Publication Search

Ekstrak tumbuhan dari famili Lauraceae diketahui memiliki potensi neurofarmakologi melalui kandungan metabolit sekunder seperti flavonoid, terpenoid, dan senyawa fenolik. Persea palustris (Swamp Bay) merupakan anggota genus Persea yang masih terbatas kajian ilmiahnya, khususnya terkait efek neurofarmakologi. Penelitian ini bertujuan untuk membandingkan efek neurofarmakologi ekstrak daun Swamp Bay (Persea palustris) terhadap mencit jantan pada berbagai konsentrasi. Penelitian dilakukan secara eksperimental laboratorium menggunakan ekstrak daun yang diperoleh melalui metode infusa dan diuji pada konsentrasi 1%, 2%, dan 4%. Hewan uji berupa mencit jantan dibagi ke dalam kelompok kontrol dan kelompok perlakuan, kemudian diamati respons sistem saraf pusat dan sistem saraf otonom melalui parameter perilaku dan fisiologis. Hasil penelitian menunjukkan bahwa ekstrak daun P. palustris memberikan efek neurofarmakologi yang bervariasi dan bersifat dose-dependent. Konsentrasi 1% cenderung menunjukkan efek stimulasi ringan, konsentrasi 2% menampilkan kecenderungan sedatif ringan hingga sedang, sedangkan konsentrasi 4% menghasilkan spektrum efek yang lebih luas, termasuk relaksasi otot dan aktivitas analeptik. Temuan ini menunjukkan bahwa ekstrak daun Swamp Bay berpotensi sebagai agen neuromodulator alami dan layak untuk diteliti lebih lanjut secara fitokimia dan mekanistik.  

This study aims to investigate the effects of tamarind leaf extract (Tamarindus indica L.) on neuropharmacological activity in mice using calculated percentages of responses based on the parameters PSM, SSSP, DSSP, SL, RO, SM, PSL, and ANA. This research was conducted as a laboratory experiment using a completely randomized design (CRD) with three treatment concentrations: 1%, 2%, and 4%. Observations were performed to assess the percentage of activity produced by each sample concentration, followed by descriptive–quantitative analysis to determine the dose–response pattern. The results showed that tamarind leaf extract produced varying responses across concentrations. The SSSP, ANA, and RO effects demonstrated increased activity at the 2% concentration, whereas other parameters (PSM, PSL, SM, SL, and DSSP) showed decreased activity. Interestingly, the SSSP parameter exhibited a positive dose–response pattern with the highest activity of 55.84% at 2%. Overall, the effectiveness of tamarind leaf extract depends on the concentration level. The 2% concentration appears to be the optimal dose for several neuropharmacological effects, while the 4% concentration was most effective only for SSSP. These findings highlight the importance of multi-concentration testing to determine effective dosing of natural products for biological applications and the need for further investigation.

Extraction is a crucial process for obtaining active compounds from natural materials, such as medicinal plants, spices, and other biomass. The success of the extraction process is greatly influenced by the method used, as each method has its own mechanism, efficiency, and yield. This study compared seven commonly used extraction methods: maceration, percolation, infusion, soxhletation, reflux, Ultrasound-Assisted Extraction (UAE), and Microwave-Assisted Extraction (MAE). Based on data collected from various scientific journals, it was found that modern methods such as UAE and MAE are capable of producing higher yields than conventional methods. Furthermore, both methods are more efficient in terms of extraction time and solvent usage, making them more environmentally friendly and suitable for industrial-scale applications. However, conventional methods such as maceration and percolation still play an important role, especially in initial research or in laboratories with limited equipment. For example, maceration is easy to perform, does not require high energy, and is suitable for heat-sensitive materials. Other factors that influence extraction results include the type of solvent, temperature, time, and the characteristics of the natural material itself. Therefore, the choice of extraction method must be tailored to the research objectives, the type of compound to be extracted, and the availability of resources and equipment. Combining several methods can also be considered to improve the efficiency and quality of the extraction results. It should be emphasized that extraction yield is influenced not only by the method, but also by the type of material, solvent, temperature, time, and particle size. Therefore, the choice of extraction method must be tailored to the nature of the material, the type of target compound, as well as the objectives and availability of resources. In some cases, a combination of extraction methods can also be used to increase efficiency and obtain optimal results.

