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Previous studies have shown that red ginger has the potential to treat PCOS because it has been proven to be able to reduce serum FSH, LH and estradiol and testosterone, inhibit the cyclooxygenase pathway, change the pituitary axis, inhibit lipoxygenase expression in various animal studies. The purpose of this study is to prove the potential of red ginger extract as a regulator of anti-androgenic, ovulation, estrogenic activity and reduce insulin resistance. The research design used was for experimental research using a post-test-only control group design. And for the analysis of the potential bioactivity of red ginger extract as an immunomodulatory agent computationally (Insilico). Animal care was carried out in the Pharmacology and Biomedicine Laboratory and has received approval from the Ethics Committee. The sample used was a female Wistar rat on the 56th day of the experiment (after modeling). All treatments were given orally for 28 times. Independent variable = Red ginger extract. Dependent variable = Dependent variables are 1. Hormones: Testosterone, LH, FSH 2. ovarian inflammation activation (PPARγ activation and anti-inflammatory cytokines IL-4 and ROS, NFKB, TNF a. 3. Insulin resistance (insulin, glucose, HOMA IR) and 4 Lipid profile (TG, HDL, LDL, cholesterol). Control variables are: 1) Gender; 2) Age; 3) Strain; 4) Food and beverage intake; 5) Maintenance and care. Quantitative and qualitative research data. using parametric tests, namely One-Way ANOVA after meeting the requirements for normal data distribution and the same data variance. The One-Way ANOVA statistical test is continued with the Tuckey test to determine the differences in each group.

Employee commitment in an organization is not just carrying out their duties and obligations as employees in accordance with their job descriptions, but doing their best with their thoughts, attention, ideas, and dedication to produce the best for the organization. The problem that occurred at X Hospital Central Jakarta was the decreasing employee commitment related to the lack of employee intensity to stay working for a long time at X Hospital Central Jakarta and there were still employees who left the work hours room with a percentage of 27%, thus reducing the overall performance of the hospital and the lack of supporting work facilities. The purpose of this study was to analyze the influence of democratic leadership style and organizational culture simultaneously on employee commitment mediated by the work environment. This research method is quantitative causality against 64 non-medical employees who have worked for at least 6 months at X Hospital Central Jakarta. The sampling method was total sampling. The data analysis method used was the Three Box Method and the Path Analysis Method with SEM AMOS. The results of the study found that democratic leadership style and organizational culture simultaneously have a positive effect on employee commitment with the mediation of the work environment, democratic leadership style does not affect employee commitment, democratic leadership style does not affect the work environment, organizational culture does not affect employee commitment, organizational culture has a positive effect on the work environment, the work environment has a positive effect on employee commitment. The implications of the study in theory will prove the influence of research variables and in managerial terms will further improve the system of facilities for work facilities and improve communication between leaders and employees in hospitals. Suggestions for the need for attention from the hospital management to improve work facilities and improve communication between leaders and employees.

Sweet tea drinks sold by street vendors are susceptible to contamination by bacteria. The presence of excess or pathogenic bacteria in sweet tea can cause health problems such as gastrointestinal infections, hence it is important to ensure sweet tea is free from bacterial contamination that is harmful to consumers' health. Penelitian ini bertujuan untuk mengetahui angka cemaran bakteri pada teh manis yang dijual oleh pedagang es teh manis di Kecamatan Plumbon Kabupaten Cirebon dan untuk mengetahui persentase teh manis yang tidak memenuhi syarat peraturan Badan POM RI No. 13 Tahun 2019 dalam parameter Angka Lempeng Total Bakteri dengan pemeriksaan pour plate (cawan tuang). This study used a survey research method. Sampling was done by total sampling. The samples of this study were 12 samples of sweet tea sold by sweet iced tea traders in Plumbon District, Cirebon Regency. Data analysis using percentages with simple calculations. Based on the results of the study, the highest bacterial contamination value was 16 × 105 colonies/mL and the lowest was 1.5 × 104 colonies/mL. Analysis of percentage data on 12 samples of sweet tea sold by sweet iced tea traders in Plumbon District, Cirebon Regency, 100% exceeded the threshold of the requirements of the Indonesian Food and Drug Administration Regulation No. 13 of 2019, making it unfit for consumption.

