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The use of medicinal plants has been an important part of people's lives since the time of our ancestors. Before the advent of modern medicine, people used various types of plants to treat mild to severe illnesses, such as fever, cough, wounds, digestive disorders, and skin diseases. Inventory of medicinal plants plays a very important role in exploring the potential of existing natural resources, especially as an effort to support the development of traditional medicine. The purpose of this study is to identify the types of medicinal plants used by local communities in traditional medicine. The method used in this study is a descriptive method through direct surveys at the research location. The findings obtained in the field concluded that all types of plants mentioned in this study are very beneficial for the people of Duhiadaa District, because they can help in treating various types of diseases experienced by the community. The types of diseases that can be treated include hypertension, gout, stomach acid, cholesterol, kidney disease, diabetes, inflammation, cancer, wounds, diarrhea and digestive disorders.

This community service program was conducted by Group 7 of KKN ITB Ahmad Dahlan Lamongan in Bapuhbandung Village, Glagah District, Lamongan Regency, aiming to address environmental and public health issues through the utilization of ecobricks and the cultivation of family medicinal plants (TOGA). The main problems identified were low awareness of plastic waste management and the underutilization of home yards for medicinal plants. The program applied a participatory assistance method involving students, parents, youth, and village officials throughout the stages of observation, planning, implementation, and evaluation. The results showed that more than 300 ecobricks were produced and assembled into an installation forming the word “BAPUHBANDUNG,” which now serves as a new village icon. In addition, medicinal plants such as ginger, turmeric, and lemongrass were planted around the installation area and residents’ yards. The evaluation indicated high community participation, good-quality ecobricks, and positive initial growth of TOGA. This program not only produced physical outputs but also increased community awareness of plastic waste management, family health independence, and the strengthening of village identity.

Drug abuse and risky social behavior remain significant social issues among adolescents, particularly in rural areas experiencing rapid information exposure and lifestyle changes. This community service program aimed to enhance adolescents’ awareness and resilience toward the dangers of drug abuse (NAPZA) while promoting a healthy lifestyle through the cultivation of family medicinal plants (TOGA) in Karangmalang Village, Ngawi Regency. The program employed a participatory descriptive approach, actively involving adolescents as the primary beneficiaries. The implementation consisted of two main stages: interactive socialization on drug abuse and risky behavior, and a workshop on cultivating medicinal plants as a form of community-based healthy living practice. The results indicated that the socialization activities improved adolescents’ understanding and awareness of drug abuse risks, as reflected in their active participation during discussions. Furthermore, the TOGA cultivation workshop provided practical benefits by introducing simple herbal remedies and offering positive, sustainable activities for the community. Overall, the integration of educational and practical approaches proved effective as a preventive and empowerment strategy to strengthen adolescent resilience and foster a healthier and more productive village environment.

Eleutherine bulbosa (Mill.) and Allium cepa L. (including garlic and onion peel) are medicinal plants that have long been traditionally used to treat cancer, diabetes, hypertension, infectious diseases, and inflammation. Recent scientific studies emphasize the importance of extract standardization to ensure consistent quality, safety, and efficacy. Standardization includes specific parameters—such as organoleptic identification, water- and ethanol-soluble extract values, phytochemical profiles, and determination of marker compounds—and nonspecific parameters such as moisture content, loss on drying, total ash, and acid-insoluble ash. Ethanol extract of E. bulbosa showed moisture and drying loss values below 10%, total flavonoid content of around 1.2%, and positive phytochemical tests for alkaloids, flavonoids, saponins, and quinones. Onion peel extract contains a high flavonoid content (7.84 mg QE/g) with moderate antioxidant capacity (DPPH IC₅₀ 152.65 µg/mL), while fermented garlic (black garlic) contains more than 12% polyphenols and more than 2% flavonoids, as well as a high level of S-allyl-L-cysteine (SAC) as a stable bioactive compound. The pharmacological activities of these standardized extracts include strong antioxidant effects, α-glucosidase inhibition for antidiabetic activity, induction of apoptosis and anti-angiogenesis as anticancer potential, membrane disruption and enzyme inhibition for antimicrobial activity, as well as COX/LOX modulation for anti-inflammatory effects. These activities are directly correlated with the secondary metabolite composition of each material. With their phytochemical richness and diverse biological activities, E. bulbosa and A. cepa have great potential as raw materials for standardized herbal products. Further in vivo studies and clinical trials are needed to validate their therapeutic efficacy and to support the development of evidence-based phytopharmaceuticals.

