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Diabetes mellitus is a chronic disease that requires long-term pharmacological therapy, increasing the risk of Drug Related Problems (DRPs). DRPs can affect the success of therapy, increase the risk of complications, and reduce the patient's quality of life. This article aims to identify the use of antidiabetic drugs, the characteristics of DRPs, and their clinical implications. The method used was a literature review of articles from 2016-2026 that are relevant to the analysis of DRPs in diabetes mellitus patients. The results of the study indicate that metformin is the most widely used antidiabetic drug, both as a single therapy and in combination. The dominant types of DRPs include drug interactions, inappropriate drug selection, inappropriate dosages, omissions from therapy, and use of drugs without indications. These DRPs can cause hypoglycemia, failure to achieve glycemic control targets, an increased risk of complications, and increased duration and cost of treatment. Based on the results of the study, it is concluded that DRPs remain a challenge in the management of diabetes mellitus therapy, requiring more optimal monitoring and an active role of pharmacists through medication review to improve the safety, effectiveness, and quality of treatment.

Stroke remains one of the leading causes of mortality and disability worldwide, including in Indonesia. The increasing prevalence of stroke and Years Lived with Disability (YLD) reflects its growing health burden. This study aimed to analyze trends in stroke prevalence and YLD in Indonesia during 2021–2023 using data from the Global Burden of Disease (GBD). A quantitative descriptive design with an ecological and time-trend approach was employed. Secondary data were obtained from the GBD Results Tool and analyzed using R version 4.4.1. The analysis focused on major geographical regions across Indonesia. The results showed a gradual increase in both stroke prevalence and YLD during the study period. Java recorded the highest prevalence and YLD, while Maluku and Papua showed lower prevalence but greater variation in YLD. These trends were associated with urbanization, unhealthy lifestyles, hypertension, diabetes, and unequal access to healthcare and rehabilitation services. Pearson correlation analysis demonstrated a very strong association between stroke prevalence and YLD (r > 0.99) across all years. The findings highlight increasing stroke burden and regional disparities, emphasizing the need for equitable healthcare access, risk factor control, and strengthened post-stroke rehabilitation programs.

This study aims to analyze the trends in the prevalence of ischemic heart disease (IHD) in Indonesia from 2019 to 2023 based on data from the Global Burden of Disease (GBD) study, with a focus on gender differences between males and females. The data used in this study includes detailed prevalence data for IHD based on province and gender. The analysis reveals that the prevalence of IHD is higher in males than in females, with greater fluctuations observed in females, particularly after menopause. Although there are significant differences in the prevalence across several provinces, risk factors such as smoking, obesity, hypertension, and diabetes contribute significantly to the increasing prevalence of this disease. However, the differences in prevalence between provinces and genders are not always statistically significant, indicating that other factors such as access to healthcare, lifestyle, and socio-economic factors also influence the distribution of this disease. This study provides valuable insights for the development of gender-based heart disease prevention policies and introduces more targeted interventions.

Diabetes Mellitus (DM) is a chronic metabolic disease characterized by persistently high blood sugar levels, which can lead to complications such as diabetic foot issues. A crucial aspect for healthcare professionals providing care to DM patients is assessing the patient's level of adherence and understanding regarding self-care and disease management. Data from the 2023 SKI (Indonesian Health Survey) indicates there were 118,184 cases of Diabetes Mellitus in Central Java. Foot care education delivered via remote services assists patients in performing proper foot care to prevent complications associated with the condition. This study aimed to determine the effectiveness of an animated video based on the Theory of Planned Behavior in improving the knowledge and adherence of patients with diabetic ulcers. A quasi-experimental design was employed, utilizing a one-group pre-test and post-test approach with a control group. Incidental sampling was used to select 60 respondents. The Mann-Whitney test yielded a p-value of < 0.05 (0.017), demonstrating that the animated video based on the Theory of Planned Behavior was effective in enhancing both adherence and knowledge among patients with diabetic ulcers. The findings suggest that this animated video, leveraging audiovisual media, can be implemented in educational settings to help prevent foot complications in patients with diabetes.

