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Based on the 2023 Indonesian Health Survey, the prevalence of overweight among adults reached 23.4% nationally and 24.5% in East Java Province. This condition highlights the need for food innovation, particularly high-fiber snacks suitable for overweight adults. This study aimed to develop cereal based on okara (soy pulp) flour and mung bean flour as an alternative high-fiber food product. Organoleptic testing was conducted on 30 semi-trained panelists evaluating color, aroma, texture, and taste using hedonic and hedonic quality tests. Data were analyzed using the Kruskal–Wallis test followed by the Mann–Whitney test, while nutrient content analysis was analyzed using One Way ANOVA followed by Duncan’s post hoc test. The results showed that in the hedonic test, color, texture, and taste parameters were significantly different (p<0.05), while aroma was not significantly different (p>0.05). In the hedonic quality test, color and taste showed significant differences (p<0.05), whereas aroma and texture did not (p>0.05). Overall, formulation 922 was the most preferred by panelists. The nutritional content of the cereal ranged from 407–410 kcal for energy, 76.44–77.53% carbohydrates, 8.91–9.66% protein, 6.80–7.30% fat, 5.20–5.51% moisture, 1.26–1.41% ash, and 9.72–10.90% total dietary fiber. The developed cereal is classified as a high-fiber food and has potential as a healthy snack for overweight adults.

Soybean is an important food commodity in Indonesia because it is the main raw material for tofu and tempeh, two major protein sources widely consumed by the population. However, domestic soybean production remains far below national demand resulting in heavy dependence on imports. In contrast maize is increasingly preferred by farmers due to its higher productivity and a more stable economic value. Therefore, maize–soybean intercropping has emerged as a promising strategy to improve land-use efficiency while increasing soybean production without reducing maize cultivation. This study systematically mapped and synthesized maize–soybean intercropping research in Indonesia and conducted a meta-analysis of Land Equivalent Ratio LER values reported across studies. Literature searches using Scopus, Web of Science, and Google Scholar identified 179 eligible publications published between 1978 and 2023. Most studies focused on agronomic factors such as variety selection spacing arrangement and fertilizer management. Meta-analysis showed average LER values of 1.47 ± 0.046 for maize–soybean intercropping and 1.36 ± 0.081 for maize–mung bean intercropping indicating advantages over monoculture systems. However, inconsistencies in methodology and reporting standards limited study comparability and sustainability assessments. Future research should integrate ecological, social, and long-term economic indicators alongside standardized reporting frameworks to strengthen evidence-based intercropping recommendations nationally for sustainable agriculture.

Health issues among the elderly are often related to declining bodily functions, digestive disorders, and specific nutritional needs for easily digestible foods. The 60-and-older age group is at high risk for gastrointestinal disorders due to low fiber intake. Therefore, alternative foods are needed that are soft in texture, neutral in taste, safe, and nutritious. One potential solution is the development of food products based on tempeh gembus with the addition of banana hearts, which are rich in fiber, soft in texture, and readily available. This study employed an experimental method using a Completely Randomized Design (CRD) to test three formulation variations (F1, F2, F3). The nutritional content of formulation F1 includes energy 111.575 kcal, carbohydrates 20.185 g, protein 6.91 g, fat 0.355 g, and fiber 6.67 g. Formula F2 contains 88.225 kcal of energy, 14.095 g of carbohydrates, 7.72 g of protein, 0.205 g of fat, 7.3 g of fiber, and 0.0015% flavonoids. Formula F3 has 107.015 kcal of energy, 7.995 g of protein, 0.295 g of fat, 6.88 g of fiber, and 0.0021% flavonoids. In conclusion, the best tempeh with added banana hearts is Formula F2, with its nutritional content, fiber, flavonoids, and BAL >10⁸ CFU/g, which has the potential to serve as a functional food and probiotic source to help improve digestive health in the elderly. Further testing is recommended directly on elderly groups, along with product shelf-life testing.

