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Breast cancer remains a major global health challenge, with treatment effectiveness often limited by drug resistance and the toxic side effects of chemotherapy on normal cells. The exploration of bioactive compounds from natural sources through a medicinal chemistry approach offers a promising alternative strategy. This study aims to examine the molecular mechanisms of action and Structure-Activity Relationships (SAR) of various natural compound scaffolds as potential breast anticancer agents. The method employed was a systematic narrative literature review of 15 recent scientific articles evaluating computational parameters, including molecular docking, as well as in vitro and in vivo activities. The results indicate that polyphenols, flavonoids such as quercetin and EGCG, and curcumin possess strong cytotoxic activity and high binding affinity toward cancer-related target macromolecules. SAR analysis demonstrates that key structural features, including the number and position of free phenolic hydroxyl groups, the presence of gallate ester groups, and conjugated diketone systems, play a crucial role in determining ligand receptor complex stability. These interactions are supported by hydrogen bonding, hydrophobic interactions, and favorable steric compatibility within receptor binding sites. Computational findings further suggest that structural optimization can enhance ligand selectivity and improve pharmacokinetic properties. This study concludes that natural phytochemical scaffolds have significant potential as lead compounds and provide a rational basis for Computer-Aided Drug Design in developing more potent, selective, multi-target, and safer breast anticancer therapies.

This study aims to analyze the representation of healthy lifestyle ideology in government digital campaigns through the Instagram content of the Ministry of Youth and Sports of the Republic of Indonesia (@kemenpora). The rapid development of social media as a medium for public communication has encouraged government institutions to utilize digital platforms to deliver policy messages in a more persuasive, visual, and interactive manner. In this context, social media content functions not only as a source of information, but also as a space  for the production of meaning and ideology that shapes public understanding of health and lifestyle. This research employs a qualitative approach using Kress and van Leeuwen’s multimodal semiotic analysis, which includes three metafunctions of meaning: representational, interactive, and compositional. The analysis is further enriched by Roland Barthes’ semiotic framework at the levels of denotation, connotation, and myth to uncover the deeper ideological meanings embedded within the campaign visuals. The findings reveal that @kemenpora’s visual content constructs a dichotomy between unhealthy food consumption and physical activity as opposing lifestyle choices. At the mythological level, the campaign reproduces the ideology of healthism, which positions health as solely an individual responsibility while obscuring the social and structural dimensions influencing public health conditions. This study concludes that government digital campaigns function not only as instruments of public education, but also as strategic communication tools that construct healthy lifestyle ideology within the digital sphere.

Cooperatives in indonesia constitute the foundational pillar of the national economy and hold a constitutionally strategic position. However, their existence is currently under pressure from the hegemony of modern markets, which are dominated by large capital interests and the penetration of digital technology. This study aims to provide a comprehensive mapping of the internal strengths and fundamental weaknesses of cooperatives within the Indonesian market system through a systematic literature review. The analysis examines 24 selected scholarly journal articles published between 2019 and 2026 to ensure the data remains relevant to current economic dynamics. The synthesis indicates that the primary strengths of cooperatives lie in their social capital, the principle of kinship (asas kekeluargaan) which fosters member loyalty, and their potential for digital adaptation as a tool to mitigate economic recessions and the dominance of multinational corporations. Conversely, the findings confirm chronic, unresolved weaknesses, including low managerial professionalism, limited access to capital, and small economies of scale that hinder price efficiency in competitive markets. External challenges, such as the Fourth Industrial Revolution and shifting consumer behaviors, demand that cooperatives undergo immediate structural transformation. This article concludes that the key to cooperative sustainability in the face of modern market hegemony lies in the implementation of agile strategic management, service digitalization, and the strengthening of strategic partnerships. Policy recommendations are directed toward reinforcing regulations that protect the cooperative ecosystem without compromising its inherent competitiveness within the market mechanism.

The rapid development of social media, particularly Twitter, has given rise to a new form of social violence known as cyberbullying. This study aims to explore the phenomenon of cyberbullying on Twitter using Ulrich Beck's Risk Society Theory as an analytical framework. The research approach used is a literature review. This study perceives cyberbullying on Twitter as a modern, systemic risk, shaped by anonymity, cancel culture, and the individualization of risk. It acknowledges that Twitter's structural features, such as pseudonymous accounts and the rapid dissemination of information, exacerbate the potential for cyberbullying, while simultaneously positioning individual users as both victims and potential perpetrators of digital violence. These findings reinforce Beck's thesis that risks in advanced modernity are self-produced, institutionally distributed, and difficult to regulate, clearly reflected in the uncontrolled spread of cyberbullying in digital public spaces.

