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Collecting donations for natural disaster victims is a form of social solidarity widely practiced by the community, including students. However, in practice, these fundraising activities must be carried out in accordance with applicable legal provisions, specifically Regulation of the Minister of Social Affairs of the Republic of Indonesia Number 8 of 2021 concerning the Implementation of the Collection of Money or Goods (PUB). This study aims to analyze the implementation of Ministerial Regulation Number 8 of 2021 in the practice of collecting donations for natural disasters by students. The research method used is a normative empirical research method with a legislative and sociological approach. Data were obtained through literature review and interviews with the Social Services Agency and student organizations. The results show that the implementation of Ministerial Regulation Number 8 of 2021 in student fundraising activities has actually taken place, but is not yet fully optimal. This is evident in the continued discovery of donation collections carried out without official permits from authorized agencies and the lack of accountability reporting for collected funds. This condition indicates that the level of compliance with administrative provisions in the implementation of fundraising is still relatively low. Therefore, increased regulatory dissemination, more effective oversight, and increased legal awareness among students are needed to ensure that fundraising activities are carried out transparently, accountably, and in accordance with applicable laws.

This study aims to examine the influence of tax awareness, tax knowledge, and tax morale on the level of individual taxpayer compliance. Income tax plays a strategic role as the primary source of financing for government expenditures in supporting national development. However, the level of taxpayer compliance in submitting Annual Tax Returns (SPT) continues to show a downward trend over time. This condition indicates a problem with compliance behavior influenced by various internal factors within taxpayers. Therefore, government efforts are needed to increase tax awareness, expand tax knowledge, and strengthen tax morale among the public. This study uses a quantitative descriptive approach with a random sampling technique. The research sample consisted of 30 individual taxpayers registered at the Kediri Pratama Tax Service Office (KPP Pratama). Data were analyzed using descriptive statistics, classical assumption tests, and hypothesis testing with the help of SPSS software. The results show that tax awareness, tax knowledge, and tax morale have a positive and significant effect on taxpayer compliance, both partially and simultaneously.

This study aims to examine the quality of public services at the Population and Civil Registration Office (Disdukcapil) of Pohuwato Regency using the SERVQUAL model, which comprises five dimensions: Tangibles, Reliability, Responsiveness, Assurance, and Empathy. This research was conducted in response to persistent public complaints regarding slow service processes, long queues, limited facilities and infrastructure, network disruptions, as well as insufficient information and uncertainty concerning service completion time. The study employed a descriptive qualitative approach through observation, interviews with Disdukcapil employees and community members, and documentation. The findings indicate that the quality of public services has not yet been optimal. The Tangibles dimension remains weak due to inadequate service facilities. Reliability has not been fully achieved as a result of delays in document issuance and system disruptions. Responsiveness among service officers is inconsistent in addressing public complaints. In terms of Assurance, officers demonstrate adequate professionalism; however, transparency in procedures and service timelines remains inconsistent. Meanwhile, in the Empathy dimension, attention to the community particularly vulnerable groups still needs improvement. Overall, the public services provided by Disdukcapil Pohuwato have not fully met community expectations and require improvements in facilities, staff competence, and the effectiveness of service systems.

This article examines the typology and classification of regional government apparatus in Indonesia by analyzing their structure and functions within local governance. The study draws on recent theoretical literature (2020–2025) and legal frameworks to map how different types of regional apparatus such as executive agencies (“dinas”), supporting agencies (“badan daerah”), secretariat, inspectorate, and territorial units are organized and classified. Using a normative-juridical and conceptual approach, the paper reviews relevant laws, regulations, and academic studies to identify patterns of structural typology and functional differentiation within local governments. The findings reveal that many local governments still apply structural-heavy models rather than functionally tailored organizations, leading to excessive bureaucracy and inefficiency. The analysis suggests that a clearer classification aligned with functional roles can improve governance effectiveness and administrative efficiency. The article concludes by recommending that local governments re-evaluate their organizational structures to better reflect the functional needs of governance, rather than merely replicate structural models.                                                               

