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Substance and prescription drug misuse among adolescents continues to escalate and demands targeted preventive strategies within the school setting. This community service activity aimed to enhance students’ knowledge about the hazards of drug abuse through an interactive, school-based educational intervention. The program was conducted on 11 November 2026 at SMA Negeri 7 Kota Batam, involving fifty grade-X students as participants. A pre-experimental one-group pretest–posttest design was employed. The intervention combined interactive lectures, real-case illustrations, and two-way discussion, with knowledge measured using a content-validated questionnaire covering ten indicators. The mean score improved from 55.2 (pretest) to 86.3 (posttest), a gain of 31.1 points, while the proportion of correct answers across indicators rose from 48.6-62.9% to 80.0-91.4%. The largest gains appeared on items concerning rational drug use and the importance of professional health guidance, whereas the legal-consequence indicator improved more modestly. Interactive, contextually relevant education proves effective in elevating adolescent knowledge of drug abuse hazards, with stronger gains on experience-near content than on abstract regulatory aspects.

Breast cancer remains a major global health challenge, with treatment effectiveness often limited by drug resistance and the toxic side effects of chemotherapy on normal cells. The exploration of bioactive compounds from natural sources through a medicinal chemistry approach offers a promising alternative strategy. This study aims to examine the molecular mechanisms of action and Structure-Activity Relationships (SAR) of various natural compound scaffolds as potential breast anticancer agents. The method employed was a systematic narrative literature review of 15 recent scientific articles evaluating computational parameters, including molecular docking, as well as in vitro and in vivo activities. The results indicate that polyphenols, flavonoids such as quercetin and EGCG, and curcumin possess strong cytotoxic activity and high binding affinity toward cancer-related target macromolecules. SAR analysis demonstrates that key structural features, including the number and position of free phenolic hydroxyl groups, the presence of gallate ester groups, and conjugated diketone systems, play a crucial role in determining ligand receptor complex stability. These interactions are supported by hydrogen bonding, hydrophobic interactions, and favorable steric compatibility within receptor binding sites. Computational findings further suggest that structural optimization can enhance ligand selectivity and improve pharmacokinetic properties. This study concludes that natural phytochemical scaffolds have significant potential as lead compounds and provide a rational basis for Computer-Aided Drug Design in developing more potent, selective, multi-target, and safer breast anticancer therapies.

Antibiotic resistance is a global health problem that requires international efforts to prevent the ineffectiveness of existing antibiotics and support the development of new antimicrobial agents. The increasing use of antibiotics in the community must be accompanied by proper understanding regarding rational antibiotic use to minimize the risk of resistance. This community service activity aimed to provide education on rational antibiotic use and the dangers of antibiotic resistance to undergraduate nutrition students at STIKes Adila, Bandar Lampung. The activity was conducted through educational sessions using flyers, presentation slides, and interactive discussions to encourage active participation and improve understanding of the topic. Evaluation was carried out using pre-test and post-test assessments to measure changes in participants’ knowledge levels. Descriptive analysis showed an improvement in participants’ knowledge, with the high knowledge category increasing from 0% during the pre-test to 85% in the post-test, while the low knowledge category decreased from 35.5% to 0% after the intervention. These findings indicate that educational interventions can effectively enhance awareness and understanding of rational antibiotic use and the prevention of antibiotic resistance. Therefore, continuous educational programs are important to promote responsible antibiotic use and support public health efforts in combating antibiotic resistance.

Antibiotic resistance is a global health problem that requires international efforts to prevent the ineffectiveness of existing antibiotics and support the development of new antimicrobial agents. The increasing use of antibiotics in the community must be accompanied by proper understanding regarding rational antibiotic use to minimize the risk of resistance. This community service activity aimed to provide education on rational antibiotic use and the dangers of antibiotic resistance to undergraduate nutrition students at STIKes Adila, Bandar Lampung. The activity was conducted through educational sessions using flyers, presentation slides, and interactive discussions to encourage active participation and improve understanding of the topic. Evaluation was carried out using pre-test and post-test assessments to measure changes in participants’ knowledge levels. Descriptive analysis showed an improvement in participants’ knowledge, with the high knowledge category increasing from 0% during the pre-test to 85% in the post-test, while the low knowledge category decreased from 35.5% to 0% after the intervention. These findings indicate that educational interventions can effectively enhance awareness and understanding of rational antibiotic use and the prevention of antibiotic resistance. Therefore, continuous educational programs are important to promote responsible antibiotic use and support public health efforts in combating antibiotic resistance.