 This study examines women’s transformational leadership in educational institutions through a systematic literature review approach. The increasing involvement of women in leadership positions in schools and universities has attracted academic attention to understand their contribution to organizational development and the improvement of educational quality. This study aims to synthesize recent empirical research findings on women’s transformational leadership in education. The method used was a Systematic Literature Review (SLR) by identifying, evaluating, and synthesizing relevant studies published between 2021–2026 through academic databases such as Google Scholar and ScienceDirect using the keywords “transformational leadership,” “women leadership,” and “education or school.” After a selection process based on inclusion and exclusion criteria, 15 empirical articles were analyzed. The findings indicate that female leaders tend to demonstrate transformational leadership characteristics, including inspirational motivation, intellectual stimulation, idealized influence, and individualized consideration. These leadership practices positively affect teacher motivation and performance, organizational commitment, organizational climate, and learning innovation. However, women in leadership positions still face challenges such as gender stereotypes, structural bias, and social expectations regarding gender roles, indicating the need for institutional support and more inclusive policies.

This study aims to explore the socio-economic structures underlying the economic behavior of chili farmers in Batudaa Pantai Subdistrict, Gorontalo Regency, with a focus on patron-client relationships as a rational coping mechanism. Using a mixed-methods approach with 60 proportionally selected respondents, this study analyzes how asymmetries in access to capital and markets create a weak bargaining position for farmers. The findings reveal a “stability paradox”: although quantitative risk analysis using the Coefficient of Variation (CV) indicates low levels of production, cost, and income risk (CV < 0.5), farmers remain trapped in a price-taker position. Relationships with middlemen (tengkulak) have transformed from mere economic transactions into social bonds of “debt of gratitude.” For farmers, patrons serve as providers of emergency liquidity and market guarantors amid horticultural price volatility. However, this systemic dependence hinders economic independence and capital accumulation at the producer level. This study recommends institutional restructuring through a new cooperative model capable of assuming the patron’s role more equitably to break the chain of structural dependence.

This study analyzes the politics of spatial planning in the land-use conversion of the Bowosie Forest in Labuan Bajo as part of the National Strategic Project (PSN) for tourism development. The transformation of the forest into an economic tourism zone demonstrates that spatial planning is not neutral, but rather an arena of power relations among the state, investors, and local communities. Through regulatory instruments such as revisions of the Regional Spatial Plan (RTRW), ministerial decrees on forest release, and the granting of Management Rights (HPL) to BPOLBF, the state has facilitated tourism investment and the commodification of space. Using a qualitative approach and David Harvey’s theory of Accumulation by Dispossession, the study finds that these policies have produced three forms of exclusion: spatial exclusion (loss of access to land and water sources), political exclusion (limited community participation in decision-making), and economic exclusion (development benefits concentrated among investors). The village government occupies a structurally limited position due to the top-down nature of the policy framework. The study concludes that the conversion of the Bowosie Forest reflects a process of capital accumulation legalized through state regulation, highlighting the need for more inclusive and socially just spatial planning.

This research aims to comprehensively map how the participatory mentoring model functions as a catalyst in the transformation of agency and social position of women, particularly in the Micro, Small, and Medium Enterprises (MSMEs) sector. This review evaluates the dialectics between external interventions and the transformation of patriarchal social structures at the local level. The study employs a Systematic Literature Review (SLR) methodology, adopting the PRISMA 2020 protocol. A systematic search was conducted on the Scopus database for empirical peer-reviewed articles published between 2021 and 2026. Through stringent inclusion and exclusion criteria, 33 articles were selected for analysis using a thematic synthesis approach. The thematic analysis resulted in five main clusters: (1)Gender-specific institutional interventions are more effective through the social enterprise model than through pure philanthropy.(2)Multidimensional structural barriers such as cultural norms and political instability continue to limit women's bargaining positions. (3)The transformation of agency often occurs through quiet encroachment in public spaces.(4)Cultural capital in traditional entrepreneurship serves as an instrument of economic autonomy while preserving identity. (5)Collective action becomes a determining factor in shifting gender norms and achieving holistic well-being. The transformation of women's social position requires an active negotiation process supported by gender-conscious structural changes, rather than mere income enhancement. Participatory mentoring must shift from mere technical transfer to a knowledge partnership capable of dismantling patriarchal narratives and building women's agency as autonomous subjects of development.