This study aims to analyze the implementation of four principles of Good Governance in an effort to improve the quality of public services at the Archives and Library Service of Gorontalo Province. The method used in this study is a descriptive research method with a qualitative approach, involving various stakeholders in the process. The results of the study indicate that the implementation of the principles of Good Governance in the Archives and Library Service of Gorontalo Province has been running well. Accountability is reflected through standard operating procedures (SOPs), effective supervision, information disclosure, and active public participation, while transparency is supported by the iArpus application and the SAKTI Card program, which allow for more accessible public access. The principle of the rule of law is consistently applied through regulations, personnel regulations, and the latest Governor's Regulation, ensuring that services become orderly and directed. Although follow-up to public input still needs to be accelerated, overall, the service demonstrates a strong commitment to professional, modern, and responsible public services.

Warfarin (commonly known by its trade name, Coumadin) is an oral anticoagulant that has been widely used for the prevention and treatment of thromboembolic disorders. Despite its clinical benefits, warfarin therapy is complicated by a very narrow therapeutic index and wide inter-individual variability in dose requirements. This variability represents a major challenge for clinicians, as inappropriate dosing may lead to serious adverse outcomes such as bleeding or thrombotic events. A growing body of evidence suggests that genetic polymorphisms are among the most important factors contributing to this variability, particularly those involving the Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) gene. VKORC1 encodes a key enzyme that functions as a bottleneck in the vitamin K cycle, playing an essential role in the regeneration of reduced vitamin K (VKH). This active form of vitamin K is required for the γ-carboxylation of vitamin K–dependent clotting factors, including prothrombin and other coagulation proteins. Polymorphisms within VKORC1 can significantly alter the enzyme’s expression and activity, thereby modifying an individual’s sensitivity to warfarin. One of the most clinically relevant variants is the -1639G>A (rs9923231) polymorphism, which reduces VKORC1 transcription and subsequently decreases enzyme activity. Patients carrying the A allele often exhibit increased sensitivity to warfarin and therefore require lower maintenance doses compared to those with the G allele. Understanding these genetic influences not only improves our knowledge of warfarin pharmacogenomics but also highlights the importance of personalized medicine in anticoagulant therapy. Incorporating VKORC1 genotyping into clinical practice could optimize dose prediction, minimize adverse events, and enhance the safety and effectiveness of warfarin therapy. This narrative review aims to provide an in-depth discussion of the complex role of VKORC1 in vitamin K metabolism and its impact on warfarin sensitivity, thereby underscoring the critical relevance of genetic factors in guiding individualized anticoagulation therapy.

Several of the best-selling small-molecule medications and natural alkaloids contain piperidine, a crucial saturated heterocyclic scaffold with a wide variety of biological functions. The hydrazide-hydrazone moiety's exceptional use in the pharmacological and biological domains made it particularly appealing. Objective: Designing and synthesizing a novel set of 4-Piperidin-1-yl-benzoic acid substituted hydrazides, Ac1-c3 and Bc1-c5, as potentially antimicrobial agents and characterizing them using IR, 1H-NMR, and mass spectroscopy. Methods: By esterifying 4- Piperidin-1-yl-benzoic acid Ac1 and then treating with hydrazine hydrate it to produce Ac3 in a good yield. The hydrazide Ac3 was condensed with the proper aldehydes or ketone to synthesis the hydrazones Bc1–c5. The in vitro bacterial activity was evaluated anti two Gram-negative bacteria, Pseudomonas aeruginosa, and Candida albicans, as well as two Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis. Results: The majority of tested compounds demonstrated significant efficacy anti Pseudomonas aeruginosa, Candida albicans. Notably, compound Bc3 emerged as the most effective derivative within the series. Conclusions: The Compounds (Bc1–c4) that were synthesized demonstrated moderate to good antimicrobial activity against a number of bacterias species and Candida albicans.