Data from the 2020 LFSP (Long Form Population Census) recorded a maternal mortality ratio of 189 per 100,000 live births, while the infant mortality rate was recorded at 16.85 per 1,000 live births. The causes of maternal mortality were hemorrhage, preeclampsia/eclampsia, infection, prolonged labor, and miscarriage. Meanwhile, the majority of infant deaths were due to low birth weight, asphyxia, and infection at birth. Stunting remains a particular concern in Tegal City. Various measures have been taken, and the stunting rate has decreased to around 13.8% according to data from early 2025. This PKM is expected to increase public knowledge on caring for pregnant women, women in labor, postpartum women, and newborns, as well as preventing stunting in children, thereby reducing maternal and infant mortality rates. The methods used in this activity include health education and outreach with a promotive and preventive approach, targeting pregnant women and mothers with infants and toddlers. Community service was held on Wednesday, December 17, 2025, from 8:30 a.m. to 12:00 p.m. at the Boegenvil Health Center in Cabawan Village, Tegal City, with 53 participants. The results of this activity showed an increase in the level of knowledge of the participants, from 11 people with a good level of knowledge to 41 people after receiving counseling, with 3 participants still having a low level of knowledge.

Data from the 2020 LFSP (Long Form Population Census) recorded a maternal mortality ratio of 189 per 100,000 live births, while the infant mortality rate was recorded at 16.85 per 1,000 live births. The causes of maternal mortality were hemorrhage, preeclampsia/eclampsia, infection, prolonged labor, and miscarriage. Meanwhile, the majority of infant deaths were due to low birth weight, asphyxia, and infection at birth. Stunting remains a particular concern in Tegal City. Various measures have been taken, and the stunting rate has decreased to around 13.8% according to data from early 2025. This PKM is expected to increase public knowledge on caring for pregnant women, women in labor, postpartum women, and newborns, as well as preventing stunting in children, thereby reducing maternal and infant mortality rates. The methods used in this activity include health education and outreach with a promotive and preventive approach, targeting pregnant women and mothers with infants and toddlers. Community service was held on Wednesday, December 17, 2025, from 8:30 a.m. to 12:00 p.m. at the Boegenvil Health Center in Cabawan Village, Tegal City, with 53 participants. The results of this activity showed an increase in the level of knowledge of the participants, from 11 people with a good level of knowledge to 41 people after receiving counseling, with 3 participants still having a low level of knowledge.

Thick leaf (Glochidion superbum) is a medicinal plant traditionally utilized by the community of East Panjang Island for the treatment of wounds, pain, and ulcers. This research was conducted to isolate the major compounds present in the ethyl acetate fraction of thick leaf and to assess its antioxidant activity using the DPPH method. The plant leaves were first cleaned, dried, and powdered, followed by maceration extraction using methanol, which resulted in an extract yield of 16.42%. The crude extract was fractionated by column chromatography using EtOAc and MeOH eluents with ratios of 9:1 (K1), 4:1 (K2), 1:4 (K3), and 1:9 (K4). UV–Vis spectrophotometric analysis showed an absorption peak at 288 nm, indicating the presence of phenolic compounds, identified as ferulic acid. Antioxidant testing using the DPPH method showed IC₅₀ values for fractions K1, K2, K3, and K4 of 12.981, 5.159, 9.658, and 10.971 µg/mL, respectively, with vitamin C as a positive control (3.563 µg/mL). Fraction K2 showed the strongest antioxidant activity. These results indicate that thick leaf contains ferulic acid with very strong antioxidant activity and has potential as a natural antioxidant source.

The main problem in this Community Service (PkM) activity is the condition of students at Al Kautsar Kraksaan Islamic Junior High School. They are in the puberty phase where emotional conditions are unstable. This situation results in problems in the form of negative social interactions, low motivation to learn, and social conflict within peer groups. For this purpose, the purpose of this PkM, we strive to provide educational and preventive assistance by increasing students' understanding of the application of scientific methods in studying behavior. In this case, we use the Participatory Action Research (PAR) method which invites students to actively collaborate with us in several important stages, namely: problem identification, action planning, evaluation, and reflection. The results of this activity show that students are able and even successful in using scientific methods to curb their behavior, in controlling emotions and rationally in making decisions in social life. This activity, in mentoring and participating in efforts to shape the character of students who are more responsible and ethical as well as more mature emotionally and socially.