Konsumsi UPF dalam jumlah besar yang terjadi secara terus menerus dalam jangka waktu panjang dapat berdampak pada peningkatan risiko obesitas dan berbagai penyakit tidak menular seperti diabetes tipe 2, kardiovaskular, sindrom metabolik, dan kanker. Penelitian ini bertujuan untuk mengetahui hubungan paparan iklan media sosial, kebiasaan membaca label pangan, dan teman sebaya dengan konsumsi UPF pada mahasiswa gizi Universitas Halu Oleo. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan kuantitatif dan menggunakan desain cross sectional. Populasi penelitian adalah mahasiswa aktif Program Studi gizi Universitas Halu Oleo. Sampel penelitian ini terdiri dari 165 mahasiswa gizi yang diambil menggunakan teknik stratified random sampling. Data dikumpulkan dengan pengisian kuesioner. Data dianalisis secara univariat dan bivariat. Analisis bivariat menggunakan uji Chi-Square. Hasil penelitian menunjukkan 62,4% responden terpapar iklan media sosial, 69,7% responden memiiki kebiasaan membaca label pangan baik, 57% responden terpengaruh teman sebaya, dan 52,1% responden sering mengonsumsi produk UPF. Analisis bivariat menunjukkan terdapat hubungan antara paparan iklan media sosial (p=0,024) dan teman sebaya (p=0,013) dengan konsumsi UPF. Tidak terdapat hubungan kebiasaan membaca label pangan dengan konsumsi UPF (p=0,3397). Paparan iklan media sosial dan teman sebaya memiliki hubungan signifikan dengan konsumsi UPF. Kebiasaan membaca label pangan tidak ada hubungan dengan konsumsi UPF.

Diabetes Mellitus (DM) adalah salah satu penyakit tidak menular yang prevalensinya terus meningkat, termasuk pada kelompok usia produktif. Deteksi dini melalui skrining glukosa darah sewaktu menjadi salah satu strategi penting dalam mengidentifikasi individu berisiko sehingga dapat dilakukan pemeriksaan konfirmasi dan penatalaksanaan lebih awal. Tujuan: untuk menganalisis hubungan antara hasil skrining glukosa darah sewaktu dengan kejadian Diabetes Mellitus pada kelompok usia produktif. Metode: Penelitian ini menggunakan desain observasional analitik dengan pendekatan cross-sectional. Sebanyak 30 responden usia 18–59 tahun yang mengikuti kegiatan Posbindu PTM di Desa Mandong dipilih menggunakan teknik purposive sampling. Analisis data dilakukan menggunakan Fisher's Exact Test dan Odds Ratio (OR) dengan tingkat kemaknaan 95% (? = 0,05). Hasil: Sebanyak 21 responden (70,0%) tidak mengalami DM dan 9 responden (30,0%) mengalami DM. Hasil analisis menunjukkan terdapat hubungan yang bermakna antara hasil skrining glukosa darah sewaktu dengan kejadian DM (p = 0,013). Responden dengan hasil skrining tidak normal memiliki kecenderungan peluang lebih tinggi mengalami DM (OR = 17,35; 95% CI: 0,90–336,24). Kesimpulan: Hasil skrining glukosa darah sewaktu berhubungan dengan kejadian Diabetes Mellitus pada usia produktif sehingga berpotensi dimanfaatkan sebagai metode skrining awal untuk mendukung deteksi dini di pelayanan kesehatan primer, yang selanjutnya perlu dikonfirmasi dengan pemeriksaan diagnostik standar.

