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Low Birth Weight (LBW) refers to infants born with a birth weight of less than 2,500 grams and remains an important issue in neonatal health due to its association with increased neonatal morbidity and mortality. To analyze the determinants of LBW based on primary studies published from 2021 to 2026. A literature review was conducted using the PRISMA approach. Article searches were performed through PubMed, Google Scholar, Scopus, ScienceDirect, and ProQuest using the keywords low birth weight, determinant factors, risk factors, BBLR, and faktor risiko with Boolean operators AND/OR. The inclusion criteria were primary studies, full-text availability, publication in Indonesian or English, and publication years from 2021 to 2026. A total of 20 articles were included, consisting of 15 international articles and 5 national sources. The review showed that LBW is influenced by interrelated maternal, nutritional, obstetric, and sociodemographic factors during pregnancy. The most dominant factors included multiple pregnancy with an adjusted OR of 21.74, maternal food insecurity with an AOR of 6.85, maternal hemoglobin level <11 g/dL with an AOR of 5.21, lack of iron-folic acid supplementation with an AOR of 4.17, maternal age ≤20 years with an AOR of 3.42, pregnancy interval <1 year with an adjusted OR of 2.92, missed antenatal care visits with an AOR of 2.74, smoking during pregnancy with an OR of 2.18, and maternal hypertension with an AOR of 1.94. LBW is influenced by multiple interrelated factors; therefore, efforts to reduce its incidence should focus on evidence-based interventions, particularly through optimizing antenatal care services, improving maternal nutritional status, and early detection of pregnancy.

This study aims to analyze promiscuous sexual behavior among adolescents as a manifestation of problematic behavior through a literature review approach. The method used was a literature review with a descriptive-analytical design, analyzing 20 national scientific articles published between 2007 and 2024. The analysis process was conducted systematically through the stages of identifying relevant sources, classifying themes, extracting important data, and synthesizing findings to build a comprehensive conceptual framework. The study results were then grouped into four main aspects: internal factors, external factors, impacts, and prevention strategies. The study results indicate that promiscuous sexual behavior among adolescents is influenced by internal factors such as knowledge, attitudes, and moral reasoning, as well as external factors such as family environment, peers, social media, and lack of parental supervision. The resulting impacts are multidimensional, encompassing health (sexually transmitted infections and unplanned pregnancies), psychological (anxiety, guilt), and social (stigma and educational disruption). Effective prevention efforts involve comprehensive sex education, active family involvement, and collaboration between schools and the community.

Preeclampsia remains a major contributor to maternal morbidity and mortality, particularly in developing countries such as Indonesia. Early detection and integrated management at the primary healthcare level are essential to prevent disease progression and improve maternal outcomes.  Modifiable risk factors such as maternal obesity, inadequate calcium intake, and poor clinical management contribute significantly to disease progression (WHO, 2021; Zhang et al., 2020). This study aimed to evaluate the effectiveness of an Integrated Maternal Health Model (IMHM) combining risk assessment, nutritional intervention, and clinical management for early prevention and control of preeclampsia in primary healthcare settings. A quasi-experimental cohort study was conducted among 104 pregnant women, consisting of 52 preeclamptic and 52 normotensive participants in community health centers in Medan, Indonesia. Data were collected across four antenatal visits, including blood pressure measurements, proteinuria (dipstick), calcium intake, supplementation adherence, and antihypertensive therapy. Statistical analyses included bivariate and longitudinal tests. The results showed that maternal obesity, history of preeclampsia, and hypertension were significant risk factors. Adequate calcium intake demonstrated a protective effect against preeclampsia (p < 0.05), consistent with recent evidence indicating that calcium supplementation can reduce the risk of preeclampsia by up to 49%. However, calcium supplementation did not significantly influence blood pressure among normotensive pregnant women. Antihypertensive therapy, particularly intensive nifedipine regimens, showed significant differences in blood pressure patterns across visits (p < 0.05). In addition, proteinuria levels significantly decreased over time (p < 0.001), indicating improvement in renal function. In conclusion, the IMHM is effective in improving maternal outcomes through a multi-component approach integrating clinical, nutritional, and monitoring strategies. This model provides a practical and scalable framework for early prevention and management of preeclampsia in primary healthcare settings.