Catcalling or verbal sexual harassment is a social phenomenon that is rampant in Indonesia. It involves unwanted sexualized remarks that dehumanize the victim and can have a psychological impact. Although Law Number 12 of 2022 on Criminal Acts of Sexual Violence (UU TPKS) has regulated non-physical sexual harassment in Article 5, its application in the field still faces various obstacles. This study aims to determine the legal formulation of the application of sanctions against perpetrators of verbal sexual harassment (catcalling). This research uses an empirical normative approach. The results show that the legal formulation of the application of sanctions against perpetrators of verbal sexual harassment has progressed with explicit regulation in Article 5 of Law Number 12 of 2022 concerning Criminal Acts of Sexual Violence (TPKS Law). To realize substantive and effective justice, it is necessary to improve the formulation of sanctions, integrate non-criminal sanctions, increase the capacity of law enforcers, and strengthen public education.

The provision of sustenance (nafaqah) is a crucial aspect of family life that is strongly emphasized in Islamic teachings. This study aims to explore the urgency of nafaqah through a thematic approach to authentic (ṣaḥīḥ) hadiths that address the obligation of financial support, viewed from legal, ethical, and social perspectives. Using the maudhū‘ī (thematic) method, this research collects and analyzes ṣaḥīḥ hadiths from major compilations such as Ṣaḥīḥ al-Bukhārī and Ṣaḥīḥ Muslim to gain a comprehensive understanding of Islamic principles regarding nafaqah. The findings reveal that providing sustenance is not only a legal duty of the husband, but also a sign of faith, compassion, and a means of maintaining social stability. This study highlights the importance of a proper understanding of nafaqah in Islam as a foundation for building a harmonious and God-pleasing family.

This article aims to know and analyze efforts to reconstruct the principle of legal certainty which is the object of the case in the Ethics Court of the Ethics Council of the Election Organizer in Indonesia. This research uses normative legal research methods or doctrinal legal research. This article shows that there is legal uncertainty in the regulation of the Ethics Council of Election Organizers. Therefore, this article provides recommendations for specific arrangements regarding legal certainty that become material elements of the case that can be submitted to the Honorary Council of Election Organizers.

This study aims to determine the types of fish caught by the local community of Es Wambi village and how the local community of Es Wambi village utilizes the fish caught. The study was conducted from May to July 2024, in Es Wambi village, Okaba District, Merauke Regency. The sampling technique used in this study was non-probability sampling. Data collection techniques used observation, interview, and questionnaire techniques. The results of the study found that the types of fish caught by the local community consisted of 11 types from sea waters and 4 types from fresh waters. Types of fish from sea waters are; stingray (Dasyatis sp), ribbonfish (Trisiulus savala), kuro fish (Eleutheronema tetradactylum), bulanak fish (Mugil chepalus), gulama fish (Jhonius sp), snapper (Lates calcarifer), glass fish (Kurtus guliferi), bambit fish (Selenotoca sp), thorn fish (Chinetodus sp), julung-julung fish (Strongylura-strongylura) and tongue fish (Cynoglassus lingua). Meanwhile, the fish caught from fresh waters are; tilapia (Oreochromis mossambicus), betik fish (Anabas Testudineus), snakehead fish (Chana striata) and tilapia (Oreochromis niloticus). The utilization of fish caught by local people based on observation results is grouped into 3 parts, namely used as consumption fish, sold fresh and processed into salted fish.  

iNKT cells, sometimes known as the immune system's "Swiss Army knife," have become key components of cancer vaccination treatments. Glycolipids that activate iNKT cells, including α-galactosylceramide (αGalCer), have been used to create self-adjuvanting anti-tumor vaccinations and can boost the immune response to co-delivered cancer antigens. The chemicals synthesis of ganglioside antigens, specifically (Neu5Gc) GM3 and GM3 antigen, and conjugations to αGalCer, and packaging into liposome as effective platforms for their in vivo deliverying are the main topics of this work. In mouse and human cell experiments, liposome containing, (Neu5Gc) GM3-αGalCer, GM3-αGalCer, and equimolar quantities of conjugates have thoroughly described and their capacities to activate iNKT cell has verified ex vivo. All subclasses of IgG antibodies were produced as a result of the candidates' potential to generate both TH1 and TH2 cytokines, according to in vivo immunization tests. Interestingly, this study shows serum antibody produced against the TACA were cross-reactive, both when they were produced separately and together. If tumor-selective antigens is selected, the ensuing antibodies response can be wider than expected, which has implications for future vaccine formulations.

