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Supraventricular tachycardia (SVT) is one of the most common arrhythmias in the pediatric population, often resulting from re-entry mechanisms involving accessory pathways or dual atrioventricular nodal physiology. Although generally well tolerated in children with structurally normal hearts, its management can be challenging, particularly in recurrent or persistent cases. This study is a case report describing a pediatric patient with hemodynamically stable SVT treated at Dr. Wahidin Sudirohusodo Hospital. Data were collected retrospectively from medical records, including history taking, physical examination, and supporting investigations such as serial electrocardiography (ECG), laboratory tests, chest radiography, and transthoracic echocardiography. Management was conducted according to current clinical guidelines, including vagal maneuvers, pharmacological therapy with beta-blockers and antiarrhythmic agents (amiodarone), and monitoring of treatment response based on clinical evaluation and ECG, along with identification and treatment of underlying triggers. We report a case of a 10-year-old female presenting with suspected SVT and pericarditis, who experienced episodes of narrow QRS complex tachycardia that were successfully converted to sinus rhythm following amiodarone administration. Echocardiographic evaluation revealed mild to moderate tricuspid regurgitation with preserved ventricular function. Laboratory and radiological findings suggested an underlying inflammatory process, which was considered a triggering factor. This case highlights the importance of a comprehensive approach in the diagnosis and management of pediatric SVT, including addressing underlying conditions and ensuring continuous monitoring to prevent recurrence.

Background: Knee osteoarthritis is a degenerative joint disease that often occurs in the geriatric population and causes pain, limited movement, and decreased function. In advanced conditions, management is carried out with Total Knee Replacement (TKR). However, post-surgery patients still experience functional limitations so that physiotherapy intervention is needed. Objective: To determine the effectiveness of static bicycle and quadriceps strengthening exercises on pain, range of motion, muscle strength, functional mobility, and quality of life in post-TKR patients. Methods: This study used a case study design in one patient with post-TKR dextra et causa bilateral knee osteoarthritis. The intervention was given for 3 weeks with a frequency of 2 times per week. Evaluation was carried out using the Numeric Rating Scale (NRS), goniometer, Manual Muscle Testing (MMT), Timed Up and Go Test (TUG), and the Knee Osteoarthritis Outcome Score (KOOS). Results: Results showed a decrease in motion pain from NRS 6 to 4 and stationary pain from 3 to 2. Knee range of motion increased from 75° to 90° of flexion and from -5° to 0° of extension. Muscle strength increased from MMT 3 to 4 in the quadriceps muscle. Functional mobility also improved, with TUG time decreasing from 22 seconds to 18 seconds. However, the KOOS score remained relatively unchanged at 38.84. Conclusion: Static bicycle and quadriceps strengthening exercises were effective in reducing pain, increasing ROM, muscle strength, and functional mobility in post-TKR patients. However, the improvement in quality of life as measured by the KOOS was not significant, requiring a longer rehabilitation period.

Background: Carpal Tunnel Syndrome (CTS) is a condition caused by compression of the median nerve at the wrist, resulting in pain, paresthesia, and decreased hand function. This condition is commonly experienced by individuals who perform repetitive wrist activities. Objective: To determine the effectiveness of a combination of neural mobilization exercises and electrotherapy modalities in improving hand function, increasing muscle strength, and reducing pain in a patient with Carpal Tunnel Syndrome. Methods: This study used a case report design involving a 57-year-old female patient (Mrs. Q) who presented with pain and sensory disturbances in the right hand. The intervention was administered for four weeks and consisted of ultrasound therapy, Transcutaneous Electrical Nerve Stimulation (TENS), grip strengthening exercises, and nerve gliding exercises. Outcome measures included pain intensity assessed using the Numeric Rating Scale (NRS), muscle strength evaluated using Manual Muscle Testing (MMT), and functional ability measured using the Wrist Hand Disability Index (WHDI). Results: The evaluation showed a reduction in pain intensity, with resting pain at 0/10, tenderness at 4/10, and movement pain at 4/10. Muscle strength improved from grade 3 to grade 4 based on MMT. Functional ability also improved, as indicated by a 20% reduction in the WHDI score. The combination of these interventions proved effective as a conservative management approach for Carpal Tunnel Syndrome. Conclusion: The administration of ultrasound, TENS, grip strengthening exercises, and nerve gliding exercises over four therapy sessions in Mrs. Q resulted in decreased pain, increased muscle strength, and improved hand functional ability.