Pregnancy is a physiological process and can be pathologically risky if there are changes in blood pressure and DJJ. Therefore, to maintain stable blood pressure or DJJ, prenatal yoga is needed. The purpose of this study was to determine the effect of prenatal yoga on blood pressure and DJJ. This research method is a quasi-experimental design using a one group pretest posttest design. Sampling of 50 respondents, using an observation sheet. The results of the study showed that the majority were aged 20-35 years as many as 43 respondents (86.0%), the majority of multigravida parity as many as 42 respondents (84.0%). Analysis of the average blood pressure pre-test 91.430 and post-test 84.810. In DJJ, the average pre-test was 144.48 and post-test 135.54, before being given prenatal yoga intervention showed MAP in the pre-hypertension category and DJJ in the normal category, then after being given intervention showed MAP and DJJ in the normal category. The conclusion of the statistical test using the paired sample t test obtained a MAP P-Value of 0.000 or P-Value ? 0.05 and for DJJ P-Value 0.000 or P-Value ? 0.05, namely Ha is accepted and Ho is rejected, which means that there is an effect of prenatal yoga on Blood Pressure and DJJ. Suggestions for further researchers to be able to add variables by involving her husband.

Background: Pain is the reason most frequently complained by patients to seek help from a health facility and this condition almost always indicates a disease condition or pathological process. Surgery as one of the causes of pain is an invasive medical procedure used to diagnose or treat disease, injury or body deformity. Objectives: To determine the effect of early mobilization on reducing the pain scale in post-operative patients at K.R.M.T Wongsonegoro Hospital Semarang. Methods: This type of research is descriptive research in the form of a case study in November 2023 at K.R.M.T Wongsonegoro Hospital Semarang. The sample was 2 post-operative patients. Data analysis by changing the data obtained in narrative form and interpreting the results. Findings: In the first respondent, after early mobilization for 3 days, the pain scale decreased from scale 6 (moderate pain) to scale 2 (mild pain), in the second respondent, before early mobilization for 3 days, the pain scale decreased from scale 7 (severe pain) to scale 3 (mild pain). Implications: provide information for nurses and future researchers regarding early mobilization as a development of nursing interventions to reduce postoperative pain

Hospitals establish Minimum Service Standards (SPM) for medical records, specifically emphasizing the requirement for completeness in filling out medical records within 24 hours of service completion and achieving a 100% completeness standard for informed consent after receiving clear information. This study aims to develop a compliance model for Professional Care Providers (PPA) in filling out medical records, incorporating motivation as an intervening variable based on knowledge and attitude variables among inpatients at Cilincing Hospital. The sampling method employed is saturated sampling, with a total sample size of approximately 82 respondents. Path Analysis is utilized for data analysis, employing AMOS software. The research findings indicate a significant influence of knowledge, attitudes, and motivation of Professional Care Providers (PPA) on the overall compliance with the completeness of medical record filling, both collectively and individually. Moreover, the study reveals a significant impact of knowledge and attitudes on the motivation of Professional Caregivers (PPA). Additionally, motivation, acting as an intervening variable, demonstrates its ability to mediate the influence of knowledge and attitudes of Professional Care Providers (PPA) on compliance with the completeness of medical record filling. 

Pseudomonas aeruginosa is a major nosocomial pathogen known for its multidrug resistance, including carbapenems. This study aimed to investigate the prevalence of carbapenem resistance in P. aeruginosa of clinical sources and sequencing of 16S rRNA and blaOXA-50 genes Methods: A total of 53 P. aeruginosa isolates from burn, wound, urinary tract, and ear infections were analyzed. Antibiotic susceptibility testing identified carbapenem-resistant isolates. Polymerase Chain Reaction (PCR) detected 16S rRNA and blaOXA-50 genes, followed by DNA sequencing and phylogenetic analysis of 16S rRNA. Results: Among the isolates, 20 (37.73%) originated from wounds, 16 (30.19%) from burns, 10 (18.9%) from urinary tracts, and 7 (13.20%) from ears. Notably, 12 isolates (22.64%) exhibited carbapenem resistance. All carbapenem-resistant isolates harbored both 16S rRNA and blaOXA-50 genes. 16S rRNA sequencing demonstrated 99.66% homology to known P. aeruginosa strains, further confirmed by phylogenetic analysis. The blaOXA-50 gene displayed high sequence identity (98%-100%) with isolates from Russia, suggesting a potential clonal relationship. Conclusion: A moderate prevalence of carbapenem-resistant P. aeruginosa was revealed by this study and based on 16S rRNA and blaOXA-50 genes sequencing, these strains offered a high genetic similarity compared to the global strains. Further investigation is required to determine the role of blaOXA-50 carbapenem resistance in this bacterium.

