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Abstract:

The implementation of Electronic Medical Records (EMR) has become an essential part of digital transformation in the healthcare sector, aiming to improve the quality, effectiveness, efficiency, and continuity of healthcare services. In Indonesia, the implementation of EMR is supported by the Regulation of the Minister of Health Number 24 of 2022, which mandates healthcare facilities to adopt electronic medical records. However, the implementation process is often challenged by various technical and non-technical factors that may affect its success. This study aims to analyze the success factors and barriers to EMR implementation in hospitals through a literature review approach. The research method used was a literature review by examining and analyzing 11 scientific articles obtained from Google Scholar and other relevant scientific sources. The findings indicate that the success of EMR implementation is influenced by three main aspects, namely human, organizational, and technological factors. Supporting factors include management commitment, user readiness, continuous training, availability of information technology infrastructure, system quality, and organizational support. Meanwhile, common barriers include limited digital literacy among healthcare workers, insufficient information technology personnel, unstable internet connectivity, system errors, inadequate facilities and infrastructure, budget limitations, and the absence of specific standard operating procedures. Furthermore, EMR implementation provides significant benefits, such as improving service efficiency, facilitating access to patient information, enhancing documentation quality, supporting communication among healthcare professionals, and increasing patient safety. Therefore, successful EMR implementation requires synergy between human resources, organizational readiness, and technological infrastructure to achieve optimal healthcare service delivery.

Diabetes Mellitus (DM) is a metabolic disease with an increasing prevalence and a risk of causing macrovascular complications such as stroke. This study aimed to describe the characteristics of Diabetes Mellitus patients with stroke complications based on CT-scan results at RSKD Dadi Makassar in 2024–2025. This was a descriptive observational study with a retrospective design using medical record data. Samples were taken using a total sampling technique, comprising 60 patients, and analyzed univariately using the Statistical Product and Service Solutions (SPSS) version 26. The results showed that the majority of respondents were in the late elderly group (>56 years) at 66.7%, female (51.7%), and from the Makassar ethnic group (63.3%). Most respondents experienced hyperglycemia in random blood glucose (66.7%) and had uncontrolled fasting blood glucose (68.3%) and HbA1c (76.7%) levels. CT-scan results were dominated by non-specific cerebral infarction (68.3%), with ischemic stroke as the most common type (93.3%), a length of stay of 5–10 days (53.3%), and right-sided hemiparesis as the most common clinical manifestation (45.0%). It was concluded that DM patients with stroke complications were generally elderly, female, had poor glycemic control, and were dominated by ischemic stroke with non-specific cerebral infarction. Abstrak. Diabetes Melitus (DM) merupakan penyakit metabolik dengan prevalensi yang terus meningkat dan berisiko menimbulkan komplikasi makrovaskular berupa stroke. Penelitian ini bertujuan untuk mengetahui gambaran karakteristik pasien Diabetes Melitus yang mengalami komplikasi stroke berdasarkan hasil CT-scan di RSKD Dadi Makassar tahun 2024–2025. Penelitian ini merupakan penelitian observasional deskriptif dengan desain retrospektif menggunakan data rekam medis. Sampel diambil dengan teknik total sampling sebanyak 60 pasien dan dianalisis secara univariat menggunakan Statistical Product and Service Solutions (SPSS) versi 26. Hasil penelitian menunjukkan mayoritas responden berusia lansia akhir (>56 tahun) sebanyak 66,7%, berjenis kelamin perempuan (51,7%), dan berasal dari Suku Makassar (63,3%). Sebagian besar responden mengalami hiperglikemia pada GDS (66,7%) serta memiliki kadar GDP (68,3%) dan HbA1c (76,7%) yang tidak terkontrol. Hasil CT-scan didominasi oleh infark serebri tidak spesifik (68,3%) dengan jenis stroke terbanyak berupa stroke iskemik (93,3%), lama rawat inap terbanyak 5–10 hari (53,3%), dan manifestasi klinis tersering berupa hemiparese dextra (45,0%). Disimpulkan bahwa pasien DM dengan komplikasi stroke umumnya berusia lanjut, berjenis kelamin perempuan, memiliki kontrol glikemik yang buruk, dan didominasi oleh stroke iskemik dengan gambaran infark serebri tidak spesifik.