Diabetes Mellitus (DM) is a metabolic disease with an increasing prevalence and a risk of causing macrovascular complications such as stroke. This study aimed to describe the characteristics of Diabetes Mellitus patients with stroke complications based on CT-scan results at RSKD Dadi Makassar in 2024–2025. This was a descriptive observational study with a retrospective design using medical record data. Samples were taken using a total sampling technique, comprising 60 patients, and analyzed univariately using the Statistical Product and Service Solutions (SPSS) version 26. The results showed that the majority of respondents were in the late elderly group (>56 years) at 66.7%, female (51.7%), and from the Makassar ethnic group (63.3%). Most respondents experienced hyperglycemia in random blood glucose (66.7%) and had uncontrolled fasting blood glucose (68.3%) and HbA1c (76.7%) levels. CT-scan results were dominated by non-specific cerebral infarction (68.3%), with ischemic stroke as the most common type (93.3%), a length of stay of 5–10 days (53.3%), and right-sided hemiparesis as the most common clinical manifestation (45.0%). It was concluded that DM patients with stroke complications were generally elderly, female, had poor glycemic control, and were dominated by ischemic stroke with non-specific cerebral infarction. Abstrak. Diabetes Melitus (DM) merupakan penyakit metabolik dengan prevalensi yang terus meningkat dan berisiko menimbulkan komplikasi makrovaskular berupa stroke. Penelitian ini bertujuan untuk mengetahui gambaran karakteristik pasien Diabetes Melitus yang mengalami komplikasi stroke berdasarkan hasil CT-scan di RSKD Dadi Makassar tahun 2024–2025. Penelitian ini merupakan penelitian observasional deskriptif dengan desain retrospektif menggunakan data rekam medis. Sampel diambil dengan teknik total sampling sebanyak 60 pasien dan dianalisis secara univariat menggunakan Statistical Product and Service Solutions (SPSS) versi 26. Hasil penelitian menunjukkan mayoritas responden berusia lansia akhir (>56 tahun) sebanyak 66,7%, berjenis kelamin perempuan (51,7%), dan berasal dari Suku Makassar (63,3%). Sebagian besar responden mengalami hiperglikemia pada GDS (66,7%) serta memiliki kadar GDP (68,3%) dan HbA1c (76,7%) yang tidak terkontrol. Hasil CT-scan didominasi oleh infark serebri tidak spesifik (68,3%) dengan jenis stroke terbanyak berupa stroke iskemik (93,3%), lama rawat inap terbanyak 5–10 hari (53,3%), dan manifestasi klinis tersering berupa hemiparese dextra (45,0%). Disimpulkan bahwa pasien DM dengan komplikasi stroke umumnya berusia lanjut, berjenis kelamin perempuan, memiliki kontrol glikemik yang buruk, dan didominasi oleh stroke iskemik dengan gambaran infark serebri tidak spesifik.

This study aimed to examine the association between physical activity and nutritional status as risk factors for noncommunicable diseases among women of reproductive age. A descriptive quantitative study with a cross-sectional approach was conducted in Kranggan Village involving 35 respondents selected through purposive sampling. Data on physical activity were collected using questionnaires, while nutritional status was assessed based on Body Mass Index (BMI). The findings showed that most respondents had moderate physical activity levels (51.4%), followed by low physical activity levels (42.8%). Regarding nutritional status, the majority of respondents were classified as overweight (51.4%) and obese (28.6%). Statistical analysis demonstrated a significant relationship between physical activity and nutritional status (p = 0.003). The results indicate that inadequate physical activity is associated with increased nutritional status problems, particularly overweight conditions. Therefore, low physical activity and excessive body weight represent interconnected risk factors contributing to the development of noncommunicable diseases among women of reproductive age. This study highlights the importance of promoting regular physical activity and maintaining balanced nutritional status as preventive strategies to reduce the risk of noncommunicable illnesses.

