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Prasman (Peperomia pellucida) merupakan tanaman obat yang diketahui mengandung berbagai senyawa metabolit sekunder seperti alkaloid, flavonoid, saponin, tanin, dan terpenoid yang berpotensi memiliki aktivitas biologis. Penelitian ini bertujuan untuk mengetahui tingkat toksisitas ekstrak metanol batang prasman terhadap mortalitas larva udang (Artemia salina L.) menggunakan metode Brine Shrimp Lethality Test (BSLT). Penelitian dilakukan secara eksperimental dengan memberikan ekstrak metanol batang prasman pada berbagai konsentrasi, yaitu 10, 100, 500, 1000, 5000, dan 10000 ppm serta kontrol. Parameter yang diamati adalah persentase mortalitas larva setelah 24 jam perlakuan. Data dianalisis menggunakan metode interpolasi dan analisis probit untuk menentukan nilai LC₅₀. Hasil penelitian menunjukkan bahwa peningkatan konsentrasi ekstrak menyebabkan peningkatan mortalitas larva secara bertahap hingga mencapai 100% pada konsentrasi 10.000 ppm. Perhitungan LC₅₀ dengan metode interpolasi menghasilkan nilai 680,2 ppm pada pengujian pertama dan 529,66 ppm pada pengujian duplo. Analisis probit pada pengujian duplo menghasilkan nilai LC₅₀ sebesar 198,97 ppm. Nilai LC₅₀ yang berada di bawah 1000 ppm menunjukkan bahwa ekstrak metanol batang prasman bersifat toksik terhadap larva Artemia salina dengan kategori moderat atau racun sedang. Aktivitas toksik tersebut diduga berasal dari kandungan metabolit sekunder yang terdapat dalam batang prasman seperti Flavonoid, saponin, tanin dan minyak atsirinya. Dengan demikian, ekstrak metanol batang prasman berpotensi sebagai sumber senyawa bioaktif yang dapat dikembangkan lebih lanjut dalam bidang farmasi, khususnya sebagai kandidat antikanker, antimikroba, dan bioinsektisida alami.

Diabetes Mellitus merupakan salah satu penyakit degeneratif dengan prevalensi yang terus meningkat, terutama pada kelompok usia lanjut. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pengetahuan masyarakat mengenai pencegahan dan pengelolaan diabetes melitus melalui edukasi pola hidup sehat dan pemanfaatan tanaman obat. Kegiatan dilaksanakan di Desa Sambirata dengan sasaran ibu-ibu Posyandu Lansia. Metode yang digunakan meliputi penyuluhan kesehatan, pemeriksaan tekanan darah, pemeriksaan gula darah sewaktu, dan edukasi pemanfaatan tanaman obatantidiabetes. Sebanyak 44 peserta mengikuti kegiatan penyuluhan dan 71 peserta mengikuti pemeriksaan kesehatan. Hasil pemeriksaan menunjukkan 29 peserta mengalami hipertensi, 3 peserta memiliki kadar gula darah di atas normal, dan 50 peserta memiliki faktor risiko diabetes melitus. Kegiatan ini meningkatkan pengetahuan dan kesadaran masyarakat mengenai pentingnya pola hidup sehat serta penggunaan tanaman obat secara rasional dalam pencegahan diabetes melitus.

The use of medicinal plants has been an important part of people's lives since the time of our ancestors. Before the advent of modern medicine, people used various types of plants to treat mild to severe illnesses, such as fever, cough, wounds, digestive disorders, and skin diseases. Inventory of medicinal plants plays a very important role in exploring the potential of existing natural resources, especially as an effort to support the development of traditional medicine. The purpose of this study is to identify the types of medicinal plants used by local communities in traditional medicine. The method used in this study is a descriptive method through direct surveys at the research location. The findings obtained in the field concluded that all types of plants mentioned in this study are very beneficial for the people of Duhiadaa District, because they can help in treating various types of diseases experienced by the community. The types of diseases that can be treated include hypertension, gout, stomach acid, cholesterol, kidney disease, diabetes, inflammation, cancer, wounds, diarrhea and digestive disorders.

