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Literature Review: Analisis Target Molekuler Dan Pendekatan Kimia Medisinal Dalam Pengembangan Terapi Kanker Servik
Saeful Amin
; Aliya Fayyaza Khairun Nisa
; Shilvia Siti Nurohmah
; Salla Sabillah
Jurnal Riset Rumpun Ilmu Kesehatan
Vol 5
, No 2
(2026)
Cervical cancer is one of the most common cancers worldwide and is largely caused by Human Papillomavirus (HPV) infection, particularly types 16 and 18. The development of this cancer is influenced by the E6 and E7 oncoproteins, which disrupt the function of p53 and Rb proteins, as well as the involvement of cellular signaling pathways such as PI3K/AKT/mTOR and EGFR. Limitations of conventional therapies, such as resistance and side effects, drive the need for more targeted and selective therape...
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Senyawa Alami sebagai Kandidat Obat Antikanker: Suatu Tinjauan Kimia Medisinal
Cheriel Dhiya Nazwa Alivia
; Saeful Amin
Jurnal Riset Ilmu Farmasi dan Kesehatan
Vol 3
, No 6
(2025)
Cancer remains a major challenge in modern medicine due to drug resistance and the adverse effects of conventional therapies, making it one of the leading causes of death worldwide. Continuous scientific efforts aim to discover safer and more effective treatments. Owing to their structural diversity, strong bioactivity, and relatively low toxicity, natural compounds show great promise as sources of anticancer drug candidates. This article aims to explore the role of medicinal chemistry in invest...
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Kajian Potensi Senyawa Aktif Bahan Alam sebagai Inhibitor Human Epidermal Growth Factor Receptor 2 (Her-2) pada Kanker Payudara : Kajian Penambatan Molekuler
Saeful Amin
; Anantha Puspatiara
; Fina Awaliah
; Widiya Zulvania
Jurnal Riset Rumpun Ilmu Kesehatan
Vol 4
, No 1
(2025)
Breast cancer is the most prevalent type of cancer in women worldwide, with approximately 2.3 million new cases or 11.7% of all cancer cases. Human Epidermal Growth Factor Receptor 2 (HER-2) is one of the important therapeutic targets in breast cancer that is overexpressed in 15-25% of cases. Conventional cancer treatments such as chemotherapy often cause adverse side effects, so safer alternative therapies are needed. This study aims to assess the potential of active compounds from medicinal pl...
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Prediksi Aktivitas Antikanker Babandotan dengan Pendekatan Kimia Medisinal dan Komputasi In Silico
Nazwa Cahya Kamila
; Saeful Amin
; Ai Sriwahyuni
; Azzindani Januar
Jurnal Riset Rumpun Ilmu Kesehatan
Vol 4
, No 1
(2025)
This research aims to explore the potential of secondary metabolites from babandotan plant (Ageratum conyzoides L.) as breast cancer drug candidates through a medicinal chemistry approach using in silico studies. Breast cancer has the highest prevalence among women in Indonesia, with conventional treatments often causing serious side effects, prompting the search for new anticancer agents from natural sources. Babandotan plant (Ageratum conyzoides L.) has been empirically proven to have cytotoxi...
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Studi Literatur : Penambatan Senyawa Komponen Tanaman Kumis Kucing ( Orthosiphon Stamineus Benth ) Sebagai Diuretik Menggunakan Metode Docking
Sefira Novi Ariyanto
; Saeful Amin
; Eva Sucianti
; Fitria Mutiara Rohmah
Jurnal Riset Rumpun Ilmu Kesehatan
Vol 4
, No 1
(2025)
Orthosiphon stamineus Benth., commonly known as kumis kucing, is a widely recognized medicinal herb in traditional medicine, particularly valued for its diuretic properties. This study aims to evaluate the potential of active compounds in O. stamineus as diuretic agents through an in silico approach using molecular docking methods. A total of 98 compounds were screened against three diuretic target receptors: 1Z9Y (furosemide receptor), 3HS4 (acetazolamide receptor), and 3VHU (spironolactone rec...