This research aims to analyze the optimization of the issuance of electronic land certificates in Gorontalo City and find out the efforts of the government (BPN) Gorontalo City in optimizing the issuance of electronic land certificates. This type of research is empirical legal research. This method involves a juridical sociological approach, namely an approach that starts from existing legal rules or norms and then harmonizes with the reality that exists in society. The results of this study indicate that the issuance of electronic land certificates (E-Certificate) in Gorontalo city is considered not optimal. Researchers found that there are 3 out of 4 indicators that have not been maximized in its implementation, namely the readiness of land office infrastructure, policy implementation, and public understanding. Furthermore, the efforts that have been made by BPN Gorontalo City in optimizing the issuance of electronic land certificates are conducting Socialization and Education to the Public, Improving Information Technology Infrastructure, Cooperation with Stakeholders, Increasing Human Resources Capacity and Resolving Obstacles and Constraints.

Early marriage is a crucial issue in Indonesia, including in Tombolikat Village, which is often not registered at the Office of Religious Affairs (KUA). This study aims to identify the process of early marriage in Tombolikat Village and analyze the legal implications of unregistered early marriages. The research method used is empirical legal research with a qualitative approach. The results showed that early marriage in Tombolikat Village is still prevalent due to social, economic and cultural factors. Marriage that is not registered with the KUA results in no legal protection for the parties involved, especially women and children. The legal implications include difficulties in managing children's birth certificates, inheritance rights, and the potential for domestic violence without adequate access to legal protection. More intensive outreach and collaboration between village governments, religious leaders, and the community are needed to reduce the rate of early marriage and ensure that every marriage is officially recorded for legal certainty and protection of citizens' rights.

Urinary incontinence occurs when a person's urine leaks unknowingly or unintentionally. Urinary incontinence varies in the form of urine excretion which is sometimes only a few drops or vice versa it is really a lot. One way to prevent urinary incontinence is to treat it, and doing Kegel exercises is one way to deal with it. (Sangga, M.W, R.C Choeron & Y Rosdiana, 2021). This community service activity aims to increase the knowledge of the elderly about urinary incontinence and how to overcome the problem of urinary incontinence. This community service activity uses the lecture method, and questions and answers and kegel gymnastics exercises. The lecture method was carried out by delivering material about urinary incontinence, the question and answer method was carried out by asking participants about the material that had been presented and doing kegel exercises in the elderly. The results of this community service activity were obtained that participants were able to understand and apply the material that had been delivered and perform kegel exercises independently. Based on the community service activities that have been carried out, the elderly are enthusiastic about accepting the entire series of activities ranging from the percentage of material delivery to the implementation of service running with Lanca, the elderly are very active in asking and answering questions and actively participating in kegel gymnastics training.

