Publication Search

Tomato (Solanum lycopersicum) is a high-value horticultural commodity in Indonesia, yet its cultivation is frequently disrupted by leaf diseases that are difficult to distinguish visually. Diseases such as Bacterial Spot, Early Blight, and Tomato Yellow Leaf Curl Virus often present overlapping visual symptoms, making early and accurate diagnosis a significant challenge for farmers. The manual identification methods currently in use are inefficient and error-prone, ultimately leading to reduced crop yield  and quality. The general objective of this study is to develop software capable of automatically classifying tomato  leaf diseases. Specifically, this research aims to implement the MobileNetV3 Small architecture based on Convolutional Neural  Network (CNN) with ImageNet pre-trained weights to classify 10 types of tomato leaf diseases. The research methodology encompasses dataset collection from Kaggle comprising 10,000 images (1,000 per class), image pre-processing through resizing to 224x224 pixels, and normalization, as well as hyperparameter optimization (optimizer, learning rate, epoch, batch size) via scheduler. Model performance is evaluated using a confusion matrix encompassing accuracy, precision, recall, and F1-score.

Various viruses due to unhygienic surfaces of eating and drinking utensils, especially those that are frequently used and repeated, if they do not meet health standards have the potential to cause disease in subsequent users as a problem faced. The purpose of fabrication is to obtain eating and drinking utensils (talam-ompreng) measuring 400x300x0.4 mm made of SS304 which are hygienic, practical, heat resistant, not easily broken, not easily worn, easy to wash and easy to carry. The fabrication method includes: design of a 40 cm long, 30 cm wide eating tray, 7 serial basins (rice container 12 x 12 cm 2 basins, side dish container 8 x 8 cm 3 basins, vegetable container 6 x 6 cm 1 basin, fruit container 6 x 6 cm 1 basin) with a depth of 30 mm, a thickness of 0.4 mm; selection of SS304 plates; design of pressing molds; checking the thickness of SS304 plates; cutting material 55 x 45 cm; pressing until flat (not bulging or thinning/torn); bending the edges around; finishing cleaning metal thorns; stamping according to order; and quality inspection of the ompreng tray according to nutritional standards. The fabrication results in a 40 cm long, 30 cm wide, 0.4 mm thick tray made of SS304 material with a total production cost of IDR 75,000/unit, and a process duration of 2 minutes/unit which implies that the eating and drinking utensils can be used repeatedly after being washed clean from viruses.

Kanker serviks atau kanker leher rahim merupakan masalah kesehatan di masyarakat. Penyakit ini banyak di derita oleh para perempuan di negara berkembang, Kanker serviks berawal dari adanya infeksi virus HPV yang terjadi karena pola perilaku hidup yang salah, penyebabnya adalah infeksi dari Human Vapiloma Virus (HPV) yang ditularkan melalui hubungan seksual dan ditemukan pada 95% kasus Kanker serviks. untuk mengetahui Hubungan Faktor Predisposisi dan Fakor Reinforcing dalam pelaksanaan Deteksi dini Kanker serviks Dengan metode IVA Test Pada Wanita Usia Subur di Desa Tembeng Putik wilayah kerja Puskesmas Wanasaba. Penelitian ini menggunakan metode survei analitik dengan pendekatan Cross Sectional. Populasinya wanita usia subur, jumlah sampel 38 orang dengan teknik pengambilan simple random sampling. Alat ukur yang digunakan adalah kuesioner, dan analisis menggunakan uji Chi Square. Hasil uji statistik menunjukkan Faktor Predisposisi (tingkat pendidikan)  didapatkan nilai p-value = 0,234 (>?=0,05), factor reinforcing (dukungan suami,)didapatkan nilai p-value = 0,004 (<?=0,05), Tidak Ada hubungan antara Faktor Predisposisi (tingkat pendidikan) dengan pelaksanaan Deteksi dini Kanker serviks metode IVA Test. Ada Hubungan antara factor reinforcing (dukungan suami,) dengan pelaksanaan Deteksi dini Kanker serviks metode IVA Test.

