Publication Search

The Garuga floribunda (Garuga floribunda Decne) plant is one of the species known for its various medicinal properties. This research aims to investigate the inhibitory activity of α- glucosidase and α-amylase enzymes and to determine the optimum concentration of the methanol extract of Garuga floribunda leaves as an antidiabetic agent. The leaves extraction is obtained through an extraction process using methanol as the solvent and tested for itsinhibitory activity against the α-glucosidase enzyme using the p-nitrophenyl-α-D- glucopyranoside (p-NPG) substrate and the α-amylase enzyme using the DNS (3,5- dinitrosalicylic acid) substrate. The method is UV-Vis spectrophotometry. The Phytochemical tests of this plant reveal the presence of flavonoids, alkaloids, saponins, tannins, steroids, and terpenoids. The inhibition test results show that the methanol extract of Garuga floribundaleaves exhibited significant inhibitory activity against both enzymes. The highest inhibition percentage against the α-glucosidase enzyme is 91.09%, indicating very high antidiabetic activity. Meanwhile, the inhibition against the α-amylase enzyme is 7.56%, showing no significant antidiabetic activity. The optimum concentration for inhibiting both enzymes is 1000 ppm.

Amyloidosis is a term for various groups of diseases with lots of amyloid protein in organs and/or tissues, causing disease. In this condition, amyloid protein is deposited in the dermis layer of the skin which is called lichen amyloidosis. Lichen amyloidosis is the most common type of cutaneous amyloidosis. The prevalence of cutaneous amyloidosis is relatively rare, only 0.2-0.3%. It is chronic in nature which usually appears later in life. This article discusses a case of a 39-year-old female patient who came with complaints of spots on both sides accompanied by itching. These complaints have been experienced since ± 2 years ago and are felt to be getting worse in the last few months. Previously the patient had used a type of topical medication obtained from the local puskesmas, but there was no improvement. Examination of the general status found the general condition of the patient looked moderately ill, conscious awareness, vital signs within normal limits. Dermatological status obtained efflorescence in the form of macules to multiple papules with hyperpigmentation, well defined, discrete available, accompanied by scaling and lichenification. Patients were treated with oral corticosteroids (methylprednisolone), topical corticosteroids (desoximethasone) and salicylic acid. Patients are also educated to avoid scratching and rubbing on the lesions. The patient showed thinning lesions after 7 days of therapy.