liver (p>0.05) did not have a significant level of variation, while the kidney (p<0.05) had a significant level of variation so that it could be concluded that the effect of N.plena Lour leaf extract have different effects on the relative weight of the heart and kidney organs.

This community service activity through mentoring and fostering Qur'an literacy activities is important in supporting the development of one's Qur'an literacy skills. Research and field practice show that ongoing effective mentoring can help children to gain a better understanding of the content of the Qur'an. The main focus of this mentoring and guidance is to improve the ability to read and write the Qur'an thoroughly and accurately, as well as ensure a deep understanding of the meaning and context of the verses of the Qur'an. This mentoring and coaching involves various methods and techniques, such as the use of interactive approaches, repetitive exercises, the use of educational technology, and the strengthening of tajweed skills. The ultimate goal of this mentoring and coaching is to create a learning environment that supports, motivates, and strengthens the individual's spiritual connection with the Qur'an, thus fostering continuous personal growth and strong character development in accordance with Islamic teachings

<em>This study aims to empirically examine the relationship between parenting perception and emotional regulation in regional students of the Faculty of Psychology class of 2020, Semarang University. In this study, the hypothesis is that there is a positive relationship between the relationship between parenting perception and emotional regulation in regional students of the Faculty of Psychology, class of 2020, Semarang University. The more positive the perception of parenting in regional students, the higher the emotional regulation in regional students. This research involved regional students of the Faculty of Psychology class of 2020 as research subjects. The data analysis used in this study used the Product Moment Correlation Technique. This research data was collected using two scales, namely the emotion regulation scale and the parenting perception scale. Data analysis was carried out using the person correlation test obtained using the SPSS (Statistical Package for Social Science) program version 20. The results showed that there was a significant relationship between parenting and emotional regulation in regional students of the Faculty of Psychology batch 20. With a correlation person = 0.001 with a correlation value of 0.336. Thus, the hypothesis in this study is accepted</em>.

<em>This research aims to determine the relationship between self-adjustment and happiness in adolescent students at the Asy-Syarifah Mranggen Islamic Boarding School. The hypothesis proposed in this research is that there is a positive relationship between self-adjustment and happiness in the students of the Asy-Syarifah Mranggen Islamic Boarding School. The more adaptive the adjustment, the higher the happiness of the students at the Asy-Syarifah Mranggen Islamic Boarding School, and vice versa. The method used in this research is a quantitative method. The characteristics of the respondents in this study were students at the Asy-Syarifah Mranggen Islamic Boarding School with an age range of 12-15 years and a maximum length of stay at the Islamic boarding school of 1 year. Data collection was carried out using the Cluster Random Sampling technique. Research data was collected using two scales, namely the Happiness Scale and the Personal Adjustment Scale. The data analysis method was carried out using Product Moment and the results of the research showed that there was a positive relationship between self-adjustment and happiness in the students of the Asy-Syarifah Mranggen Islamic Boarding School and the correlation coefficient value r?? = 0.551 with a p value &lt; 0.001 was obtained, so the hypothesis in this study was accepted.</em>