Diabetes mellitus is one of the chronic diseases whose prevalence is increasing worldwide. This disease is characterized by high blood glucose levels due to impaired insulin production or function, the hormone that regulates blood sugar levels. This study aims to examine the effect of wild betel leaf extract (Piper aduncum) on the inhibition of glucose transport using the ileum of white rats (Rattus norvegicus) with the infusion method. This research is a pre-experimental study with a posttest-only control design using white rats and wild betel leaves. The study demonstrates that wild betel leaves (Piper aduncum L.) and red betel leaves (Piper crocatum) have significant potential in inhibiting glucose transport and reducing blood sugar levels. This is evident from the significant decrease in the rate of glucose transport after the administration of wild betel leaf extract, indicating an inhibitory effect on glucose transporters such as SGLT-1 and GLUT-2.

Drinks made from natural ingredients, especially those from family plants, have health benefits for improving the immune system in the body. Processing of family medicinal plants (TOGA) has different benefits such as turmeric, ginger, galangal, lemongrass, lime and honey. When combined, herbal plants provide more comprehensive health benefits compared to consuming one type of herbal alone. It is hoped that the combination can provide healing benefits for various diseases by processing it into herbal drinks such as infused water. Infusion is a liquid preparation made by extracting vegetable simplicia such as ginger, turmeric, galangal, lemongrass, honey and lime with water at a temperature of 90˚C for 15 minutes while stirring occasionally. Socialization regarding the use of infused water needs to be carried out among the public, such as teenagers at high school level. With the existence of the KKN program "Save the Country through Education" at Abdurrab University in 2024, it is necessary to socialize the manufacture of infused water to students at the Pekanbaru Taruna Vocational School on Jalan Rajawali Sakti Keluran Delima, Tuah Madani District, Pekanbaru City, Riau. This outreach is very important and must be carried out because of the many benefits of a combination of herbal plants for a naturally healthy young generation. The aim of this socialization activity is to find out the benefits of consuming infusion water for body health to increase body endurance.

Ciplukan leaves, kamilen flowers, and stevia leaves are widely used herbal plants known for their pharmacological activities, which are mainly attributed to the presence of secondary metabolite compounds. These compounds play an important role in providing therapeutic effects such as antioxidant, anti-inflammatory, and antimicrobial properties. One approach to enhancing the effectiveness of these plants is by combining them into a single preparation. This study aims to identify the content of secondary metabolite compounds in a combined infusion (infusa) of ciplukan leaves, kamilen flowers, and stevia leaves. The research method used is a laboratory experimental approach, which includes plant determination, preparation of infusion, and phytochemical screening. The infusion process is carried out to extract active compounds using water as a solvent under controlled conditions. The phytochemical screening is conducted to qualitatively detect the presence of various bioactive compounds. The results of the screening on three formulations (F1, F2, and F3) show that all infusa preparations contain several important secondary metabolites, including alkaloids, flavonoids, saponins, tannins, and terpenoids. These findings indicate that the combination of the three herbal plants has the potential to provide enhanced pharmacological effects due to the diversity of active compounds present in the formulation.

Medicinal plants have been known and used worldwide for thousands of years. One type of medicinal plant that is often used is gaharu. The efficacy of gaharu leaves provides properties as a fever reducer, increases appetite, launches menstruation, and relieves pain. This study aims to determine whether there is an analgesic effect from the methanol extract of gaharu leaves in male Wistar rats using the heat stimulation method. This study was an experimental study using twenty-five male Wistar rats divided into five groups. Group I (negative control), rats were treated with 1% CMC-Na. Group II (positive control), rats treated with mefenamic acid 45 mg/kg BW. Group III, IV, and V rats were treated with gaharu leaf methanol extract suspension (100; 200, and 400) mg/kg BW. Pain stimulation was carried out by dipping the rat tail into a 40°C water bath. Data on response time to pain, stimuli were analyzed using the One-Way Analysis of Variance (ANNOVA) method with a 95% confidence level followed by a post-hoc Tukey test to determine which group had the same or significantly different effect. The results showed that the normal response time data for mice to painful stimuli ranged from 2.79 to 3.57 seconds. 1% CMC-Na treatment in mice was unable to increase the response time to a significant pain stimulus (p>0.05). Mefenamic acid treatment 45 mg/Kg BW significantly increased the response time to painful stimuli (p<0.05) with the longest average response time to painful stimuli, namely 8.87 seconds. Based on the method used in this research, methanol extract of agarwood leaves 400 mg/kgBW has almost the same analgesic effect as mefenamic acid 45 mg/KgBW.

