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Diabetes mellitus is a chronic disease that requires long-term pharmacological therapy, increasing the risk of Drug Related Problems (DRPs). DRPs can affect the success of therapy, increase the risk of complications, and reduce the patient's quality of life. This article aims to identify the use of antidiabetic drugs, the characteristics of DRPs, and their clinical implications. The method used was a literature review of articles from 2016-2026 that are relevant to the analysis of DRPs in diabetes mellitus patients. The results of the study indicate that metformin is the most widely used antidiabetic drug, both as a single therapy and in combination. The dominant types of DRPs include drug interactions, inappropriate drug selection, inappropriate dosages, omissions from therapy, and use of drugs without indications. These DRPs can cause hypoglycemia, failure to achieve glycemic control targets, an increased risk of complications, and increased duration and cost of treatment. Based on the results of the study, it is concluded that DRPs remain a challenge in the management of diabetes mellitus therapy, requiring more optimal monitoring and an active role of pharmacists through medication review to improve the safety, effectiveness, and quality of treatment.

Partographs are an important instrument in labor monitoring that functions to detect complications early, monitor labor progress, and support appropriate clinical decision-making. However, incomplete filling of partographs is still a problem in various health service facilities and has the potential to affect the quality of midwifery services. This study aims to find out the completeness of filling in the partograph in childbirth monitoring at the Wajo Health Center UPTD Baubau City. This study uses a quantitative method with a descriptive design. The research population is all partograph documents for the period November 2025 to March 2026 as many as 40 documents. The sampling technique used total sampling and obtained 32 documents that met the research criteria. Data were collected using an observation checklist sheet and analyzed univariately through frequency and percentage distributions. The results showed that as many as 28 documents (87.5%) had not been fully filled out and only 4 documents (12.5%) had been filled in completely. The components with the highest level of completeness were uterine contractions (100%), drugs and fluids (96.9%), and labor progress (93.8%). Meanwhile, the components of maternal information (12.5%) and maternal condition (31.3%) had the lowest level of completeness. Most of the filling of partographs at the Wajo Health Center UPTD still does not meet the completeness standards. It is necessary to strengthen supervision, training, and periodic monitoring to improve the quality of childbirth documentation and support the safety of mothers and babies

Irrational drug use remains a common health problem in the community, including the use of medications without following dosage instructions, discontinuation of treatment before completion, the use of antibiotics without prescriptions, and improper drug storage. These problems were also identified among residents of Candirejo Village, West Ungaran District, who still have limited knowledge regarding the safe use of daily medications. This community service activity aimed to improve public knowledge and awareness regarding rational and safe medication use. The implementation methods included program socialization, health education sessions, distribution of educational media in the form of leaflets and posters, and evaluation through question-and-answer sessions and simple quizzes. Educational materials covered how to read medication labels, proper dosage and duration of use, differences between over-the-counter drugs and prescription drugs, risks of antibiotic misuse, and proper medication storage methods. The results of the activity showed an increase in community understanding regarding medication use instructions, the importance of reading labels, the dangers of using antibiotics without prescriptions, and correct drug storage practices. Participants also demonstrated high enthusiasm and active participation during the activities. This program is expected to improve community health literacy and encourage more appropriate, safe, and responsible medication use behavior in daily life.

Risk factors for melasma have been identified at several points such as the use of birth control pills, cosmetics, sun exposure, estrogen therapy, decreased thyroid and ovarian function, ovarian tumors, nutrition, drugs that are classified as phototoxic or photoallergic, and epilepsy drugs. This article aims to determine the incidence of melasma and its risk factors. This study uses articles collected from the Google Scholar database. The data collection step uses the keyword "Risk Factor Melasma" according to the title and keyword criteria. The articles used are publications in the 2018-2023 year range. The stages of analysis are carried out using VOSviewer software for visualization and trend analysis in the form of bibliometric maps. The bibliometric approach was applied to identify publication patterns, research developments, and relationships among topics related to melasma risk factors. Based on the visualization results, 100 selected documents were published within 5 years, from 2018 to 2023. The findings provide an overview of the main research trends and contribute to a better understanding of the incidence of melasma and the factors associated with its occurrence

Family Medicinal Plants (TOGA) are one form of natural resource utilization that can be used as an alternative traditional medicine as well as an effort to improve public health. Medicinal plants are widely used by the community because they are easy to obtain, relatively safe, and have lower costs compared to modern medical drugs. This study aims to examine the utilization of TOGA plants as an effort to improve the health of the people of Kudu Ganting Village through a literature study approach. The method used was a literature review by examining various scientific sources such as books, journals, and research reports related to family medicinal plants. The results of the study indicate that plants such as ginger, turmeric, lemongrass, temulawak, and betel leaves provide various health benefits, including improving body immunity, treating digestive disorders, and functioning as natural antiseptics. Therefore, the utilization of TOGA plants can serve as an effort to improve community health while also making productive use of home yard land.