Low Back Pain (LBP) secara terminologi medis, merupakan gejala ketidaknyamanan yang dialami oleh seseorang akibat nyeri pada punggung bagian bawah. Kabupaten Muna Barat menempati urutan ke 11 dari 15 Kabupaten setelah kabupaten Kolaka Utara tertinggi di Sulawesi Tenggara yang menunjukan prevalensi Low Back Pain (LBP). Berdasarkan diagnosis dokter, penduduk umur ?15 tahun mengalami penyakit Low Back Pain (LBP) sebesar 2,15% dari 440 jiwa yang mengalami gangguan kesehatan.Tujuan dari peneliti ini adalah untuk mengetahui Faktor yang Berhubungan dengan Keluhan Low Back Pain pada Pekerja Pembuat Batu Bata di Kecamatan Kusambi Tahun 2026. Penelitian ini menggunakan pendekatan Cross Sectional dengan jumlah sampel sebanyak 125 orang yang diambil menggunakan teknik Alokasi Propostional. Analisis yang dilakukan meliputi analisis univariat untuk mendeskripsikan distribusi frekuensi variabel dan analisis bivariat menggunakan metode chi-square. Hasil penelitian menunjukan bahwa ada hubungan antara usia dengan keluhan LBP (p-value=0,000), tidak ada hubungan antara jenis kelamin dengan keluhan LBP (p-value=0,276), ada hubungan antara posisi kerja dengan keluhan LBP (p-value=0,000), tidak ada hubungan antara durasi kerja dengan keluhan LBP (p-value=0,648), ada hubungan antara beban kerja dengan keluhan LBP (p-value=0,012).Kesimpulan dari penelitian ini yaitu faktor yang berhubungan dengan keluhan low back pain yaitu variabel usia, posisi kerja dan beban kerja, sedangkan varibel jenis kelamin dan durasi kerja tidak berhubungan.

Pengelolaan limbah medis merupakan salah satu upaya penting dalam menjaga kesehatan lingkungan rumah sakit serta mencegah terjadinya pencemaran lingkungan dan penularan penyakit. Limbah medis yang tidak dikelola dengan baik dapat menimbulkan risiko kesehatan bagi petugas kesehatan, pasien, pengunjung rumah sakit, dan masyarakat sekitar. Keberhasilan pengelolaan limbah medis dipengaruhi oleh berbagai faktor, di antaranya pengetahuan, sikap, dan tindakan petugas kesehatan sebagai pelaksana utama dalam proses pengelolaan limbah medis. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan, sikap, dan tindakan petugas kesehatan dengan upaya pengelolaan limbah medis di Rumah Sakit Aliyah II Kota Kendari Tahun 2026.Penelitian ini menggunakan metode kuantitatif dengan rancangan cross sectional. Populasi penelitian berjumlah 81 petugas kesehatan yang seluruhnya dijadikan sampel dengan teknik total sampling. Pengumpulan data dilakukan menggunakan kuesioner dan lembar observasi. Analisis data dilakukan secara univariat dan bivariat menggunakan uji Chi-Square dengan tingkat kepercayaan 95% (?=0,05). Hasil penelitian menunjukkan bahwa sebagian besar responden memiliki pengetahuan kurang baik sebanyak 62 responden (76,5%), sikap negatif sebanyak 72 responden (88,9%), tindakan kurang baik sebanyak 68 responden (84,0%), dan upaya pengelolaan limbah medis kurang baik sebanyak 42 responden (51,9%). Hasil uji statistik menunjukkan bahwa terdapat hubungan antara pengetahuan dengan upaya pengelolaan limbah medis (p=0,002) dan tindakan dengan upaya pengelolaan limbah medis (p=0,004). Sementara itu, sikap petugas kesehatan tidak menunjukkan hubungan yang signifikan dengan upaya pengelolaan limbah medis (p=0,059).Berdasarkan hasil penelitian dapat disimpulkan bahwa pengetahuan dan tindakan petugas kesehatan berhubungan dengan upaya pengelolaan limbah medis, sedangkan sikap petugas kesehatan tidak berhubungan dengan upaya pengelolaan limbah medis di Rumah Sakit Aliyah II Kota Kendari Tahun 2026.