Diabetes Melitus (DM) merupakan kondisi kronis yang ditandai dengan meningkatnya konsentrasi glukosa dalam darah. Penyakit ini dapat terjadi akibat ketidakmampuan tubuh memproduksi insulin. Kekurangan insulin, atau ketidakmampuan sel untuk meresponsnya, menyebabkan kadar glukosa darah tinggi (hiperglikemia), yang merupakan indikator klinis diabetes. Penelitian ini bertujuan untuk menganalisis daya terima, kandungan zat gizi, dan nilai indeks glikemik Cookies berbahan dasar tepung ubi jalar ungu dan rumput laut sebagai pangan alternatif bagi penderita diabetes melitus. Penelitian ini menggunakan  quasi experimental dengan rancangan RAL (Rancangan Acak Lengkap) dengan 3 kali pengulangan. yaitu P1 (60 g tepung ubi jalar ungu : 40 g tepung rumput laut), P2 (65 g : 35 g), dan P3 (70 g : 30 g). Uji organoleptik dilakukan terhadap 30 panelis tidak terlatih menggunakan metode hedonik. Analisis kandungan gizi meliputi kadar air, abu, protein, lemak, dan karbohidrat, sedangkan indeks glikemik dihitung menggunakan metode incremental area under the curve (iAUC). Hasil penelitian menunjukkan bahwa perlakuan P3 merupakan formulasi terbaik dan paling disukai panelis pada atribut warna, rasa, tekstur, dan kerenyahan. Hasil analisis kandungan gizi Cookies per 100 gram pada perlakuan P3 diperoleh kadar air 4,73%, kadar abu 3,25%, protein 6,71%, lemak 12,80%, dan karbohidrat 61,13%. Cookies juga memiliki kadar gula total sebesar 16,11%, kadar pati 36,2%, dan available carbohydrate sebesar 55,93%. Nilai rata-rata indeks glikemik Cookies sebesar 21,5 dan termasuk kategori indeks glikemik rendah.

Diabetes Melitus (DM) tipe 2 kini mulai mengancam kelompok usia remaja akibat pergeseran gaya hidup dan pola konsumsi di lingkungan sekolah. Penelitian ini bertujuan untuk mengeksplorasi secara mendalam kebiasaan konsumsi makanan manis dan gaya hidup sedentari yang berisiko memicu diabetes melitus pada siswa-siswi Sekolah Menengah Pertama (SMP). Metode penelitian menggunakan pendekatan deskriptif kualitatif. Data dihimpun melalui wawancara mendalam terhadap informan kunci (siswa) dan informan triangulasi (pengelola kantin dan guru UKS), serta diobservasi melalui lingkungan pangan sekolah. Analisis data dilakukan secara tematik untuk mengidentifikasi pola perilaku harian. Hasil eksplorasi ini diharapkan dapat memberikan gambaran riil mengenai faktor sosiokultural dan lingkungan sekolah yang membentuk preferensi pangan tidak sehat pada remaja sebagai dasar intervensi preventif.

Diabetes melitus tipe 2 (DMT2) merupakan penyakit metabolik kronis yang ditandai oleh hiperglikemia akibat resistensi insulin dan gangguan sekresi insulin. Kondisi hiperglikemia yang tidak terkontrol dalam jangka panjang dapat menyebabkan berbagai komplikasi kronis, seperti neuropati diabetik, penyakit kardiovaskular, dan penyakit ginjal kronis hingga end-stage renal disease (ESRD). Komplikasi tersebut berkontribusi terhadap peningkatan angka morbiditas, mortalitas, serta penurunan kualitas hidup pasien. Laporan kasus ini bertujuan untuk menggambarkan manifestasi klinis dan penatalaksanaan pasien DMT2 tidak terkontrol dengan komplikasi multisistem. Dilaporkan seorang wanita berusia 52 tahun dengan riwayat DMT2 tidak terkontrol yang datang dengan keluhan lemas, mual, dan muntah. Pemeriksaan laboratorium menunjukkan hiperglikemia berat dengan kadar glukosa darah sewaktu 650 mg/dL, disertai gangguan fungsi ginjal, anemia, dan gangguan elektrolit. Pemeriksaan ultrasonografi abdomen menunjukkan adanya kolesistitis. Pasien didiagnosis dengan DMT2 tidak terkontrol disertai komplikasi hiperglikemia berat, neuropati diabetik, end-stage chronic kidney disease, dan kolesistitis. Penatalaksanaan dilakukan melalui pemberian terapi cairan, insulin, antibiotik, koreksi elektrolit, serta terapi suportif lainnya. Selama perawatan, kondisi klinis pasien menunjukkan perbaikan secara bertahap. Kasus ini menegaskan bahwa pengendalian glikemik yang optimal, pemantauan rutin, serta penatalaksanaan komprehensif sangat penting dalam mencegah progresivitas komplikasi kronis dan multisistem pada pasien DMT2.

Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose levels due to impaired insulin secretion, insulin action, or both. Uncontrolled diabetes can lead to various complications and decreased quality of life. Moringa oleifera leaves contain bioactive compounds, including flavonoids, vitamins A, C, and E, as well as selenium, which possess antioxidant properties and are believed to help reduce blood glucose levels. This study aims to determine the effect of Moringa leaf decoction on reducing blood glucose levels in patients with diabetes mellitus in Padaleu Village, Kambu District, Kendari City. The study employs a quantitative pre-experimental design using a one-group pretest-posttest approach. The population consists of 35 diabetes mellitus patients, with 17 respondents selected through purposive sampling. Blood glucose levels are measured before and after the administration of Moringa leaf decoction using a glucometer and observation sheets. Respondents receive 200 ml of Moringa leaf decoction daily for five consecutive days. Data analysis is conducted using paired statistical tests to determine differences in blood glucose levels before and after the intervention. The findings of this study are expected to provide scientific evidence regarding the effectiveness of Moringa leaf decoction as a non-pharmacological therapy for controlling blood glucose levels among diabetes mellitus patients. Furthermore, the results may contribute to nursing science development and serve as a reference for healthcare providers and future researchers in implementing complementary therapies for diabetes management.

Complications of Diabetes Mellitus often arise and without being realized have developed to cause acute and chronic complications that make it difficult for DM sufferers to maintain their condition and will affect the condition of DM sufferers that impact the quality of life of sufferers. Consuming too many carbohydrates causes insulin in the body to work extra, so that the insulin's ability to work in the body will be reduced, which can cause blood sugar to rise. Nutritional therapy can be done by replacing carbohydrate intake with tubers that are low in glucose levels, one of which is Ganyong and pharmacological therapy through herbal medicines, one of which is sentalo leaf tea which is easily obtained and inexpensive. The objectives of this community service activity are to improve the knowledge, skills and quality of service of partners in the implementation of family posyandu related to DM. The method used is empowering posyandu groups through educational activities and training. The results of this activity show an increase in knowledge and skills of partners before and after the community service activity was carried out. And an increase in visits to the posyandu after the implementation of PMT using ganyong flour as the raw material.

Type 2 diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia due to impaired insulin secretion, insulin resistance, or a combination of both. HbA1c levels are used as an indicator of long-term glycemic control in patients with type 2 diabetes mellitus. Insulin therapy is one of the treatment options given to help achieve glycemic control targets. The purpose of this study was to determine the difference in HbA1c levels of type 2 diabetes mellitus patients with insulin and non-insulin therapy at PKU Muhammadiyah Gamping Hospital. This research method used a descriptive study with a cross-sectional approach. The subjects in this study were 80 type 2 diabetes mellitus patients who had used insulin and non-insulin therapy for less than 1 year, using Purposive Sampling techniques and data analysis using SPSS with Chi-Square and Mann-Whitney tests. This study has obtained ethical approval from PKU Muhammadiyah Gamping Hospital. This study shows that the characteristics of gender and age of type 2 DM patients with insulin and non-insulin therapy are dominated by women at 60.0% and 43.3%, while elderly patients at 60.0% and 53.3%. Of the 50 patients using insulin, 45 patients (90.0%) had controlled HbA1c and 5 patients (10.0%) were uncontrolled. Meanwhile, all non-insulin patients, 30 patients (100%), had uncontrolled HbA1c. Based on this study, there is a significant difference in HbA1c levels between type 2 diabetes mellitus patients with insulin and non-insulin therapy with a p-value <0.001. Patients using insulin therapy tend to have better glycemic control than patients not using insulin therapy.