Pemanfaatan tanaman obat sebagai sumber fitofarmaka terus berkembang seiring meningkatnya kebutuhan akan agen terapeutik berbasis bahan alam yang aman. Salah satu tanaman yang berpotensi dikembangkan adalah daun soliti (Wrightia arborea), yang diketahui mengandung senyawa bioaktif seperti flavonoid, alkaloid, saponin, terpenoid, dan glikosida. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak daun soliti terhadap respons fisiologis dan perilaku mencit sebagai model hewan uji. Penelitian menggunakan desain eksperimental laboratorik dengan rancangan post-test only. Ekstrak daun soliti diperoleh melalui metode maserasi menggunakan pelarut etanol dan dibuat dalam konsentrasi 1%, 2%, dan 4%. Hewan uji berupa mencit putih jantan dibagi ke dalam kelompok perlakuan, kemudian diamati respons fisiologis dan perilakunya. Parameter yang diamati meliputi parasimpatomimetik, stimulasi dan depresi sistem saraf pusat, simpatolitik, relaksasi otot, parasimpatolitik, serta analeptik. Hasil penelitian menunjukkan bahwa ekstrak daun soliti memberikan pengaruh yang bervariasi terhadap respons fisiologis dan perilaku mencit dengan pola dosis-respons yang tidak linier. Konsentrasi 1% menunjukkan efek tertinggi pada beberapa parameter, konsentrasi 2% menunjukkan penurunan respons, sedangkan konsentrasi 4% meningkatkan kembali respons tertentu, khususnya sistem saraf otonom. Temuan ini mengindikasikan adanya efek bifasik. Penelitian ini menyimpulkan bahwa ekstrak daun soliti berpotensi dikembangkan sebagai kandidat fitofarmaka, namun diperlukan penelitian lanjutan untuk mengkaji mekanisme kerja dan aspek keamanannya.  

Pemanfaatan tanaman obat sebagai sumber terapi berbasis bahan alam masih menjadi fokus penting dalam penelitian, khususnya pada tanaman yang telah lama digunakan secara empiris namun memiliki keterbatasan bukti ilmiah. Rambutan (Nephelium lappaceum L.) merupakan salah satu tanaman yang secara tradisional dimanfaatkan untuk mengatasi berbagai gangguan kesehatan, tetapi kajian farmakologis terhadap efek daun rambutan pada sistem saraf masih terbatas. Penelitian ini bertujuan untuk mengevaluasi aktivitas neurofarmakologis serbuk simplisia daun rambutan terhadap sistem saraf pusat dan sistem saraf otonom pada berbagai konsentrasi. Penelitian ini merupakan studi eksperimental laboratorium yang menggunakan mencit sebagai hewan uji. Serbuk simplisia daun rambutan diberikan secara oral pada konsentrasi 1%, 2%, dan 3%. Parameter neurofarmakologis yang diamati meliputi aktivitas parasimpatomimetik, parasimpatolitik, simpatomimetik, simpatolitik, aktivitas analeptik, stimulasi dan depresi sistem saraf pusat, serta relaksasi otot. Pengamatan dilakukan berdasarkan perubahan perilaku dan respons fisiologis hewan uji.

Pemanfaatan tanaman obat sebagai sumber agen neurofarmakologis alami semakin mendapat perhatian seiring meningkatnya prevalensi gangguan sistem saraf dan keterbatasan penggunaan obat sintetis. Salah satu tanaman yang berpotensi namun masih terbatas kajian ilmiahnya adalah Kesambi (Schleichera oleosa), yang secara tradisional digunakan untuk berbagai keperluan pengobatan. Penelitian ini bertujuan mengevaluasi pengaruh variasi konsentrasi ekstrak daun Kesambi terhadap efek neurofarmakologi, serta mengidentifikasi pola respons dosis dan konsentrasi paling efektif dalam memodulasi sistem saraf pusat dan otonom. Penelitian ini menggunakan desain eksperimental dengan hewan uji yang dibagi ke dalam kelompok kontrol dan kelompok perlakuan. Ekstrak daun Kesambi diperoleh melalui metode maserasi menggunakan pelarut akuades dan diberikan secara per oral pada konsentrasi 1%, 2%, dan 4%. Evaluasi efek neurofarmakologis dilakukan melalui skrining perilaku terhadap delapan parameter, yaitu parasimpatomimetik, stimulasi sistem saraf pusat, depresi sistem saraf pusat, simpatolitik, relaksasi otot, simpatomimetik, parasimpatiolitik, dan analeptik. Hasil penelitian menunjukkan bahwa ekstrak daun Kesambi menimbulkan variasi respons neurofarmakologis yang dipengaruhi oleh konsentrasi. Konsentrasi 4% memberikan efek paling dominan pada sebagian besar parameter, khususnya depresi sistem saraf pusat, relaksasi otot, dan modulasi sistem saraf otonom, sedangkan konsentrasi 2% menunjukkan efek stimulasi sistem saraf pusat yang optimal. Temuan ini menunjukkan potensi ekstrak daun Kesambi sebagai neuromodulator.  