Dengue fever remains a major global health challenge, particularly in tropical regions, due to the high transmission of Dengue virus by Aedes aegypti and the limited sustainability of current control strategies. Artocarpus odoratissimus, an endemic Bornean plant, contains diverse secondary metabolites with potential pharmacological activities; however, a systematic synthesis of its biomedical relevance to Dengue is still lacking. This study aimed to systematically evaluate the biomedical potential of A. odoratissimus in Dengue prevention and control through a systematic literature review. This study employed a systematic literature review method following the PRISMA 2020 guidelines. Literature searches were conducted in Scopus, ScienceDirect, SpringerLink, PubMed, Google Scholar, Garuda, SINTA, and other relevant scientific databases for publications from January 2016 to February 2026. A total of 303 records were identified, and after duplicate removal, title and abstract screening, and full-text eligibility assessment, 23 studies were included for narrative synthesis. The findings revealed that A. odoratissimus contains major bioactive compounds, including flavonoids, phenolics, arylbenzofurans, stilbenoids, and prenylated chalcones, which demonstrate antioxidant, anti-inflammatory, immunomodulatory, and potential antiviral activities based on in vitro and molecular docking studies. Fruit peel, seeds, and stem bark exhibited the strongest biological evidence, particularly in reducing oxidative stress, inhibiting inflammatory mediators, and potentially interacting with Dengue viral target proteins. Furthermore, several species within the Artocarpus genus showed larvicidal and ovicidal activities against Aedes aegypti, highlighting the potential development of A. odoratissimus as a plant-based biolarvicide candidate.

Dengue fever remains a major global health challenge, particularly in tropical regions, due to the high transmission of Dengue virus by Aedes aegypti and the limited sustainability of current control strategies. Artocarpus odoratissimus, an endemic Bornean plant, contains diverse secondary metabolites with potential pharmacological activities; however, a systematic synthesis of its biomedical relevance to Dengue is still lacking. This study aimed to systematically evaluate the biomedical potential of A. odoratissimus in Dengue prevention and control through a systematic literature review. This study employed a systematic literature review method following the PRISMA 2020 guidelines. Literature searches were conducted in Scopus, ScienceDirect, SpringerLink, PubMed, Google Scholar, Garuda, SINTA, and other relevant scientific databases for publications from January 2016 to February 2026. A total of 303 records were identified, and after duplicate removal, title and abstract screening, and full-text eligibility assessment, 23 studies were included for narrative synthesis. The findings revealed that A. odoratissimus contains major bioactive compounds, including flavonoids, phenolics, arylbenzofurans, stilbenoids, and prenylated chalcones, which demonstrate antioxidant, anti-inflammatory, immunomodulatory, and potential antiviral activities based on in vitro and molecular docking studies. Fruit peel, seeds, and stem bark exhibited the strongest biological evidence, particularly in reducing oxidative stress, inhibiting inflammatory mediators, and potentially interacting with Dengue viral target proteins. Furthermore, several species within the Artocarpus genus showed larvicidal and ovicidal activities against Aedes aegypti, highlighting the potential development of A. odoratissimus as a plant-based biolarvicide candidate.

Malware represents an evolving cybersecurity threat that demands more effective detection methods. Conventional signature-based detection systems have limitations in identifying new variants, driving the development of deep learning-based approaches. This research implements and evaluates four variants of the YOLOv11 algorithm (n, s, m, l) for malware classification based on visual image representation. The dataset consists of 22,056 malware and benign images, divided into 70% training, 15% validation, and 15% testing across 8 classes (adware, backdoor, benign, downloader, spyware, trojan, virus, worm). Each model was trained for 100 epochs with batch size 32 using Google Colab with GPU support. Results demonstrate that all variants achieve high accuracy (97.8%-98.1%) with YOLOv11m as the best performer (98.1%). YOLOv11n offers optimal balance between accuracy (97.9%) and efficiency (1.5M parameters, 0.3 ms/img inference) ideal for real-time applications. This research surpasses previous methods such as K-NN (97.18%) and hybrid CNN (96.55%) with superior inference speed (0.3-0.9 ms/img vs tens to hundreds of ms/img), proving the effectiveness of YOLOv11 for fast, accurate, and scalable malware detection.