Hypertension is a non-communicable disease often referred to as a silent killer because it generally does not present noticeable symptoms. Several risk factors contribute to the development of hypertension, including high body mass index (BMI) and low levels of physical activity. However, data regarding the association between BMI, physical activity, and hypertension at Pakuan Baru Public Health Center, Jambi City, remain limited. Therefore, this study aimed to determine the relationship between body mass index and physical activity with hypertension among adults at Pakuan Baru Public Health Center, Jambi City. This study employed a quantitative approach with a cross-sectional design. The research was conducted at Pakuan Baru Public Health Center, Jambi City, from November 19 to December 6, 2025. The study population consisted of all adult patients with hypertension at Pakuan Baru Public Health Center, totaling 2,797 individuals. A sample of 93 respondents was selected using an accidental sampling technique. Data were collected using observation sheets through measurements of height and weight to calculate BMI, as well as the Global Physical Activity Questionnaire (GPAQ). Data analysis was performed using univariate and bivariate analyses with the chi-square statistical test. The univariate analysis showed that 27 respondents (29.0%) were classified as severely obese, 42 respondents (45.2%) had a low level of physical activity, and 28 respondents (30.1%) were categorized as having stage 2 hypertension at Pakuan Baru Public Health Center, Jambi City. The bivariate analysis revealed a significant relationship between body mass index and physical activity with blood pressure among patients with hypertension (p = 0.000). It is expected that healthcare providers at Pakuan Baru Public Health Center will continue to provide education regarding the importance of controlling body mass index and engaging in regular physical activity, as these factors contribute to increased blood pressure among patients with hypertension.

The effectiveness of hypertension prevention in communities depends critically on individuals’ knowledge of risk factors and their attitudes toward healthy behaviors. This study examines the relationship between mothers’ knowledge and attitudes toward hypertension prevention behavior in South Polongbangkeng District, Takalar Regency, 2026. An observational analytic quantitative design with a cross-sectional approach was employed. A total of 200 mothers were selected as respondents. Data were collected using structured questionnaires assessing knowledge, attitude, and hypertension prevention behavior, then analyzed using chi-square test at a significance level of α = 0.05. Results showed that the majority of respondents had good knowledge (89.0%), good attitudes (91.0%), and good hypertension prevention behavior (77.0%). Statistical tests revealed a significant association between mothers’ knowledge and hypertension prevention behavior (p = 0.000) and between mothers’ attitudes and hypertension prevention behavior (p = 0.000). It is concluded that mothers’ knowledge and attitudes are significantly associated with hypertension prevention behavior. Health workers are recommended to strengthen health education and promotion programs targeting mothers to support hypertension prevention in the community.

Entamoeba histolytica is an intestinal protozoan that can cause diarrhea through fecal–oral transmission due to the consumption of food or water contaminated with parasitic cysts. Based on data from the Badan Pusat Statistik in 2017–2019, Simpang Keramat District, particularly Paya Leupah Village, still had limited access to clean water and low ownership of permanent sanitary latrines, which may increase the risk of environmental contamination. This study aimed to analyze the characteristics of dug wells and the risk factors associated with Entamoeba histolytica contamination in community well water. An observational analytic study with a cross-sectional design was conducted on 50 dug wells selected using purposive sampling. Data were obtained through field observations and laboratory examinations of well water samples. The results showed that most wells had distances to septic tanks that did not meet health standards (58%) and inadequate well floor conditions (82%), while the majority of wells had depths that fulfilled the recommended standard (76%). All well water samples tested negative for Entamoeba histolytica cysts; therefore, the association between risk factors and contamination could not be determined.