This community service program aims to enhance the knowledge and skills of the community in Pulau Akar, Setokok Village, Batam City, in utilizing Family Medicinal Plants (TOGA) for optimizing health based on traditional methods. The program was carried out through training involving housewives, community leaders, and local health cadres. The methods used include an initial survey, practical training on types of medicinal plants, their benefits, processing methods, and the distribution of TOGA seedlings to be planted at participants' homes. Additionally, group discussions were held to reinforce understanding and organize TOGA utilization within the community. The results of this program showed a significant increase in participants' understanding and skills regarding the use of TOGA for treating minor ailments and disease prevention. The community began planting TOGA around their homes, creating herbal gardens that can be used as a source of natural medicine. Furthermore, the emergence of local leaders actively disseminating knowledge about TOGA was an important outcome of this service. Social change was also evident as the community became more aware of the importance of managing health independently using local resources. It is hoped that this program will continue with regular training and the strengthening of TOGA utilization groups to ensure the sustainability of this program in the future.

Karangtalun Village, located in Kalidawir District, Tulungagung Regency, East Java, has significant potential for developing Family Medicinal Plants (TOGA) to support community-based health practices. However, the utilization of TOGA in daily health care remains limited due to a lack of knowledge and practical skills among residents. At the same time, the community faces a growing social challenge—digital exposure among young children, which negatively affects their physical, psychological, and social well-being. To address these issues, a capacity-building program was implemented for women involved in the Integrated Guidance Post (Posbindu) through training on TOGA cultivation and digital literacy education using the Community-Based Participatory Research (CBPR) approach. This participatory model actively engaged community members in the planning, implementation, and evaluation stages. The program results showed an increase in participants’ understanding of TOGA as an alternative for self-care and traditional medicine, greater awareness of the adverse effects of excessive gadget use among children, and positive behavioral changes in parenting, such as setting screen-time limits and replacing gadget use with creative family activities. These findings demonstrate that integrating local wisdom–based education with digital literacy can effectively strengthen family resilience and promote sustainable well-being in the digital era.

Karangtalun Village, located in Kalidawir District, Tulungagung Regency, East Java, has significant potential for developing Family Medicinal Plants (TOGA) to support community-based health practices. However, the utilization of TOGA in daily health care remains limited due to a lack of knowledge and practical skills among residents. At the same time, the community faces a growing social challenge—digital exposure among young children, which negatively affects their physical, psychological, and social well-being. To address these issues, a capacity-building program was implemented for women involved in the Integrated Guidance Post (Posbindu) through training on TOGA cultivation and digital literacy education using the Community-Based Participatory Research (CBPR) approach. This participatory model actively engaged community members in the planning, implementation, and evaluation stages. The program results showed an increase in participants’ understanding of TOGA as an alternative for self-care and traditional medicine, greater awareness of the adverse effects of excessive gadget use among children, and positive behavioral changes in parenting, such as setting screen-time limits and replacing gadget use with creative family activities. These findings demonstrate that integrating local wisdom–based education with digital literacy can effectively strengthen family resilience and promote sustainable well-being in the digital era.

