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Hypertension is one of the most common health problems among the elderly and has the potential to cause serious complications such as heart disease and stroke. Dietary patterns and lifestyle factors are known to play an important role in increasing blood pressure, particularly fat intake and sleep quality. This study aimed to analyze the relationship between fat intake and sleep quality with the incidence of hypertension among elderly individuals in the coastal area of Tuban District. This study used an analytical observational design with a case-control approach. The total number of respondents in this study was 136 elderly individuals, consisting of 68 cases (elderly with hypertension) and 68 controls (elderly without hypertension). Data on fat intake were obtained using a 24-hour food recall method, while sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Data were analyzed using the Pearson Chi-Square test with a significance level of α ≤ 0.05. The results showed that there were significant relationships between fat intake (p = 0.000) and sleep quality (p = 0.000) with the incidence of hypertension among the elderly in the coastal area of Tuban District. Elderly individuals with high fat intake and poor sleep quality were more frequently found in the hypertension group compared to the non-hypertension group. In conclusion, fat intake and sleep quality are associated with the occurrence of hypertension among the elderly. Hypertension control efforts can be carried out through limiting fat intake and maintaining good sleep quality.

The problem that occurs in stroke patients is damage to the autonomic nervous system that regulates intestinal peristalsis, causing a decrease in the defecation reflex and leading to constipation. If constipation is not treated properly, it will affect the quality of life of stroke patients. Constipation can be treated pharmacologically and non-pharmacologically. One non-pharmacological treatment is abdominal massage. Abdominal massage can stimulate the parasympathetic nervous system, which can increase digestive system motility, reduce tension in the abdominal muscles, and have a relaxing effect on the sphincter. The design used in the preparation of the final scientific paper for the nursing study was a one-group pretest-posttest case study with abdominal massage intervention on three respondents who had experienced constipation for ≥ 72 hours. Abdominal massage was given once a day for 10-15 minutes for three consecutive days. The constipation scores using the Constipation Assessment Scale (CAS) were as follows: respondent 1, Mrs. L, from 13 to 6; Mrs. W, from 12 to 11; and Mrs. W, from 15 to 11. There was a decrease in the CAS score before and after the abdominal massage was administered, but it was not yet able to significantly alleviate constipation in stroke patients. The application of this EBP is expected to provide additional information on the administration of abdominal massage to stroke patients experiencing constipation for ≥72 hours.

Non-hemorrhagic stroke occurs due to blockage of blood flow to the brain by a thrombus or embolus. The blockage results in focal neurological disorders that affect the musculoskeletal system, namely weakness in the extremities, which gives rise to nursing problems of impaired physical mobility. To overcome the problem of impaired physical mobility, rubber ball grip exercises (ball squeezing) are given. These exercises have been shown to increase muscle strength, prevent joint stiffness, and improve blood circulation. This scientific paper was conducted to determine the description of nursing care for non-hemorrhagic stroke patients with nursing problems of impaired physical mobility. During the meeting, the nurse provided rubber ball grip exercises (ball squeezing) for 10-15 minutes for 3 times in 24 hours. Evaluation of these actions showed that the patient who initially experienced weakness in the upper extremities with muscle strength 2-3 and after being given rubber ball grip exercises (ball squeezing), the problem of impaired physical mobility was resolved, as evidenced by the patient being able to perform therapy, the extremities feeling slightly lighter, and muscle strength 4. Therefore, it is recommended that non-hemorrhagic stroke patients be given rubber ball grip exercises (ball squeezing) to overcome impaired physical mobility.

Hypertension is a highly prevalent non-communicable disease often referred to as "The Silent Killer" because it rarely shows symptoms until it causes serious complications such as stroke, kidney failure, and heart disease. This community service activity aims to optimize the Mobile Blood Pressure Monitoring Program as a hypertension screening method in Sanahu Village. The methods used include participant data collection, blood pressure checks with a manual sphygmomanometer, and health education on hypertension prevention. A total of 96 participants participated in this activity, and the results showed that 58 participants (60.4%) were hypertensive. This program has proven effective in reaching communities with limited access to health services and raising public awareness about the importance of early detection of non-communicable diseases. In addition, this activity succeeded in providing knowledge to the community about how to prevent hypertension and the importance of maintaining a healthy lifestyle, which is expected to reduce the incidence of hypertension in the future.