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Peran Kimia Medisinal dalam Pengembangan Obat Anti Sars Cov-2: Eksplorasi Senyawa Bioaktif dari Teh Hijau (Camellia Sinensis)
Fitya Fithrotun Najiah
; Citra Kusumaningsih
; Saeful Amin
; Hanifiani Kamila
Jurnal Riset Rumpun Ilmu Kesehatan
Vol 4
, No 1
(2025)
COVID-19 is a viral respiratory disease that has caused a global health emergency and was declared a pandemic by the World Health Organization. The lack of certain drug molecules or treatment strategies for this disease is making it worse. Therefore, effective drug molecules are urgently needed to fight COVID-19. Specific therapies for the SARS-COV2 virus are still being developed in several countries around the world. One of the molecular targets that is thought to be specific to SARS-COV 2 is...
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Potensi Kaempferol dan Kalkon Tergeranilasi Sebagai Kandidat Terapi Penyakit Jantung Koroner (PJK) Melalui Pendekatan Molecular Docking
Saeful Amin
; Tevani Almanda Ramdani
; Maitsa Gita Salsabila
; Teguh Nizar Zulmi
Jurnal Riset Rumpun Ilmu Kesehatan
Vol 4
, No 1
(2025)
Coronary heart disease (CHD) is one of the leading causes of death worldwide due to impaired blood and oxygen supply to the heart muscle. This study aims to explore the potential of two natural compounds—kaempferol from Moringa oleifera and geranylated chalcone (GTDC) from Artocarpus altilis—as therapeutic candidates for CHD through a molecular docking approach. Medicinal chemistry analysis revealed that kaempferol exhibits significant affinity for the NF-κB protein, forming key hydrogen bonds w...
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Literature Review: Analisis Khasiat Tanaman Pala (Myristica Fragnans Houtt) dalam Pengobatan Halitosis Oleh Bakteri
Saeful Amin
; Naila Naziba
; Hayuning Putri Ambi
; Salsabila Sasikirana
Jurnal Riset Rumpun Ilmu Kesehatan
Vol 4
, No 1
(2025)
Halitosis, or bad breath, is a multifactorial condition that is often caused by anaerobic bacterial activity in the oral cavity, especially on the dorsum surface of the tongue. The use of natural ingredients as an alternative halitosis treatment is a concern, one of which is the nutmeg plant (Myristica fragrans), which has various active compounds such as essential oils, saponins, flavonoids, and alkaloids. This study aims to assess the potential of nutmeg plants in inhibiting the growth of bact...
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Pendekatan Kimia Medisinal dalam Optimasi Senyawa Bioaktif dari Bahan Alam sebagai Kandidat Obat Antikanker
Saeful Amin
; Neng Padia Amelia
; Tiara Oktavia Ramadhan
; Silvia Dwi Putri
Jurnal Riset Rumpun Ilmu Kedokteran
Vol 4
, No 1
(2025)
Cancer is one of the leading causes of death in the world, with the incidence rate continuing to increase every year. Conventional treatments such as chemotherapy and radiotherapy often have limitations, especially related to selectivity towards cancer cells and toxic side effects caused to normal cells. Therefore, an alternative approach that is more effective and safe is needed. One promising approach is the utilization of bioactive compounds from natural materials that are optimized through a...
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Eksplorasi Kimia Medisinal untuk Terapi Kolesterol Tinggi : Analisis Struktur-Aktivitas dan Target Molekuler Obat
Saeful Amin
; Putri Nasywa Nabilah Ma’rifatillah
; Intan Permatasari
; Siti Maryam
Jurnal Riset Rumpun Ilmu Kesehatan
Vol 4
, No 1
(2025)
Hypercholesterolemia is a significant global health problem, with a high prevalence in Indonesia. Although conventional therapies such as statins have been the mainstay of treatment, limited efficacy and side effects necessitate the development of new, more effective and selective drugs. This article explores the role of medicinal chemistry in the discovery and development of cholesterol-lowering drugs, focusing on structure-activity analysis (SAR) and molecular targets. Through structure-based...
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