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Purpose –This article aims to integrate three strategic pillars in strengthening Indonesia's defense human resources (HR), namely Crew Resource Management (CRM) in military medicine, national biological defense, and STEM-based education. Design/methodology/approach –The research used a systematic literature review approach by examining literature from international databases (Elsevier, Springer, Wiley, Taylor & Francis, ACM, IEEE, ScienceDirect, SAGE, DOAJ, JSTOR) and reputable national journals (SINTA, GARUDA, BRIN). The analysis was conducted thematically with normative, empirical, and conceptual approaches. Findings –The study results show that: (1) CRM effectively improves communication, coordination, and decision-making of military medical teams in crisis situations; (2) the establishment of a Biological Defense Agency is urgently needed to address the threat of pandemics, bioterrorism, and transnational biosecurity; and (3) STEM education has been proven to strengthen innovation, adaptability, and the competence of the younger generation of defense personnel. The integration of these three aspects results in the CRM–Bio-Defense–STEM Nexus conceptual framework as the foundation for developing Indonesian defense human resources towards the 2045 vision. Practical implications –This study recommends strengthening national policies through: (1) a STEM-based defense curriculum, (2) CRM training in military medical education and operations, and (3) the establishment of a special biological defense institution as the front line in facing biological threats.Originality/value –This article provides a new contribution in the form of an integrative conceptual model of CRM–Bio-Defense–STEM that has never been studied holistically in the context of Indonesian defense, while also offering a strategic framework for the development of adaptive, innovative, and resilient national defense human resources.

Bioterrorism is an intentional act of terror by making pathogenic germs or toxins with the aim of killing or causing harm to individuals or populations (humans, animals and plants) which results in political, economic, social and cultural conditions. Law Number 4 of 1984 concerning Outbreaks of Infectious Diseases, until the arrival of the Covid 19 pandemic and the emergence of a lawsuit against the Law to the Constitutional Court. Not in accordance with the development of the Law on Infectious Disease Outbreaks that is no longer relevant to various current conditions. Revision of the Law on Combating Outbreaks of Infectious Diseases is an unavoidable necessity at this time. Revision of the Plague Law should be the task and responsibility of the DPR. The Central Government through the Task Force for the Acceleration of Handling COVID-19 has made four strategies that will be consistently implemented to strengthen the physical distancing policy as a basic strategy to overcome the Corona COVID-19 Virus pandemic.