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Cardiovascular dysfunction is a disorder of the blood vessels, such as hypertension, heart failure, and stroke. In 2016, cardiovascular disease was the leading cause of death worldwide, based on data from the World Health Organization (WHO). Coronary Heart Disease (CHD) is the leading cause of death, along with stroke, as shown by the Sample Registration System survey in 2014.This case involves a 64-year-old male, Mr. N, who presented to the emergency department of RSUD dr. Fauziah Bireuen with complaints of chest pain that developed gradually and worsened over the past month. The pain was located across the entire chest and radiated to the back and neck. The pain was described as severe, like being crushed by a heavy load, worsened during strenuous activities such as cutting grass and chopping wood, and relieved when the patient bent forward. The pain could occur at any time, with a Visual Analog Scale (VAS) score of 10 (severe pain). The patient also reported easy fatigue during heavy physical activity over the past month. Laboratory examination revealed elevated leukocytes, mean corpuscular volume (MCV), segmented neutrophils, troponin I, cholesterol, and triglycerides. The patient was diagnosed with extensive anterior ST-elevation myocardial infarction (STEMI) post successful fibrinolytic therapy.

Hypertension is a major modifiable risk factor contributing to the development of Acute Coronary Syndrome (ACS), which includes STEMI, NSTEMI, and unstable angina. The increasing prevalence of hypertension worldwide raises concern regarding its impact on cardiovascular outcomes. This study aimed to describe the profile of ACS patients with hypertension receiving angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) therapy in the Intensive Coronary Care Unit (ICCU) of RSUD Dr. Soetomo Surabaya. Using a descriptive cross-sectional method, data from 91 patients treated between July 2021 and October 2024 were analyzed. Variables included demographic characteristics, clinical classification of ACS, hypertension degree, comorbidities, types and doses of ACEI/ARB administered. The results showed that most patients were male (73%) and aged over 65 years (40%). Chi-square analysis revealed no significant relationship between hypertension degree, ACS classification, or most comorbidities with drug selection or dosage (p>0.05), except for a significant association between coronary heart disease comorbidity and ARB selection. These findings suggest that in hypertensive ACS patients, the choice between ACEI and ARB therapy is predominantly based on individual comorbidity profiles rather than blood pressure severity or ACS type. The study highlights the importance of personalized treatment approaches considering patient comorbidities to optimize cardiovascular outcomes.

Hypertension is a primary risk factor for cardiovascular diseases, including stroke, coronary artery disease, atrial fibrillation, and peripheral vascular disease. Often referred to as "The Silent Killer," its onset is frequently asymptomatic, making early detection challenging. Effective interventions, both pharmacological and non-pharmacological, are necessary to manage hypertension and reduce complications. Long-term treatment requires adherence to prescribed medications, with self-care management playing a vital role in minimizing hypertension's adverse effects. Self-efficacy, or an individual's belief in their abilities, is crucial for improving medication adherence and self-care activities. This study aimed to examine the correlation between self-efficacy and self-care management in relation to medication adherence among hypertension patients at RSUD Mandau District. A non-experimental, quantitative, analytic correlation study with a cross-sectional design was conducted, involving 38 hypertension patients. Self-efficacy was measured using the MASES-R (Medication Adherence Self-Efficacy Scale-Revision), medication adherence was assessed with the MMAS-8 (8-item Morisky Medication Adherence Scale), and self-care management was evaluated using the HBP-SCP (Hypertension Self-Care Profile). The findings revealed a significant correlation between self-efficacy and medication adherence (p=0.000, r=0.594). Additionally, self-care management was significantly correlated with medication adherence (p=0.027, r=0.360). In conclusion, self-efficacy and self-care management both significantly correlate with medication adherence in hypertension patients at RSUD Mandau District.