Perimenopause is an important phase in a woman's life characterized by extensive hormonal changes as the ovaries gradually lose their function. During this period, the body experiences significant hormonal fluctuations, particularly a decrease in estrogen and progesterone production, which can cause various physical discomforts such as fatigue. One way to overcome fatigue is through low-impact exercise. This exercise is a light, safe activity that can improve physical fitness and enhance the body's endurance, thereby potentially reducing fatigue levels in perimenopausal women. This study used a descriptive method with a case study approach conducted on two perimenopausal women, Mrs. T and Mrs. N. The results of the nursing care showed that after six sessions of low-impact exercise over two weeks, the fatigue levels of both respondents decreased, as evidenced by their Fatigue Assessment Scale (FAS) scores. Mrs. S's FAS score decreased from 28 to 23, while Mrs. N's decreased from 30 to 27. The symptoms experienced by Mrs. T decreased on the third day and further decreased on the sixth day. For Mrs. N, symptoms decreased on the third day and further decreased on the fifth day. The results of this study indicate that low-impact exercise is effective as an intervention for fatigue issues in perimenopausal women.

Wounds can be defined as the loss and damage of anatomical cells or skin function. Wound healing consists of coagulation, inflammation, proliferation, and remodeling stages. This study aims to determine the effectiveness of the leaf fraction of the thick (Glochidion superbum) on wound healing in male white mice (Mus musculus). This study is experimental. This study used 24 male mice that were given a 10 mm long cut wound. Fractionation was carried out using the liquid-liquid extraction method. Fractionation used 3 different types of solvents, namely methanol, ethyl acetate, and n-hexane. The results showed that the ethyl acetate fraction had a faster wound healing effectiveness than the other groups. The ethyl acetate fraction contains a phenolic compound, namely methyl gallate. Methyl gallate has an important role in wound healing. Methyl gallate has the potential to be an antibacterial, antioxidant, and anti-inflammatory. The results of the Bonferroni post-hoc statistical analysis confirmed the effectiveness of the ethyl acetate fraction in faster wound healing. The thick leaf fraction was effective in healing incisions in male white mice. The ethyl acetate fraction was more effective in accelerating incision healing.

Bitter melon (Momordica charantia) is a medicinal plant traditionally used to control blood glucose levels and improve digestive health. These benefits are closely associated with its bioactive metabolite content. This article aims to characterize the bioactive metabolites of bitter melon and to review their potential bioactivity in glycemic control and digestive function. The method employed includes a literature-based characterization of metabolites, identification of major classes of active compounds, and evaluation of analytical techniques commonly applied in natural product research, such as phytochemical screening, chromatography, and spectroscopic analysis. The results indicate that bitter melon contains various bioactive metabolites, including flavonoids, alkaloids, saponins, triterpenoids, and polyphenols, which contribute to blood glucose reduction by enhancing insulin sensitivity and inhibiting glucose absorption. Furthermore, these compounds support digestive health by improving digestive enzyme activity, exhibiting anti-inflammatory effects, and maintaining gut microbial balance. In conclusion, bitter melon represents a promising source of natural bioactive compounds with significant potential for application in health and pharmaceutical development.

