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Complexometry titration is a titration based on the formation of complex compounds between cations and complex forming substances. Complexometry is the formation of colored complexes by metals using standard solutions. The purpose of this study was to determine the percentage of levels in calcium lactate samples. According to the pharmacopoeia edition VI calcium lactate tablets contain no less than 94.8% and no more than 186%.  The results obtained from the determination of calcium lactate levels using the Complexometry titration method obtained a level result of 74.68%

This research aims to determine calcium lactate levels using the complexometric titration method, which involves the formation of a complex between metal ions and ligands, specifically using EDTA   (Ethylenediaminetetraacetate) as a titrant. The sample was dissolved in distilled water, the murexide indicator was added, and titrated with complexon III solution until the color changed from orange to violet as a marker for the end point of the titration. Data analysis shows that the percentage of calcium lactate levels in replication (1) is 93.32%, replication (2) 101.60%, replication (3) 95.93%, replication (4) 103.78%, replication (5) 109.02%, replication (6) 87.87%, replication (7) 95.93% and replication (8) 100.95%, and the percentage obtained the average purity is 98.55%. However, replications 5 and 6 did not comply with the standards of the Indonesian Pharmacopoeia VI edition (94.0–106.0%). This research shows that the complexometric titration method is effective in determining calcium lactate levels with good accuracy, as long as it is carried out with appropriate procedures and strict control of the analysis conditions.