This study examines changes in nutritional knowledge, dietary patterns, nutrient intake, and food acculturation among first-year migrant and non-migrant students. A 5 months prospective cohort design was employed involving 32 students from the Faculty of Public Health, Universitas Airlangga. Students were randomly divided equally into migrant and non-migrant groups. Data were collected using questionnaires, food frequency questionnaires, 3×24-hour food recall, and analyzed using descriptive and inferential statistics. The findings indicated no significant differences or changes in nutritional knowledge between groups throughout the observation period (p > 0.05). However, dietary patterns varied, with migrant students showing increased consumption of practical and fast foods. Nutrient intake, particularly energy and protein, was initially lower among migrant students but improved significantly over time, reflecting adaptation to a new environment. Food acculturation was evident among migrant students, with a significant increase in scores during the study period (p = 0.007), indicating gradual adjustment to local eating habits. These results highlight the influence of environmental adaptation on students’ dietary behavior and emphasize the need for targeted nutrition interventions to promote healthy eating habits during the early university transition.

Cervical cancer is one of the most common cancers worldwide and is largely caused by Human Papillomavirus (HPV) infection, particularly types 16 and 18. The development of this cancer is influenced by the E6 and E7 oncoproteins, which disrupt the function of p53 and Rb proteins, as well as the involvement of cellular signaling pathways such as PI3K/AKT/mTOR and EGFR. Limitations of conventional therapies, such as resistance and side effects, drive the need for more targeted and selective therapeutic agents. This study aims to analyze the main molecular targets of cervical cancer and the medicinal chemistry approaches used in its therapeutic development. The method involved a review of 12 open access articles using molecular docking, molecular dynamics, QSAR, and network pharmacology approaches. The findings identified two main target groups: viral targets comprising the HPV E6 and E7 oncoproteins, and cellular targets including the PI3K/AKT/mTOR pathway, EGFR, PARP1, CDK1, and VEGFR. Various medicinal chemistry strategies, from structure-based and ligand-based drug design to multi-target network pharmacology approaches, proved effective in identifying potential inhibitor candidates. Bioactive compounds such as quercetin, gossypol, bixin, and rutin demonstrated stable interactions with these targets. However, further experimental validation is needed to support the development of clinically effective and safe therapies.

Preeclampsia remains a major contributor to maternal morbidity and mortality, particularly in developing countries such as Indonesia. Early detection and integrated management at the primary healthcare level are essential to prevent disease progression and improve maternal outcomes.  Modifiable risk factors such as maternal obesity, inadequate calcium intake, and poor clinical management contribute significantly to disease progression (WHO, 2021; Zhang et al., 2020). This study aimed to evaluate the effectiveness of an Integrated Maternal Health Model (IMHM) combining risk assessment, nutritional intervention, and clinical management for early prevention and control of preeclampsia in primary healthcare settings. A quasi-experimental cohort study was conducted among 104 pregnant women, consisting of 52 preeclamptic and 52 normotensive participants in community health centers in Medan, Indonesia. Data were collected across four antenatal visits, including blood pressure measurements, proteinuria (dipstick), calcium intake, supplementation adherence, and antihypertensive therapy. Statistical analyses included bivariate and longitudinal tests. The results showed that maternal obesity, history of preeclampsia, and hypertension were significant risk factors. Adequate calcium intake demonstrated a protective effect against preeclampsia (p < 0.05), consistent with recent evidence indicating that calcium supplementation can reduce the risk of preeclampsia by up to 49%. However, calcium supplementation did not significantly influence blood pressure among normotensive pregnant women. Antihypertensive therapy, particularly intensive nifedipine regimens, showed significant differences in blood pressure patterns across visits (p < 0.05). In addition, proteinuria levels significantly decreased over time (p < 0.001), indicating improvement in renal function. In conclusion, the IMHM is effective in improving maternal outcomes through a multi-component approach integrating clinical, nutritional, and monitoring strategies. This model provides a practical and scalable framework for early prevention and management of preeclampsia in primary healthcare settings.

Nitrogen is an essential element for soybean growth, particularly in the formation of vegetative organs and seed protein. The nitrogen requirement of soybean plants varies according to their growth stages. This study aimed to quantify nitrogen levels in soil and plant tissues of Anjasmoro soybean variety over a 13-week cultivation period. Observations were conducted weekly by collecting soil and plant samples from three randomly selected polybags. Nitrogen analysis was performed using a colorimetric Kjeldahl method. The results showed that nitrogen supply was obtained not only from soil media and fertilizers, but also from biological nitrogen fixation facilitated by symbiotic microbes forming root nodules as well as non-symbiotic soil microbes. The lowest total soil nitrogen content was recorded at 0 weeks after planting (WAP) at 0.20%, while the highest was observed at 7 WAP at 0.82%. The lowest total nitrogen content in plant tissue occurred at 8 WAP at 1.80%, whereas the highest was recorded at 4 WAP at 8.07%. Soybean plants experienced etiolation due to suboptimal light intensity, resulting in a vegetative phase that was prolonged by two weeks. Nitrogen uptake during this extended vegetative period reached 4.6%. The average total nitrogen absorbed by the plants during cultivation was 2.881 g per plant, while total nitrogen accumulation in the system increased by 26.285 g per plant.

