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Background: Diabetes Mellitus (DM) is a disease that cannot be completely cured or cannot even be completely cured. The vile shard plant is empirically used by the community to treat diabetes (DM). This study aims to conduct phytochemical screening and test the activity of 96% ethanol extract of kejibeling leaves (Strobilanthes crispus (L.) Bl.) as a herbal antidiabetic in male white mice (Mus musculus) with alloxan induction. Method: This research is an experimental laboratory research with a true experimental posttest control design using a completely randomized design (CRD) with 5 treatments and 5 replications. Treatment P1 (without treatment) as normal control (N), P2 as positive control (+), P3 as negative control (-), P4 kejibeling leaf extract 250 mg/kg BW, P5 kejibeling leaf extract 500 mg/kg BW. Result:The results of phytochemical screening showed the presence of alkaloids, flavonoids, tannins, saponins, terpenoids and steroids. SPSS results show that the data is normally distributed (p>0.05) and homogeneous (p>0.05). The results of the ANOVA on the treatment of giving keji beling leaf extract 250 mg/Kg BW showed a sig. 0.393 (p>0.05) and treatment of 500 mg/Kg BW obtained a sig value. 0.517 (p>0.05). Conclusion:The conclusion from the research results shows that administering doses of 250 mg/kg BW and 500 mg/kg BW of keji beling leaf extract can reduce blood sugar levels in mice. It is hoped that the results of this research will be useful for the community as an antidiabetic therapy using kejibeling leaves (Strobilanthes crispus (L.) Bl.).

Wounds can be defined as the loss and damage of anatomical cells or skin function. Wound healing consists of coagulation, inflammation, proliferation, and remodeling stages. This study aims to determine the effectiveness of the leaf fraction of the thick (Glochidion superbum) on wound healing in male white mice (Mus musculus). This study is experimental. This study used 24 male mice that were given a 10 mm long cut wound. Fractionation was carried out using the liquid-liquid extraction method. Fractionation used 3 different types of solvents, namely methanol, ethyl acetate, and n-hexane. The results showed that the ethyl acetate fraction had a faster wound healing effectiveness than the other groups. The ethyl acetate fraction contains a phenolic compound, namely methyl gallate. Methyl gallate has an important role in wound healing. Methyl gallate has the potential to be an antibacterial, antioxidant, and anti-inflammatory. The results of the Bonferroni post-hoc statistical analysis confirmed the effectiveness of the ethyl acetate fraction in faster wound healing. The thick leaf fraction was effective in healing incisions in male white mice. The ethyl acetate fraction was more effective in accelerating incision healing.

MICE tourism (Meetings, Incentives, Conferences, Exhibitions) is a sub-sector with high economic value and a unique capacity to play a diplomatic role through interaction between international actors. At the regional level, the ASEAN (Association of Southeast Asian Nations) Summit (Summit) has been used by Indonesia not only for economic purposes, but also as an arena for public diplomacy and soft power development. This article examines how the ASEAN Summit (especially the series of ASEAN 2023 activities spread across several locations including Labuan Bajo, Yogyakarta, and Jakarta) shows the function of MICE as a soft power instrument in Indonesian tourism diplomacy. By combining a literature review on soft power and tourism diplomacy, an analysis of official documents, MICE industry reports, and a case study of the 2023 ASEAN Summit, this paper identifies the mechanisms of influence, determinants of effectiveness, economic and reputational impact, and policy challenges. The results show that the ASEAN Summit provides a great opportunity for nation branding and international public engagement, but its effectiveness depends on policy synergy, MICE infrastructure readiness, image management, and post-event strategies to turn temporary exposure into long-term benefits.

Objective: Autoimmune diseases are complex disorders that arise when the immune system loses tolerance to self-antigens, leading to chronic inflammation and tissue damage. To understand disease pathogenesis and to evaluate therapeutic efficacy, animal models are widely used in autoimmune research. This review aims to analyze various types of animal models employed in studies of autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), type 1 diabetes mellitus (T1DM), and multiple sclerosis (MS), with a particular focus on reproducibility and clinical applicability. Methods: This study was conducted through the selection and analysis of scientific literature published over the last ten years (2015–2025), using specific keywords including “clinical application,” “autoimmunity,” “animal models,” “humanized mice,” “lupus,” “rheumatoid arthritis,” “reproducibility,” and “translational research.” Literature searches were performed in major databases such as Google Scholar, PubMed, ScienceDirect, and Scopus. Results: Spontaneous models, such as NOD and MRL/lpr mice, exhibit close resemblance to human disease pathogenesis but are influenced by strain variability and environmental factors. Induced models, including collagen-induced arthritis (CIA) and experimental autoimmune encephalomyelitis (EAE), allow greater control over disease onset but do not fully capture the clinical complexity observed in humans. Humanized models demonstrate high translational relevance; however, their use is constrained by high costs and technical limitations. Conclusion: No single animal model is universally ideal for studying autoimmune diseases. Model selection should be based on biological relevance, reproducibility of outcomes, and the potential for clinical translation in autoimmune disease research.

Continuous chemical control of rat pests (Rattus spp.) can sometimes lead to resistance and resurgence problems, and even some cases of inaccurate targeting ultimately killing livestock. The idea of ​​​​repelling rats in rice fields using vibrations of crickets and other natural animals transmitted via radio has been done and the results are quite optimal for rat control, but it has not been done in corn cultivation. The purpose of this study was to determine the effect of cat sound audio on the intensity of rat pest attacks (Rattus spp.) in corn (Zea mays L.) plantations. The research location was in a farmer's land owned by a farmer in Dagan Village, Solokuro District, Lamongan Regency. Determination of sampling points using the diagonal method, each into 5 sub-observation plots. In each sub-plot, markers were placed as sampling points. Audio with cat and bird sounds was played continuously from 05.00 pm - 07.00 am. Observations were conducted at 7:00 a.m. at all sampling points at 30 and 60 days after planting. Observations were conducted for three days using audio and three days without audio. Damage symptoms were observed directly at each sampling point. Corn plants showing symptoms were then recorded and analyzed using the Damage Intensity formula. Observations showed that the use of cat sound audio was able to reduce the level of rat infestation. At 30 days after planting, the damage percentage was reduced by 8.33%. Meanwhile, at 60 days after planting, the damage percentage was reduced by 18.33%.

Inflammation is a physiological response to tissue injury, infection, or harmful stimuli, characterized by redness, swelling, heat, and pain. However, excessive or chronic inflammation may lead to tissue damage and degenerative diseases. Long-term use of non-steroidal anti-inflammatory drugs is associated with gastrointestinal and cardiovascular side effects, highlighting the need for safer natural alternatives. Taro leaves (Colocasia esculenta) are traditionally used to treat swelling and wounds and contain bioactive compounds such as flavonoids, alkaloids, tannins, saponins, and triterpenoids with potential anti-inflammatory effects. This study aimed to evaluate the anti-inflammatory activity of ethanol extract of taro leaves and determine the most effective dose. An experimental study was conducted using male white mice (Mus musculus) divided into five groups: negative control (Na-CMC), positive control (sodium diclofenac), and three treatment groups receiving extract doses of 25, 50, and 75 mg/kg BW. Inflammation was induced by 1% carrageenan injection. The extract significantly reduced inflammation, with the highest inhibition (84.13%) observed at 75 mg/kg BW, comparable to diclofenac.