The concept of supremum is fundamental in real analysis and plays a crucial role in the optimization of single-variable real functions. In practice, not all functions attain their supremum explicitly, which necessitates numerical approaches to evaluate their behavior computationally. This study aims to analyze the supremum of several one-dimensional real functions with different characteristics using a grid-search method implemented in Python. Four functions were examined: a parabolic function, a rational function with a sharp peak, a discontinuous piecewise function, and a function with a vertical asymptote. The analysis involved modeling the functions, discretizing the domain, performing numerical approximation of the supremum, verifying the results against analytical values, and using graphical visualization to observe the function behavior near the supremum. The findings indicate that the supremum of the parabolic, rational, and piecewise functions can be accurately identified, with results consistent with analytical expectations despite minor deviations caused by grid resolution limitations in the rational function. Meanwhile, the function with a vertical asymptote yields an unbounded supremum, which cannot be attained within the domain. These results demonstrate that Python provides stable and reliable numerical estimates of the supremum across various types of one-dimensional real functions, validating the effectiveness of computational methods in supporting conceptual understanding of supremum.

This study examines the phonological disorder in the form of mild articulatory dysarthria experienced by actress Junior Roberts in an entertainment media interview on the Cinema 21 YouTube channel. The study was conducted using a phonological approach, specifically articulatory phonetics, to analyze the inaccuracy of pronunciation of language sounds in spontaneous speech. This study used a qualitative descriptive method with the Free Listening and Speaking (SBLC) technique as a means of data collection. The analysis results indicate that the phonological disorder experienced by the subject is evident in the phoneme /r/ through three main processes: substitution (/r/ is replaced by /l/ or /y/), elision (the /r/ sound is lost), and distortion (the /r/ sound is heard muffled). This disorder is caused by articulatory muscle weakness due to neuromotor dysfunction. Despite this, the subject displayed a positive attitude and made her speech characteristics a personal identity in the entertainment world. This study confirms that the study of phonology does not only focus on the sound aspects of language but also encompasses the physiological, psychological, and social dimensions that influence human speech production.

Fasting as a spiritual and health practice has been practiced for thousands of years in various religious and cultural traditions around the world. In the last decade, researchers have shown increasing interest in the health aspects of fasting, not only from a physiological but also a psychological perspective. This phenomenon is interesting to study further, especially in the context of modern society which often faces stress, anxiety, and various mental disorders. The approach used in this study was a qualitative approach with a literature study method that analyzed in depth various reference sources related to the mental impact of fasting. The results of the review of several studies show that fasting has been proven to have an effect on mental health because it has a significant impact on overall mood improvements, with reduced anxiety levels and increased feelings of calm. Furthermore, another important aspect of mental health is cognitive function, which includes attention, concentration, memory, and executive function. It was found that cognitive alertness is generally maintained during short- to medium-term fasting, but begins to decline after longer fasting durations. Fasting also has an impact on extraordinary psychological resilience and good mental health despite advanced age. Researchers attribute this extraordinary mental resilience to the consistent practice of long-term fasting, which may have induced significant neuroplastic and psychological adaptations.

In the development of a construction project, cost control is very important in the process of managing project costs. Many problems will be encountered in a construction project such as wasteful use of materials, unskilled labor and late completion of the project. This causes waste of costs that do not match the specified budget. In the construction project of the Rectorate of the Sorong City Health Polytechnic building, a budget of Rp. 36,570,996,788.55 is required. This study aims to make savings on previously planned costs, in addition to knowing the comparison of total project costs after analysis. The method used in this study is the Value Engineering method. The Value Engineering method is a method used to identify and eliminate unnecessary activities or reduce costs without reducing function. There are 4 stages of the work plan in this method, namely: Information Stage, Creative Stage, Analysis Stage, and Recommendation Stage. After conducting the Value Engineering analysis, savings of Rp. 654,875,786.25 or 1.79% of the total project cost were obtained. The analysis was conducted on the two highest-cost work items: wall and floor work. For the wall work, it was recommended that the HPL wall covering be replaced with plasterboard, while for the floor work, it was recommended that the 60x60 granite be replaced with 60x60 ceramic tiles.