Spinal anesthesia is one of the regional anesthesia methods that is often chosen in various surgical procedures, especially in the area of the lower extremities, pelvis, and lower abdomen. The most common complication encountered in this technique is the occurrence of hypotension, which can affect tissue perfusion and hemodynamic stability of the patient. This study aims to examine the incidence of hypotension in spinal anesthesia, including mechanisms, risk factors, and management. The method used in this study is literature review with a scientific source search process conducted through various databases PUBMED, Sciencedirect, Researchgate, and Google Scholar with a publication year range of 2016 to 2026. The results showed that hypotension arises as a consequence of an obstacle in the sympathetic nervous system, which provokes dilation of blood vessels as well as reduced venous return. Risk factors include age, body mass index, patient position, block height, duration of surgery, fluid status, Injection Point, and type of anesthetic drug used. Management is carried out by administering fluids, vasopressors, as well as strict hemodynamic monitoring. A good understanding of the risk factors and mechanisms of hypotension is expected to improve patient safety during spinal anesthesia..

Emotional mental health in adolescents is an important focus because this age group is highly vulnerable to academic and social pressures, as well as the demands of personal development. Emotional problems such as anxiety, stress, and depression that are not recognized early on can interfere with concentration, social relationships, and psychological well-being. This study aims to review the literature related to the early detection of emotional mental disorders in adolescents, so that it can serve as a basis for the development of prevention and intervention strategies. The method used is a literature review, analyzing a number of recent research articles discussing risk factors, symptoms, and early screening methods using instruments such as the Self Reporting Questionnaire (SRQ) and the Strengths and Difficulties Questionnaire (SDQ). The results of the study show that the most common symptoms include anxiety, fatigue, concentration disorders, and relationship problems with peers in adolescents, as well as academic pressure in students. Early screening has been proven to help identify individuals at risk so that intervention can be carried out more quickly. The use of technology, such as web-based expert systems, can also speed up the screening process and improve the accuracy of assessments. It is recommended that educational institutions and health services be more active in conducting mental health screening, providing promotional education, and designing preventive programs. Further research should use analytical or experimental designs to explore risk factors and the effectiveness of interventions in greater depth.

Adolescence is a period of development characterized by rapid physical, emotional, and social changes, making adolescents vulnerable to various forms of violence, including sexual harassment. This phenomenon occurs in various contexts, including family, school, community, and digital environments, and has serious impacts on adolescents' psychological, social, and academic well-being. This study aims to comprehensively examine the phenomenon of sexual harassment among adolescents and its implications for guidance and counseling services in educational settings. The method used is a literature review by reviewing various relevant scientific articles from the past six years obtained through electronic databases. The analysis process was carried out using content analysis techniques by grouping findings based on main themes, namely forms of sexual harassment, risk factors, impacts, and the role of guidance and counseling services. The results of the study indicate that sexual harassment among adolescents occurs in various forms, both directly and through digital media, with complex causal factors encompassing individual, family, social, and cultural aspects. The impacts are not only physical, but also psychological and social in the long term. Guidance and counseling services play a crucial role in preventive, curative, and developmental efforts through education, mentoring, and strengthening students' social skills. The implications of this research emphasize the importance of strengthening guidance and counseling services as a systematic strategy in creating a safe and responsive school environment to cases of sexual harassment in adolescents.

Low levels of maternal knowledge and appropriate nutritional practices, combined with limited continuity of nutrition education from health workers, remain significant risk factors for maternal and child health problems, including stunting. The GEMPITA Program (Gerakan Edukasi MPASI Tepat dan Aman / Safe and Appropriate Complementary Feeding Education Movement) was implemented as a community service initiative to improve nutritional knowledge, skills, and practices among families in the working area of Teratak Public Health Center. The program employed structured methods, including socialization, education, training, demonstrations, mentoring, and non-formal monitoring and evaluation. The target participants were mothers with children aged 6–24 months, as well as health workers and community health cadres. Program effectiveness was assessed using pretest posttest measurements and direct observation of behavioral changes. The results demonstrated a significant improvement in maternal knowledge regarding appropriate complementary feeding, enhanced skills in age-appropriate food preparation, and improved hygienic and nutritious feeding practices. In addition, the capacity of health workers to deliver nutrition education was strengthened. Overall, the GEMPITA Program proved effective in improving family nutrition practices and reinforcing the role of the public health center in stunting prevention through a sustainable community empowerment approach.