Granola bar is an instant snack product in the form of a bar that has high nutritional value and generally commercial products use imported ingredients such as oats and almonds, but can be developed using local food ingredients such as Job's Tears seeds and walnuts that have high nutritional content such as carbohydrates, protein, fiber, fat, and antioxidants. This study aims to obtain the ratio of Job's Tears seeds and walnuts to produce granola bars with the best physicochemical and organoleptic characteristics. The method used is a Randomized Block Design (RBD) with one treatment factor in the form of the ratio of Job's Tears seeds and walnuts (100:0, 80:20, 70:30, 60:40, and 50:50) with five replications to obtain 25 experimental units. Data were analyzed using Analysis of Variance (ANOVA) and Honestly Significant Difference (HSD) test. The results showed that the ratio of Job's Tears seeds and walnuts significantly affected the levels of fat, protein, carbohydrate, total calories, as well as organoleptic attributes including taste, aroma, texture, and overall preference. This research contributes to efforts Granola bar is an instant snack product in the form of a bar that has high nutritional value and generally commercial products use imported ingredients such as oats and almonds, but can be developed using local food ingredients such as Job's Tears seeds and walnuts that have high nutritional content such as carbohydrates, protein, fiber, fat, and antioxidants. This study aims to obtain the ratio of Job's Tears seeds and walnuts to produce granola bars with the best physicochemical and organoleptic characteristics. The method used is a Randomized Block Design (RBD) with one treatment factor in the form of the ratio of Job's Tears seeds and walnuts (100:0, 80:20, 70:30, 60:40, and 50:50) with five replications to obtain 25 experimental units. Data were analyzed using Analysis of Variance (ANOVA) and Honestly Significant Difference (HSD) test. The results showed that the ratio of Job's Tears seeds and walnuts significantly affected the levels of fat, protein, carbohydrate, total calories, as well as organoleptic attributes including taste, aroma, texture, and overall preference. This research contributes to efforts to diversify local Indonesian food as raw materials for highly nutritious functional food products diversify local Indonesian food as raw materials for highly nutritious functional food products.

As an agricultural country, Indonesia is able to meet the demand for animal protein in the form of meat. Pigs are a potential business opportunity for some people because they are a promising livestock business. The study aims to determine the characteristics of livestock farmers and preferences for pig livestock in Tasinifu Village, Mutis District, North Central Timor Regency. This study was designed using a survey method. The technique for determining the research location used a purposive technique (intentionally) because Tasinifu Village is a village that has the highest pig population in Mutis District, TTU Regency. Data analysis was done using a quantitative descriptive method. The results of the study showed that livestock farmers were aged 18-40 years (31.67%), female farmers (55%), the highest level of education was elementary school (61.67%), the highest number of family dependents was 4-6 people (23.33%), livestock experience was 2-10 years (95%), dominant livestock ownership was 2-5 pigs with the majority of farmers working as farmers (97%), with land area owned 0-025/ha (66.67%). Pigs aged 5-7 months (41.67%), the most commonly raised breed is the Timor pig (75%), with female Calamine (58.33%), black skin (55%), and medium body weight (80%). The livestock raising sistem is intensive (80%), and the use of feed and agricultural waste (62%).

This study aims to evaluate the growth performance of KUB chickens fed with a combination of fermented agricultural waste, specifically Maggot BSF (Hermetia illucens) and Azolla microphylla. A total of 96 KUB chickens aged 30 days were used in a Completely Randomized Design (CRD) with four treatments and four replications. The treatments consisted of a basal diet substituted with the fermented waste combination at levels of 0% (P0), 5% (P1), 10% (P2), and 15% (P3). Parameters observed included feed consumption, body weight gain (BWG), and Feed Conversion Ratio (FCR). The results showed that increasing the level of waste substitution significantly affected feed consumption due to the bulky nature of the fiber, yet body weight gain remained stable across all treatments. The FCR values ranging from 3.21 to 3.25 indicated that the high-quality protein from Maggot BSF effectively compensated for the reduced feed intake. It is concluded that the substitution of fermented agricultural waste up to 15% (P3) is an optimal and efficient formulation to maintain the growth performance of KUB chickens.