Background: Cardiac catheterization is the most widely used diagnostic and hemodynamic intervention procedure in the world for the treatment of coronary heart disease (CHD). Cardiac catheterization can cause anxiety in patients who will undergo it. Objective: To analyze the factors that influence the anxiety of patients who will undergo cardiac catheterization. Method: This study is a descriptive analytical study with a cross-sectional approach conducted at Murni Teguh Memorial Hospital Medan. The study population was 40 people, and all of them were used as samples (total sampling). The research instrument was a questionnaire. Data analysis was carried out univariately and bivariately using the Chi-Square test with a significance level of 95% (= 0.05). Results: This study shows that there is a significant influence between knowledge, family support, past experience, and education level on the anxiety of patients who will undergo cardiac catheterization at Murni Teguh Hospital Medan. This is proven by the chi square test with p values for each knowledge (p = 0.000); family support (p = 0.002); past experience (p = 0.003); and education (p=0.003) which are all less than 0.005. Conclusion: Cardiac catheterization patient anxiety is influenced by knowledge, family support, past experience, and education level. Suggestion: It is recommended that further researchers increase the number of samples and independent variables, considering that many factors influence patient anxiety before cardiac catheterization/angiography

Hypertension substantially increases the risk of developing secondary conditions, including stroke, renal disease, coronary heart disease, and heart failure. Early management is therefore essential to prevent complications and adverse outcomes. Evidence indicates that untreated hypertension contributes to approximately 60% of stroke cases. Public knowledge regarding hypertension-related complications remains limited, and many individuals are unable to identify early signs of stroke the most common complication associated with hypertension. This study aimed to assess the knowledge of hypertensive patients regarding stroke risk and management at Santa Elisabeth Hospital Medan in 2024. A descriptive research design was employed. The sample consisted of 67 hypertensive patients attending the outpatient clinic, selected through purposive sampling. Data were presented using frequency distribution tables. The findings revealed that 52.2% of respondents demonstrated poor knowledge, 32.8% had moderate knowledge, and only 14.9% showed good knowledge regarding stroke risk and management. These results underscore the need for patients to adopt healthier lifestyles and for the hospital to strengthen educational efforts by providing more engaging and interactive learning materials for patients and their families.

Hypertension is one of the global public health issues with serious implications as it may lead to severe complications such as stroke, coronary heart disease, and kidney failure. Elderly individuals are among the most vulnerable groups, with the highest prevalence found in the age group of 65–74 years (57.6%) and those over 75 years (63.8%). Non-pharmacological treatment for hypertension includes regular and consistent elderly gymnastics. This study aims to examine the effect of elderly gymnastics on blood pressure among elderly individuals with hypertension at the Rumoh Sejahtera Geunaseh Sayang Nursing Home, Ulee Kareng, Banda Aceh. The study applied a quasi-experimental design with a deductive approach. The population consisted of 55 elderly individuals, and 17 were selected as the sample using total sampling technique. The elderly gymnastics intervention was conducted three times a week, from April 17th to 22nd, 2025. Blood pressure was measured before and after the intervention using a pre-test and post-test observation sheet. Data analysis was performed using the Wilcoxon test, suitable for non-parametric data. Results showed that on the first day, there was no significant difference in systolic and diastolic blood pressure (p = 0.091). On the second day, systolic blood pressure showed a significant decrease (p = 0.003), while diastolic pressure remained non-significant (p = 0.161). On the third session, a significant reduction occurred in both systolic (p = 0.000) and diastolic (p = 0.001) blood pressure. Conclusion: Elderly gymnastics has an effect on reducing blood pressure in elderly individuals with hypertension. This intervention may serve as an effective and applicable non-pharmacological therapy in daily life.

Coronary heart disease is one of the major health problems that not only affects the physical condition of patients but also impacts their psychological state, particularly anxiety. Anxiety levels in patients with coronary heart disease usually increase when they are about to undergo invasive medical procedures such as Percutaneous Coronary Intervention (PCI). Anxiety can be influenced by several factors, including age, gender, educational level, and occupation. High levels of anxiety may worsen the patient’s clinical condition, making appropriate non-pharmacological interventions highly necessary to help reduce anxiety. This study aims to determine the effect of spiritual support in the form of dzikir on the anxiety levels of patients with coronary heart disease. The research design used was a true experimental design with a pretest-posttest control group design. The sample consisted of 30 respondents who were evenly divided into two groups: 15 respondents in the intervention group and 15 respondents in the control group. The sampling technique used was total sampling. The instrument for measuring anxiety was the Hamilton Anxiety Rating Scale (HARS). The results showed that providing spiritual support in the form of dzikir was effective in reducing patient anxiety, with a p-value of 0.001. In addition, there was a significant difference in post-therapy anxiety levels between the control and intervention groups, with a p-value of 0.019 (p < 0.05). These findings demonstrate that dzikir, as a form of spiritual support, can be used as a non-pharmacological intervention to reduce anxiety in patients with coronary heart disease. Thus, spiritual support can be an important component of nursing care for patients in the ICU.