Abstrak. Kualitas ekonomi di negara-negara Asia dipengaruhi oleh berbagai faktor sosial, keamanan, dan lingkungan yang kompleks. Penelitian ini menggunakan Generalized Linear Models (GLM), yaitu regresi Poisson dan Binomial Negatif, untuk menganalisis hubungan antara variabel-variabel seperti Governance, Social Capital, Safety and Security, Living Conditions, Education, dan Natural Environment terhadap tingkat kualitas ekonomi. Hasil analisis menunjukkan bahwa model Poisson menghadapi keterbatasan karena adanya overdispersion, yang tercermin dari nilai AIC yang tidak terdefinisi dan residual deviance yang relatif tinggi. Sebaliknya, model Binomial Negatif lebih efektif dalam menangani data dengan variansi lebih besar dari rata-rata, menghasilkan nilai residual deviance yang lebih rendah dan AIC yang lebih baik. Dalam model Binomial Negatif, variabel Social Capital terbukti signifikan dengan koefisien yang menunjukkan pengaruh positif terhadap kualitas ekonomi. Penelitian ini menegaskan bahwa model Binomial Negatif lebih cocok untuk memodelkan data kualitas ekonomi di kawasan Asia, dengan Social Capital sebagai variabel yang paling berpengaruh, yang akan memberikan wawasan yang berguna bagi pengambilan kebijakan untuk meningkatkan kualitas ekonomi di kawasan ini.

This research aims to analyze the impact of promotions on interest in studying at Ichsan University, Gorontalo. As Competition in Higher Education Continues to Increase, Effective Support Strategies Are Key to Attracting Prospective Students. The method used in this research is a questionnaire survey distributed to new students entering Ich San Gorontalo University. The data obtained were analyzed using simple regression analysis techniques and statistical tests to determine the relationship between promotion variables and interest in studying. Research results show that UIG promotions carried out through social media are very effective in attracting the attention of prospective students. The most widely used media are Instagram and flyers/brochures which are proven to be more effective than other platforms. However, there is a need to increase the effectiveness of advertising, especially in relation to the relevance of the information conveyed.  UIG Can Significantly Increase Applicant Interest by Improving Advertising Content to Match the Needs of Prospective Students

Due to the quick advancement of digital technology, online purchasing and selling has become easier. Online transactions do, however, come with a number of drawbacks, including fraud, mismatches between products and their descriptions, and privacy violations. With reference to Law Number 8 of 1999 on Consumer Protection, the purpose of this study is to examine the legal safeguards that Indonesian consumers have when making purchases online. The study's results, which were obtained using a normative juridical research methodology with an emphasis on statutory regulatory analysis, indicate that while the Consumer Protection Law creates a basic legal framework, more oversight and regulations are necessary to ensure its greater efficacy when applied in the digital sphere.

Persimpangan merupakan simpul dalam jaringan transportasi dimana duaatau lebih ruas jalan bertemu dan pada simpang inilah terdapat potensi konflik lalulintas yang mungkin akan terjadi. Terutama pada simpang empat bersinyal Hangtuah kota Tegal, dimana salah satu upaya untuk mengurangi konflik lalu lintas dengan melakukan pengaturan ulang waktu siklus dan fase pada simpang. Simpang diberi pengaturan APILL bertujuan untuk menghindari terjadinya konflik lalu lintas sehingga dapat meningkatkan keselamatan, dan sebagai upaya untuk mempertahankan kapasitas jalan. Metode yang digunakan dalam analisis kinerja simpang adalah menggunakan  perhitungan menggunakan MKJI dan software PTV VISSIM.Sedangkan untuk analisis konflik lalu lintas dengan melakukan pengamatan langsung dan dibandingkan dengan software SSAM untuk mengetahui jumlah konflik yang terjadi. Langkah selanjutnya yaitu dengan memberikan rekomendasi penanganan dari permasalahan konflik lalu lintas dengan menggunakan softwarePTV VISSIM.

This Project Focuses On The Disinfection Of Surfaces And Items From Microorganisms, Particularly COVID-19, Using Ultraviolet Radiation. UV Germicidal Irradiation, Particularly In The 200-280 Nm Range, Is Highly Effective In Killing Many Microorganisms. To Test Klebsiella, Two Designs Were Constructed Using Canadian UV Leds And Chinese UV LEDS. The Results Showed Successful Disinfection With A High Microorganism Killed Ratio. The Chinese Design Had The Highest Disinfection Percentage Ratio Of 69.24%, While The Canadian Design Achieved 89.66%. Although The Canadian Design Is More Expensive, It Shows Excellent Results And Is Worth The Cost.