Hydrocephalus is defined as active distension of the brain’s ventricular system, resulting from inadequate flow of cerebrospinal fluid from its site of production to its site of absorption into the systemic circulation. Hydrocephalus can affect anyone at any age; pediatric hydrocephalus affects 1 in 1,000 live births and is the most common cause of brain surgery in young patients. Hydrocephalus is a pathological condition characterized by abnormal accumulation of cerebrospinal fluid (CSF) due to increased production, impaired flow, or reduced absorption. Ventricular enlargement occurs in response to increased CSF volume and can lead to structural damage to the brain parenchyma. This condition can be congenital or acquired. One key point in prenatal diagnosis is the differentiation between fetal hydrocephalus and non-hypertensive ventriculomegaly. The former qualifies for intrauterine treatment with good outcomes. However, the latter can result in either favorable or catastrophic outcomes due to a damaging etiology, as seen in viral infections such as Zika virus. For an accurate diagnosis, fetal MRI is performed to detect brain anomalies, in addition to fetal ultrasound (to detect common complications), karyotype testing, and TORCH testing (toxoplasma, rubella, cytomegalovirus, herpes simplex). Obstetric management of fetal hydrocephalus depends on the gestational age at diagnosis and the presence of other anomalies. Treatment options include termination of pregnancy before the fetus is viable, placement of a ventriculoamniotic shunt, cephalocentesis before delivery, and/or cesarean section.

Corona Virus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The first case was identified in Wuhan, China, in December 2019. The World Health Organization declared COVID-19 a Public Health Emergency of International Concern (PHEIC) on January 30, 2020, and a pandemic on March 11, 2020. This study aimed to determine the results of CT Value images on the first and second swab tests of children with COVID-19 in Indramayu. A descriptive design was used with total sampling, involving 54 respondents. Secondary data were analyzed using univariate analysis. On the first swab test, 27 children (50.0%) had a strong positive Ct Value, 26 children (48.1%) were positive, and 1 child (1.9%) had a weak positive Ct Value. On the second swab test, 23 children (71.9%) were positive, 6 children (18.8%) were strong positive, and 3 children (9.4%) were weak positive. All children tested positive on the first swab, while 32 (59.3%) remained positive and 22 (40.7%) became negative on the second swab. Most children showed decreased infection severity, although some remained positive.

The right to privacy and the right to health are fundamental human rights that are closely interconnected. The protection of privacy for patients with Human Immunodeficiency Virus (HIV) constitutes a critical issue, given that HIV status is classified as highly sensitive health data and is particularly vulnerable to stigma and discrimination. In Indonesia, the legal framework governing the protection of HIV patients’ health data has been normatively strengthened through the Personal Data Protection Law and the Health Law; however, its implementation continues to face various challenges. This article aims to analyze the right to privacy of HIV patients and the obligations of the state in protecting sensitive health data, as well as to examine the limitations and exceptions to the disclosure of HIV-related data within the framework of law and human rights. This study employs a normative legal research method using statutory, conceptual, and human rights-based approaches. Legal materials are analyzed qualitatively through juridical interpretation and prescriptive analysis. The findings indicate that HIV status is legally categorized as sensitive personal data that is entitled to a high level of legal protection. The state bears tripartite obligations to respect, protect, and fulfill the privacy rights of HIV patients. Nevertheless, a gap persists between legal norms and their implementation, particularly in the management of electronic medical records. The protection of HIV patients’ privacy rights requires strengthened legal implementation, regulatory harmonization, and the adoption of a human rights-based approach to ensure that data protection does not conflict with public health interests.