A 64-year-old male patient presented to the emergency department (ED) of RS Cut Meutia with complaints of left-sided chest pain radiating to both arms, which had been occurring for two days prior to his hospital admission. The chest pain was described as sharp, sudden, and progressively worsening, and it persisted without relief from positional changes. The pain intensity was rated as 9/10 and was accompanied by cold sweats and nausea. The patient had a history of type 2 diabetes mellitus for 15 years and had been on antidiabetic medications, although he could not recall the names of the medications. The patient was a smoker but had quit smoking upon being diagnosed with diabetes. Vital signs and general status were within normal limits upon examination. Local examination of the heart revealed a murmur on auscultation. Laboratory results showed anemia, leukocytosis, hyperglycemia, and hypercholesterolemia. Electrocardiography (EKG) indicated signs of inferior STEMI (ST-Elevation Myocardial Infarction). The patient was treated with furosemide 1 amp/12 hours, atorvastatin 1x20 mg, arixtra 1x0.25 mg, aspilet 1x8 mg, clopidogrel 1x75 mg, nitrokaf retard 2x2.5 mg, and bisoprolol 1x2 mg, along with non-pharmacological management, including three-way catheter insertion and oxygen therapy at 2-4 liters per minute. Acute Coronary Syndrome (ACS) carries a poor prognosis if not managed promptly and correctly. Understanding the appropriate management of ACS is crucial in preventing further myocardial occlusion and improving patient outcomes. Therefore, rapid and accurate intervention is vital in improving the prognosis for patients with ACS.

Red beans (Phaseolus vulgaris L.) are a type of legumes (Leguminaceae) that have a high content of starch and fiber. The high fiber content causes red beans to prevent coronary heart disease. Red beans also have a low glycemic index so they can lower cholesterol levels in the blood and the risk of diabetes. Red beans also contain phenolic compounds that act as antioxidants in the body. Red beans are classified as food ingredients that can support the increase in nutritional value because they are classified as a relatively affordable source of vegetable protein. The purpose of this counseling is to provide knowledge and processed skills from local commodities, in this case red beans, to students majoring in Agribusiness of Agricultural Products at SMK Negeri 1 Bawen. This activity was attended by 68 students majoring in Agribusiness and Agricultural Products and 1 assistant teacher from SMK Negeri 1 Bawen, Semarang Regency. The method of this red bean processing extension activity is to increase the knowledge and skills of making processed local food products with several methods: a. The lecture method provides the theory and practice of making kidney bean cookies. b. Practice method of making red bean cut ice. c. The question and answer method, used to provide feedback to participants about the material that has been presented during the activity. d. Evaluation is given by providing pre test and post test. After the implementation, it showed that the target, namely students of SMK Negeri 1 Bawen, increased their knowledge and understood the importance of post-harvest handling and processing of red beans with the practice of making red bean cut ice. This is based on questions and answers, interviews and questionnaires shared before and after the activity. From the results of the questionnaire conducted before and after the activity, it showed that: After the implementation, there was a 50.17% increase in knowledge about kidney bean processing, Knowledge about making kidney beans into cut ice increased by 65.32% and Knowledge of other processed kidney beans such as kidney bean cookies showed that there was an increase of 67.15% after counseling. The conclusions that can be drawn from this counseling activity are (1) Processed red bean extension activities can increase the knowledge and understanding of the participants (2) The responses given by the counseling participants show a fairly satisfactory interest and there is a desire to apply the newly acquired knowledge to be socialized in the surrounding environment.

