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Ibuprofen is an antipyretic and anti-inflammatory drug classified as Biopharmaceutics Classification System (BCS) class II, characterized by low water solubility and high permeability. Its limited solubility may reduce the dissolution rate and influence therapeutic effectiveness. This study aimed to formulate ibuprofen suppositories using cocoa butter (oleum cacao) as the suppository base through the melting method. Each suppository was prepared with a total weight of 2500 mg containing 125 mg ibuprofen, oleum cacao as the base, tween 80 as an emulsifier, and liquid paraffin as a mold lubricant. Before formulation, a displacement value test was performed to determine the exact amount of base required. The prepared suppositories were evaluated through organoleptic examination, weight uniformity, melting time, and dissolution testing. The evaluation results demonstrated that the suppositories possessed acceptable physical characteristics, uniform weight distribution, appropriate melting properties, and satisfactory dissolution behavior. Based on these findings, ibuprofen suppositories formulated with oleum cacao fulfilled pharmaceutical quality requirements in accordance with the Indonesian Pharmacopoeia standards.

Effervescent granules are a pharmaceutical dosage form that offer advantages in terms of ease of use, improved palatability, and rapid solubility in water. This study aimed to formulate and evaluate the physical properties of vitamin C Effervescent granules using the dry granulation method. The main materials used included ascorbic acid as the active substance, citric acid and tartaric acid as acid sources, and sodium bicarbonate as the base source. Evaluation was carried out on organoleptic properties, flow properties, pH, angle of repose, moisture content, density, compressibility index, and dispersion time. The results showed that the granules met the requirements for organoleptic properties, pH (4–5), angle of repose (38.41°), compressibility index (12.3%), and dissolution time (49.62 seconds). However, the flow property (29.11 seconds) and moisture content (6.47%) did not meet the established standards. These findings indicate that the formulated granules met most of the evaluation parameters but still require optimization, particularly in the drying process and flow properties, to obtain a more stable and high-quality dosage form.

The prevalence of non-communicable degenerative diseases in Indonesia continues to rise, particularly affecting adolescents and productive age populations due to unhealthy lifestyle patterns and free radical exposure. Purple sweet potato leaves (Ipomoea batatas L.), a locally abundant resource often regarded merely as agricultural by-product, contain significant bioactive compounds including polyphenols, flavonoids, anthocyanins, and terpenoids demonstrating potent antioxidant properties with IC50 values of 47.99 ppm. This study employs a qualitative descriptive literature review approach, analyzing 28 scientific publications spanning 2018-2025 sourced from Google Scholar and PubMed databases to examine the potential of purple sweet potato leaves as effervescent tablet raw material for degenerative disease prevention. Findings reveal that bioactive constituents effectively neutralize free radicals, prevent lipid peroxidation, and protect cellular structures from oxidative damage linked to diabetes, cancer, and cardiovascular disorders. The effervescent tablet formulation provides strategic advantages including enhanced solubility, accelerated absorption rates due to elimination of disintegration processes, pleasant carbonation sensation masking unpleasant active ingredient taste, and superior gastrointestinal tolerance. This innovation offers promising prospects for degenerative disease prevention through local food resource utilization, though experimental validation regarding optimal formulation, effective dosage determination, and clinical efficacy assessment remains necessary for practical implementation.

This research focuses on the synthesis and characterization of the double salt copper(II) ammonium sulfate hexahydrate, Cu(NH4)2(SO4)2·6H2O. The study aims to obtain the compound in crystalline form and evaluate its properties through yield calculation, solubility testing, and Fourier Transform Infrared (FTIR) spectroscopy. The synthesis involved reacting copper(II) sulfate pentahydrate (CuSO4·5H2O) with ammonium sulfate ((NH4)2SO4) under controlled conditions, followed by crystallization. The process produced 10.84 grams of crystalline Cu(NH4)2(SO4)2·6H2O with an 86.23% yield, indicating efficient synthesis. Solubility tests showed that the crystals were polar, soluble in polar solvents like water and hydrochloric acid (HCl), partially soluble in ammonium hydroxide (NH4OH), and insoluble in less polar solvents like ethanol and chloroform (CHCl3). FTIR analysis confirmed the presence of functional groups such as O–H, N–H, and S–O stretching vibrations, supporting the proposed molecular structure. The findings demonstrate that Cu(NH4)2(SO4)2·6H2O can be efficiently synthesized, and its physicochemical properties align with theoretical expectations. This study contributes to the understanding of double salt synthesis and characterization, relevant for inorganic chemistry, material science, and potential applications in catalysis and coordination chemistry.