Extraction is a crucial process for obtaining active compounds from natural materials, such as medicinal plants, spices, and other biomass. The success of the extraction process is greatly influenced by the method used, as each method has its own mechanism, efficiency, and yield. This study compared seven commonly used extraction methods: maceration, percolation, infusion, soxhletation, reflux, Ultrasound-Assisted Extraction (UAE), and Microwave-Assisted Extraction (MAE). Based on data collected from various scientific journals, it was found that modern methods such as UAE and MAE are capable of producing higher yields than conventional methods. Furthermore, both methods are more efficient in terms of extraction time and solvent usage, making them more environmentally friendly and suitable for industrial-scale applications. However, conventional methods such as maceration and percolation still play an important role, especially in initial research or in laboratories with limited equipment. For example, maceration is easy to perform, does not require high energy, and is suitable for heat-sensitive materials. Other factors that influence extraction results include the type of solvent, temperature, time, and the characteristics of the natural material itself. Therefore, the choice of extraction method must be tailored to the research objectives, the type of compound to be extracted, and the availability of resources and equipment. Combining several methods can also be considered to improve the efficiency and quality of the extraction results. It should be emphasized that extraction yield is influenced not only by the method, but also by the type of material, solvent, temperature, time, and particle size. Therefore, the choice of extraction method must be tailored to the nature of the material, the type of target compound, as well as the objectives and availability of resources. In some cases, a combination of extraction methods can also be used to increase efficiency and obtain optimal results.

The use of medicinal plants as herbal beverages has long been a part of Indonesian culture. However, the less preferred taste and aroma are obstacles to consumer acceptance. Cat's Whiskers leaves (Orthosiphon aristatus) are known to contain bioactive compounds that act as antioxidants, while Key Lime leaves (Citrus aurantifolia) have a fresh aroma and functional properties that can enhance flavor and health benefits. This study aims to evaluate the effect of adding Key Lime leaves (Citrus aurantifolia) on the chemical characteristics, sensory properties, and effectiveness of brewed Cat's Whiskers (Orthosiphon aristatus) leaf beverages.Five formulations with varying concentrations of Key Lime leaves (0%, 5%, 10%, 15%, and 20%) were tested based on the parameters of moisture content, ash content, pH, solubility, antioxidant activity, and organoleptic tests including color, aroma, taste, and texture. The results showed that the addition of Key Lime leaves significantly improved the chemical quality and sensory acceptability, with the best formulation obtained in treatment P4 (20% Key Lime leaves + 15g Cat's Whiskers), which provided an optimal balance between stability, nutritional content, and organoleptic quality. The addition of Key Lime leaves is recommended as an innovation in the development of functional herbal beverages based on Cat's Whiskers.