The problem with a 4-stroke gasoline engine-driven electric generator is a decrease in tool performance due to wear on important components for the stator, cooling fan, air filter, oil filter, and gasket. The purpose of component replacement planning is to obtain replacement costs, maintenance schedules in 2027, and the ratio of maintenance costs to profits. The component replacement planning method includes collecting maintenance data from previous years, applying the inspection-replace-repair-overhaul (IRRO) method, assessing component conditions, predicting component lifespan, predicting labor costs, predicting supporting equipment to be used in maintenance, predicting spare part replacement times, predicting maintenance costs in 2027, and calculating the ratio of maintenance costs to profits. The results of the replacement planning obtained maintenance costs in 2027 amounting to IDR 570,007,- with an estimated electric generator rental rate of IDR 30,000,-/hour which has the potential to be rented for 128 hours/year, a profit of IDR 3,840,000,- was obtained, and the ratio of maintenance costs to profits was 14.84% which implies that a 2.5 kW electric generator that uses gasoline-pertalite fuel of around 1.5 liters/hour at maximum power is still suitable for use in the next few years and has the potential to generate profits.

This study discusses the introduction of digital signature patterns using the Backpropagation method on Artificial Neural Network (JST) to identify a person's characteristics and potential. The increasing use of digital identities demands a verification system that is more secure, accurate, and adaptive to the variations of each individual's signature. The main problem faced in the signature recognition system is the low level of accuracy when the visual features of the signature have similarities between users, both in terms of shape, size, and stroke pressure. In addition, variations of signatures made by the same individual are also a challenge in the identification process. As a solution, this study implements Principal Component Analysis (PCA) to extract important features from the signature image before the training process using JST. PCA is used to reduce the data dimension so that the learning process becomes more efficient and optimal. A total of 80 signature images were used in this study, consisting of 60 training data and 20 test data. The results showed that the system was able to achieve an accuracy level of 92.5%. These findings prove that the combination of PCA and JST methods is effective in recognizing digital signature patterns and has the potential to be applied to digital security-based biometric identification systems.

This research examines the mentoring of nationalistic activities by students from the Al-Azhar Menganti Gresik Institute and field supervisors at MI Darunnajah Lebani Suko, Wringinanom District, Gresik Regency, in commemoration of Heroes' Day. Thru a descriptive qualitative approach, this program involves four main activities: the red and white parade, patriotic love songs, little warrior strokes (coloring and writing hero stories), and a colossal drama of patriotic fervor. These activities are creatively designed and based on direct experience to instill nationalistic values in elementary school students. The research results show a significant improvement in students in terms of courage, discipline, creativity, cooperation, and respect for national symbols such as the flag and national anthem. Collaboration between students as facilitators, teachers as pedagogical directors, and the school environment creates a conducive learning ecosystem where participatory methods are more effective than conventional approaches. This experiential learning approach not only enhances cognitive understanding of the struggles of national and local heroes but also builds emotional empathy and social skills. Positive impacts include high student enthusiasm, reduced learning boredom, and character strengthening in accordance with the Pancasila Student Profile, such as mutual cooperation and integrity. Overall, this mentoring program serves as a relevant model for non-formal character education that can be replicated in other schools to strengthen nationalism from an early age amidst the challenges of post-pandemic globalization and individualism.

Hypertension substantially increases the risk of developing secondary conditions, including stroke, renal disease, coronary heart disease, and heart failure. Early management is therefore essential to prevent complications and adverse outcomes. Evidence indicates that untreated hypertension contributes to approximately 60% of stroke cases. Public knowledge regarding hypertension-related complications remains limited, and many individuals are unable to identify early signs of stroke the most common complication associated with hypertension. This study aimed to assess the knowledge of hypertensive patients regarding stroke risk and management at Santa Elisabeth Hospital Medan in 2024. A descriptive research design was employed. The sample consisted of 67 hypertensive patients attending the outpatient clinic, selected through purposive sampling. Data were presented using frequency distribution tables. The findings revealed that 52.2% of respondents demonstrated poor knowledge, 32.8% had moderate knowledge, and only 14.9% showed good knowledge regarding stroke risk and management. These results underscore the need for patients to adopt healthier lifestyles and for the hospital to strengthen educational efforts by providing more engaging and interactive learning materials for patients and their families.