Kompleksitas subsistem elektromekanis pada sistem Radiografi Digital (DR) menuntut pendekatan diagnostik yang terstruktur untuk mencegah waktu henti yang lama dan menghindari pembongkaran yang tidak perlu. Penelitian ini bertujuan untuk menerapkan prinsip Deteksi dan Isolasi Kerusakan (FDI), dengan menggunakan metode isolasi blok, guna mendiagnosis dan mengatasi gangguan pada sistem pengunci magnetik meja pasien pada unit Philips SRO 33100. Pendekatan FDI diterapkan dengan memisahkan blok kontrol listrik dari blok aktuator mekanis secara sistematis, serta melakukan analisis perbandingan terhadap dua aktuator yang identik. Pengukuran listrik menunjukkan bahwa kedua unit kunci magnetik kiri dan kanan menerima tegangan masukan normal sebesar 23,48 V. Perhitungan koreksi relatif menghasilkan nilai 2,5%, yang masih berada dalam batas toleransi aman sebesar 10%, sehingga mengonfirmasi integritas blok kontrol listrik. Namun, analisis perbandingan mengungkapkan ketidakhadiran respons mekanis yang lengkap pada unit kiri, memungkinkan kesalahan diisolasi secara tepat ke kegagalan aktuator internal tanpa membongkar sirkuit kontrol yang utuh. Berdasarkan diagnosis definitif ini, tindakan korektif diambil melalui penggantian komponen dan kalibrasi penyesuaian celah. Uji fungsional pasca-perbaikan mencatat tegangan operasional stabil sebesar 23,45 V dan menunjukkan respons mekanis yang sepenuhnya sinkron, memulihkan gerakan mengambang empat arah. Studi ini menunjukkan bahwa kerangka kerja isolasi blok berbasis FDI yang diusulkan menyediakan strategi yang efektif dan berbasis bukti untuk mengidentifikasi kegagalan elektromekanis, sehingga meminimalkan kebutuhan akan prosedur pemecahan masalah yang invasif. Akibatnya, pendekatan ini merupakan metode diagnostik yang sangat efektif yang menghilangkan kebutuhan akan pembongkaran yang luas, menawarkan kerangka kerja yang andal yang dapat diterapkan secara luas untuk pemecahan masalah peralatan medis lainnya.

Angka kematian neonatus masih tergolong tinggi dan menjadi masalah kesehatan baik secara global maupun nasional. Asfiksia neonatorum adalah salah satu penyebabnya tingginya angka kematian bayi baru lahir di Indonesia (27,0%). Di Kabupaten Lombok Barat, asfiksia neonatorum menjadi penyebab tertinggi kedua kasus kematian neonatal di Kabupaten Lombok Barat selama tahun 2020. Untuk mengetahui hubungan antara preeklamsia dengan kejadian asfiksia neonatorum di RSUD Awet Muda Narmada Kabupaten Lombok Barat Tahun 2021. Penelitian ini menggunakan metode observasional analitik dengan desain case control. Populasi terjangkau untuk kelompok kasus dalam penelitian ini yaitu seluruh bayi baru lahir hidup dengan asfiksia neonatorum di RSUD Awet Muda Narmada Kabupaten Lombok Barat Periode Januari sampai Oktober 2021 yang berjumlah 41 kasus, sedangkan populasi terjangkau untuk kelompok kontrol yaitu bayi bayi baru lahir hidup tidak asfiksia neonatorum di RSUD Awet Muda Narmada Kabupaten Lombok Barat pada periode yang sama berjumlah 765 kasus. Pengambilan sampel kasus dengan teknik total sampling sejumlah 41 kasus, dan pengambilan sampel dilakukan dengan menggunakan teknik simple random sampling sejumlah 41 kasus.  Data diambil dari register dan rekam medis pasien. Data dianalisis secara univariat dan bivariat dengan uji Chi-Square. Hasil analisis dengan uji Chi-Square menunjukkan nilai signifikansi 0,001 (p < 0,05) yang menunjukkan bahwa ada hubungan yang signifikan preeklamsia dengan kejadian asfiksia neonatorum. Ada hubungan preeklamsia dengan kejadian asfiksia neonatorum di RSUD Awet Muda Narmada tahun 2021. Diharapkan ibu hamil lebih waspada terhadap terjadinya preeklamsia, dan bagi bidan lebih meningkatkan upaya skrining faktor risiko pada ibu hamil, terutama preeklamsia sehingga dapat mencegah terjadinya asfiksia neonatorum.