This paper presents a narrative review focusing on the significance of in silico methodologies in identifying and evaluating natural bioactive compounds as promising antidiabetic agents. By examining scientific publications from 2020 to 2025, the review highlights substantial evidence that various plant-derived metabolites such as flavonoids, phenolic acids, terpenoids, and glycosides from Orthosiphon stamineus, Moringa oleifera, Syzygium polyanthum, Tinospora crispa, and Albizia saman demonstrate notable affinity toward several crucial enzymes implicated in type 2 diabetes, including DPP-4, SGLT-2, α-glucosidase, and PTP1B. Findings from molecular docking analyses and ADMET simulations indicate that many of these compounds exhibit favorable pharmacokinetic behavior, strong receptor interactions, and minimal toxicity, suggesting their potential as multitarget natural therapeutics with synergistic modes of action. Utilizing in silico screening as an initial step effectively predicts biological activity and pharmacological profiles prior to experimental validation through in vitro and in vivo testing, thus reducing both time and research expenditure. The synergy between computational modeling, medicinal chemistry, and phytochemical exploration establishes a scientific framework that supports the advancement of rational, safe, and sustainable herbal-based antidiabetic drug development derived from Indonesia’s vast biodiversity and encourages self-reliance within the national pharmaceutical sector.

kuliah kerja nyata (KKN) merupakan bentuk pengabdian kepada Masyarakat yang bertujuan memberikan pengalaman langsung kepada mahasiswa dalam mengidentifikasi  dan menyelesaikan permasalahan di lingkungan desa. KKN kelompok 04 STIKes Ibnu Sina Ajibarang dilaksanakan di Desa Kotayasa, kecamatan sumbang, kabupaten Banyumas pada 28 juli – 5 september 2025. Metode yang digunakan berupa observasi, wawancara, dan pelaksanaan program berbasis kebutuhan Masyarakat. Hasil kegiatan menunjukan adanya peningkatan pengetahuan dan keterampilan Masyarakat, antaralain melalui sosialisasi perilaku hidup bersih dan sehat (PHBS) di sekolah dasar, kegiatan posyandu balita dan lansia, penyuluhan stunting, serta sosialisasi penggunaan obat  NSAID dan kortikostiroid. Selain itu, kegiatan inovatifs seperti pembuauan sabun cuci piring, budidaya tanaman obat keluarga (TOGA) , senam Bersama PKK, hingga lomba mewarnai untuk anak-anak berhasil meningkatkan partisipasi dan kemandirian Masyarakat. Factor pendukung meliputi antusiasme warga, dukungan perangkat desa, dan kerja sama lintas sektor.sementara hambatan yang mucul berupa keterbatasan waktu, dana, serta kondisi cuaca. Secara keseluruhan, kegiatan ini  memberikan kontribusi positif dalam aspek Kesehatan, Pendidikan, ekonomi kreatif, dan sosial budaya di Desa Kotayasa.

Community Service Program (Kuliah Kerja Nyata/KKN) is a compulsory activity for university students as a form of community engagement and application of academic knowledge in real life. One of the work programs carried out was the education and cultivation of Family Medicinal Plants (Tanaman Obat Keluarga/TOGA), which aimed to improve the knowledge and practical skills of the community in Telaga Sam Sam Village, Kandis District, in cultivating and utilizing TOGA. Family medicinal plants have long been known to possess great potential as an alternative treatment for common illnesses such as fever, cough, stomachache, and skin itching, making them highly relevant to daily community health needs.The program was implemented through counseling sessions, interactive discussions, training, and hands-on practice of planting TOGA in the residents’ yards. The community actively participated in recognizing, cultivating, and maintaining various types of medicinal plants such as ginger, turmeric, galangal, lemongrass, and betel leaf. In addition to enhancing understanding, this activity encouraged households to practice simple herbal preparation techniques for family use.The results of the program showed a significant increase in community awareness regarding the importance of utilizing TOGA as a primary step in maintaining family health, while also contributing to the creation of a greener, cleaner, and healthier living environment. Furthermore, the activity not only improved community knowledge but also strengthened independence and self-reliance in utilizing local resources to support sustainable health practices.

Community Service Program (Kuliah Kerja Nyata/KKN) is a compulsory activity for university students as a form of community engagement and application of academic knowledge in real life. One of the work programs carried out was the education and cultivation of Family Medicinal Plants (Tanaman Obat Keluarga/TOGA), which aimed to improve the knowledge and practical skills of the community in Telaga Sam Sam Village, Kandis District, in cultivating and utilizing TOGA. Family medicinal plants have long been known to possess great potential as an alternative treatment for common illnesses such as fever, cough, stomachache, and skin itching, making them highly relevant to daily community health needs.The program was implemented through counseling sessions, interactive discussions, training, and hands-on practice of planting TOGA in the residents’ yards. The community actively participated in recognizing, cultivating, and maintaining various types of medicinal plants such as ginger, turmeric, galangal, lemongrass, and betel leaf. In addition to enhancing understanding, this activity encouraged households to practice simple herbal preparation techniques for family use.The results of the program showed a significant increase in community awareness regarding the importance of utilizing TOGA as a primary step in maintaining family health, while also contributing to the creation of a greener, cleaner, and healthier living environment. Furthermore, the activity not only improved community knowledge but also strengthened independence and self-reliance in utilizing local resources to support sustainable health practices.