This paper presents a narrative review focusing on the significance of in silico methodologies in identifying and evaluating natural bioactive compounds as promising antidiabetic agents. By examining scientific publications from 2020 to 2025, the review highlights substantial evidence that various plant-derived metabolites such as flavonoids, phenolic acids, terpenoids, and glycosides from Orthosiphon stamineus, Moringa oleifera, Syzygium polyanthum, Tinospora crispa, and Albizia saman demonstrate notable affinity toward several crucial enzymes implicated in type 2 diabetes, including DPP-4, SGLT-2, α-glucosidase, and PTP1B. Findings from molecular docking analyses and ADMET simulations indicate that many of these compounds exhibit favorable pharmacokinetic behavior, strong receptor interactions, and minimal toxicity, suggesting their potential as multitarget natural therapeutics with synergistic modes of action. Utilizing in silico screening as an initial step effectively predicts biological activity and pharmacological profiles prior to experimental validation through in vitro and in vivo testing, thus reducing both time and research expenditure. The synergy between computational modeling, medicinal chemistry, and phytochemical exploration establishes a scientific framework that supports the advancement of rational, safe, and sustainable herbal-based antidiabetic drug development derived from Indonesia’s vast biodiversity and encourages self-reliance within the national pharmaceutical sector.

The food and beverage industry are generally known for its stability. Nevertheless, this sub-sector underwent fluctuations as a result of the COVID-19 pandemic, one of which was in its firm value. The study investigates how firm value is affected by key organizational characteristics, including financial performance, the scale of the firm, and the rate of sales growth. A firm's value is measured by its PBV (Price to Book Value). The study's measure of financial performance is a combination of Return on Equity (ROE) and the CR, DER, and TATO ratios. This study uses a quantitative approach. The study's population is composed of F&B firms publicly traded on the Indonesia Stock Exchange throughout 2019–2023. A purposive sampling technique was used to select the sample based on predefined requirements, leading to a total of 125 samples from 25 companies. Data were processed using WarpPLS version 8.0 to evaluate the research model through model fit, structural testing, and hypothesis testing. The results show that the model meets the required fit indices and has strong explanatory power. The findings reveal that profitability (ROE) and leverage (DER) have a positive and significant effect on firm value, while liquidity (CR) and sales growth exert a negative and significant effect. On the other hand, activity ratio (TATO) and firm size do not significantly influence firm value.

Cancer remains a major challenge in modern medicine due to drug resistance and the adverse effects of conventional therapies, making it one of the leading causes of death worldwide. Continuous scientific efforts aim to discover safer and more effective treatments. Owing to their structural diversity, strong bioactivity, and relatively low toxicity, natural compounds show great promise as sources of anticancer drug candidates. This article aims to explore the role of medicinal chemistry in investigating, modifying, and optimizing natural bioactive compounds to develop more effective, selective, and stable anticancer agents with improved bioavailability. A narrative review was conducted using scientific literature published between 2020 and 2025 from PubMed, ScienceDirect, Google Scholar, and ResearchGate. The findings indicate that eugenol, berberine, hesperidin, piperine, and quercetin exhibit anticancer activities through apoptosis induction, inhibition of proliferation, and antioxidant and anti-inflammatory mechanisms. Modern medicinal chemistry relies on understanding structure–activity relationships (SAR), chemical modification, and nanoparticle formulation to enhance biological performance. In addition, in silico techniques such as molecular docking and QSAR analysis are applied to study ligands and receptors and predict bioavailability improvements. The development of natural products as rational, effective, and safe anticancer drug candidates is strengthened by integrating experimental, computational, and pharmaceutical approaches.

This community service program aimed to enhance students’ pharmaceutical literacy through the introduction of drug classification logos at SMP Muhammadiyah 04 Pangkatrejo. The background of this activity was the low level of drug-use literacy among adolescents, often leading to irrational self-medication. The activity employed a quantitative descriptive design with a one-group pretest–posttest approach. Educational interventions included interactive counseling, PowerPoint presentations, visual media using logo sticks, and pretest–posttest evaluation. Data were analyzed using the Wilcoxon Signed Rank Test. The results showed a significant improvement in students’ knowledge (p = 0.000), with mean scores increasing from 58% to 81% after the intervention. The highest gain was observed in the recognition of logo colors and drug classifications. Satisfaction analysis revealed that 96% of participants expressed satisfaction with the learning process, especially regarding material clarity and the presenters’ readiness to answer questions. The study concludes that participatory educational methods and visual media effectively improve rational drug-use awareness among junior high school students. Future programs are recommended to expand similar activities to other schools and integrate digital media for sustained impact on public health literacy.