Indonesia is recognized as one of the world’s richest countries in terms of biodiversity, including a wide variety of traditional medicinal plants. One of the lesser-known yet promising local species is matoa (Pometia pinnata J.R. Forst & G. Forst), whose leaves have been traditionally used by local communities to treat various ailments, including diarrhea and seizures. This study aims to investigate the pharmacological effects of matoa leaf extract, with a particular focus on its anticonvulsant activity, while also reviewing its potential chemical constituents as a basis for herbal medicine development. The research was conducted using a combination of literature review and experimental testing on mice (Mus musculus) induced with strychnine to trigger seizures. Key observed parameters included seizure onset time and survival duration (dead time) following the administration of either synthetic drugs or matoa leaf extract. The results demonstrated that the matoa leaf extract exhibited significant anticonvulsant effects, as indicated by prolonged seizure onset and increased survival time in test animals. These pharmacological effects are presumed to be related to the presence of active compounds such as flavonoids, tannins, and alkaloids, which may contribute to the stabilization of the central nervous system. Compared to conventional synthetic anticonvulsants, matoa leaf extract may offer a safer, plant-based alternative with potentially fewer side effects. The findings of this study provide valuable scientific evidence supporting the potential of Pometia pinnata leaves in the development of Indonesian herbal phytopharmaceuticals. Furthermore, they highlight the importance of further research, including preclinical and clinical trials, to validate efficacy, determine optimal dosages, and ensure safety for human use.

Pain is an unpleasant sensation that can interfere with an individual's quality of life and requires effective management. Synthetic analgesics such as ketorolac, codeine, etoricoxib, and celecoxib are commonly used to relieve pain, but long-term use can cause adverse side effects, including gastrointestinal disturbances, dependence, and cardiovascular risks. Therefore, it is important to find safer, natural alternatives. One promising alternative is the extract of the dragon’s tail leaf (Rhaphidophora pinnata), a plant traditionally used in Indonesian medicine as a pain reliever. This study aims to evaluate and compare the analgesic effects of Rhaphidophora pinnata leaf extract with several synthetic drugs using the writhing test on male mice (Mus musculus). The mice were induced with pain by injecting a 0.5% acetic acid solution. The treatments included ketorolac, codeine, etoricoxib, celecoxib, and Rhaphidophora pinnata leaf extract. The results showed that all treatments, including both synthetic drugs and Rhaphidophora pinnata leaf extract, produced significant analgesic effects compared to the negative control (Na CMC 0.5%). Ketorolac showed the highest effectiveness, followed by codeine, etoricoxib, and celecoxib. Although the Rhaphidophora pinnata leaf extract showed potential as a natural analgesic, its effectiveness varied among individual test animals. Some mice showed a better response to the leaf extract, but overall, the analgesic effect was still lower than that of synthetic drugs. These findings support the use of medicinal plants as a safer alternative to synthetic analgesic drugs. Moreover, this study provides a foundation for further research aimed at isolating active compounds from Rhaphidophora pinnata leaf extract to develop more effective and safer pain-relieving medications.

Abstrak. Osteoporosis is a degenerative bone disease characterized by a decrease in bone mass and strength, particularly in postmenopausal women. Traditional plant-based therapy presents an attractive alternative given the rich local bioactive potential and limited access to pharmacological treatments. One important biochemical indicator in bone regeneration is the level of alkaline phosphatase (ALP). The aim of this study is to evaluate the potential of various Indonesian traditional medicinal plants as bioactive agents in the prevention of osteoporosis, with an emphasis on increasing ALP levels. This method employed a literature search by collecting several scientific articles discussing the anti-osteoporosis activity of traditional medicinal plants through in vitro, in vivo, and clinical observation studies. The results obtained show that traditional medicinal plants such as Turmeric (Curcuma longa), Black pepper (Piper nigrum), Bromelain (Ananas comosus), Papaya (Carica papaya), Japanese knotweed (Reynoutria japonica Houtt.), Veratrum nigrum, Sickle senna (Cassia tora), Red ginger (Zingiber officinale var. rubrum), Clove (Syzygium aromaticum L.), White turmeric (Curcuma zeadoaria), and Celery (Apium graveolens) are capable of reducing the number of osteoclasts and promoting bone formation. These findings consistently demonstrate a positive role in bone health through increased ALP levels. Indonesian traditional medicinal plants hold great potential as evidence-based anti-osteoporosis agents, particularly through enhancing ALP levels and osteoblast activity. This literature review supports the development of local herbal therapy as a promotive and preventive alternative against osteoporosis.