Silica gel is one of the most commonly used adsorbents in the fractionation of bioactive compounds from medicinal plants. This is due to its ability to separate compounds based on differences in polarity, thus simplifying the purification process of active components. Fractionation itself is a crucial step in phytochemical research, as it aims to obtain active compounds in a purer, standardized form, and ready for further testing, both biologically and pharmacologically. This study aims to review the effectiveness of silica gel in the fractionation of active compounds from various types of medicinal plants. The study was conducted through a systematic literature review method with a qualitative-descriptive approach to 35 scientific articles published in the last five years. The articles analyzed were those that presented primary data on the use of silica gel in the fractionation process of medicinal plants. The results of the study showed that silica gel was proven effective in separating various polar compounds such as flavonoids, alkaloids, and phenolic compounds from crude extracts of medicinal plants. Some studies have even succeeded in isolating pure compounds that have significant biological activities, such as antioxidants, antimicrobials, and anti-inflammatory. The effectiveness of fractionation with silica gel is influenced by several important factors, such as the type and composition of the solvent, the elution technique (gradient or isocratic), and the support of advanced analytical methods such as thin-layer chromatography (TLC) and spectroscopy (UV-Vis, FTIR, and NMR). However, the use of silica gel still has several limitations, including the relatively high solvent requirements and long elution times. From the results of this study, it can be concluded that silica gel has great potential in supporting the fractionation process and isolation of bioactive compounds from medicinal plants. Therefore, optimization of silica gel-based fractionation techniques is important to support research and development of more efficient, standardized, and sustainable phytopharmaceutical products.

Abstrak. Osteoporosis is a degenerative bone disease characterized by a decrease in bone mass and strength, particularly in postmenopausal women. Traditional plant-based therapy presents an attractive alternative given the rich local bioactive potential and limited access to pharmacological treatments. One important biochemical indicator in bone regeneration is the level of alkaline phosphatase (ALP). The aim of this study is to evaluate the potential of various Indonesian traditional medicinal plants as bioactive agents in the prevention of osteoporosis, with an emphasis on increasing ALP levels. This method employed a literature search by collecting several scientific articles discussing the anti-osteoporosis activity of traditional medicinal plants through in vitro, in vivo, and clinical observation studies. The results obtained show that traditional medicinal plants such as Turmeric (Curcuma longa), Black pepper (Piper nigrum), Bromelain (Ananas comosus), Papaya (Carica papaya), Japanese knotweed (Reynoutria japonica Houtt.), Veratrum nigrum, Sickle senna (Cassia tora), Red ginger (Zingiber officinale var. rubrum), Clove (Syzygium aromaticum L.), White turmeric (Curcuma zeadoaria), and Celery (Apium graveolens) are capable of reducing the number of osteoclasts and promoting bone formation. These findings consistently demonstrate a positive role in bone health through increased ALP levels. Indonesian traditional medicinal plants hold great potential as evidence-based anti-osteoporosis agents, particularly through enhancing ALP levels and osteoblast activity. This literature review supports the development of local herbal therapy as a promotive and preventive alternative against osteoporosis.

Fever and cough are diseases that often attack humans. Fever and cough are early signs of infection of a disease that attacks the body. This qualitative study was initiated to identify the types of plants, organs used, and local wisdom inherent in the traditional medicine practices of the people of East Java Province in dealing with fever and cough. Data collection was carried out through literature survey methods and journal reviews. Data sourced from articles in the Google Scholar, Google, and ResearchGate databases were then analyzed using a qualitative descriptive approach.The results of the study showed that there were 9 species of plants used for fever and cough medicine, including turmeric (Curcuma domestica), lime (Citrus X aurantiifolia), fennel (Foeniculum vulgare), starfruit (Averrhoa bilimbi L), kencur (Kaempferia galanga), mengkudu (Morinda citrifolia), katuk (Sauropus androgynus (L.) Merr), tapakliman (Elephantopus scaber), lemongrass (Adropogon nardus). The plant has certain content that can cure fever and cough. Fruit, leaves, rhizomes, and roots are parts of the plant organs that are often used by the community.