Social media has brought significant changes in the way humans interact, construct meaning, and shape social identities. In Indonesia, TikTok is the most widely accessed social media platform, reaching 32% of users. TikTok is not only a medium of entertainment but also a space for the production and reproduction of values, tastes, and social standards. The TikTok algorithm presents personalized content according to user preferences, creating a continuous flow of information that is visually and repetitively consumed. From an anthropological perspective, this article aims to analyze how algorithms influence the formation of digital identity and generate new status symbols in virtual spaces. This research uses a qualitative approach with ethnographic methods and literature studies on TikTok usage practices. The results of the study show that indicators of popularity such as the number of views, followers, likes, and interaction rates become new forms of status symbols that represent users’ social influence in the digital world. From an anthropological perspective, TikTok can be understood as a new cultural space where algorithms act as structural agents that influence social practices, identity production, and symbolic hierarchies within digital society. This study emphasizes that algorithms function not only as technical technologies but also as cultural forces that shape how individuals understand themselves and their social positions within the social media ecosystem.

This study aims to critically examine the concept of economic justice proposed by Abu Ubaid al-Qasim bin Sallam in his work Al-Amwal and to evaluate its relevance to contemporary economic dynamics. The research applies a qualitative approach using a library research method, in which Al-Amwal serves as the primary source, supported by various secondary references related to Islamic economics and theories of distributive justice. The data were analyzed through content analysis to identify Abu Ubaid’s core ideas, followed by a comparative approach to relate his framework to modern economic principles and practices. The findings reveal that Abu Ubaid’s concept of economic justice is both distributive and structural in nature. It not only emphasizes equitable wealth distribution but also highlights the importance of systemic regulation and public policy oriented toward social welfare. Zakat is positioned as a central instrument for wealth redistribution aimed at reducing social inequality and alleviating poverty. Furthermore, the state plays a strategic role in managing public resources transparently and fairly to ensure collective prosperity. Ethical values are also fundamental in economic activities to prevent exploitation, injustice, and imbalance. Overall, Abu Ubaid’s economic thought remains highly relevant in addressing modern challenges, particularly issues of income inequality, social justice, and sustainable development in today’s global economic system.

The implementation of Patient Safety Goals remains a major challenge in hospital management, particularly in ensuring consistent compliance among nurses. This study aims to analyze the influence of nurses’ knowledge and motivation on the implementation of Patient Safety Goals, with clinical leadership positioned as a mediating variable. A quantitative cross-sectional design was employed in a general hospital in Jakarta, Indonesia. Data were collected from 119 nurses across inpatient, outpatient, emergency, and operating units using structured questionnaires. The data were analyzed using Structural Equation Modeling (SEM) with AMOS, supported by the Three-Box Method to assess the level of variable achievement. The results indicate that nurses’ knowledge and motivation have a significant direct effect on clinical leadership. Clinical leadership also demonstrates a significant positive effect on the implementation of Patient Safety Goals. Furthermore, clinical leadership plays a significant mediating role in the relationship between both nurses’ knowledge and motivation and the implementation of Patient Safety Goals. The model explains 76.67% of the variance in Patient Safety Goal implementation, highlighting the strategic role of clinical leadership in translating individual competencies into safe clinical practices. These findings contribute to healthcare management literature by reinforcing the importance of clinical leadership as an organizational mechanism that strengthens patient safety performance. From a managerial perspective, the study emphasizes that improving patient safety outcomes requires not only enhancing nurses’ knowledge and motivation, but also systematically developing clinical leadership competencies. Hospital management is encouraged to invest in leadership development programs, supportive supervision, and non-punitive incident reporting systems to ensure sustainable implementation of Patient Safety Goals.

This study aims to analyse the role of digital literacy of the State Civil Apparatus (ASN) in supporting the implementation of smart cities and improving the quality of public services in the Sorong City Regional Secretariat. The research method used is qualitative with a descriptive approach, through in-depth interviews with structural officials within the Sorong City Secretariat. The results of the study show that the level of digital literacy of civil servants is still varied and greatly influenced by the duties and functions of the position, generational background, and the intensity of the use of digital technology in daily work. The implementation of the smart city concept in Sorong City has not been fully optimal due to limited infrastructure, readiness of human resources, budget support, and coordination between regional apparatus organisations. Nevertheless, digitalisation has had a positive impact on the efficiency of public services, especially in the aspects of administration, transparency, and ease of access to information for the public. This study also found that the success of digital governance is highly determined by the commitment of regional leaders, internal policies that support the digital capacity building of civil servants, and continuous training and mentoring. Therefore, strengthening the digital literacy of civil servants is a strategic and sustainable priority policy to support the development of smart cities and digital public services that are effective, inclusive, and accountable in Sorong City.