Cough and flu are common health problems experienced by the public, with high prevalence across various age groups. The widespread practice of self-medication in the community highlighted the need for proper education regarding the rational and appropriate selection of medications. This educational activity was conducted at two strategic locations: the Car Free Day (CFD) in Solo and Taman Jaya Wijaya in Mojosongo. The method involved direct socialization, distribution of educational leaflets, and interactive question-and-answer sessions. The education focused on the differences between dry and productive coughs, appropriate medication choices, flu medicine content, and the use of natural remedies such as herbal treatments. A total of 41 participants from diverse backgrounds joined the activity enthusiastically. The results showed an increase in public understanding of cough classifications, medicine components, and the importance of reading drug labels before purchase. The sessions also emphasized the need to match medications with symptoms and advised consulting healthcare professionals if symptoms did not improve within three days. Positive responses from participants indicated that direct education effectively raised awareness and encouraged more rational and safe self-medication practices.

Cough and flu are common health problems experienced by the public, with high prevalence across various age groups. The widespread practice of self-medication in the community highlighted the need for proper education regarding the rational and appropriate selection of medications. This educational activity was conducted at two strategic locations: the Car Free Day (CFD) in Solo and Taman Jaya Wijaya in Mojosongo. The method involved direct socialization, distribution of educational leaflets, and interactive question-and-answer sessions. The education focused on the differences between dry and productive coughs, appropriate medication choices, flu medicine content, and the use of natural remedies such as herbal treatments. A total of 41 participants from diverse backgrounds joined the activity enthusiastically. The results showed an increase in public understanding of cough classifications, medicine components, and the importance of reading drug labels before purchase. The sessions also emphasized the need to match medications with symptoms and advised consulting healthcare professionals if symptoms did not improve within three days. Positive responses from participants indicated that direct education effectively raised awareness and encouraged more rational and safe self-medication practices.

Voter education is an important instrument in realizing a quality and sustainable democracy. Through the process of voter education socialization, it is hoped that the public can understand in depth their rights and obligations in the implementation of elections, as well as encourage active and responsible participation in the democratic process. Citizen participation in democratic social life must be based on adequate knowledge, critical reflection, and awareness of the rights and responsibilities as voters. A good understanding of the effectiveness of voter education socialization can shape a critical, rational, and independent attitude in exercising the right to vote, thereby strengthening the foundations of a clean and integrity-based democracy. This community service was carried out in the Selogiri District, Wonogiri Regency, with the aim of providing political education to the public regarding the importance of participation in the 2024 simultaneous regional head elections. Through a Participatory Action Research (PAR) approach, the community was actively involved as subjects in the activity process, not just as objects receiving information. Community service activities are carried out by integrating outreach into various village events, aimed at attracting residents to attend, interact, and directly discuss local political issues and forms of participation in the regional elections. Through these activities, it is hoped that the community will have a more comprehensive understanding of the importance of their role in determining the direction of regional policy through the regional elections. This education is also expected to raise awareness to vote based on conscience, without intervention or negative influences such as money politics, which has been a major challenge in every election at both the central and regional levels.

Background: Menstrual disorders that are often found in women include late menstruation, and the amount of menstrual blood. Almost 75% of adolescents experience menstruation, including irregular cycles, pain, long and heavy bleeding during menstruation. The menstrual cycle is not only influenced by biological factors such as lifestyle, hormonal disorders, nutritional status, but can also be influenced by social and environmental factors. The purpose of this study was to determine the factors that influence the menstrual cycle in adolescent girls at MAN 1 Semarang City. Method: This type of research is quantitative with a cross-sectional approach. The sample of this study amounted to 168 respondents. The respondent selection used probability sampling technique. This study used univariate, bivariate, and multivariate analysis tests. The analysis used was Spearman's rho and multiple logistic regression. Results and Conclusions: The results of this study indicate that the factors age, menarche, diet, nutritional status, and hemoglobin levels have no relationship to the menstrual cycle in female adolescents, but from the factors of stress, physical activity, fast food consumption habits, and sleep quality there is a relationship to the menstrual cycle in female adolescents at MAN 1 Semarang City where for stress level obtained p value: 0.002, physical activity with p value: 0.012, fast food consumption habits with p value: 0.035, and sleep quality with p value: 0.022. The factors that most influence the menstrual cycle in female adolescents at AN 1 Semarang City are stress levels with p value 0.002 and Od Ratio 3.365.