The use of medicinal plants as herbal beverages has long been a part of Indonesian culture. However, the less preferred taste and aroma are obstacles to consumer acceptance. Cat's Whiskers leaves (Orthosiphon aristatus) are known to contain bioactive compounds that act as antioxidants, while Key Lime leaves (Citrus aurantifolia) have a fresh aroma and functional properties that can enhance flavor and health benefits. This study aims to evaluate the effect of adding Key Lime leaves (Citrus aurantifolia) on the chemical characteristics, sensory properties, and effectiveness of brewed Cat's Whiskers (Orthosiphon aristatus) leaf beverages.Five formulations with varying concentrations of Key Lime leaves (0%, 5%, 10%, 15%, and 20%) were tested based on the parameters of moisture content, ash content, pH, solubility, antioxidant activity, and organoleptic tests including color, aroma, taste, and texture. The results showed that the addition of Key Lime leaves significantly improved the chemical quality and sensory acceptability, with the best formulation obtained in treatment P4 (20% Key Lime leaves + 15g Cat's Whiskers), which provided an optimal balance between stability, nutritional content, and organoleptic quality. The addition of Key Lime leaves is recommended as an innovation in the development of functional herbal beverages based on Cat's Whiskers.

The selection of appropriate solvents in sterile injection formulations plays a pivotal role in determining the stability, efficacy, and safety of pharmaceutical products. Among the commonly utilized solvents, Dimethyl Sulfoxide (DMSO), Polyethylene Glycol (PEG), and pyrogen-free water exhibit distinct physicochemical properties and functional roles. This study aims to analyze the characteristics, functions, and implications of these three solvents within the context of sterile injectable preparations. The research methodology involves a comprehensive review of six peer-reviewed scientific articles published within the last five years, focusing on solvent performance, compatibility, and safety profiles. Findings reveal that DMSO is highly effective in dissolving lipophilic compounds due to its strong solvating capacity. However, its use at elevated concentrations may lead to irritation and cytotoxicity, necessitating careful dosage regulation. PEG, particularly in its flexible molecular weight variants, serves as a co-solvent and viscosity modifier, enhancing solubility and stability of active pharmaceutical ingredients. Pyrogen-free water, characterized by its inertness and biocompatibility, remains the gold standard for injection solvents, offering minimal risk and broad applicability across drug classes. The study underscores the importance of aligning solvent selection with the physicochemical nature of the drug, intended route of administration, and patient safety considerations. Furthermore, the potential for combining solvents to achieve optimized formulations is highlighted as a promising avenue for future pharmaceutical development. Such combinations may offer enhanced solubility, reduced toxicity, and improved delivery mechanisms, particularly for complex or poorly soluble compounds. In conclusion, understanding the nuanced roles of DMSO, PEG, and pyrogen-free water is essential for formulating safe and effective sterile injections. This research contributes to the growing body of knowledge supporting rational solvent selection and encourages further exploration into innovative solvent systems for advanced drug delivery.

Physical modification of starch using microwave heat treatment (MHT) technology serves as an efficient and environmentally friendly alternative to enhance the functional properties of starch without chemical additives. This article aims to examine the influence of microwave power and heating duration on the swelling power and solubility of various starch types, including tapioca, taro, sago, and lotus rhizome. A review of four studies revealed that power and time parameters significantly affect the crystalline structure of starch granules, resulting in either enhancement or reduction of their functional properties. High power or prolonged heating may decrease swelling power due to crystal restructuring and granule disruption, while solubility increases as a result of amylose and amylopectin degradation. MHT has proven to accelerate the heating process in a volumetric and efficient manner, improving water absorption capacity and viscosity. Despite its drawback of uneven heat distribution, this method remains relevant as a physical modification technique aligned with green processing principles in the food industry.

Nanomaterials have a variety of uniqueness and attractiveness, it is considered necessary to carry out literature study, beside the laboratory investigation, among others, on the nanoparticle structure and energy gap of ZnO nanoparticles doped with aluminum (Al) resulting from synthesis using various methods. In this study, the structure of the nanoparticles was divided into three types, namely crystal structure, crystallite size, and morphology. The crystal structure of the Al doped ZnO nanoparticles is hexagonal wurtzite. It is found, that, a decrease in crystallite size occurs as the doping of Al into ZnO increases to its solubility limit. A similar pattern also occurs in particle size. The high concentration of Al doping results in agglomeration. The morphology of Al doped ZnO nanoparticles in some references of this study are rod, spherical, and irregular spheres. The energy gap value of Al doped ZnO nanoparticles increases with the increasing concentration of Al doping in ZnO. So, it can be said, that Al as a doping material has an influence on the structure and optical properties of ZnO nanoparticles.    