Type 2 diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia due to impaired insulin secretion, insulin resistance, or a combination of both. HbA1c levels are used as an indicator of long-term glycemic control in patients with type 2 diabetes mellitus. Insulin therapy is one of the treatment options given to help achieve glycemic control targets. The purpose of this study was to determine the difference in HbA1c levels of type 2 diabetes mellitus patients with insulin and non-insulin therapy at PKU Muhammadiyah Gamping Hospital. This research method used a descriptive study with a cross-sectional approach. The subjects in this study were 80 type 2 diabetes mellitus patients who had used insulin and non-insulin therapy for less than 1 year, using Purposive Sampling techniques and data analysis using SPSS with Chi-Square and Mann-Whitney tests. This study has obtained ethical approval from PKU Muhammadiyah Gamping Hospital. This study shows that the characteristics of gender and age of type 2 DM patients with insulin and non-insulin therapy are dominated by women at 60.0% and 43.3%, while elderly patients at 60.0% and 53.3%. Of the 50 patients using insulin, 45 patients (90.0%) had controlled HbA1c and 5 patients (10.0%) were uncontrolled. Meanwhile, all non-insulin patients, 30 patients (100%), had uncontrolled HbA1c. Based on this study, there is a significant difference in HbA1c levels between type 2 diabetes mellitus patients with insulin and non-insulin therapy with a p-value <0.001. Patients using insulin therapy tend to have better glycemic control than patients not using insulin therapy.

Stunting is a multifactorial public health problem influenced by various risk factors that may emerge during the prenatal period. Early identification of stunting risk during pregnancy is important to support preventive interventions. This study aimed to develop a stunting risk prediction model based on maternal prenatal factors using the Random Forest algorithm. Secondary data from 172 pregnant women, consisting of 83 stunting cases and 89 non-stunting cases, were analyzed. The predictor variables included maternal age during pregnancy, height, hemoglobin level, mid-upper arm circumference (MUAC), smoking history, hypertension, asthma, and diabetes mellitus. The research stages consisted of data preprocessing, model training using Stratified 5-Fold Cross Validation, performance evaluation, external testing, and feature importance analysis. Internal evaluation results showed an accuracy of 60%, precision of 60.6%, recall of 57.3%, F1-score of 58.9%, and AUC of 0.6688. External testing yielded an accuracy of 70% and an AUC of 0.6167. Feature importance analysis identified maternal age during pregnancy as the most influential variable in the prediction process. The findings indicate that maternal prenatal factors have potential for early stunting risk identification, although the predictive performance remains moderate. This approach may serve as a foundation for developing early screening tools to support targeted interventions among high-risk pregnancies.

Diabetes mellitus (DM) is a chronic metabolic disease characterized by elevated blood glucose levels due to insufficient insulin production or ineffective insulin utilization. The prevalence of DM in Indonesia reached 11.7% in the 2023 National Health Survey, with Brebes Regency recording 568 DM cases in 2025 and increasing to 157 cases in Tonjong Village in January 2026. This case study aims to describe comprehensive nursing care for Ny. M, a 52-year-old patient diagnosed with endocrine system disorder (diabetes mellitus), in the family of Tn. I at Karang Anyar Village, Tonjong District, Brebes Regency. The method used was a case study with data collection through interview, observation, physical examination, blood glucose measurement, and literature review conducted on December 26–28, 2025. The assessment found subjective data: the patient frequently felt fatigue, tingling in both legs, excessive thirst, and increased urination frequency. Objective data: pale and fatigued face, blood pressure 150/100 mmHg, pulse 95x/min, respiration 22x/min, temperature 36.7°C, and random blood glucose (RBG) 155 mg/dl. Two nursing diagnoses were established: blood glucose instability and readiness for enhanced knowledge. Interventions implemented included hyperglycemia management (monitoring blood glucose, dietary education, complementary herbal therapy with ginger and honey), and health education regarding DM complications. Evaluation results showed that after 2 days of nursing visits, fatigue decreased, blood glucose improved (RBG 130 mg/dl), and the patient's knowledge about DM complications was resolved.