This study investigates the role of profit-based tangible assets and sales growth (ProTAPP) in enhancing the relationship between market ratios and financing decisions in property and real estate companies across Southeast Asia from 2019-2023. Using agency theory, pecking order theory, and trade-off theory, the research examines how EPS, TATO, and CR influence DER, with ProTAPP serving as a mediating variable. The analysis, based on panel data from ASEAN countries including Indonesia, Malaysia, Thailand, and Singapore, aims to provide practical insights for investors, corporate managers, and policymakers in optimizing financing strategies within the property and real estate sector. The study emphasizes the significance of tangible assets and sales growth dynamics in financial decision-making for achieving an optimal capital structure. Findings reveal that ProTAPP significantly mediates the relationship between EPS, TATO, CR, and DER in Southeast Asian property and real estate firms. The impact of these independent variables on DER through ProTAPP varies by country, reflecting specific market dynamics and company strategies. These results offer valuable guidance for developing more effective financing strategies in the sector.

This study investigates the role of profit-based tangible assets and sales growth (ProTAPP) in enhancing the relationship between market ratios and financing decisions in property and real estate companies across Southeast Asia from 2019-2023. Using agency theory, pecking order theory, and trade-off theory, the research examines how EPS, TATO, and CR influence DER, with ProTAPP serving as a mediating variable. The analysis, based on panel data from ASEAN countries including Indonesia, Malaysia, Thailand, and Singapore, aims to provide practical insights for investors, corporate managers, and policymakers in optimizing financing strategies within the property and real estate sector. The study emphasizes the significance of tangible assets and sales growth dynamics in financial decision-making for achieving an optimal capital structure. Findings reveal that ProTAPP significantly mediates the relationship between EPS, TATO, CR, and DER in Southeast Asian property and real estate firms. The impact of these independent variables on DER through ProTAPP varies by country, reflecting specific market dynamics and company strategies. These results offer valuable guidance for developing more effective financing strategies in the sector.      

One common household waste often encountered and rarely processed is used cooking oil. Used cooking oil is the residual oil from frying that has been repeatedly used. The common practice of reusing or improperly disposing of it by the community is considered hazardous as it has the potential to poison the body and pollute the environment. One effort to utilize used cooking oil is by recycling the waste into raw materials for making aromatherapy candles and essential oil scented soaps. This purpose activity is empower the community of Nglebak to utilize household waste and transform it into economic materials. This activity is carried out through research methods, material presentation, processing practice, and discussion. The research results on aromatherapy candles indicate that a formulation of used cooking oil and coconut wax at a ratio of 2:1 can produce ecofriendly aromatherapy candles with an ideal appearance and duration. The research results on soap indicate that stirring for 30 minutes with a volume of 60 mL of KOH (Potassium Hydroxide) is the ideal formulation for making essential oil scented soaps as it yields the most with a pH that complies with SNI No. 40-4058-1996

Education has the function of instilling, developing, and implementing rational values, regularity, diligence, and productive attitudes which in turn are able to bring about humans who have noble character, are devoted to God Almighty, and have human values. Pancasila and Citizenship Education or what is more often called PPKn is one of the subjects that must be given to students in order to form good citizens, loyal to Pancasila and the 1945 Constitution. The aim of this activity is to increase the competency of PPKn teachers in the field of Anti-Corruption Education, eradicating corruption through more effective and systematic educational strategies through students and teachers in anti-corruption outreach efforts. The implementation method is training which aims to increase understanding of the dangers of criminal acts of corruption and strengthen commitment as an extension of the eradication of corruption, followed by training in the form of mentoring prospective Anti-Corruption Counselors. It is hoped that the results of this activity will be that participants will later become anti-corruption educators, which requires a strong will and determination to lead the anti-corruption movement, namely perfection in conveying basic anti-corruption information and integrity. willing to have anti-corruption teacher qualifications