Patient safety and nursing care quality are two crucial aspects of healthcare delivery. Todays, ensuring a robust patient safety culture is fundamental to achieving high standards in nursing care. This present study aims to investigate the relationship between patient safety culture and nursing care quality. In addition, job satisfaction assessed as mediating variable. Using convenience sampling technique, a total of 236 nurse participated in the survey during February until April 2024. The respondents are nurses who works in private hospital, located in Tangerang. SPSS 26 is employed as a statistical tool to assess path analysis. The result showed that patient safety culture has a positive influence on nursing care quality. Patient safety culture also shares positive effect on nurse’s job satisfaction. In addition, based on the sable test result, job satisfaction significantly mediates the connection between patent safety culture and nursing care quality. These findings suggest that enhancing patient safety culture not only improves the quality of nursing care but also boosts nurses’ job satisfaction. Therefore, interventions aimed at strengthening patient safety culture can provide dual benefits in improving healthcare outcomes.

Ultraviolet (UV) radiation, especially UVB and UVA, plays an important role in the pathogenesis of skin damage. Excessive sun exposure causes various skin problems, such as burning, dehydration, and premature aging, and increases the risk of skin cancer. Precautions such as using sunscreen, protective clothing, and avoiding peak UV exposure times are essential. Using the PDCA (Plan-Do-Check-Act) cycle, we carry out facial skin health checks, including education about sun protection, identification of skin problems, and follow-up interventions. 33 participants (11 men and 22 women) participated in this activity. It was found that the average wrinkle, roughness, moist, and UV damage were 17%, 20%, 46%, and 22.18% respectively. Early counseling and screening is essential to increase awareness, change behavior, and prevent skin problems, ultimately improving skin health and improving quality of life.

Management is a series of activities that include planning, organizing, directing and controlling organizational resources in order to achieve goals efficiently and effectively (Stoner, 2009). In this context, financial management training at Karmel Vocational School is a strategic step to prepare students to face the challenges of the digital era business world. Qualitative research through observations, interviews and documentation studies shows that this training has had a significant positive impact. Students gain an understanding of financial management, online marketing strategies, product innovation, and the use of digital platforms to build brand awareness and measure the effectiveness of marketing campaigns. Apart from that, this training succeeded in developing proactive, creative, innovative and adaptive attitudes which are important in the modern business world. The results of the training showed an increase in students' self-confidence to start an independent business, reduce dependence on formal work, and consider financial management as a career path . To increase effectiveness, it is recommended to expand the scope of training to include e-commerce and data analysis, strengthen partnerships with industry players, and integrate training into the vocational school curriculum. Thus, it is hoped that this training will be able to increase the competitiveness of Karmel Vocational School students, prepare them to face the dynamic business world, and support the sustainability of skills-based learning programs.

Hospitals must be able to adapt quickly and develop the right strategy to survive, to become a large and strong hospital is one of them by carrying out an acquisition strategy. However, the post-acquisition integration phase process is the most critical stage that often makes the industry fail in managing human resources and can cause employee anxiety to employee resistance. This research aims to analyze the influence of organizational identification and transformational leadership on employee identification and willingness to collaborate, as well as employee identification on willingness to collaborate in the post-acquisition integration phase at Grand Family Hospital. This research is quantitative correlation research. The population is all 127 nurses who work at Grand Family Hospital. The sampling method was random sampling and 127 respondents were used. Data collection used a questionnaire with analysis techniques using path analysis. The research results show that organizational identification and transformational leadership partially influence employee identification and the willingness to collaborate, and employee identification influences the willingness to collaborate. Simultaneously, organizational identification, transformational leadership, and employee identification influence the willingness to collaborate. Hospitals need to pay attention to the relationship between organizational identification, transformational leadership, and employee identification simultaneously. Integrating strategies and policies that strengthen these three aspects together can create a work environment that supports and motivates employees to work together effectively. Organizational identification, transformational leadership and Worker Identification have a significant effect on the willingness to cooperate in the post-integration phase of the acquisition.

Healthcare waste (HCW) is a significant environmental and public health concern due to its hazardous nature, particularly the presence of emerging pollutants such as pharmaceuticals, heavy metals, and pathogens. The improper disposal and management of healthcare waste contribute to pollution and pose long-term risks to both human health and ecosystems. This study examines the toxicity risks associated with HCW in areas near healthcare facilities with inadequate waste management practices, showing an increase in toxicity risks by 22% to 30%. The research develops a cumulative risk assessment model that integrates human exposure with ecological risks, considering both direct and synergistic effects of pollutants. The model incorporates various components, including pollutant analysis, bioaccumulation mapping, and long-term exposure modeling, to assess the environmental and health risks of HCW. The findings highlight that inadequate waste management leads to significant pollutant accumulation in local ecosystems, with direct implications for biodiversity and human health. Additionally, the study emphasizes the benefits of applying the One-Health approach, which considers the interconnectedness of human, animal, and environmental health, offering a more integrated understanding of the risks posed by HCW pollutants. The research advocates for the incorporation of the One-Health model in healthcare waste management policies to mitigate risks and improve sustainability. Future studies should refine the cumulative risk assessment model and expand it to encompass other environmental waste sources, providing a more comprehensive understanding of pollutant impacts and advancing mitigation strategies.