Biofloc technology is a super-intensive fish cultivation method, which benefits heterotrophic bacteria to harvest organic chemical compounds and amines from fish metabolic residues to be converted into bacterial proteins. The use of probiotics is very important to be carried out in cultivation activities, Probiotics are living microorganisms that have a beneficial effect on humans by balancing the microflora in their intestines. The bacteria in probiotics have a mechanism in forming several enzymes for feed digestion. This study aims to determine the effect of administering Pro Top probiotics with different doses on the absolute weight growth of tilapia (Oreochromis niloticus). Probiotics are mixed with feed with a biofloc cultivation system. The method used in this study is an experimental method with a Completely Randomized Design (CRD) with 4 treatments and 6 replications, namely by adding different doses to the treatment. Treatment A (0.5 grams / kg), B (1 gram / kg), C (2 grams / kg) and D (5 grams / kg). The parameters observed are absolute weight growth. Supporting parameters for air quality are temperature, pH, and DO. Data were analyzed using the ANOVA test. Based on the results of the study, it shows that administering different doses of Pro Top probiotics has a significant effect on the absolute weight growth of tilapia (Oreochromis niloticus). Treatment A (0.5 grams/kg) gave the lowest absolute weight growth of 31.05 grams and treatment D (5 grams/kg) gave the highest absolute weight growth of 40.30 grams. Air quality parameters including air temperature ranged from 25.3 – 26.1°C, acidity level around 7.5 – 8.0. And dissolved oxygen ranged from 4.7 – 5.3 ppm. The results of the analysis of variance (ANOVA) of the three air quality parameters showed no difference between the treatments of tilapia (Oreochromis niloticus).  

Chronic Energy Deficiency (CED) in pregnant women remains a health problem in Indonesia, including in Sleman District. CED can be overcome through the provision of supplementary foods (PMT) based on local foods that are high in energy and protein. This study aims to determine the effectiveness of local PMT on upper arm circumference (UAC) in pregnant women with CED. The study design used an analytical observational approach with a cross-sectional approach. The sampling technique used in this study was total sampling, involving 47 pregnant women with CEM who received local PMT for at least 90 days in 2024 at the Cangkringan and Sleman Community Health Centers. The secondary data in this study were the results of LILA measurements before and after the provision of local PMT. The Wilcoxon Signed Test was used to analyze the difference in LILA. The results showed that the median LILA before PMT administration was 22 cm and after PMT administration was 23.6 cm, with an increase of 1.6 cm. There was a significant difference between LILA before and after local PMT administration (p = 0.000). After local PMT administration, 51.06% of pregnant women had LILA > 23.5 cm. It is hoped that further research can explore the intake of pregnant women with KEK during local PMT administration as additional data to examine the effectiveness of local PMT on LILA in pregnant women with KEK.

Vaname shrimp (Litopenaeus vannamei) has a fast growth rate, good tolerance to a wide range of salinity and temperature, and resistance to several common shrimp diseases. Vaname shrimp has an efficient feed conversion making it more economical to cultivate, and its international market demand is high. The research method used four treatments of fermented soybean meal doses, namely 0% (control), 15%, 25%, and 35%, each with 3 replications. The feed was formulated using Pearson’s Square method targeting 35% protein, and the soybean meal was fermented using tempe yeast method. The observed parameters included daily growth rate (%), absolute weight gain (grams), survival rate (%), feed utilization efficiency (FUE), and feed conversion ratio (FCR). The results showed that the treatment with 25% fermented soybean meal dose gave the best results with a daily growth rate of 6.42%, absolute weight gain of 0.22 grams, survival rate of 90.66%, and the highest feed utilization efficiency of 0.66.