Wahno Subdistrict in Abepura District, Jayapura City, faces drainage problems that disrupt the area’s water management function. The varied topography, population growth, and the community’s habit of disposing waste into drainage channels have reduced the system’s capacity and caused frequent waterlogging during rainfall. This study aims to analyze the existing condition of the drainage channels in Wahno and to evaluate their effectiveness in conveying stormwater flow. The research methods include field surveys, channel dimension measurements, capacity calculations, and analysis of the effective volume compared to actual conditions affected by waste and sedimentation. The data were analyzed using quantitative and descriptive approaches to assess the performance level of the drainage system. The results show that most drainage channels in Wahno are not functioning optimally, with an average effectiveness of only 45–60% due to blockages caused by waste and sedimentation. The main factors reducing drainage effectiveness are decreased storage capacity, substandard design, and lack of regular maintenance. It is concluded that improvements to channel capacity, better waste management, and routine maintenance programs are necessary to enhance the drainage system’s effectiveness.

The design of the 3:30 Kopi website poster was carried out as an effort to present an effective and modern promotional medium to support information needs and introduce the café’s digital platform to the wider community. In line with the development of the digital era, local SMEs such as 3:30 Kopi are required to remain competitive by utilizing visual media that is both communicative and appealing. This poster functions not only as an information tool but also as a branding strategy to strengthen the café’s identity in the eyes of consumers, particularly in the Ciledug area and its surroundings. The visual concept of the poster was designed with careful consideration of both aesthetics and function. The use of brown and cream tones symbolizes the warm and natural character of coffee, while also creating a friendly and elegant impression. Typography was chosen with a simple yet bold style to ensure information is easy to understand. The main elements, featuring a mockup of the website displayed on both laptop and mobile devices, emphasize the flexibility and responsiveness of the platform, which can be accessed anytime and anywhere. In addition, the inclusion of a QR code provides a modern solution that facilitates quick and practical interaction between the audience and the website. Cultural-inspired ornaments derived from 3:30 Kopi’s signature menu further reinforce its visual identity while adding aesthetic value. Through this poster design, 3:30 Kopi is expected to increase brand awareness, attract new visitors, and strengthen its image as a café that not only offers coffee but also provides a productive social space suited to the needs of modern society.

Patients who are admitted to the Intensive Care Unit (ICU) often require mechanical ventilation due to respiratory failure. One of the common problems that arises in patients with mechanical ventilation is the buildup of sputum, which can interfere with the ventilation process as well as lower the tidal volume. To overcome this, a combination of clapping and suction interventions are used as a therapeutic method with the aim of helping to clear the airways and improve ventilation function. This study aims to determine the effect of the combination of clapping and suction on tidal volume in patients with respiratory failure using mechanical ventilation. The research design used a pre-experiment with a one-group pretest-posttest approach on 43 respondents in the ICU room. Interventions in the form of clapping and suction are given in a structured manner according to standard nursing procedures. The results showed that the majority of respondents were female (53.5%), with the most medical diagnosis being SNH (23.3%). Most of the respondents were in the late adult age category (32.6%) and used PCV ventilation mode (51.2%). Before the intervention, most respondents had a low tidal volume (72.1%), while after the intervention the majority had an increase to the normal category (90.7%). The Wilcoxon test showed a value of p = 0.001, which means that there is a significant effect of the combination of clapping and suction on the increase in tidal volume. Thus, it can be concluded that the combination of clapping and suction is an effective intervention in increasing tidal volume in patients with respiratory failure with mechanical ventilation at the ICU of RSI Sultan Agung Semarang.