Breast cancer remains a major global health challenge, with treatment effectiveness often limited by drug resistance and the toxic side effects of chemotherapy on normal cells. The exploration of bioactive compounds from natural sources through a medicinal chemistry approach offers a promising alternative strategy. This study aims to examine the molecular mechanisms of action and Structure-Activity Relationships (SAR) of various natural compound scaffolds as potential breast anticancer agents. The method employed was a systematic narrative literature review of 15 recent scientific articles evaluating computational parameters, including molecular docking, as well as in vitro and in vivo activities. The results indicate that polyphenols, flavonoids such as quercetin and EGCG, and curcumin possess strong cytotoxic activity and high binding affinity toward cancer-related target macromolecules. SAR analysis demonstrates that key structural features, including the number and position of free phenolic hydroxyl groups, the presence of gallate ester groups, and conjugated diketone systems, play a crucial role in determining ligand receptor complex stability. These interactions are supported by hydrogen bonding, hydrophobic interactions, and favorable steric compatibility within receptor binding sites. Computational findings further suggest that structural optimization can enhance ligand selectivity and improve pharmacokinetic properties. This study concludes that natural phytochemical scaffolds have significant potential as lead compounds and provide a rational basis for Computer-Aided Drug Design in developing more potent, selective, multi-target, and safer breast anticancer therapies.

Gastroesophageal Reflux Disease (GERD) merupakan gangguan saluran pencernaan di mana isi lambung berulang kali kembali ke kerongkongan, menyebabkan berbagai gejala dan komplikasi. Prevalensi GERD di Indonesia pada tahun 2023 dilaporkan sebesar 42,3% dengan 274.396 kasus. Data rekam medis RSUD Banyumas menunjukkan peningkatan kasus GERD dari 71 kasus (2023) menjadi 118 kasus (2024). Tujuan: Mendeskripsikan penerapan asuhan keperawatan pada pasien Nn. S dengan Gastroesophageal Reflux Disease (GERD) di Ruang Melati RSUD Banyumas. Metode: Studi kasus deskriptif dengan pendekatan proses asuhan keperawatan, dilakukan pada tanggal 27–28 Januari 2026 di Ruang Melati RSUD Banyumas melalui wawancara, observasi, pemeriksaan fisik, studi dokumentasi, dan studi literatur. Hasil: Diagnosis keperawatan yang muncul adalah nyeri akut berhubungan dengan agen pencedera fisiologis (D.0077), nausea berhubungan dengan gangguan pada esofagus (D.0076), dan defisit pengetahuan berhubungan dengan kurang terpapar informasi (D.0111). Intervensi yang dilakukan meliputi manajemen nyeri, manajemen mual, dan edukasi kesehatan. Kesimpulan: Setelah dilakukan implementasi keperawatan selama 2 hari, diagnosis nyeri akut dan nausea teratasi sebagian, sedangkan diagnosis defisit pengetahuan teratasi penuh. Discharge planning dilakukan dengan menganjurkan teknik relaksasi napas dalam, aromaterapi minyak kayu putih, serta modifikasi pola hidup sehat.

Medical waste is a by-product of healthcare activities that may have negative impacts on human health and the environment if not properly managed. This study aims to examine strategic planning for medical waste management in healthcare facilities and evaluate the risk of environmental contamination in the digital era. The method used was a literature review by examining various relevant scientific sources. The findings indicate that medical waste management still faces several challenges, including non-compliance with established standards, limited human resources, and the risk of environmental pollution. The utilization of digital technologies such as the Internet of Things (IoT), Artificial Intelligence (AI), RFID, and Blockchain has the potential to improve the effectiveness of monitoring and managing medical waste. Therefore, strategic planning supported by digital technology, human resource capacity building, and regulatory compliance is essential for achieving safe and sustainable medical waste management.