Impaired emotion regulation and decreased quality of life are common, yet often untreated, sequelae of stroke. Conventional rehabilitation primarily targets physical and cognitive recovery, leaving affective disturbances unaddressed. This study examined the efficacy of a structured Buddhist meditation program—Mindful Resilience After Stroke (MRAS)—for improving emotion regulation and quality of life in stroke survivors. Forty-two ischemic/hemorrhagic stroke patients (3–18 months post-onset) were consecutively recruited and randomly allocated to an intervention group (n = 21) receiving an 8-week MRAS protocol (1 × 60 min/week) or a control group (n = 21) receiving standard care only. Emotion regulation was assessed with the Difficulties in Emotion Regulation Scale-Short Form (DERS-SF) and quality of life with the Stroke-Specific Quality of Life Scale (SS-QOL). Between-group changes (Δ post-pre) were analyzed using independent t-tests or Mann–Whitney U tests (α = 0.05). The intervention group showed a significantly greater reduction in emotion-regulation difficulties than controls (ΔDERS-SF −18.4 ± 5.1 vs. −3.2 ± 4.3; p < 0.001; d = 1.62). Quality-of-life gains were also larger in the intervention group (ΔSS-QOL 35.7 ± 8.9 vs. 7.1 ± 6.5; p < 0.001; d = 1.89). The most improved sub-domains were emotional acceptance, emotional awareness, and impulse control (DERS-SF), as well as energy, mood, and social participation (SS-QOL). No intervention-related adverse events were reported. MRAS is an effective and safe adjunctive intervention to enhance emotion regulation and quality of life after stroke. Embedding mindfulness practices grounded in Buddhist tradition into stroke rehabilitation offers a holistic, culturally adaptable approach for neuropsychological services in Indonesia.

Hipertensi merupakan salah satu kondisi medis yang dapat menyebabkan berbagai komplikasi serius, seperti penyakit jantung koroner, stroke, dan gagal ginjal . Manajemen perawatan diri (self-care management) menjadi faktor penting dalam mengontrol tekanan darah pada penderita hipertensi . Self-care management mencakup regulasi diri, kepatuhan terhadap pengobatan, pemantauan tekanan darah, serta interaksi dengan tenaga medis . Penelitian ini menggunakan pendekatan kuantitatif dengan desain deskriptif korelasional dan metode cross-sectional . Sampel penelitian berjumlah 159 pasien hipertensi yang berobat di RS Islam Sultan Agung Semarang. Dari analisis univariat, mayoritas responden berada dalam rentang usia 45-59 tahun, berpendidikan terakhir SD, bekerja sebagai wiraswasta, serta memiliki tekanan darah tinggi selama rata-rata 3 tahun. Hasil analisis bivariat menunjukkan terdapat hubungan signifikan antara self-care management dan tekanan darah sistolik (p = 0,035) serta tekanan darah diastolik (p = 0,041) . Kesimpulannya terdapat hubungan antara self-care management dengan tekanan darah pada pasien hipertensi . Dengan meningkatkan self-care management, pasien dapat mengelola tekanan darah secara lebih efektif.

Hypertension or high blood pressure is a medical condition that can cause serious complications, such as stroke and heart disease. The causes of hypertension are very diverse, ranging from unhealthy diet, lack of physical activity, stress, to genetic factors. The phenomenon that occurs at the UPTD Menteng Palangka Raya Health Center, namely that there are still many families who have not carried out their role as the right family members and have not been able to overcome family health problems, for example, such as compliance with taking hypertension medication in family members who suffer from hypertension. The purpose of this study is to determine the relationship between family roles and medication adherence in family members with hypertension. This type of research is correlational using a cross-sectional  approach using a spearman rank statistical test. The sampling technique used in consecutive sampling at the Menteng Palangka Raya Health Center. Sampling in this study is based on the inclusion criteria set. Data collection in this study used questionnaires on family roles and medication adherence that had gone through validity and reliability tests with Cronbach's alpa for family role 0.89 and Cronbach's alpa for medication adherence 0.92. Based on statistical tests using  Spearman's rank , a correlation coefficient value of 0.812 with a significance value of <0.001 was obtained. It can be concluded that there is a significant relationship between the role of the family and medication compliance at the Menteng Palangka Raya Health Center. The relationship between family roles and medication adherence in family members with hypertension at the Menteng Palangka Raya Health Center.”