This paper explores the transformative influence of artificial intelligence (AI) on the accounting profession, particularly within the Accountant General of the Federation (OAGF). The research investigates how AI-driven innovations are reshaping traditional accounting practices and redefining the role of accountants. By conducting a systematic literature review, this study identifies three primary dimensions of AI’s impact: the automation of repetitive tasks such as data entry, transaction processing, and reconciliation; enhanced data analytics capabilities, which include predictive modeling and real-time decision support; and the evolution of accountants' roles toward more strategic and value-added activities, such as financial advisory and risk management. The automation of routine processes through AI allows accountants to focus on higher-level tasks that require judgment, creativity, and expertise, ultimately enhancing the overall efficiency of the accounting function. Furthermore, AI’s advanced data analytics tools provide more accurate insights, enabling accountants to offer more effective financial guidance and make more informed decisions. As AI reduces the time spent on manual processes, accounting professionals can improve their role in advising on business strategy, improving risk management, and identifying new growth opportunities. The study’s findings underscore the importance of embracing AI in the accounting profession, not only to improve operational efficiency, reduce costs, and scale operations but also to enable accountants to stay competitive in a rapidly evolving technological landscape. The paper concludes by emphasizing that adopting AI is essential for accountants to remain relevant and continue providing valuable contributions to their organizations. Future research should focus on the long-term implications of AI on accounting ethics and the development of necessary skills for accounting professionals to thrive in the age of AI.

Bekasam is a traditional fermented food made from snakehead fish (Channa striata) through spontaneous fermentation with the addition of salt and rice over several days. This fermentation process promotes the growth of indigenous microorganisms, particularly lactic acid bacteria (LAB), which play a crucial role in developing distinctive flavors and potentially providing health benefits. LAB are well-known for their probiotic effects, such as maintaining gut microbiota balance and enhancing immune system function. This study aimed to identify the presence of LAB in bekasam using the Gram staining method. Samples were taken from bekasam that had been fermented for three days. Bacterial isolation was conducted by culturing the samples on appropriate media, followed by Gram staining to observe bacterial morphology and cell wall characteristics under a microscope. Observations revealed a predominance of Gram-positive, rod-shaped (bacillus) bacteria, which are the primary morphological characteristics of LAB. This morphology is consistent with bacterial groups such as Lactobacillus spp., which are commonly found in traditional fermented products. These findings strengthen the assumption that snakehead fish–based bekasam is not only a traditional food source with rich flavors but also has potential as a natural probiotic source. This potential opens opportunities for bekasam to be developed as a functional food that supports digestive health and immune function. Further research is recommended to perform molecular identification to accurately determine bacterial species and to evaluate their probiotic activity in vivo. Thus, bekasam holds not only cultural and culinary value but also added value in the field of health and the functional food industry.

Cell-based therapy is an innovative approach currently experiencing rapid development in the biomedical field, particularly in the areas of immunotherapy and gene therapy. This approach utilizes living cells, such as genetically modified T cells, to recognize and destroy abnormal cells such as cancer cells or cells with genetic mutations. The development of gene engineering technologies, such as CRISPR/Cas9, has enabled scientists to precisely edit damaged genes, thereby repairing or restoring normal cell function. This study aims to examine recent advances in cell-based therapy, focusing on cell modification techniques, the efficiency of the immune system in targeting cancer cells, and the integration of gene therapy technology and immune cells. Furthermore, this study also identifies several challenges that remain, including the risk of side effects due to undesirable immune reactions, the genetic stability of the modified cells, and the long-term sustainability or viability of transplanted cells. While these challenges remain serious concerns, several clinical studies have shown that cell-based therapy has significant potential in the treatment of difficult-to-treat diseases, such as advanced cancer and rare genetic disorders. The results of this study demonstrate that cell-based therapy not only offers a new approach to treatment but also opens the door to more personalized and precise therapies. However, for broader implementation in clinical practice, further, in-depth research is needed regarding safety, long-term efficacy, and strict regulation. This research is expected to make a significant contribution to the development of more effective and safe future therapies.