The readiness of officers to carry out Electronic Medical Records (RME) needs to be measured using the Technology Readiness Index (TRI) method, which is an index used to measure the readiness of new technology users to achieve goals in daily life and work. This research aims to determine the readiness of Electronic Medical Record (RME) users using the Technology Readiness Index (TRI) case study at Daha Husada Regional Hospital. This is a descriptive research with an evaluation study where the research subjects are the head of medical records and 3 medical records officers in the inpatient registration section at Daha Husada Regional Hospital using a total saturated sampling technique. Data collection uses interview techniques. Data presentation is presented using narrative. The results of the research show that of the 4 variables used to measure the readiness of medical record users, medical record officers at Daha Husada Regional Hospital are ready to use medical records, even though they are ready there are still difficulties experienced and feelings of insecurity when using Electronic Medical Records (RME), namely Medical records can be accessed anywhere and are not yet integrated according to the user's wishes. Therefore, Daha Husada Regional Hospital should further tighten its electronic medical record data security system.

Transformasi digital di sektor kesehatan, khususnya melalui penerapan Rekam Medis Elektronik (RME) dan telemedicine, telah membawa perubahan signifikan dalam efisiensi dan kualitas pelayanan kesehatan di Indonesia. Namun, di balik berbagai manfaat tersebut, muncul persoalan serius terkait perlindungan privasi dan keamanan data pasien, interoperabilitas sistem, serta kepastian hukum yang masih belum memadai. Penelitian ini bertujuan untuk mengkaji penerapan RME dalam layanan kesehatan, mengidentifikasi permasalahan keamanan dan perlindungan data pasien, serta menganalisis kepastian hukum dalam layanan kesehatan berbasis teknologi di Indonesia. Metode yang digunakan adalah studi literatur sistematis dengan pencarian artikel melalui database Google Scholar, dibatasi pada publikasi tahun 2022–2026. Dari 8.780 artikel yang ditemukan, proses seleksi bertahap menghasilkan 3 artikel final yang memenuhi kriteria inklusi dan dianalisis secara deskriptif kualitatif. Hasil penelitian menunjukkan bahwa interoperabilitas RME di Indonesia masih terhambat oleh ketidaksesuaian standar data, keterbatasan infrastruktur, dan regulasi yang belum memadai. Penerapan teknologi mutakhir seperti blockchain, cloud computing, dan kecerdasan buatan terbukti mampu meningkatkan keamanan dan efisiensi pengelolaan data pasien. Sementara itu, regulasi telemedicine yang ada belum terintegrasi secara komprehensif dan belum mampu memberikan kepastian hukum yang memadai bagi tenaga kesehatan maupun pasien. Kesimpulannya, diperlukan harmonisasi regulasi, standardisasi data nasional, peningkatan infrastruktur, serta penguatan kapasitas sumber daya manusia agar ekosistem kesehatan digital Indonesia dapat berkembang secara aman, terintegrasi, dan berkeadilan bagi seluruh pihak yang terlibat.

Data security in Electronic Medical Records (EMR) is a crucial issue in health information governance in Indonesia. This study evaluates the compliance of health facility information security systems with Ministry of Health Regulation (PERMENKES) No. 24 of 2022 and Personal Data Protection Law (UU PDP) No. 27 of 2022, and analyzes the impact of non-compliance on service quality and patient trust. The method employed is a systematic narrative literature review on the Google Scholar database (2023–2026) using the keywords "data security and privacy," "electronic medical records," and "CIA Triad," focusing on the implementation of Confidentiality, Integrity, and Availability. The four healthcare facilities examined have implemented controls such as role-based access control, Electronic Signatures (TTE), Virtual Private Networks (VPN), data encryption, and SSL/TLS protocols in accordance with PERMENKES provisions and Article 35 of the UU PDP. However, the effectiveness of implementation is hindered by weak authentication due to the use of simple passwords and excessively long auto-logout durations, the absence of comprehensive written standard operating procedures (SOPs), low staff compliance with security protocols, and minimal patient awareness regarding personal data protection rights. These weaknesses heighten the risk of patient data breaches as well as potential administrative sanctions and fines, and carry negative implications for service quality and public trust. Recommendations include strengthening internal security policies, developing written SOPs, providing continuous training for healthcare workers, implementing stronger authentication mechanisms (e.g., multi-factor authentication/MFA), and conducting patient awareness programs to ensure regulatory compliance and maintain public confidence.