This study is based on the need to develop a more effective concentrate ration for lactating dairy cows, as existing formulations in the field are greatly influenced by the availability of ingredients and varying quality. Therefore, this study focuses on optimizing concentrate in dairy cow feed rations to meet SNI standards, which include crude protein (CP), Total Digestible Nutrients (TDN), Calcium (Ca), and Phosphorus (P), with more efficient results in terms of price and nutrition. This study uses the Whale Optimization Algorithm (WOA) metaheuristic approach, which balances the exploration and exploitation processes in finding the best solution to optimization problems. This algorithm has fewer parameters than other metaheuristics such as GA, PSO, and DE. WOA runs naturally in continuous space without the need for genetic operators such as crossover and mutation. The dataset used contains types of dairy cow feed ingredients along with nutritional requirements and prices so that researchers can process the data into efficient feed concentrate that is suitable for lactating dairy cows.

Stunting is a phenomenon of growth impairment experienced by infants and young children under 5 years of age, particularly toddlers aged 0–59 months. Based on Global Prevalence Data, approximately 21.9% to 22% of toddlers worldwide experience stunting. Several factors that contribute to stunting include breastfeeding and complementary feeding (MP-ASI) practices. This study aims to explore the association between experiences of exclusive breastfeeding and complementary feeding (MP-ASI) and the incidence of stunting among children in the Kampa Community Health Center area. The method used in this study was a cross-sectional approach. The study was conducted during the period of January 8–13, 2024, at the Kampa Community Health Center, involving toddlers aged 6–59 months, with a population of 1,576 toddlers. The sample consisted of 68 mothers who had stunted toddlers, measured using a height-for-age (H/A) Z-score of less than -2 standard deviations (SD). The sampling technique applied was total sampling. Data collection was carried out using a microtoise and questionnaires. Data analysis was performed using the Chi-square method. The findings showed a significant relationship between a history of exclusive breastfeeding and the incidence of stunting with a P value of 0.00 < 0.05, as well as a significant relationship between exclusive complementary feeding (MP-ASI) and the incidence of stunting in toddlers with a P value of 0.04 < 0.05. It is recommended that health workers organize counseling classes on lactation and conduct demonstrations on how to prepare complementary foods (MP-ASI), focusing on the use of affordable local food ingredients that are rich in animal protein. In addition, continuous training for community health cadres needs to be carried out to improve early detection through accurate anthropometric measurements, so that toddlers at risk of stunting can be promptly managed.

Floods and landslides in Hutanabolon Village, Tukka District, Central Tapanuli Regency have disrupted access to food and health services, particularly for vulnerable groups such as children. Public kitchens, as the frontline of emergency nutrition response, face challenges in providing food that meets the specific nutritional needs of children. This study aims to evaluate the effectiveness of public kitchens at Disaster Emergency Response Posts (TDB) in meeting the nutritional needs of post-disaster children, identify supporting and inhibiting factors, and formulate recommendations for improving the public kitchen management system. The research employed a descriptive evaluative approach using survey methods, structured interviews, direct observation, 24-hour dietary recall, and anthropometric measurements (weight and height). The study subjects included 15 children aged 1–12 years and 8 public kitchen managers selected purposively. Data were analyzed descriptively by comparing nutritional intake against the Recommended Dietary Allowance (RDA) standards and analyzing kitchen management practices based on emergency nutrition guidelines. The findings revealed that children's average energy intake was only 1,140 kcal/day (below the minimum standard of 1,200–2,000 kcal/day) and protein intake was 18.7 g/day (below the standard of 20–35 g/day). A total of 33.3% of children were classified as having malnutrition to severe malnutrition based on weight-for-age indicators. Public kitchen management showed weaknesses in menu planning (100% had no child-specific menu), managers' nutritional knowledge (62.5% categorized as low), food availability (75% relied on instant aid without variation), and limited cross-sectoral coordination (50%). The effectiveness of public kitchens in meeting children's nutritional needs after disasters remains low.