Based on data from the South Nias District Health Office, the number of hypertension cases at Bawomataluo Public Health Center increased steadily from 2022 to 2024. This condition posed a high risk of leading to severe complications such as heart disease, stroke, kidney failure, and damage to other organs. This study aimed to examine the factors influencing compliance with blood pressure control among hypertensive patients within the working area of Bawomataluo Public Health Center in the year 2025. This research employed a quantitative method using an analytic survey design with a cross-sectional approach. The population consisted of 185 individuals who had been diagnosed with hypertension over the past six months (from July to December 2024). A purposive sampling technique was used to select 127 participants. Data analysis included univariate, bivariate, and multivariate analyses. Using logistic regression with the forward method, the results showed that knowledge had a significance value of 0.002 with an Exp(B) of 5.680; family support had a significance value of 0.000 with an Exp(B) of 6.740; motivation had a significance value of 0.000 with an Exp(B) of 6.947; and self-confidence had a significance value of 0.001 with an Exp(B) of 5.706. Among these, motivation was identified as the most dominant factor due to having the highest odds ratio (Exp(B)). The findings indicated that knowledge, family support, motivation, and self-confidence significantly affected compliance with blood pressure control among hypertensive patients at Bawomataluo Public Health Center. Motivation emerged as the most influential factor. It was recommended that the health center actively provide support and encouragement to patients suffering from hypertension.

Patients admitted to the Intensive Care Unit (ICU) often experience physiological disturbances caused by both medical conditions and intensive treatment procedures. One of the most common problems encountered is sleep disturbance. Several factors contribute to poor sleep quality in ICU patients, including repeated medical procedures, environmental noise from medical equipment and staff activities, discomfort due to body positioning, frequent interactions with health workers, continuous exposure to lighting, pain, and the underlying disease process. Persistent sleep disturbances can delay the healing process, increase blood pressure, and even elevate the risk of stroke. This study aimed to analyze the relationship between anxiety levels and sleep quality in compos mentis patients in the ICU of Sultan Agung Islamic Hospital Semarang. The research design employed a correlational approach with a cross-sectional method. A total of 30 respondents were selected according to the inclusion criteria. Data were collected using the Pittsburgh Sleep Quality Index (PSQI) to measure sleep quality and the Hamilton Anxiety Rating Scale (HARS) to assess anxiety levels. The Chi-Square test was used for statistical analysis. The results showed an equal distribution of male and female respondents (15 each). Ten respondents had a post-laparotomy medical diagnosis, and the majority belonged to the late elderly age group (10 respondents). Most respondents experienced moderate anxiety (18 respondents), while poor sleep quality was reported by 17 respondents. The Chi-Square test revealed a p-value of 0.001, indicating a significant relationship between anxiety levels and sleep quality. In conclusion, higher anxiety levels were associated with poorer sleep quality among compos mentis patients in the ICU. These findings highlight the importance of nursing interventions that address both the physical and psychological aspects of patients to improve sleep quality and support recovery.

Breast cancer is the leading cause of death globally, following heart disease and stroke. One of the most commonly used treatments is chemotherapy, which offers various benefits but also causes physical and mental side effects. One of the psychological side effects often experienced is anxiety. Extreme fear and the threat of death from cancer can affect adherence to treatment. This study aims to assess the relationship between anxiety levels and medication adherence in breast cancer chemotherapy patients at RSUD Semarang. This research used a quantitative approach with a descriptive correlational method, involving 110 participant samples. The questionnaires used for data collection were DASS-42 to measure anxiety levels and MMAS-8 to assess medication adherence. The study was conducted from June 30 to July 31, 2025, in the Oncology Center room of RSUD Sultan Agung Semarang. Bivariate analysis using Pearson's correlation test showed a p-value of 0.001 < 0.05, indicating a significant relationship between anxiety levels and medication adherence in breast cancer chemotherapy patients. The measured correlation coefficient of -0.325** shows a moderately strong negative relationship, meaning that the higher the anxiety level, the lower the patient's adherence to medication. Based on these findings, it is recommended that nurses in the oncology unit provide additional education and support to patients regarding their anxiety. Effective psychological support can help patients reduce anxiety and increase adherence to treatment, which in turn can improve the outcomes of chemotherapy treatment.