Stroke is one of the non-communicable diseases that is the leading cause of disability and death in the world. Clinical factors such as hypertension, diabetes mellitus, body mass index (BMI), and unhealthy lifestyle are known to contribute to the incidence of stroke. Oe-Cusse Referral Hospital serves as the main referral center in the treatment of stroke cases, but data on contributing clinical factors and medical treatment and rehabilitation strategies are still limited. This study aims to analyze the clinical factors that contribute to the incidence of stroke and describe medical treatment and rehabilitation strategies in stroke patients at Oe-Cusse Referral Hospital.This study is a quantitative study with a cross-sectional observational design. The research sample amounted to 50 stroke patients who were treated in the January-November 2025 period, selected using purposive sampling techniques. Data were collected through medical records and questionnaires related to medical treatment and rehabilitation. Data analysis was carried out using the SPSS program, including descriptive analysis and logistic regression to see the relationship between clinical factors (hypertension, diabetes mellitus, lifestyle, BMI, and other factors) and stroke incidence. The results of the descriptive analysis showed that the average age of stroke patients was 56.2 ± 9.8 years, with an age range of 39–78 years. The average BMI of the patient was 27.5 ± 3.1 kg/m² which indicates a tendency to be overweight. The average systolic blood pressure of the patient was 150 ± 18 mmHg, indicating the predominance of hypertension in stroke patients. The average length of rehabilitation lasted 6.3 ± 1.8 weeks. Logistic regression analysis showed a significant relationship between clinical factors, especially hypertension, BMI, and diabetes mellitus, and stroke incidence. Clinical factors such as hypertension, high BMI, and diabetes mellitus contribute significantly to the incidence of stroke at Oe-Cusse Referral Hospital.

Hypertension and hypercholesterolemia are closely related non-communicable diseases and major risk factors for cardiovascular disease, particularly in older adults. These conditions are influenced by medical, behavioral, family, and environmental factors, requiring a holistic family medicine approach through home visits. This study aimed to describe the clinical condition, family function, and environmental factors of a 60-year-old female patient with hypertension and hypercholesterolemia using the APGAR and SCREEM approaches. This study employed a qualitative descriptive design in the form of a case report involving Mrs. S (60 years old) in Lebbek Village, Pamekasan Regency. Data were collected through anamnesis, physical examination, total cholesterol measurement using a GCU meter, environmental observation, and assessment of family function and environmental factors. The results showed blood pressure values of 161/96 mmHg and 160/96 mmHg on repeated measurement, with a total cholesterol level of 154 mg/dL. The patient had a high-salt and high-fat diet with low physical activity. APGAR assessment indicated poor family function with a total score of 4, particularly in the partnership and resolve domains, while the growth domain was categorized as accepting. SCREEM analysis identified education as the main barrier. In conclusion, management of this condition requires family-based interventions focusing on improving family cooperation and health education tailored to the patient’s literacy level.

Stunting is a major public health problem that reflects chronic malnutrition and adversely affects children’s physical growth, cognitive development, and future productivity. The first 1,000 days of life represent a critical window during which stunting develops and determines long-term health outcomes. This study aims to review evidence on the determinants of childhood stunting and the effectiveness of prevention interventions within public health policy frameworks in Indonesia.A literature review was conducted using peer-reviewed articles, policy documents, and national reports published in the last decade. The literature was analyzed to identify key risk factors, intervention strategies, and policy impacts on stunting reduc-tion.The findings show that stunting is primarily driven by inadequate dietary intake, low socioeconomic status, limited caregiver nutrition knowledge, and poor access to health and sanitation services. National data indicate a decline in stunting prevalence in Indonesia from 24.4% in 2021 to 21.6% in 2022. Evidence consistently highlights that integrated interventions targeting the first 1,000 days of life, including maternal nutrition improvement, breastfeeding promotion, appropriate complementary feeding, and multisectoral collaboration, are effective in reducing stunting.In conclusion, reducing childhood stunting requires sustained, integrated, and policy-based interventions that prioritize early-life nutrition to improve human capital and support long-term national development.