Background: HIV (Human Immunodeficiency Virus) and AIDS (Acquired Immune Deficiency Syndrome) remain global health issues, including in Indonesia. One of the management strategies is antiretroviral therapy (ART), which requires a high level of adherence to be effective. Objective: This study aims to analyze the effect of reminders on adherence to ARV treatment among people living with HIV (PLHIV) at the Tembuku I Community Health Center. Methods: This study employed a quasi-experimental design using a one-group pretest-posttest approach. The sample consisted of 30 PLWHA selected using total sampling, and data were analyzed using the Wilcoxon test. Results: Univariate analysis revealed that the average age of respondents was 35 years; the majority were female, had a high school education, and worked as homemakers and farmers. Bivariate analysis revealed that prior to the intervention, the majority of PLWHA (70%) had low adherence levels, whereas after the intervention, adherence levels increased to 100%. Statistical test results showed a p-value < 0.05, indicating a significant effect of social media-based reminders on improving ARV adherence in the Tembuku I Community Health Center area. Conclusion: The use of social media-based reminders is effective in improving adherence to ARV treatment among people living with HIV. This intervention can be recommended as a simple and practical strategy to support the success of ARV therapy in primary health care settings.

Introduction: Dengue fever is a viral infection transmitted through the bite of infected female Aedes aegypti mosquito, caused by four dengue virus serotypes (DEN-1 to DEN-4), with clinical manifestations ranging from asymptomatic to severe disease and may be accompanied by warning sign. Concurrent infections, such as acute diarrhea, may worsen outcomes, particularly in children. Case Report: A nine-month-old female presented with a five-day history of intermittent fever and watery diarrhea. Additional symptoms included vomiting, lethargy, and decreased appetite. Physical examination showed a moderately ill appearance and sunken eyes. Laboratory findings revealed positive dengue IgM, negative dengue IgG, thrombocytopenia (22,000/µL), and hematocrit of 37%. The patient was diagnosed with dengue fever with warning sign and acute diarrhea. Management included intravenous crystalloid fluids, antipyretics, antibiotics, H2 receptor antagonists, and zinc supplementation. Conclusion: Dengue with warning sign and concurrent acute diarrhea in children increases the risk of morbidity and mortality. Early and appropriate management is essential to prevent disease progression and improve clinical outcomes.

Litopenaeus vannamei is a brackish-water aquaculture commodity that is highly favored by the Indonesian community and represents one of the country’s leading aquaculture products, with production continuing to increase in response to rising domestic and export demand. One of the main factors triggering disease in L. vannamei is the presence of Vibrio sp. bacteria, which are recognized as serious pathogens in various aquaculture organisms and serve as causative agents of bacterial diseases. These bacteria naturally inhabit marine environments and are categorized as opportunistic, meaning they become pathogenic when environmental conditions decline and host health is compromised. Disinfectants are chemical substances used to inhibit or eliminate microorganisms such as bacteria, viruses, and fungi (excluding bacterial spores) on non-living surfaces. One disinfectant material is Smart Care (Intracare B.V., The Netherlands), which contains stabilized hydrogen peroxide with a prolonged-release mechanism. This study employed an experimental method using a Completely Randomized Design (CRD) with four treatments and five replications. The treatments included a control (without H₂O₂) and applications of H₂O₂ at concentrations of 1 ml/L, 2 ml/L, 3 ml/L, and 4 ml/L. The results indicated that the addition of hydrogen peroxide at different concentrations did not produce statistically significant differences in suppressing the growth rate of Vibrio sp. Nevertheless, treatment C (3 ml/L H₂O₂) showed the highest inhibitory effect, with no bacterial colony growth observed. Therefore, the application of H₂O₂ at 3 ml/L demonstrates potential in reducing Vibrio sp. growth and supporting sustainable shrimp aquaculture practices.

The hospital laundry installation is a non-medical supporting unit with a high risk of occupational health and safety (OHS) hazards due to direct exposure to chemicals, machinery, and contaminated linen. Potential hazards in this unit include physical (heat, noise), chemical (detergents and disinfectants), biological (viruses and bacteria from linen), and ergonomic (improper working posture) risks. This study is a descriptive quantitative research with a semi-quantitative approach. The aim is to identify, assess, evaluate, and control OHS risks in the laundry unit. Data were collected through observation, interviews, and document review with seven laundry staff members. Risk assessment was conducted using a risk matrix based on the AS/NZS 4360:2004 standard. The results show that several risks ranged from low to very high levels, including infection from linen, chemical exposure, noise, and injury from machinery. Risk control measures implemented include applying the hierarchy of controls, starting from elimination, substitution, engineering controls, Administratif controls, and the use of personal protective equipment (PPE). It is concluded that improvements in supervision, staff training, and facility upgrades are necessary to minimize occupational accidents in the laundry installation.