Development of products based on ingredients rich in nutrients and bioactive compounds needs to be developed. High sources of antioxidants can be found from various fruits and their waste. Dragon fruit peels is known to contain various antioxidant compounds that are useful for body health. Instant dragon fruit peels drink is an instant food product processed from dragon fruit waste. The instant drink processing technique in this study uses conventional methods.The purpose of this study was to determine the effect of heating time on the chemical quality of instant drink powder in terms of water content and ash content and organoleptic tests were also carried out to determine the effect of the process on the sensory characteristics of color, taste, and aroma. Based on the results obtained, the water content of instant dragon fruit peels powder ranged from 1.97-1.98%, KND 3 samples with a heating treatment of 30 minutes had the highest water content (1.98%). The ash content value of the product ranged from 0.17-0.83% where the KDN3 treatment (heating time 30 minutes) showed the highest ash content (0.83%). The results of the analysis of this study showed a solubility of 97.6-99.15%. The results of the organoleptic test (hedonic test) on the color attribute showed a significant difference (P>0.05) between the 10 and 20 minute heating treatments with the product from the heating results with a heating time of 30 minutes where the panelists liked the color and aroma of the product from the 10 and 20 minute heating time treatments.

Cyclodextrin inclusion complexes have been widely used in the pharmaceutical industry to improve drug solubility and bioavailability. Analysis of these complexes using HPLC requires the development of appropriate and validated methods. To analyze and compare various HPLC methods used for the analysis of cyclodextrin inclusion complexes, and to identify challenges and trends in method development. A literature review was conducted of articles published in the last 10 years, focusing on HPLC methods for the analysis of cyclodextrin inclusion complexes. Parameters compared included column type, mobile phase composition, flow rate, and detection method. The majority of studies used C18 columns with varying lengths and particle sizes. The composition of the mobile phase varied, reflecting the diversity of properties of the complexes analyzed. The flow rate was generally 1.0 mL/min, with the exception of the HPLC/MS method. Detection methods included UV-Vis, PDA, fluorescence, and mass spectrometry. The main challenges included the dynamic equilibrium of the complexes and stability during analysis HPLC method development for the analysis of cyclodextrin inclusion complexes requires optimization of various parameters to overcome specific challenges. Future trends are towards the use of advanced technologies such as UHPLC and high-resolution mass detection.

This research aims to provide an overview of experimental procedures to determine the correct price and solubility product (Ksp) as materials in introductory chemistry practical work. This research was preceded by an experiment to assess solubility values ​​and products, and then a descriptive analysis was carried out regarding the results obtained. Based on the results of the study, it is known that the steps for determining Ksp are (1) Calculating the mass of substances that can dissolve in a specific volume of solvent, (2) Calculating the mass of substances that can dissolve in 1 liter of solvent (solubility in g/L), (3) Calculating moles substances that can dissolve in 1 liter of solvent (molar solubility in units of mol/L), (4) Calculate the concentration of each ion, and (5) Calculate the Ksp of the compound from the concentration of each ion raised to the power of the reaction coefficient.

The cereal products available in the market mostly focus only on practicality and ignore the nutritional content. It is necessary to increase the nutritional content of these products by using local Indonesian raw materials such as sweet potatoes and corn.  The objectives of this study are: 1) to determine the effect of temperature and proportion of purple sweet potato flour and corn flour on the characteristics of cereals produced, 2) to assess the level of preference of panelists for the physical, chemical and sensory qualities of cereals produced. The study design used a factorial randomized design complete with a proportion treatment of purple sweet potato flour and corn. Test parameters include water content, degree of swelling, water absorption, texture, antioxidants, and sensory evaluation. The conclusion in this study is that the comparative treatment of purple sweet potato flour and corn and temperature did not have a real effect on water content, degree of development, water absorption index (IPA), water solubility index (IKA), texture and antioxidants but had an effect on sensory properties

Perkawinan antara orang-orang yang dibaptis, oleh Kristus Tuhan diangkat ke martabat sakramen. Ada rahmat sakramental dalam perkawinan ini. Perkawinan antara seorang Katolik dengan seorang yang tidak dibaptis, perkawinan antar-iman, bukanlah sebuah sakramen. Apakah perkawinan antar-iman ini tanpa rahmat? Apakah perkawinan antar- iman tidak dapat diceraikan? Untuk menjawab pertanyaan ini digunakan dokumen- dokumen Gereja Katolik dan pendapat beberapa teolog moral.