Fever and cough are diseases that often attack humans. Fever and cough are early signs of infection of a disease that attacks the body. This qualitative study was initiated to identify the types of plants, organs used, and local wisdom inherent in the traditional medicine practices of the people of East Java Province in dealing with fever and cough. Data collection was carried out through literature survey methods and journal reviews. Data sourced from articles in the Google Scholar, Google, and ResearchGate databases were then analyzed using a qualitative descriptive approach.The results of the study showed that there were 9 species of plants used for fever and cough medicine, including turmeric (Curcuma domestica), lime (Citrus X aurantiifolia), fennel (Foeniculum vulgare), starfruit (Averrhoa bilimbi L), kencur (Kaempferia galanga), mengkudu (Morinda citrifolia), katuk (Sauropus androgynus (L.) Merr), tapakliman (Elephantopus scaber), lemongrass (Adropogon nardus). The plant has certain content that can cure fever and cough. Fruit, leaves, rhizomes, and roots are parts of the plant organs that are often used by the community.

Indonesia's biodiversity holds great potential for drug development, including through the use of traditional medicinal plants such as tapak liman (Elephantopus scaber L.), suruhan (Peperomia pellucida L. Kunth), and temu ireng (Curcuma aeruginosa Roxb.). These plants have been used in traditional medicine and are known to contain bioactive compounds with potential anticancer properties. Tapak liman contains compounds capable of inducing apoptosis in cancer cells. Suruhan is known to have cytotoxic and immunomodulatory effects, while temu ireng contains compounds with antioxidant and anticancer activity. This study aims to identify and quantify the bioactive compounds in these three plants using Gas Chromatography-Mass Spectrometry (GC-MS) and to explore their therapeutic potential in cancer treatment. The results of GC-MS analysis successfully identified six main compounds that have potential as anticancer agents, namely Phytol, Caryophyllene, Apiol, Germacrone, Germacrene B, and one additional compound. Temu ireng contains Germacrone, Germacrene B, and Caryophyllene, while suruhan contains Caryophyllene, Apiol, and Phytol. Meanwhile, tapak liman shows the presence of bioactive compounds that support cytotoxic activity. The focus of this study is on the interaction of bioactive compounds with the Bcl-2 protein, which plays a role in inhibiting apoptosis in cancer cells. Additionally, molecular analysis revealed that Germacrone, Germacrene B, Caryophyllene, and Apiol can also bind to the p53 protein, known as a guardian of the genome and a trigger for apoptosis. These findings suggest that the three plants have high potential as natural sources of anticancer agents. Further in vitro and in vivo studies are recommended to test the biological efficacy of these compounds in the context of cancer therapy, thereby bridging traditional knowledge with modern scientific approaches in the development of natural-based medications.

Malaria remains a significant public health issue in Indonesia, particularly in endemic areas such as Keerom Regency, Papua. Efforts to control this disease face challenges due to Plasmodium resistance to synthetic drugs, highlighting the need for safer and more effective alternative treatments. This study aims to identify the secondary metabolite content of several local plants traditionally used as antimalarial remedies. An experimental laboratory study was conducted using phytochemical screening methods. The plants examined included turmeric rhizome (Curcuma longa), meniran leaves (Phyllanthus niruri), papaya leaves (Carica papaya), sambiloto (Andrographis paniculata), and brotowali (Tinospora crispa). Extraction was carried out using the maceration method with 96% ethanol as the solvent. The results showed that all samples contained secondary metabolites such as flavonoids, alkaloids, tannins, and saponins, which are known for their antiplasmodial activity. Extract yields ranged from 18% to 24%, with turmeric rhizome showing the highest yield. These findings suggest that local plants from Keerom Regency hold potential as raw materials for the development of herbal antimalarial drugs. This study serves as a preliminary step for further in vitro and in vivo bioactivity testing.