. Introduction: Nurses have a high risk of transmitting pathogens through their hands, because nurses spend the longest time with patients. Apart from this, a nurse must be able to comply with predetermined nursing duties and ethics, including "hand hygiene five moments" which is the term used for washing hands. Objective: To determine the factors related to inpatient nurses' compliance with implementing the five moments and hand hygiene at AZRA Bogor Hospital. Method: This type of research is quantitative with the method used, namely a cross-sectional design with a population of nurses who are still actively working at AZRA Bogor Hospital with a sample size of 87 respondents. Data collection techniques use observation sheets and questionnaires with several closed questions. Data analysis in this study used the chi square test. Results: The highest age of inpatient nurses was 64.4% at the age of 26 -35 years at AZRA Bogor Hospital, Diploma III (D3) education was 59.8%, PK 3 career level was 36.8%, good knowledge was 63.2%, compliance was 59.8%. Variables related to factors related to inpatient nurse compliance are age and education. Variables that have no relationship are career level and knowledge. Conclusion: Implementation of five moments and hand hygiene in hospitals to prevent transmission of HAIs to patients, visitors and health workers.

Primary dysmenorrhea is menstrual pain that is not based on a pathological condition. Female students who experience primary dysmenorrhea will certainly feel that their learning activities are disrupted, and this often results in them being absent or unable to attend school. This research aims to determine the relationship between primary dysmenorrhea and the learning activities of female students at SMK Bina Putra Nugraha Kadupandak Cianjur, West Java in 2023. The type of research is quantitative with a cross sectional design. The population is all 38 female students of Bina Putra Nugraha Vocational School. The sampling technique uses nonprobability sampling with a total sampling technique. The data analysis used was univariate and bivariate using the Spearman's Rank Correlation Coefficient test. Based on data analysis, the results obtained were from 38 respondents, the largest distribution of respondents were female students who experienced moderate pain during menstruation, namely with a frequency of 23 respondents (60.5%), and mild pain with 15 respondents (39.5%). while the results of learning activities showed that the majority of respondents were female students whose learning activities were disrupted due to the impacts caused by primary dysmenorrhea with a frequency of 33 respondents (86.8%) being disturbed. From the results of the Spearman rank correlation test, it can be seen that the value of p = 0.003 (p < 0.05). The results of the correlation coefficient show that there is a relationship between primary dysmenorrhea and the learning activities of female students at SMK Bina Putra Nugraha Kadupandak Cianjur, West Java in 2023. Therefore, the proposed hypothesis means that Ho is rejected and Ha is accepted.

Blood transfusion safety is a top priority in the management of transfusion services, considering the risk of pathogen transmission and adverse transfusion reactions. With advances in technology, there are significant opportunities to improve blood filtration and processing processes, which could significantly reduce these risks. This study aims to evaluate the effectiveness of new technologies in screening and processing transfusion blood in reducing pathogen contamination and improving patient safety. This research method involves a comparative analysis of historical data on the incidence of transfusion reactions and the incidence of infection transmission before and after the implementation of pathogen filtering technology and improved blood processing systems in several blood transfusion centers. The results showed that the use of the latest pathogen screening technologies, together with improved blood processing methods, contributed significantly to reducing the incidence of infection transmission and adverse transfusion reactions. Data analysis also shows an increase in patient satisfaction and confidence in the blood transfusion process. The conclusions of this study suggest that the integration of new technologies in the screening and processing of transfusion blood is an effective strategy to improve patient safety and reduce transfusion-related risks

This research is aimed at analyzing the influence of service quality and physical facilities on WoM (Word of Mouth) with Patient Experience as an intervening variable at Mekar Sari Hospital. The research method used in this research is a correlational quantitative research type with a cross-sectional research design approach by looking at the influence of service quality and physical facilities on WoM with satisfaction as an intervening variable.The sampling technique used purposive sampling, namely a sampling technique using the criteria of internal medicine inpatients at Mekar Sari Hospital. The research sample involved 110 respondents. Path analysis is used as a WoM model analysis tool with patient experience as an intervening variable.The results of this study found a joint positive influence of service quality and physical facilities on WoM with patient experience as an intervening variable. The quality of service and physical facilities have a positive influence on both patient experience and WoM.