Patients admitted to the Intensive Care Unit (ICU) frequently experience physiological disturbances that significantly affect their sleep quality. These disturbances are triggered by various factors, including repeated medical procedures, environmental noise, discomfort from medical devices, intensive interactions with healthcare workers, inappropriate lighting that disrupts circadian rhythms, pain, and the underlying disease process. Sleep disturbances in ICU patients may slow down the healing process, elevate blood pressure, trigger metabolic disorders, and increase the risk of serious complications such as stroke. This study aims to examine the relationship between anxiety levels and sleep quality among compos mentis patients in the ICU of Sultan Agung Islamic Hospital, Semarang. The research employed a correlational design with a cross-sectional method. A total of 30 respondents were included based on specific criteria. Anxiety levels were measured using the Hamilton Anxiety Rating Scale (HARS), while sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Data were analyzed using the Chi-Square test to determine the relationship between the two variables. The findings showed that the distribution of male and female respondents was balanced (15 respondents each). The most common medical diagnosis was post-laparotomy (10 respondents), with the dominant age category being late elderly (10 respondents). Anxiety levels were predominantly in the moderate category (18 respondents), while the majority of respondents demonstrated poor sleep quality (17 respondents). Statistical analysis revealed a p-value of 0.001, indicating a significant relationship between anxiety levels and sleep quality. In conclusion, the study highlights that higher levels of anxiety are associated with poorer sleep quality among compos mentis patients in the ICU. These findings emphasize the importance of nursing interventions aimed at reducing anxiety to improve patient sleep quality and support recovery.

Stroke adalah penyebab kematian nomor dua dan penyebab kecacatan di seluruh dunia. Salah satu cara yang dapat digunakan untuk mencegah stroke pada penderita hipertensi adalah dengan menemukan dan mengendalikan faktor risiko yang dapat dimodifikasi. Tujuan penelitian ini adalah untuk mengidentifikasi gambaran faktor risiko dan tingkat risiko stroke berdasarkan stroke risk score card pada penderita hipertensi di klinik romana tanjung anom tahun 2024. Penelitian ini menggunakan rancangan bersifat deskriptif . Metode pendekatan yang digunakan adalah cross sectional. Teknik pengambilan  sampel yang digunakan accidental sampling dengan jumlah responden penderita hipertensi sebanyak 98 orang. Instrument yang digunakan dalam penelitian ini adalah Stroke Risk Score Card. Hasil penelitian lebih dari setengah penderita hipertensi memiliki tingkat risiko stroke rendah 57 orang (58,2%). Faktor risiko stroke yang dimiliki penderita hipertensi berurutan dari faktor risiko terbanyak yaitu tekanan darah tinggi 66 orang (67,3%), pemalas / tidak pernah olahraga 56 orang (57,1%), hiperkolestrolemia 30 orang (30,6%), Overweight 30 orang (30,6%), atrial fibrilasi tidak teratur 11 orang (11,2%), perokok 9 orang (9,2%), riwayat diabetes mellitus 6 orang (6,1%), dan riwayat stroke dalam keluarga 5 orang (5,1%). Sebagian besar penderita hipertensi memiliki risiko rendah terkena stroke. Pencegahan primer merupakan upaya penting untuk mencegah stroke, sehingga dianjurkan untuk dilakukan secara rutin.

Magnetic Resonance Imaging (MRI) with Arterial Spin Labeling (ASL) is a non-invasive technique commonly used to assess cerebral perfusion, especially in stroke patients. However, ASL images often suffer from low contrast and high noise, which can hinder diagnostic accuracy in visualizing perfusion areas and detecting ischemic lesions. Image enhancement techniques, such as the unsharp mask, offer a potential solution to improve image quality. The effectiveness of this enhancement depends on the kernel size used in the unsharp mask filter. This study evaluates the impact of different kernel sizes (3×3, 5×5, and 7×7) on the quality of ASL brain images, focusing on both quantitative and qualitative improvements. A total of 63 ASL brain MRI images from stroke patients were processed using unsharp mask filters with the three kernel sizes. Quantitative analysis measured Signal-to-Noise Ratio (SNR) and Contrast-to-Noise Ratio (CNR), while qualitative assessment involved three radiologists independently evaluating five aspects of image quality: perfusion area clarity, grey-white matter contrast, ischemic lesion boundary visibility, noise level, and overall visual quality. Statistical tests, including Friedman and Wilcoxon, were applied to compare results across the kernel sizes. Results revealed that the 3×3 kernel achieved the best results in both quantitative and qualitative assessments, with the highest SNR, CNR, and visual quality scores. Significant differences (p < 0.05) were found between kernel sizes, confirming the superiority of the 3×3 kernel. The 7×7 kernel reduced noise but caused oversmoothing, negatively impacting image sharpness. In conclusion, the 3×3 kernel provides an optimal balance between noise reduction and edge preservation, enhancing ASL brain image quality for stroke diagnosis.