Indonesia has around 3,500 species of therapeutic plants, one of which is utilized by the individuals of Selilau Town, Aru Islands Rule, Maluku Area.. This study aims to examine 15 types of medicinal plants that are used traditionally, including plant parts, properties, active compound content, and pharmacological activity based on scientific literature from the last 10 years. This survey points to recognize species of restorative plants commonly utilized in neighborhood conventional medication, look at the plant parts utilized, handling strategies, and maladies treated based on neighborhood experiences and to survey logical writing to decide the dynamic compound substance and pharmacological movement of each distinguished plant. The comes about of the think about appeared that the foremost broadly utilized plant is the leaf portion. Some of them are: Momordica charantia (bitter melon) for cough; Urena lobata (pulutan) to smooth postpartum blood; Morinda citrifolia (mengkudu) for broken bones; Erythrina variegata (dadap) for body recovery; Myrmecodia pendens (ant nest) for swelling and beriberi; and Carica papaya (papaya) for malaria. Other plants such as Manihot esculenta, Tradescantia spathacea, Graptophyllum pictum, Hemigraphis alternata, Mimosa pudica, Jatropha curcas, Psidium guajava, Nypa fruticans, and Stachytarpheta jamaicensis are also used for various health complaints. Active compounds such as flavonoids, alkaloids, tannins, and saponins support pharmacological activities such as anti-inflammatory, antioxidant, antipyretic, gastroprotective, and immunostimulant. This study emphasizes the importance of documenting traditional knowledge as an effort to preserve and develop local wisdom-based medicines.

Pimpinella pruatjan is a native Indonesian medicinal plant increasingly threatened by overexploitation and limited cultivation techniques. This study aims to systematically review the role of tissue culture in the conservation and production of its secondary metabolites. Using the Systematic Literature Review (SLR) method, data were gathered from scientific literature published in the last five years through open-access databases. The findings reveal that tissue culture techniques not only effectively regenerate purwoceng but also significantly enhance the production of bioactive compounds such as flavonoids, betaine, and sterols. This study demonstrates that biotechnology-based tissue culture is a strategic solution for conserving endangered medicinal plants while optimizing their utilization for biodiversity-based pharmaceutical industries.

The inventory of medicinal plants involves collecting and organizing data regarding natural resources for resource management planning and serving as a database to reveal the potential of plants in a given area. This study aims to inventory the types of medicinal plants found in the home gardens of the residents of Negeri Latu, Amalatu District, West Seram Regency. The data collection methods employed were exploration and descriptive surveys. The gathered data was subsequently analyzed to identify the benefits or uses of the plants based on relevant literature. The results indicate that 57 species of medicinal plants were found in the home gardens of the residents of Negeri Latu. These plants possess various properties, including antidiabetic, antimalarial, anti-inflammatory, antioxidant, anticholesterol, anticancer, antidysentery, analgesic, antipyretic, and mosquito-repellent effects. This finding highlights the significant potential of home gardens in Negeri Latu as a rich natural resource of medicinal plants. The diversity of plant species reflects the local traditional knowledge of utilizing flora as a natural solution to various health issues.

Breast cancer is the most prevalent type of cancer in women worldwide, with approximately 2.3 million new cases or 11.7% of all cancer cases. Human Epidermal Growth Factor Receptor 2 (HER-2) is one of the important therapeutic targets in breast cancer that is overexpressed in 15-25% of cases. Conventional cancer treatments such as chemotherapy often cause adverse side effects, so safer alternative therapies are needed. This study aims to assess the potential of active compounds from medicinal plants as HER-2 inhibitors through a molecular docking approach. The literature review method was used by analysing related research articles in the last five years obtained from PubMed and Google Scholar databases. The results showed that several active compounds have high potential as HER-2 inhibitors, including beta cystosterol from guava leaves (Psidium guajava L.) with a binding energy value of -12.3 kcal/mol, vitexin from dandang gendis (Clinacanthus nutans L.) with a value of -9.3 kcal/mol, and isovitexin from basil mekah (Ocimum gratissimum) with a value of -9.11 kcal/mol. These findings provide a basis for further development of natural active compounds as potential breast anticancer drug candidates with minimal side effects.