Congenital Megacalyces is a rare anomaly of the renal pelvis-calyceal system characterized by non-obstructive calyx dilatation due to renal medulla hypoplasia. This condition is often misinterpreted as hydronephrosis, leading to unnecessary surgical interventions. Advances in genomic technology and precision imaging have opened up opportunities to understand the molecular basis and anatomical structure of this anomaly more deeply. A literature review was conducted through PubMed, ScienceDirect, and Google Scholar, covering publications that discuss the relationship between genomics, imaging, and clinical management of congenital kidney abnormalities. The integration of Next Generation Sequencing (NGS), 3D MRI reconstruction imaging, and AI-based radiomics analysis has proven to enhance diagnostic accuracy, differentiate between obstructive and non-obstructive abnormalities, and assist in determining appropriate conservative therapies. Case studies demonstrate the association between SETBP1 mutations and the development of bilateral megacalyces, as well as the effectiveness of long-term monitoring based on multimodal data. The integration of genetic, imaging, and clinical data is a strategic step toward precision medicine in the management of Congenital Megacalyces. This approach improves diagnostic accuracy, reduces unnecessary invasive interventions, and supports individualized therapy based on genetic and anatomical risk factors.

Adolescent mental health is an essential component of optimal growth and development, yet it often receives less attention compared to academic achievement. Adolescents are in a vulnerable developmental stage characterized by emotional changes, social pressure, and environmental demands, which increase the risk of mental health problems. This activity aimed to improve knowledge and promote positive attitudes among junior high school students regarding adolescent mental health, including its definition, signs and symptoms, risk factors, and prevention strategies. The method used was a health education intervention employing a pre-test and post-test design. The activity was conducted at Al Amanah Junior High School, South Tangerang City, involving 25 students. The evaluation instrument consisted of a 10-item multiple-choice questionnaire with a maximum score of 100. The results showed that the average pre-test score was 98.40%, while the post-test score increased to 99.60%, indicating a 1.20% improvement. Although the increase was relatively small due to the high baseline knowledge (ceiling effect), the findings demonstrate that the educational intervention effectively reinforced students’ understanding of adolescent mental health. In addition, interactive discussions during the session contributed to increased awareness and reduced stigma related to mental health issues. This mental health education program has the potential to support early prevention efforts and foster a more supportive school environment for adolescents’ psychological well-being.

Low back pain (LBP) is one of the most common musculoskeletal complaints globally and is the main cause of decreased work productivity. One of the risk factors that has been widely studied in the literature is prolonged sitting duration. Prolonged sitting activities cause increased static pressure on the lumbar spine, fatigue of the supporting muscles, as well as a decrease in local blood flow that can trigger chronic pain. This study is a literature review with a meta-analytical approach that aims to analyze the relationship between long-term sitting and the incidence of LBP. The review process was carried out following PRISMA guidelines through searches on PubMed, Scopus, ScienceDirect, and Google Scholar databases for publication in 2020–2025. Of the 20 previous studies analyzed, most showed a positive association between sitting time and an increased risk of LBP, both in adults, adolescents, and children. Sitting for more than 6 hours per day increases the risk of LBP by 33%, especially in individuals with low physical activity. In addition, longer sitting durations with poor posture and minimal active rest were found in the group of office workers and professional drivers who had a high prevalence of LBP. Physical activity has been shown to play a protective role against the risk of LBP, while ergonomic interventions such as lumbar support can reduce pain complaints. Although most studies were observational, the consistency of results supports the importance of prevention through reduced sitting time, increased physical activity, and ergonomic work environment settings. These findings provide a scientific basis for multidimensional interventions to effectively reduce the incidence of LBP.  