Factual verification of political party membership constitutes a critical administrative stage in electoral management, as it directly affects electoral integrity and democratic legitimacy. In Indonesia, this process remains predominantly reliant on conventional door-to-door verification methods, which face structural constraints including time limitations, excessive administrative burden, high costs, and vulnerability to procedural errors and electoral disputes. Meanwhile, the advancement of e-government and Electronic-Based Government Systems (E-Government) has created opportunities to adopt more accountable and verifiable digital identity mechanisms. This study aims to conceptualize and examine Electronic Know Your Customer (E-KYC) as an administrative governance model for verifying political party membership to strengthen electoral integrity within an e-government framework. Employing a mixed-methods approach with a sequential explanatory design, quantitative data were collected through a survey of 44 election officials at district and municipal election commissions in Central Java Province, Indonesia. Qualitative data were obtained through in-depth interviews with key institutional actors. The findings demonstrate a positive and significant relationship between the adoption of E-KYC and strengthened administrative electoral integrity, democratic public service values, and institutional readiness. Qualitative evidence further indicates that challenges to electoral integrity stem primarily from weaknesses in administrative procedures rather than from political contestation itself. This study concludes that E-KYC should be positioned not merely as a technological innovation but as an institutionalized administrative governance model, contingent upon regulatory clarity, system interoperability, and organizational capacity building.

This study aims to analyze the development of human resources in relation to the assessment center for Civil Servants (PNS) at the Karas District Office, Fakfak Regency. The objectives of this study are to determine the effect of human resource development on the assessment center, and to identify the human resource development variables that most dominantly influence the PNS assessment center. This research uses a qualitative approach with data collection methods including interviews, observations, questionnaires, surveys, and experiments. The data were analyzed qualitatively and quantitatively to explain the relationship between human resource development and the assessment center. The qualitative analysis results show that PNS at the Department of Mining and Energy, Fakfak Regency, who hold Echelon IV/a structural positions, number 15 people (0.71%), while PNS with the rank of Pembina Level I/IV/b number 5 people (0.24%). Based on gender, the majority of PNS are male (15 people or 0.71%) who have participated in human resource development through career development. PNS with a Bachelor's degree (S-1) number 11 people (0.52%), and those aged 41-50 years and over 50 years number 12 people (0.57%).

Digital transformation in the healthcare sector requires hospitals to optimize patient-centered care services to enhance competitiveness. Hospital operational success is often reflected in the volume of patient visits, which is influenced by the quality of the patient experience and the effectiveness of administrative digitization. This study aims to analyze the influence of patient experience on the volume of patient visits, with the digitization of registration and payment services as a mediating variable at Ciputra Hospital Surabaya. A quantitative approach using explanatory research methods was applied in this study. Data were collected from 250 respondents selected through purposive sampling and analyzed using Structural Equation Modeling–Partial Least Squares (SEM-PLS). The results show that patient experience has a strong unidirectional correlation with the adoption of digitalized registration and payment services. Furthermore, this digital integration has been shown to have a significant impact on increasing the volume of patient visits. Theoretically, the digitalization of registration and payment services serves as a significant mediator bridging the relationship between patient experience and patient visit decisions. These findings confirm that improving the patient experience through administrative automation can create process efficiency, ease of accessibility, and convenience, which are crucial for customer loyalty. From a managerial perspective, this study implies that strengthening digital infrastructure is a fundamental strategy for hospital management to improve service quality, strengthen market position, and ensure the sustainability of institutional competitiveness amidst the rapid digital transformation of healthcare services.

The development of rural economies based on locally superior commodities is an integral part of inclusive and sustainable development strategies. Sumberdem located in Wonosari Subdistrict, Malang Regency, possesses significant potential for the development of coffee-based ecotourism. However, this potential remains largely underutilized due to several structural and institutional constraints. Key challenges include inadequate supporting infrastructure, limited capacity of local human resources, and the absence of downstream processing for coffee products. This community engagement program implemented an adaptive approach known as the Lumintu model, rooted in the Participatory Rural Appraisal (PRA) framework. Field assessments revealed critical limitations such as poor road access to plantation areas, insufficient agricultural irrigation, and weak digital connectivity. Moreover, the capacity of village institutions—such as the Village-Owned Enterprises (BUMDesa) and coffee farmer groups—remained low, resulting in local coffee products with limited added value. The initial implementation of the program has shown promising results, particularly in strengthening institutional capacity through training on tourism business management and high–value coffee processing. Furthermore, product diversification through the development of coffee-based agrotourism and digital marketing innovations has been successfully introduced. Overall, this community engagement initiative has provided a concrete solution to rural development challenges in Sumberdem Village. Moving forward, the village is expected to strengthen its position as a sustainable coffee ecotourism destination and improve the long-term economic well-being of its residents. The proposed development model also holds the potential for adaptation and replication in other rural areas with similar characteristics, thereby supporting the broader achievement of the Sustainable Development Goals (SDGs).