Malaria remains a significant public health issue in Indonesia, particularly in endemic areas such as Keerom Regency, Papua. Efforts to control this disease face challenges due to Plasmodium resistance to synthetic drugs, highlighting the need for safer and more effective alternative treatments. This study aims to identify the secondary metabolite content of several local plants traditionally used as antimalarial remedies. An experimental laboratory study was conducted using phytochemical screening methods. The plants examined included turmeric rhizome (Curcuma longa), meniran leaves (Phyllanthus niruri), papaya leaves (Carica papaya), sambiloto (Andrographis paniculata), and brotowali (Tinospora crispa). Extraction was carried out using the maceration method with 96% ethanol as the solvent. The results showed that all samples contained secondary metabolites such as flavonoids, alkaloids, tannins, and saponins, which are known for their antiplasmodial activity. Extract yields ranged from 18% to 24%, with turmeric rhizome showing the highest yield. These findings suggest that local plants from Keerom Regency hold potential as raw materials for the development of herbal antimalarial drugs. This study serves as a preliminary step for further in vitro and in vivo bioactivity testing.

TOGA (Tanaman Obat Keluarga) adalah tanaman yang ditanam di sekitar tempat tinggal oleh keluarga karena memiliki manfaat sebagai obat. Tanaman ini juga sering disebut sebagai apotek hidup. Beberapa jenis TOGA yang umum dibudidayakan meliputi empon-empon, rempah-rempah, belimbing, delima, kangkung, dan daun pepaya. Budidaya TOGA dapat menjadi salah satu cara untuk meningkatkan kesejahteraan keluarga, terutama dalam aspek pangan. Namun, masih banyak masyarakat yang belum menyadari pentingnya tanaman ini bagi kehidupan mereka. Oleh karena itu, diperlukan upaya peningkatan kesadaran melalui penyuluhan dan pelatihan budidaya TOGA. Kegiatan ini bertujuan untuk memperluas pemahaman serta meningkatkan keterampilan masyarakat dalam mengelola tanaman obat keluarga. Program ini dilaksanakan di Desa Wonodadi, Kabupaten Blitar, dengan pendekatan berupa ceramah dan demonstrasi.

The prevalence of hypertension in Indonesia in 2020 is 31.7% of the population aged 18 years and over. Around 80% of people with hypertension are classified as essential hypertension. Blood pressure in hypertensive sufferers can be lowered pharmacologically and non-pharmacologically. Pharmacological reduction can be done by taking drugs recommended to lower blood pressure. Non-pharmacologically, you can reduce blood pressure by modifying your lifestyle and consuming medicinal plants. Medicinal plants can be used as alternative medicines for the prevention and control of hypertension which do not have side effects, are cheap and easy to obtain because they can be cultivated yourself. The aim of this community service is to provide education about the benefits of medicinal plants for first aid for minor health problems through traditional medicine which has the potential to treat and prevent hypertension. The service method carried out consists of two stages, namely counseling and planting traditional medicinal plants. This activity was attended by 20 participants. From the results of the evaluation and discussion, participants enthusiastically asked about herbs around their homes and people were willing to plant herbs in their yards.

The community in Sumberkalong Village, Wonosari District, Bondowoso Regency faces several issues related to the use of Family Medicinal Plants (TOGA), including lack of knowledge, underutilized home gardens, and the absence of active community groups managing TOGA. A participatory approach is needed to address these issues sustainably. This community service activity aims to improve public knowledge and skills regarding the cultivation and utilization of TOGA, promote the optimal use of home gardens, and establish community-based TOGA activist groups. The method used is Participatory Action Research (PAR) through stages of problem identification, participatory planning, collaborative implementation, observation, reflection, and follow-up actions. The results show increased public awareness and enthusiasm in cultivating TOGA, the formation of small TOGA groups, and program sustainability through cooperation between residents and local health cadres.