A high-fat diet can cause hyperlipidemia, which is one of the main risk factors for atherosclerosis. Papaya flowers (Carica papaya L.) contain antioxidants that have the potential to inhibit the development of atherosclerotic lesions. This study aims to determine the effect of papaya flower extract on the histopathological features of the aorta of Wistar rats induced by a high-fat diet. The study design is a posttest only-trial group design. The study sample consisted of 25 male Wistar rats divided into 5 groups with treatment for 21 days. Group A received no treatment. Group B was given high-fat diet consisting of 3 mL of pork fat and 2 g of duck egg yolk. Group C was given high-fat diet and simvastatin 0.18 mg/200 gBW. Groups D and E were given high-fat diet and papaya flower extract 125 mg/kgBW and 250 mg/kgBW, respectively. The parameter used is the histopathological description of the aorta in the form of foam cell formation. The results showed that there were few foam cell in group A. Group B had many foam cells in the tunica intima and media of aorta. Group C, D and E showed a reduction in the number of foam cells. The administration of papaya flower extract (Carica papaya L.) was effective in inhibiting foam cell formation in the aorta of Wistar rats induced by a high-fat diet, with a better effect seen at a dose of 250 mg/kgBW, which was almost comparable to simvastatin.

Background: Sexually Transmitted Infections (STIs) represent a global public health challenge. The increasing number of Sexually Transmitted Infection (STI) cases is a serious concern worldwide. A lack of education or minimal knowledge, along with risky behavior, contributes significantly to the high STI rates, particularly among the young age group. Purposes: The objective of this study is to conduct a comprehensive analysis of the major types of Sexually Transmitted Infections (STIs)—namely Gonorrhea, Hepatitis B, HIV/AIDS, Syphilis, and HPV—by identifying their risk factors and determining the most effective prevention strategies. Method:The researchers employed a literature review method. The data search process was conducted systematically on Google Scholar, limiting sources only to articles available in full text and having open access. Results: The literature review concludes that the factors of knowledge, attitude, behavior, and age significantly influence an individual's risk of contracting Sexually Transmitted Infections (STIs). Therefore, prevention efforts must be carried out comprehensively, encompassing promotive (awareness enhancement), preventive (prevention), curative (treatment), and rehabilitative (recovery) activities. Practically, this prevention must include sexual health education, adoption of safe sexual behavior, implementation of routine health checks (screening), and vaccination (specifically for Hepatitis B and HPV). Conclusion: Overall, controlling the spread of STIs requires active and collaborative roles from all parties—including the government, health workers, and the community. The main key to suppressing the spread and burden of STI diseases in the community is through improving appropriate sexual health education, improving access to health services, and periodic health screening.  

Myopia is a multifactorial disease, affected by various hereditary and environmental conditions. This literature review aims to evaluate the association between risk factors in incidence of myopia in children aged 6 to 12 years old. A cross-sectional study of elementary students in MI Patihan Kidul, Ponorogo, East Java was performed. Eligible samples were 6 to 12 years old students. Examination was performed on September 7th 2023. The students underwent short history taking, body mass index (BMI), and visual acuity examination. Age, sex, BMI, family history of myopia, sleeping time, screen time, and duration of outdoor activity were examined as risk factors. A total of 336 children met the inclusion criteria, of which 48 (14.2%) of them had myopia. Family history of myopia was proven to increase the risk for myopia on their children (p value 0.012, OR 0.436).  Heredity is a well-established risk factor for myopia. This literature review provides evidence on the positive correlation between family history and the occurrence of myopia in children. 

The increasing proportion of the elderly population in Indonesia has led to a rise in degenerative health problems, one of which is osteoporosis. Osteoporosis is a bone disease characterized by decreased bone density, increasing the risk of fractures, particularly among elderly women. Low calcium intake, lack of physical activity, and limited knowledge regarding osteoporosis prevention are major contributing factors. This community service activity aimed to improve the knowledge of Aisyiyah women in Cirebon Regency regarding osteoporosis in the elderly, including its definition, risk factors, impacts, and prevention strategies through proper nutrition and regular physical activity. The activity was conducted from October to December at the Aisyiyah Study Hall in Cirebon Regency, targeting pre-elderly and elderly women. The methods used included health education through lectures and interactive question-and-answer sessions, supported by laptops, LCD projectors, and PowerPoint presentations. Evaluation of participants’ knowledge was carried out using oral pre-tests and post-tests related to the delivered material. The results indicated an improvement in participants’ understanding of osteoporosis, the importance of adequate calcium intake, and the role of physical activity in maintaining bone health. This community service program is expected to contribute to increasing health awareness and reducing the risk and prevalence of osteoporosis among the elderly.