High consumption of sugar-sweetened beverages (SSBs) has become an increasing public health concern, particularly among adolescents. Excessive SSB intake is a major risk factor for various non-communicable diseases, including type 2 diabetes mellitus, cardiovascular diseases, obesity, dental caries, and certain types of cancer. This study aimed to analyze the factors associated with the level of sugar-sweetened beverage (SSB) consumption among adolescents. This study employed a descriptive literature review approach. Data were obtained from national and international journals relevant to the topic of SSB consumption among adolescents. The selected articles were analyzed to identify factors associated with SSB consumption. The findings indicated that SSB consumption among adolescents is influenced by several factors, including individual factors (gender and knowledge), socioeconomic factors (peer influence and pocket money allowance), environmental factors (mass media exposure and beverage availability), and psychological factors (stress level and preference for sweet tastes). This study highlights that SSB consumption is a multifactorial behavior influenced by various interacting determinants. Therefore, comprehensive interventions targeting both individual and environmental factors are needed to reduce SSB consumption among adolescents.

A chronic metabolic disease characterized by elevated blood glucose levels due to insulin resistance or impaired insulin secretion is classified as type 2 diabetes mellitus. The prevalence of diabetes continues to rise each year and has become one of the major challenges in global health due to its potential to cause serious complications, such as cardiovascular disease, kidney failure, neuropathy, and vision impairment. In addition to pharmacological therapy, the use of herbal plants is increasingly being developed as a complementary therapy because they are considered safer, more readily available, and contain bioactive compounds with potential antidiabetic properties. This review article aims to assess the effectiveness of several herbal plants namely cinnamon (Cinnamomum cassia), fenugreek (Trigonella foenum-graecum), bitter melon (Momordica charantia), and moringa (Moringa oleifera) in aiding the management of type 2 diabetes mellitus based on various research findings. This study employs a literature review method by collecting and analyzing various national and international scientific publications related to the antidiabetic activity of these four plants. The review results indicate that all plants have potential as adjunct therapies for diabetes because they contain active compounds such as flavonoids, polyphenols, cinnamaldehyde, charantin, quercetin, trigonelline, and saponins, which can help reduce blood glucose levels, optimize cellular response to insulin, increase GLUT4 activity, and help minimize oxidative damage. Based on the study results, moringa and cinnamon plants demonstrated the most consistent effectiveness in contributing to blood sugar control in individuals with type 2 diabetes mellitus. Thus, these herbal plants have the potential to be used as complementary therapies in the management of type 2 diabetes mellitus; however, their use must still adhere to proper dosing and should not replace primary medical therapy.

A chronic metabolic disease characterized by elevated blood glucose levels due to insulin resistance or impaired insulin secretion is classified as type 2 diabetes mellitus. The prevalence of diabetes continues to rise each year and has become one of the major challenges in global health due to its potential to cause serious complications, such as cardiovascular disease, kidney failure, neuropathy, and vision impairment. In addition to pharmacological therapy, the use of herbal plants is increasingly being developed as a complementary therapy because they are considered safer, more readily available, and contain bioactive compounds with potential antidiabetic properties. This review article aims to assess the effectiveness of several herbal plants namely cinnamon (Cinnamomum cassia), fenugreek (Trigonella foenum-graecum), bitter melon (Momordica charantia), and moringa (Moringa oleifera) in aiding the management of type 2 diabetes mellitus based on various research findings. This study employs a literature review method by collecting and analyzing various national and international scientific publications related to the antidiabetic activity of these four plants. The review results indicate that all plants have potential as adjunct therapies for diabetes because they contain active compounds such as flavonoids, polyphenols, cinnamaldehyde, charantin, quercetin, trigonelline, and saponins, which can help reduce blood glucose levels, optimize cellular response to insulin, increase GLUT4 activity, and help minimize oxidative damage. Based on the study results, moringa and cinnamon plants demonstrated the most consistent effectiveness in contributing to blood sugar control in individuals with type 2 diabetes mellitus. Thus, these herbal plants have the potential to be used as complementary therapies in the management of type 2 diabetes mellitus; however, their use must still adhere to proper dosing and should not replace primary medical therapy.