Adolescence is a crucial developmental phase often marked by a lack of responsibility, which can lead to negative behaviors such as juvenile delinquency and promiscuity. Therefore, developing a responsible character in adolescents is essential to guide them toward positive behavior. One effective approach is through life skills education implemented in the local village (gampong) environment. This community service initiative aims to instill a sense of responsibility in adolescents by involving them in the planting and maintenance of family medicinal plants (TOGA). Through this activity, adolescents are expected to develop care, discipline, and responsibility, which are reflected in their commitment to nurturing the plants. The activity was implemented in Gampong Cot Alue, Ingin Jaya District, Aceh Besar, and carried out over two days, from February 14 to 15, 2025. The method used in the planning and execution of the TOGA planting involved five stages: (1) creating an activity plan, (2) preparing tools and materials, (3) preparing the planting area, (4) plant nurseries, and (5) creating plant identification markers. These stages were designed to introduce a structured approach to life skills and community engagement.The outcomes of the program demonstrated an increase in adolescents' awareness and understanding of the importance of TOGA. Additionally, there was a noticeable improvement in their sense of responsibility and participation in daily activities beyond school. The broader community, particularly the youth, gained valuable knowledge about the benefits of TOGA for disease prevention, treatment, and health maintenance, contributing to a healthier and more proactive lifestyle within the village environment.

This study examines the diversity of medicinal plants in Las-Lasan Village, Klaten, and develops a research-based learning module for high school students. This research is part of a research and development project encompassing the following stages: preliminary study, planning, initial product development, revision of the initial product, limited field testing, and revision of the second product. The learning module design is based on existing learning modules used in high schools and integrated with the research findings on medicinal plant diversity. The learning module was validated by learning module experts and experts in plant diversity. Data analysis of expert validation results was conducted using quantitative descriptive analysis. The study concludes that the medicinal plant diversity learning module based on research in Las-Lasan Village, Klaten is highly feasible for use in high school biology learning. By integrating empirical data, the module enhances students’ understanding of ecology and biodiversity, promotes independent learning, and supports contextual, critical, and applicable education.

This article discusses the maintenance of Family Medicinal Plants (TOGA) in Mata Wawatu Village as an effort to improve public health. The aim of this program is to provide information to the public regarding the benefits and cultivation techniques of medicinal plants. The methods employed include qualitative research with a descriptive approach, encompassing observations, interviews, and documentation collection. The findings of this study indicate that this initiative has successfully enhanced the community's understanding of TOGA and encouraged them to utilize medicinal plants in their daily lives. This program is expected to improve the health and well-being of the community and reduce dependence on chemical medications

Jurang Hamlet is one of the hamlets located in Girirejo Village, Tempuran District, Magelang Regency. In general, people in Jurang Hamlet have a fairly large yard land. The land can be used and optimized, one of which is by planting family medicinal plants (TOGA). TOGA is a plant that is usually used as a traditional medicine to treat various diseases and is usually grown in the yard of the house. There are problems that occur in Jurang Hamlet, namely the lack of understanding and knowledge related to the planting and utilization of TOGA. In addition to increasing public knowledge and understanding, this activity is also intended to empower the PKK women of Jurang Hamlet in terms of managing medicinal plants in the yard of the house. This community empowerment activity uses three methods: (1) Preparation of TOGA seeds, (2) Socialization of effective TOGA planting methods, (3) Socialization of the benefits of each TOGA to be planted, (4) The distribution of TOGA seedlings and the planting of TOGA together. From the results of the TOGA planting activities that have been carried out by the residents of Jurang Hamlet, it is known that the residents of Jurang Hamlet have become more aware of how to plant TOGA well and also some of the benefits of each plant seed that has been distributed.