ST-Elevation Myocardial Infarction (STEMI) is one of the manifestations of acute coronary syndrome (ACS) and is a leading cause of disability and death worldwide. The mortality rate for STEMI is reported to reach 6%–14% of all ACS deaths. Reperfusion therapy is the primary treatment, with fibrinolytics an important option, especially in healthcare facilities that do not have the capacity to perform primary Percutaneous Coronary Intervention (PCI) in less than 12 hours. The success of fibrinolytics is influenced by various risk factors, such as hypertension, dyslipidemia, diabetes mellitus, a history of heart disease, and the duration of the attack. This study aims to determine the relationship between these factors and the success rate of fibrinolytics in STEMI patients. This study used a retrospective descriptive design with a cross-sectional method. The sampling technique used total sampling of patients diagnosed with STEMI and receiving fibrinolytic therapy according to inclusion and exclusion criteria at Dr. Fauziah Hospital. Statistical analysis was performed using the Chi-Square correlation test to assess the relationship between clinical variables and fibrinolytic success. The results showed no significant association between hyperglycemia (p = 0.823), hypertension (p = 0.240), or a history of heart disease (p = 0.704) and fibrinolytic success. Similarly, the onset of stroke variable did not show a significant association with reperfusion outcomes. In conclusion, classic risk factors such as hyperglycemia, hypertension, and a history of heart disease were not associated with fibrinolytic success in STEMI patients at Dr. Fauziah Hospital. These results suggest that fibrinolytic success is likely influenced by other factors, such as timing of drug administration, protocol adherence, and individual variation in response to therapy. Further research with a larger sample size and a prospective design is recommended to strengthen these findings.

Acute Coronary Syndrome (ACS) is an emergency condition in which a group of symptoms of acute ischemic chest pain are part of coronary heart disease (CHD) and require immediate treatment. The prevalence of CHD in Aceh is higher than the national average of 1.6% or around 20,244 people. This study is expected to describe the prevalence, number of deaths (mortality) and average length of stay (LOS) of STEMI patients during hospitalization so that this data can significantly enhance knowledge for health practitioners and be used as a warning to be more aware of STEMI incidents in Aceh. This study uses a retrospective descriptive research design with a research sample of all patients diagnosed with ACS with ST-Elevation who were hospitalized at Dr. Fauziah Hospital in June 2022-June 2023. The data collection technique is total sampling obtained from medical record data. It was concluded that the majority of patients were male, namely 80.7% (71 patients), the highest age was 45-60 years with 45 cases (51.1%). History of CHD was the dominant risk factor (62% of cases). The most dominant type of ACS with ST-Elevation was Anterior STEMI as many as 32 cases (52.3%) with onset <12 hours (51% of cases) and predominantly came with KILLIP I (62.5% of cases). The most dominant management was with conservative therapy 56 cases (61.4%). The average length of patient care was 5 days (45.1%) and the most outcomes with outpatients as many as 72 cases (81.8%).

Coronary Heart Disease (CHD) is the leading cause of death in Indonesia. CHD is a disease caused by blockages in blood vessels (atherosclerosis) that disrupt blood flow to the heart. There are several risk factors for CHD, including smoking and hypertension. The purpose of this study was to determine the relationship between smoking and hypertension in patients with CHD. This research method uses the methodliterature review. Data were obtained from secondary data using documentation techniques. This documentation was done by searching for articles through Google Scholar and Pubmed. The selected articles were in accordance with the research variables and inclusion criteria. The articles were analyzed using the procedurecompare, contrast, criticize, synthesize, dan summarize. From the study, 3 articles were obtained that had data related to smoking and CHD variables (p < 0.05) and 3 articles that had data related to hypertension and CHD variables (p < 0.05). Conclusion: There is a significant relationship between smoking and hypertension in CHD patients.

Acute Coronary Syndrome (ACS) is a medical emergency that is still a major cause of global morbidity and mortality. The success of ACS treatment and prevention of recurrence is highly dependent on self-care. However, many ACS patients have difficulty performing self-care due to low self-efficacy. This study aims to explain the relationship between self-efficacy and self-care in ACS patients. This study used a correlation analytic design with a cross-sectional approach. The study population was 62 outpatients at the Heart Clinic, with a sample of 41 people selected using purposive sampling. Self-efficacy was measured using the Cardiac Self-Efficacy Scale (CSE scale) and self-care using the Self-Care of Coronary Heart Disease Inventory (SC-CHDI). The study was conducted in April-May 2025. Data were analyzed using the Pearson product moment correlation test. The results showed a p value of 0.004 (p <α), which means there is a relationship between self-efficacy and self-care in ACS patients. The direction of the relationship is positive, meaning that the higher the self-efficacy, the better the self-care, and vice versa with the closeness of the relationship in the weak category (r 0.437). Self-efficacy is positively related to better self-care behavior in ACS patients. Therefore, nurses can integrate self-care improvement care through comprehensive self-efficacy education.