Background: Pentol is a round-shaped snack that is popular with elemtary school children with a savory taste, affordable price, and easy to find in the school environment. However, uncontrolled consumption of pentol raises concerns about fat and sodium chloride (NaCl) content. Objective: This study aims to determine the levels of fat and NaCl contained in pentol snacks sold at Tondo Urban Village Elementary School, PaluCity. Method: This study used a Complate Random Design (RAL) on five pentol samples in five elementary school in Tondo Village, with two repetitions. Fat content was analyzed by the Soxhlet method, While sodium chloride (NaCl) content was analyzed by Mohr titration. The data were analyzed using the Kruskal-Wallis test. Findings: The fat content in five pentol sampels at Tondo Urban Village Elementary School ranged from 2,16-4,75% (maximum SNI limit of 10%), while sodium chloride content was 1,55-2,15% (maximum SNI limit of 2,5%). Statistical tests (p=0,4>0.05) showed no significant difference between samples. Although still below the SNI limit, the fat and sodium content is quite high for school children’s snacks. Conclusion: The fat and NaCl content of pentol sancks at Tondo Urban Village Elementary School, Palu City is still below the SNI limit, but the consumption of these snacks need to be limited. Implications: it is hoped that there will be further researchers who analyzed carbhohydrates, proteins and other additives such as preservatives in pentol snacks.        

Severe preeclampsia is a condition characterized by systolic blood pressure exceeding 160 mmHg and diastolic pressure exceeding 110 mmHg, occurring after 20 weeks of gestation and accompanied by edema and proteinuria. One intervention used to save both mother and fetus is a cesarean section. This final nursing scientific paper analyzes the implementation of evidence-based practice, specifically warm foot soak therapy, for mothers with severe preeclampsia during the pre- and postpartum periods who are at risk for ineffective cerebral perfusion. This descriptive case study method used a nursing care approach. Assessment results identified five major nursing problems, including the risk for ineffective cerebral perfusion. After four days of warm foot soak therapy, this problem was resolved, as blood pressure decreased from 147/101 mmHg to 120/88 mmHg. Conclusion: Warm foot soak therapy effectively lowers blood pressure in pre- and postpartum mothers with severe preeclampsia. Recommendation: Nurses can implement warm

Corn milk yogurt is a fermented product that has a low protein content. One of the efforts to increase the protein content of corn milk yogurt is by adding spirulina and soy protein isolate as a source of high protein. The objectives of this research are 1) to study the formulation of high protein corn milk yogurt with the addition of spirulina and soy protein isolate; 2) to study the characteristics of corn milk yogurt. Corn yogurt with the addition of spirulina (0.08, 0.12 and 0.16%) and soy protein isolate (4.5, 8.5 and 12.5%) were tested for physicochemical and sensory characteristics. Results revealed Corn yogurt addition with of 0.08-0.16% spirulina and 4.5 - 12.5% soy protein isolates have protein content of 1.94 - 7.04%, water content of 76.0-81.1%, fat content of 0.66 – 1.17%, 14.5-16.6% of carbohydrate content, viscosity of 328.3-1128.7 mPas, total solids 16.01-17.93oBrix, pH of 3.41-3.67, lactic acid bacteria of 51 x 107 CFU/ml – 76 x107 CFU/ml.  Corn yogurt has sensory characteristics including yogurt taste of 2.60-3.68, green color of 2.42-3.82, yellow color of 1.45-2.53, corn flavor 2.27-2.60, beany flavor 2.70-3.17, spirulina flavor 2.23-3.08, viscosity 2.62-3.82 and preference of 2.25-2.9. The best formulation for making corn yogurt is a combination treatment with 8.5% soy protein isolate concentration and 0.12% spirulina with a protein content of 5.41%. While yogurt is preferred, this formula still needs some fine tuning to eliminate the fishy scent caused by the spirulina

Nephrotic syndrome (NS) is a kidney disorder characterized by massive proteinuria, hypoalbuminemia, edema, and hypercholesterolemia, most commonly occurring in children. This disease can be caused by various conditions, such as minimal change disease, FSGS, or lupus nephritis. This case report discusses a 16-year-old boy who experienced nephrotic syndrome with symptoms of swelling throughout his body, accompanied by decreased appetite and a productive cough. The patient presented with complaints of swelling throughout his body that began 7 days after hospitalization and was accompanied by coughing and shortness of breath. A physical examination revealed massive edema, abdominal hypertympany, and shifting dullness. Laboratory tests revealed proteinuria, hypoalbuminemia, and decreased serum albumin. Other supporting tests confirmed nephrotic syndrome. The patient received medication therapy including diuretics, corticosteroids in the form of methylprednisolone, and albumin. Nephrotic syndrome in children can develop gradually and requires management that includes steroids, diuretics, and close monitoring of kidney function and electrolytes. Early detection and appropriate treatment can help improve the patient's prognosis.