Diuretics act on the kidneys to increase the excretion of water and sodium chloride. The working principle of diuretics in general is to reduce electrolyte reabsorption by the renal tubules, where an increase in electrolyte excretion will be accompanied by an increase in water excretion which is needed to achieve osmotic balance. Bangun-Bangun leaf contains polyphenolic compounds, saponins, glycosides, flavonoids, and essential oils. Bangun-Bangun leaves types of flavonoids, namely quercetin, apigenin, luteolin, salvigenin, and genkwanin. Apigenin is known as a compound that functions as a diuretic. IDBB was obtained from the infusion technique with distilled water and then the infusion was used on 25 diuretic rats which were divided into 5 groups. Group I (negative) Na-CMC 0.5%, group II, III, IV, IDBB doses of 10, 20, 40%, and group V (positive) Furosemide 3.6 mg/kgBW were given orally. Rats were given aquadest orally at a dose of 15 ml/kgBW. Mice were placed in metabolic cages, then a physical examination of urine was carried out every 1 hour for 6 hours. The results showed that the IDK with the best dose was 40% which gave an increase in urine volume, had an effect on urine pH, had an effect on urine specific gravity, had an effect on urine color, and had an effect on urine clarity.    

Latar Belakang: Permasalahan ISPA masih menjadi salah satu penyebab kematian akibat penyakit menular di dunia. Hampir 4 juta orang meninggal karena infeksi saluran pernapasan akut tiap tahun. Pemberian herbal tradisional sebagai terapi non farmakologi dapat digunakan sebagai terapi pendamping perawatan medis dalam menangani ISPA pada balita. Kandungan herbal jahe dan madu dikenal dapat menurunkan tingkat keparahan batuk di malam hari sehingga mengurangi gangguan tidur. Kualitas tidur yang baik dapat memperbaiki kondisi ISPA sehingga tidak terjadi komplikasi yang lebih buruk. Tujuan: Memberikan edukasi terkait minuman herbal jahe dan madu sebagai pendamping obat farmakologi terhadap kejadian ISPA. Metode: Pelaksanaan kegiatan ini dilakukan secara langsung bertatap muka dengan sasaran sehingga lebih efektif, meyakinkan dan mengakrabkan hubungan antara penyuluh dan sasaran serta cepatnya respon.. Hasil : Klien memahami dan mengerti tentang manfaat dan teknik terapi pemberian minuman jahe merah dan madu. ,Klien memahami dan mengerti tentang langkah-langkah melakukan terapi pemberian minuman jahe merah dan madu sebagai pendamping obat farmakologi. Saran: Diharapkan dapat digunakan sebagai obat herbal yang aman tanpa menimbulkan efek samping

Hyperglycemia occurs when the body's condition is too much blood glucose that exceeds normal limits in the body because the body does not produce insulin properly. Betel leaves and ginger rhizomes have long been used by the people in Indonesia as traditional medicines that are believed to reduce blood glucose levels. This study aims to determine the effectiveness of betel leaves and ginger rhizomes empirically to reduce blood glucose levels in hyperglycemia male rats. Betel leaves and rhizomes of ginger are made in the form of infusions and used on 30 heads of hyperglycemia mice divided into 6 groups. Normal group, negative group induced alloxane, positive group (glibenklamide), betel leaf infusion group, ginger rhizome infusion group, betel leaf infusion combination group and ginger rhizome infusion, testing was carried out for 30 days. Data were analyzed with IBM SPSS 20.0 ANOVA and post hoc tukey HSD assays. The results showed that betel leaf infusion at a dose of 2 ml / kg BB and ginger rhizome infusion dose of 2ml / kg BB single administration could reduce blood glucose levels while in combination administration it was seen that there was less effective in reducing blood glucose levels in male white rats.    

Keberadaan tanaman sebagai obat sudah dikenal sejak ribuan tahun lampau. Penggunaan dan cara pengolahan yang benar dari tanaman obat dapat membantu mengobati dan mengurangi masalah kesehatan masyarakat. Peran serta perguruan tinggi STIKES Muhammadiyah Manado dalam menjalankan Tridharma perguruan tinggi salah satunya pengabdian kepada masyarakat terkait dengan kurangnya pengetahuan dan pengembangan tumbuhan obat tradisional di lingkungan masyarakat sehingga diperlukan “Swamedikasi dan Pelatihan Pembuatan Infusa Tanaman Herbal Di Desa Ilo-Ilo Kelurahan Pandu Kecamatan Mapanget” dari tumbuhan yang berada di sekitar lingkungan.. Metode pelaksanaan kegiatan dengan melakukan penyuluhan, diskusi, tanya jawab dan pelatihan tentang pembuatan sediaan herbal berupa infusa dari berbagai tanaman yang berada di sekitar lingkungan seperti daun afrika, daun gedi, daun jeruk, rimpang jahe, rimpang kunyit, buat tomat, buah lemon, bunga rosella kepada masyarakat. Hasil yang dicapai dari kegiatan pengabdian masyarakat ini adalah masyarakat dapat melakukan swamedikasi dan mengetahui serta membuat alternatif pengobatan terhadap penyakitnya sendiri.