The growth of the digital sector during the Coronavirus Disease (COVID) 19 pandemic has an impact on how individuals use technology and behave in social situations, introducing new work opportunities.  However, work participation in the digital industry based on gender at the global level is still significant which can have an impact on gender gaps and the role of female workers. In terms of access to production and distribution of roles, female workers in the digital industry make widespread similarities with the presence of male workers. In-depth research is required to understand whether or not there is a gender gap in the digital industry, especially in the context of Indonesia, as a modern phenomenon. Previous studies have begun to discuss gender participation in non-digital industries, such as the garment sector, but have not yet discussed the dynamics of the gender gap and the role of women. This study utilizes social role theory to quantify the extent of the gender gap and the dynamics of women's roles in industrial technology. This study examines 3 female workers in 3 distinct digital technology companies using a qualitative method and a multiple case study approach. The results of this study reveals that the digital technology industry in the education, technology, and transportation sector is inclusive and promotes the role of women despite the fact that woman constitute a minority of workers. The role of women is supported by the equal of expectations towards the role of female workers, including the system of labor allocation and rewards that do not take gender into account. This research can further serve as a reference for other digital enterprise sectors and other industries when developing policies and programs to support and enhance the work role of women.

. The Framingham Risk Score (FRS) assesses coronary heart disease (CHD) risk and predicts acute coronary events. Metabolic markers like LDL cholesterol, fasting blood glucose, uric acid, triglycerides, and TG/HDL ratio play critical roles in atherosclerosis and cardiovascular risk. Elevated LDL cholesterol, fasting blood glucose, and uric acid contribute to plaque formation, inflammation, and vascular damage, while high triglycerides and low HDL cholesterol exacerbate atherogenesis. This study explores the relationship between these markers and FRS to enhance CHD risk prediction and support targeted cardiovascular interventions. This study analyzed LDL cholesterol, fasting blood glucose, uric acid, triglycerides, and TG/HDL ratio with Framingham Risk Score in 85 participants, excluding those with incomplete data or chronic illnesses. The analysis found significant correlations between metabolic parameters and the 10-year myocardial infarction risk. LDL cholesterol, triglycerides, and uric acid showed moderate positive associations with cardiovascular outcomes, while the triglyceride-to-HDL ratio and fasting blood glucose had weaker but significant correlations. These findings highlight lipid profiles and metabolic markers as key contributors to cardiovascular risk. This study highlights significant correlations between LDL cholesterol, fasting blood glucose, uric acid, triglycerides, and the triglyceride/HDL ratio with 10-year cardiovascular risk. These findings emphasize the importance of lipid profiles, glycemic control, and metabolic markers in predicting coronary outcomes and guiding targeted preventive interventions for improved cardiovascular risk management.

Coronary heart disease (CHD) remains a leading cause of mortality worldwide. Early detection is essential to reduce complications and improve patient outcomes. This study aims to develop a classification model using machine learning algorithms to predict CHD risk based on clinical symptoms. The dataset used is the Cleveland Heart Disease dataset from the UCI Machine Learning Repository, consisting of 303 patient records with 14 clinical features. The preprocessing stage involved handling missing values, normalizing features, and transforming categorical variables. Four classification algorithms were applied: K-Nearest Neighbors (K-NN), Decision Tree, Random Forest, and Support Vector Machine (SVM). Each model was trained using stratified 10-fold cross-validation to ensure generalizability. Evaluation using accuracy, precision, recall, F1-score, and ROC-AUC metrics showed that the Random Forest algorithm achieved the highest performance with 87.2% accuracy. Feature importance analysis indicated that chest pain type, resting blood pressure, cholesterol, and ST depression were the most influential indicators. These results demonstrate that machine learning, particularly Random Forest, can effectively support early diagnosis of CHD in clinical settings and has the potential to be integrated into clinical decision support systems (CDSS).