This Community Service Program is entitled "Health Education Services to Prevent Hypercholesterolemia in Students at the H. Nur Abdullah Al-Qur'an Memorization Islamic Boarding School." Hypercholesterolemia is a medical condition characterized by high blood cholesterol levels, which can increase the risk of heart disease and stroke. This disease can be prevented and managed with lifestyle changes and appropriate medication. The goal of this Community Service Program is to increase students' awareness and knowledge of hypercholesterolemia and provide education on effective prevention and management methods. This Community Service Program is conducted through health counseling, health checks, and education on healthy lifestyles. The target students in this study were students from the H. Nur Abdullah Al-Qur'an Memorization Islamic Boarding School. Prior to the counseling session, 50 students were given a pre-test questionnaire regarding their knowledge of hypercholesterolemia. After the counseling session, a post-test questionnaire on hypercholesterolemia was administered, which showed an increase in knowledge, as evidenced by the post-test results. Following the counseling and health examinations, the students targeted in this study, from the Nur Abdullah Al- Quran memorization Islamic boarding school, showed increased awareness and knowledge about hypercholesterolemia. Most participants also demonstrated healthier lifestyle changes, such as increasing fruit and vegetable consumption and engaging in regular physical activity. This Community Service Program (PKM) demonstrates that health education and counseling can increase the awareness and knowledge of hypercholesterolemia among the students targeted in this study, from the Nur Abdullah Al-Quran memorization Islamic boarding school. Therefore, the students targeted in this community service session, from the Nur Abdullah Al-Quran memorization Islamic boarding school, can effectively implement prev ention and management strategies to reduce the risk of heart disease and stroke.

Camshaft lift is an important parameter that determines the height of the valve lift, calculated from the valve position when it is completely closed to the fully open position. This component plays a crucial role in regulating the flow of the air and fuel mixture into the combustion chamber. This study aims to improve the performance of a 200cc 4-stroke motorcycle engine through camshaft lift modification, which is expected to affect the characteristics of engine torque and power. Modifications were carried out by designing two types of modified camshafts, namely series A and series B, as a comparison to the standard camshaft. The research method used is experimental testing using a dynamometer to measure engine torque and power at various speeds, ranging from 4,000 to 10,000 RPM. The data obtained were analyzed to determine the effect of each type of camshaft on engine performance. The test results show that the B series camshaft provides the most significant performance improvement compared to the standard and A series camshafts. At 7,500 RPM, the standard camshaft produces an average torque of 19.2 Nm, the A series camshaft 19.6 Nm, while the B series camshaft reaches 21.2 Nm. Meanwhile, at 10,000 RPM, the average power of the standard camshaft is recorded at 22.2 HP, the A series camshaft 24.1 HP, and the B series camshaft reaches 26.3 HP. This increase indicates that the camshaft lift modification is able to optimize the duration and height of the valve opening, so that the supply of the fuel and air mixture to the combustion chamber becomes more efficient. Thus, camshaft modification, especially the B series, is an effective and applicable solution in increasing the performance output of a 200cc motorcycle engine without having to make major changes to the overall engine structure.

Stem cells are unspecialized cells with the ability to self-renew over long periods of time without undergoing significant changes in their basic properties. The discovery of adult stem cells has revolutionized therapeutic and regenerative medicine and led to the development of new therapies for previously untreatable terminal conditions. Hematopoietic stem cell transplantation was the first example of successful stem cell therapy and has been widely used in the treatment of a variety of diseases, including leukemia, adult T-cell lymphoma, and multiple myeloma. Meanwhile, autologous mesenchymal stem cell transplantation is increasingly being used to repair mesenchymal tissues and other organs such as the lung and heart, and has shown promise in the treatment of stroke, multiple sclerosis, and diabetes. Interest in the therapeutic potential of other adult stem cells including neural, mammary, intestinal, inner ear, and testicular stem cells is also growing. The discovery of induced pluripotent stem cells has opened new insights into the epigenetic mechanisms underlying pluripotency and carcinogenesis. This study employed a qualitative approach with a literature review method, aiming to conduct an in-depth review of the scientific literature related to the development of stem cell therapy and its epigenetic implications. Through a systematic analysis of various academic sources, this study seeks to formulate a comprehensive conceptual understanding and identify future directions for safer and more targeted stem cell therapy development.