The rapid development of information technology has pushed the dissemination of news through online media, demanding a language that is fast, concise, and informative to ensure accurate news delivery. This necessity positions the syntactic structure, particularly the phrase, as a critical element in determining the quality and communication effectiveness of digital news. This study has a dual objective: to comprehensively identify and analyze the types of phrases found in five online news articles published by CNBC Indonesia in August 2025, and to elucidate the grammatical function of each phrase  within the context of news sentences. The method employed is a descriptive qualitative method, involving a systematic process of reading, noting, and accurately analyzing the textual data repeatedly. The results indicate a diversity  of phrase types, with a significant dominance of  noun and verb phrases. The findings also include adjectival, prepositional, adverbial, numerical, exocentric, and endocentric phrases, which collectively enrich the linguistic structure, enhance information richness, and greatly facilitate reader comprehension of the news content. These findings not only highlight the specific patterns of phrase usage in digital news writing but also provide deep insights into their structural and grammatical roles. This study is expected to serve as a valuable reference for linguistic research and language learning, as well as offering practical guidance for online media practitioners to continuously improve the clarity, effectiveness, and quality of news writing in the digital realm.

State revenue holds a vital position in sustaining national development and the functioning of government, with taxation serving as the primary contributor to Indonesia’s State Budget (APBN). The substantial reliance on tax income obliges the government to manage the taxation system in an optimal, efficient, and sustainable manner. Nevertheless, the attainment of tax revenue targets in practice remains challenged by various issues, including structural, administrative, and strategic limitations. This study seeks to examine the role of strategic tax management in supporting the achievement of state revenue objectives. The research adopts a literature review approach by analyzing textbooks, national and international scholarly journals, official government publications, and relevant regulatory frameworks. The data are analyzed using a descriptive qualitative method through processes of classification, comparison, and synthesis of findings from previous studies. The findings reveal that strategic tax management has a crucial influence on enhancing state revenue performance through coherent policy formulation, flexible strategy execution, and ongoing performance assessment. The integration of information technology, the reinforcement of tax administration, and the improvement of taxpayer compliance emerge as key determinants in achieving revenue targets. Accordingly, strategic tax management constitutes a fundamental tool for ensuring fiscal resilience and promoting sustainable national development.

Gender inequality in Indonesian politics forms part of broader structural and cultural dynamics that shape women’s positions in the public sphere. In historical studies, the thought of R.A. Kartini is often interpreted primarily as a symbol of educational and moral emancipation, while the political dimension of her ideas receives limited attention. This study aims to examine Kartini’s political thought as reflected in her letters, positioning her as a political subject who articulated critiques of social structures, customary norms, and patriarchal power relations through non-formal means. This research adopts a qualitative approach with a library-based research design. The data are derived from an analysis of Kartini’s letters compiled in Door Duisternis tot Licht and supported by relevant academic literature. A descriptive-analytical method with a thematic approach is employed to explore political ideas and discourses embedded in the texts. Kartini’s thought in this study is understood as a form of political awareness that extends beyond individual emancipation and relates to broader issues of women’s political participation. This research contributes to the study of women’s politics by offering a historical perspective that places women as political subjects.

This study aims to examine the effect of microcredit on the level of community welfare in Kecamatan Sumbawa, with study locations in Kelurahan Pekat and Brang Bara. Microcredit is positioned as one of the strategic instruments in efforts to empower the economy of low-income communities, especially through increasing access to financing, income generation, and social welfare. This research uses a quantitative approach with Structural Equation Modeling (SEM) method based on Partial Least Square (PLS). The study population consisted of 100 micro-entrepreneurs in the two villages who had received microcredit from local financial institutions. The variables analyzed include ease of credit access (X1), credit repayment (X2), income (Y), and community welfare (Z) which acts as a mediating variable. The results of the analysis show that easy access to microcredit does not have a significant effect on income or community welfare. In contrast, the variable of microcredit repayment has a positive and significant effect on community welfare. In addition, income also has a positive and significant influence on welfare, indicating that an increase in income is a key factor in determining the economic and social welfare of microcredit recipient households. This finding confirms that the success of the microcredit program is more influenced by the effectiveness of the management and sustainability of the credit repayment system, rather than solely by the ease of access to financing.