Dengue Hemorrhagic Fever (DHF) is a disease caused by the dengue virus and transmitted through the bite of the Aedes aegypti mosquito. According to the WHO, 40% of the world's population is at risk of dengue fever, with a significant increase in cases in the last two decades, especially in 2019. After declining during the Covid-19 pandemic, cases surged again in 2023, including in previously unaffected areas. In Indonesia, Ministry of Health data shows an increasing trend in cases, with 186,324 cases and 1,120 deaths by week 35 of 2024. Environmental factors and community behavior influence the spread of dengue-causing mosquitoes. This study aims to determine the relationship between these factors and the incidence of dengue fever in Central Lampung Regency. This study aims to determine the relationship between environmental factors and community behavior with the incidence of Dengue Hemorrhagic Fever (DHF) in Central Lampung Regency. This study is an observational analytical study using a case control study design. The research instruments used were questionnaires and observation sheets. The data analysis technique used the chi square test. From the results of the study it is known that out of 9 variables, 4 variables have a relationship with the incidence of DHF, namely the availability of container covers (p value = 0.023 <0.05), frequency of container drainage (p value = 0.001 <0.05), the presence of larvae in containers (p value = 0.006 <0.05), and respondent attitudes (p value = 0.023 <0.05). Based on research in Central Lampung Regency, of the nine variables examined, four were shown to be associated with the incidence of Dengue Hemorrhagic Fever (DHF). Therefore, it is crucial to raise public awareness and routinely implement Dengue Prevention (PSN) or 3M, both independently and collectively. Dengue prevention needs to be carried out not only through sanctions (punishment), but also through a promotive and preventive approach involving individuals, communities, environmental policies, and supervision from relevant agencies. These efforts must be comprehensive and sustainable, involving all levels of society.

The COVID-19 pandemic emerged as a global health crisis that revealed China's political strategies in intricate ways. This study examines the political aspects of China's response to the outbreak, focusing on its information management, domestic policies, and international diplomacy. By analyzing narratives surrounding the virus's origins and its global spread, the research also assessed the pandemic's impact on Indo-China relations[1] across diplomatic and economic dimensions. The pandemic period also coincided with a sharp deterioration in bilateral trust between India and China, highlighted by the Galwan Valley clash and subsequent tensions along the Line of Actual Control, which deepened strategic mistrust and hardened India’s policy stance. The findings illuminate how political maneuvering has redefined China's geopolitical standing during this crisis, providing insights into the evolving landscape of Indo-Pacific relations. By uncovering these complexities, this study contributes to a nuanced understanding of health geopolitics and the underlying power dynamics.    

Herpes zoster is a skin infection caused by the reactivation of the varicella-zoster virus, characterized by unilateral skin lesions corresponding to dermatome distribution and complaints of pain or itching. This disease is more common in adults and the elderly, especially in individuals with reduced immunity due to stress or work overload. A case was reported of a 40-year-old woman who worked as a nurse and came to a primary health care facility complaining of itching and red spots on her right breast area that had spread to the surrounding area two weeks before the examination and had worsened in the last few days. Physical examination revealed unilateral red skin lesions in a dermatomal pattern without crossing the midline of the body, consistent with the early phase of herpes zoster. Management was comprehensive, including medication, patient education about the disease and skin care, prevention of complications, and family support. A holistic approach is necessary to improve the success of therapy and the patient's quality of life.

HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system. Viral load is a key indicator in monitoring HIV, where higher viral load indicates a worsening condition in the patient and can lead to the progression of the disease to AIDS (Acquired Immunodeficiency Syndrome). Viral load can also predict the likelihood of opportunistic infections, which are the leading causes of morbidity and mortality in individuals with HIV and AIDS. Objective: To analyze the relationship between the duration of ARV therapy and viral load in PLWHA at RSUP Dr. Kariadi Semarang in 2025. Results: The Spearman correlation test (rₛ = -0.405; p = 0.002) shows a significant negative correlation between the duration of ARV therapy and viral load in PLWHA. The longer the patient undergoes ARV therapy, the lower the viral load. Among patients who have undergone therapy for more than 12 months, 80.43% had an undetectable viral load, while in the 6–12 month therapy group, only 33.33% had an undetectable viral load. Conclusion: There is a significant relationship between the duration of ARV therapy and viral load. Longer ARV therapy tends to lower viral load in PLWHA. Further research is needed to understand the factors that influence viral load and the effectiveness of ARV therapy.

Viral hepatitis is a systemic disease that primarily affects the liver and is characterized by a necroinflammatory process that plays a significant role in clinical and laboratory manifestations. Chronic hepatitis is defined as liver inflammation lasting more than six months, with persistent elevations in aminotransferases and characteristic histological features, and carries a risk of progression to cirrhosis and hepatocellular carcinoma. Chronic hepatitis C virus infection occurs due to an ineffective host immune response to the virus, allowing the infection to persist. The innate immune system, particularly type I interferon, plays a key role in the initial defense mechanisms against viral replication. Various antiviral therapies, such as interferon, nucleoside analogs, and nucleotide analogs, are currently available, which have been shown to reduce viral load and inhibit disease progression. Appropriate therapy is expected to prevent long-term complications in patients with chronic hepatitis.

Beef demand in Indonesia continues to increase, particularly during religious holidays. Bali cattle, one of the main sources of beef, face a serious threat from Jembrana disease, a viral infection that compromises the immune system and causes significant economic losses. This study aimed to determine the correlation between spleen weight, body temperature, and cycle threshold (Ct) values in Bali cattle following Jembrana virus inoculation. A correlational method was applied to eight female Bali cattle injected with Jembrana virus inoculum. Physiological changes in body temperature were monitored, followed by necropsy to assess spleen weight. In addition, Real-Time Polymerase Chain Reaction (RT-PCR) was performed before and after inoculation to detect viral presence and determine Ct values. Data were analyzed using SPSS with Pearson correlation tests. The results revealed a very strong positive correlation between spleen weight and body temperature, while a very strong negative correlation was observed between spleen weight and Ct values. These findings indicate that Jembrana virus inoculation leads to increased body temperature and splenic enlargement in Bali cattle, accompanied by a decrease in Ct values, reflecting higher viral loads. Therefore, the administration of antipyretics, anti-inflammatory drugs, analgesics, vitamins, and antibiotics prior to vaccination is recommended to reduce the risk of hyperthermia, splenic swelling, decreased Ct values, and secondary infections.

Men who have Sex with Men (MSM) are a key population with a high risk of Human Immunodeficiency Virus (HIV) infection. In Papua, the increasing number of HIV cases among this group remains a public health challenge, highlighting the need for comprehensive analysis of sociodemographic and clinical characteristics. This study aimed to analyze the sociodemographic and clinical profiles of HIV/AIDS patients among the MSM population at the Kotaraja Reproductive Health Clinic, Jayapura City. An observational analytic study with a cross-sectional and retrospective approach was conducted using medical record data from 2023 to 2024. A total of 21 HIV/AIDS patients among MSM who met the inclusion criteria were included in the study. Data were analyzed descriptively to assess age, occupation, education level, ethnicity, marital status, clinical stage, sexual orientation, and the presence of sexually transmitted infections (STIs). The results showed that most patients were in the productive age group of 20–24 years (47.6%), had secondary education (71.5%), worked as private employees (57.1%), were non-Papuan (95.3%), and were unmarried (100%). The majority were diagnosed at WHO clinical stages I and II (95.6%). Most patients identified as homosexual (90.5%), while 9.5% identified as bisexual. Concomitant STIs were identified in 47.6% of patients, all of which were syphilis. In conclusion, HIV/AIDS among MSM in Jayapura predominantly affects young productive-age individuals with distinct social and clinical characteristics, emphasizing the importance of early screening and culturally sensitive, integrated HIV prevention strategies.