This study aims to examine the concept of crisis response in the Qur'an and its relevance to medical triage practices in contemporary healthcare settings. The method used is a qualitative approach with thematic interpretation (maudhu’i) of Qur’anic verses related to saving lives, emergency conditions (darurah), justice, responsibility, and human limitations. The analysis focuses on how Qur’anic ethical principles can provide guidance in situations where medical resources are limited and difficult decisions must be made. The results show that the Qur'an offers an ethical framework that emphasizes the priority of saving human life, flexibility in emergencies, justice in decision-making, proportional consideration of benefit and harm, and recognition of human limitations in determining outcomes. These principles are closely aligned with the values of modern medical bioethics, namely beneficence, non-maleficence, autonomy, and justice. Therefore, the Qur'anic perspective can serve as an integrative ethical foundation for medical triage practices, not only in terms of professional and interpersonal responsibility, but also as part of spiritual accountability before God. This research contributes to the development of interdisciplinary studies between Qur'anic studies, Islamic ethics, and medical bioethics.    

This study aims to examine the concept of crisis response in the Qur'an and its relevance to medical triage practices in contemporary healthcare settings. The method used is a qualitative approach with thematic interpretation (maudhu’i) of Qur’anic verses related to saving lives, emergency conditions (darurah), justice, responsibility, and human limitations. The analysis focuses on how Qur’anic ethical principles can provide guidance in situations where medical resources are limited and difficult decisions must be made. The results show that the Qur'an offers an ethical framework that emphasizes the priority of saving human life, flexibility in emergencies, justice in decision-making, proportional consideration of benefit and harm, and recognition of human limitations in determining outcomes. These principles are closely aligned with the values of modern medical bioethics, namely beneficence, non-maleficence, autonomy, and justice. Therefore, the Qur'anic perspective can serve as an integrative ethical foundation for medical triage practices, not only in terms of professional and interpersonal responsibility, but also as part of spiritual accountability before God. This research contributes to the development of interdisciplinary studies between Qur'anic studies, Islamic ethics, and medical bioethics.    

The management of medicines and Medical Consumables (MCs) plays a crucial role in improving the quality of pharmaceutical services in hospitals. Common problems include stock imbalances, such as shortages and overstocking, which negatively affect service efficiency, increase operational costs, and raise the risk of product expiration. These issues are often caused by inadequate planning that is not based on consumption data, as well as limited knowledge of pharmacy personnel in applying appropriate inventory control methods.This community service activity aimed to improve the knowledge and skills of pharmacy staff in managing inventory using fast moving and slow moving methods based on real hospital data. The implementation method consisted of education, training, and hands-on mentoring conducted in several stages. The activity began with the analysis of medicine and medical consumables usage data from January to December 2025 at Labuang Baji Regional General Hospital, followed by training on pharmaceutical logistics management, and continued with practical exercises on classification and inventory control. Evaluation was carried out through discussions, case studies, and observation of participants’ ability to apply the methods.The results showed that 50.7% of medicines and 52.4% of medical consumables were categorized as fast moving, while the remaining items were classified as slow moving. After the intervention, there was a significant improvement in participants’ understanding of inventory classification, stock turnover analysis, and data-based planning. Participants were also able to identify items at risk of stock-outs and overstocking, enabling more appropriate control measures.This activity had a positive impact on the efficiency of pharmaceutical inventory management, reduced the risk of stock-outs and overstocking, and supported the improvement of healthcare service quality. Therefore, the fast moving and slow moving methods can be considered effective and applicable approaches for data-driven pharmaceutical inventory management in hospital settings