Chronic Kidney Disease (CKD) or chronic kidney failure is a condition that occurs due to a decrease in the kidney's ability to maintain balance in the body so that hemodialysis therapy is needed to replace the kidney function. Hemodialysis therapy can cause various physical effects and mental conditions of patients so that it can affect the patient's quality of life. Objective : to determine the relationship between anxiety levels and quality of life of CKD patients undergoing hemodialysis at Lakipada Hospital. Research Method : the research design used is quantitative research with a Cross Sectional approach, using a " saturated sampling" sampling technique with a sample size of 40 respondents. The independent variable is the level of anxiety and the dependent variable is the quality of life. Data were analyzed using the Chi-Square statistical test at a significance level of α <0.05. Research Results : it was found that there was a relationship between anxiety levels and quality of life in CKD patients undergoing hemodialysis with a p-value = 0.000. Conclusion : there is a relationship between anxiety levels and quality of life in CKD patients undergoing hemodialysis.

Premature ovarian failure (POF) is a condition where the ovaries stop functioning before the age of 40 years, resulting in permanent infertility. IVF with own eggs in POF patients has a very low success rate, so egg donation is the most effective alternative. This review aims to evaluate the effectiveness of using egg donors in IVF programs in women with POF, through an analysis of 20 studies systematically selected from international scientific databases. The results of the study showed that egg donation consistently increased the clinical pregnancy and live birth rates in POF patients, although accompanied by obstetric risks such as gestational hypertension and preeclampsia. New reproductive technologies such as in vitro maturation (IVM), stem cell therapy, and platelet-rich plasma (PRP) also provide additional prospects for restoring ovarian function. In conclusion, egg donation is a major strategy in the management of infertility due to POF, which requires the support of an integrated clinical, ethical, and policy approach.

Nephrolithiasis, commonly known as kidney stone disease, can be experimentally induced in animal models using ethylene glycol (EG) in combination with ammonium chloride, which closely mimics calcium oxalate stone formation in humans. This condition is associated with significant renal tissue injury, including glomerular atrophy, tubular necrosis, and hyaline droplet accumulation, ultimately impairing kidney function. The present study aimed to investigate the histopathological changes in the kidneys of EG-induced rats and evaluate the nephroprotective potential of combined avocado (Persea americana) and gooseberry (Physalis angulata) leaf extracts. A total of 30 male Sprague Dawley rats were randomly divided into five groups: a standard control (no induction), a negative control (EG-induced without treatment), a positive control (EG-induced and treated with a commercial nephroprotective agent), and two treatment groups receiving the combined extracts at different doses. Nephrolithiasis induction was performed over 28 days, followed by oral administration of the respective treatments. At the end of the experiment, kidney tissues were collected and processed for histological examination using hematoxylin-eosin staining to assess the extent of tissue damage. The negative control group exhibited the most severe histopathological alterations, with hyaline droplet formation reaching 15.0 ± 5.25%. In contrast, extract-treated groups demonstrated a marked reduction in tissue damage, with the most significant improvement observed in the group receiving 300 mg/kg avocado extract and 100 mg/kg gooseberry extract, which recorded hyaline droplet formation of only 5.27 ± 2.74%, a result comparable to that of the standard control group. These findings suggest that the combination of P. americana and P. angulata leaf extracts confers protective effects against EG-induced renal injury. Therefore, this herbal combination may represent a promising natural nephroprotective agent that warrants further investigation in preclinical and clinical settings.

Organic church and church management are often viewed as two opposing approaches: one emphasizes spiritual vitality and relational community life, while the other focuses on structure, planning, and organizational sustainability. This study argues that these approaches need not be placed in tension; rather, they can be integrated into a coherent and holistic framework of ministry. Using a descriptive qualitative approach through literature analysis, this research explores how the concept of the organic church in New Testament ecclesiology can be integrated with key principles of modern church management. Insights from Bonhoeffer (1954) on communal life, Erickson (1998) on the nature of the body of Christ, and Tomatala (2014) on congregational development provide the foundational basis for this integrative model. The findings indicate that the organic church contributes life, relational depth, and the dynamic work of the Holy Spirit, whereas church management offers direction, coordination, and the structural space needed for spiritual gifts to function. Together, these dimensions produce a living structure that is flexible, relational, theological, and accountable. The study concludes that the contemporary church requires structures that support life rather than replace it.