The growth of the digital sector during the Coronavirus Disease (COVID) 19 pandemic has an impact on how individuals use technology and behave in social situations, introducing new work opportunities.  However, work participation in the digital industry based on gender at the global level is still significant which can have an impact on gender gaps and the role of female workers. In terms of access to production and distribution of roles, female workers in the digital industry make widespread similarities with the presence of male workers. In-depth research is required to understand whether or not there is a gender gap in the digital industry, especially in the context of Indonesia, as a modern phenomenon. Previous studies have begun to discuss gender participation in non-digital industries, such as the garment sector, but have not yet discussed the dynamics of the gender gap and the role of women. This study utilizes social role theory to quantify the extent of the gender gap and the dynamics of women's roles in industrial technology. This study examines 3 female workers in 3 distinct digital technology companies using a qualitative method and a multiple case study approach. The results of this study reveals that the digital technology industry in the education, technology, and transportation sector is inclusive and promotes the role of women despite the fact that woman constitute a minority of workers. The role of women is supported by the equal of expectations towards the role of female workers, including the system of labor allocation and rewards that do not take gender into account. This research can further serve as a reference for other digital enterprise sectors and other industries when developing policies and programs to support and enhance the work role of women.

Coronary heart disease (CHD) is one of the leading causes of death worldwide due to impaired blood and oxygen supply to the heart muscle. This study aims to explore the potential of two natural compounds—kaempferol from Moringa oleifera and geranylated chalcone (GTDC) from Artocarpus altilis—as therapeutic candidates for CHD through a molecular docking approach. Medicinal chemistry analysis revealed that kaempferol exhibits significant affinity for the NF-κB protein, forming key hydrogen bonds with residues involved in the inflammatory process of atherosclerosis. Meanwhile, GTDC demonstrates strong binding to the P2Y12 receptor, which plays a crucial role in platelet aggregation, with a docking score lower than that of the natural ligand ADP. Structurally, hydroxyl group positioning and the lipophilic geranyl chain enhance both bioactivity and pharmacokinetic properties. In conclusion, a medicinal chemistry approach involving in silico docking, structure–activity relationship (SAR) analysis, and ligand optimization strategies confirms the potential of kaempferol and GTDC as promising multifunctional therapeutic agents for CHD. Further validation through in vivo studies and clinical testing is required.    

Ferritin is considered a protein that contains iron and includes two types of subunits: ferritin light chain (FTL) and ferritin heavy chain (FTH), which increases when inflammation increases, especially in the heart and kidneys, and helps in converting ferrous iron into iron. The light subunit is present in the liver and spleen and has a role in storing iron (1). Coronavirus (COVID-19) caused by the new coronavirus SARS-CoV-2 is a disease It is new to humanity, as it is accompanied by symptoms during the disease, including blood abnormalities, with activation of the immune system and phagocytic monocytes, and damage to the lungs. In our study, we showed that ferritin is an indicator of the severity of the disease and mortality (2). Acute respiratory syndrome (Coronavirus), which causes pneumonia and damages the heart, liver, and kidneys, is caused by the appearance of acute inflammatory cytokines that lead to death (3). A cytokine is a small protein that transmits messages to help stimulate the body’s immune response, and its rise causes increased inflammation, and these Cytokines secreted by macrophages (TNF-α, IL-10, IL-6) where there is high inflammation in the plasma. An indicator of the progress and severity of the disease (3).

Cardiovascular disease especially coronary heart disease (CHD) and stroke, is the main cause of global death, with increased blood lipid levels as one of the risk factors. This research offers the potential of anthocyanin-rich berry supplements in reducing low-density lipoprotein cholesterol (LDL-C) levels and improving blood lipid profiles through a meta-analysis of randomized controlled trial studies (RCTs). Data was collected from various databases and filtered based on inclusion and exclusion criteria. Analysis shows that consumption of berry supplements containing anthocyanins can reduce LDL-C levels by 0.29 mmol/L compared to the control group, with a p value <0.05 and I2 = 79%, indicating that the variation between these studies is heterogeneous. These findings are in line with previous research which showed a 13.6% reduction in serum LDL-C levels in the group consuming anthocyanins. In the whortleberry exposure group, the results showed that of the two journal articles analyzed, the data points fell outside the confidence interval (CI), indicating there was no significant difference in the results of the studies. The use of anthocyanins on berries other than whortleberries showed a significant effect, while on whortleberries, the difference with or without anthocyanins was not significant. The results of this study emphasize the importance of consuming anthocyanin-rich berry supplements in improving blood lipid profiles and reducing the risk of cardiovascular disease, and support the development of anthocyanin-based nutritional supplements as an effective public health strategy.