Cervical cancer is one of the most common cancers worldwide and is largely caused by Human Papillomavirus (HPV) infection, particularly types 16 and 18. The development of this cancer is influenced by the E6 and E7 oncoproteins, which disrupt the function of p53 and Rb proteins, as well as the involvement of cellular signaling pathways such as PI3K/AKT/mTOR and EGFR. Limitations of conventional therapies, such as resistance and side effects, drive the need for more targeted and selective therapeutic agents. This study aims to analyze the main molecular targets of cervical cancer and the medicinal chemistry approaches used in its therapeutic development. The method involved a review of 12 open access articles using molecular docking, molecular dynamics, QSAR, and network pharmacology approaches. The findings identified two main target groups: viral targets comprising the HPV E6 and E7 oncoproteins, and cellular targets including the PI3K/AKT/mTOR pathway, EGFR, PARP1, CDK1, and VEGFR. Various medicinal chemistry strategies, from structure-based and ligand-based drug design to multi-target network pharmacology approaches, proved effective in identifying potential inhibitor candidates. Bioactive compounds such as quercetin, gossypol, bixin, and rutin demonstrated stable interactions with these targets. However, further experimental validation is needed to support the development of clinically effective and safe therapies.

Komplikasi pasca operasi merupakan salah satu masalah klinis yang sering terjadi pada pasien bedah umum dan dapat berdampak pada peningkatan morbiditas, lama rawat inap, serta biaya pelayanan kesehatan. Berbagai faktor diduga memengaruhi terjadinya komplikasi pasca operasi, antara lain usia, jenis kelamin, lama operasi, jenis anestesi, dan status fisik pasien berdasarkan klasifikasi American Society of Anesthesiologists (ASA). Penelitian ini bertujuan untuk menganalisis faktor risiko yang berhubungan dengan kejadian komplikasi pasca operasi pada pasien bedah umum di rumah sakit. Penelitian menggunakan desain kuantitatif analitik dengan pendekatan cross-sectional terhadap pasien pasca operasi yang memenuhi kriteria inklusi dan eksklusi penelitian. Pengumpulan data dilakukan melalui telaah rekam medis pasien, kemudian dianalisis menggunakan uji bivariat dan multivariat untuk mengetahui hubungan serta faktor yang paling dominan memengaruhi komplikasi pasca operasi. Hasil penelitian menunjukkan bahwa lama operasi, jenis anestesi, dan status ASA merupakan faktor yang paling berpengaruh terhadap kejadian komplikasi pasca operasi. Sementara itu, faktor usia dan jenis kelamin menunjukkan hubungan yang bervariasi pada masing-masing kelompok pasien. Temuan penelitian ini menegaskan pentingnya identifikasi faktor risiko sejak fase preoperatif sebagai upaya pencegahan komplikasi dan peningkatan kualitas pelayanan perioperatif di rumah sakit.

The case of medical malpractice involving a toddler in Bima has attracted public attention and raised the urgency of evaluating legal accountability mechanisms in healthcare. This study aims to analyze the law enforcement process and the forms of legal responsibility that can be imposed on medical personnel and healthcare institutions suspected of involvement. Using a normative juridical approach, this study examines relevant laws, doctrines, and legal literature, including provisions in the Medical Practice Law, the Health Law, the Hospital Law, and the Criminal Code. The results indicate that law enforcement in malpractice cases can be pursued through administrative, civil, and criminal channels, depending on the level of negligence and the resulting consequences. Medical personnel can be held personally liable for violations of professional standards, while healthcare institutions can be held accountable based on the principle of vicarious liability. This study concludes that the case in Bima underscores the importance of strengthening regulations, improving medical service standards, and ensuring transparency in law enforcement to protect patient rights, particularly children.

This regulation, which requires all healthcare facilities to implement EMR by December 31, 2023, stemmed from the emergence of Health Ministerial Regulation No. 24 of 2022. Santosa Hospital, Bandung Kopo, has implemented EMR, but no research has been conducted on it. This study aimed to determine the effect of EMR implementation on service quality in the emergency unit at Santosa Hospital, Bandung Kopo. The research methods used were descriptive verification analysis and multiple linear regression analysis. Data collection used a questionnaire distributed to all emergency unit staff. The results of the descriptive analysis were generally considered very good. The results of the verification analysis, both partially, showed a negative and insignificant effect on system quality and service quality, while information quality and use statistics showed a positive and significant effect. Simultaneously, these positive and significant effects were proven, and the researchers recommend maintaining and further improving them.