Bacterial infections are diseases that can be transmitted by bacteria from sufferers to others, either directly or indirectly. Cases of bacterial infections are more common among children. The use of antibiotics is needed to treat life-threatening conditions caused by bacteria by killing bacteria or making it difficult for bacteria to grow and reproduce. Antibiotics are a type of drug given to prevent bacterial infections, or are drugs given to high-risk patients. This research method is a descriptive study by collecting medical record data to find out the description of bacterial infections and the use of antibiotics in pediatric inpatients at RSU Cut Meutia Aceh Utara in 2022. This research technique used purposive sampling with a sample size of 183 samples. The results of this study showed that 183 children suffered from bacterial infections and received injection antibiotic therapy, the majority were boys, namely 106 children (57%), the age group with the most number of sufferers, namely aged 0‒5 years, totaling 76 children (41%), the percentage of bacterial infections most commonly found in pediatric inpatient wards at RSU Cut Meutia Aceh Utara in 2022, namely typhoid fever as much as 33%, the class of antibiotics most commonly used at RSU Cut Meutia is cephalosporins (93%).

The management of ethical drug inventory is a crucial aspect of supporting the smooth delivery of healthcare services in hospitals. Improper management of ethical drugs can lead to stockouts or overstock, which results increased operational costs and the risk of drug expiration. This study aims to analyze the inventory control of ethical drugs at RSUD Inche Abdoel Moeis Samarinda using the Economic Order Quantity (EOQ), Safety Stock, and Reorder Point methods. The data used in this study are the consumption of ethical drugs during 2024, obtained from the hospital’s Pharmacy Installation. The data analysis method involves calculating ordering and holding costs, determining the optimal order quantity using EOQ, and calculating Safety Stock and ROP to maintain drug availability during lead time. The results of this study indicate that the application of the EOQ method provides a more optimal and efficient order quantity compared to previous policies. Furthermore, Safety Stock and ROP calculations assist the hospital in preventing ethical drug shortages and creating a more structured ordering schedule. Thus, the implementation of EOQ, Safety Stock and ROP methods can improve the efficiency of ethical drug inventory management while supporting the continuity of healthcare services at RSUD Inche Abdoel Moeis Samarinda.

Leprosy is a chronic infectious disease caused by Mycobacterium leprae, an obligate intracellular bacterium that affects the skin, peripheral nerves, upper respiratory mucosa, and eyes. Type 2 diabetes mellitus (T2DM) is a comorbidity that can worsen the course of leprosy. The female patient, Mrs. D, aged 55 years came to the emergency room of Cut Meutia Hospital with the main complaint of red bumps accompanied by pain on the face, hands, chest, and back since 3 days ago and additional complaints such as fever, joint pain, and numbness and loss of feeling in the legs, weakness, frequent thirst, and frequent urination. Dermatologic status is obtained in the facial region in the form of erythema nodules with firm boundaries with numular size, multiple. Laboratory examination showed anemia and leukocytosis. The therapy given was MDT MB package, ferrous sulfate 1x325 mg and PRC transfusion 3 kolf. Complaints arose acutely after the patient resumed taking MDT (multidrug therapy) leprosy drugs which had previously been stopped for more than 3 months. Based on the time of onset of symptoms, history of leprosy treatment, and the manifestation of systemic inflammatory lesions with signs of neurotropism, it can be suspected that the patient is experiencing a type 2 leprosy reaction or Erythema Nodosum Leprosum (ENL).

Chronic Coronary Syndrome (CCS) is a contemporary term that replaces stable coronary artery disease (CAD) and describes a spectrum of clinical conditions resulting from chronic abnormalities of the coronary arteries. This condition is characterized by a mismatch between myocardial oxygen supply and demand that is transient and reversible, commonly presenting as stable angina pectoris. CCS contributes significantly to global cardiovascular morbidity and mortality, including in Indonesia. The underlying pathophysiology primarily involves atherosclerosis and microvascular dysfunction leading to myocardial ischemia. Diagnosis is established through comprehensive history taking, physical examination, and both invasive and non-invasive investigations such as electrocardiography, stress testing, and cardiac imaging. Risk stratification using pre-test probability plays a crucial role in guiding further diagnostic evaluation. The management of CCS aims to relieve symptoms and prevent adverse cardiovascular events through pharmacological and non-pharmacological approaches, as well as revascularization when indicated. Pharmacological therapy includes antianginal agents, antiplatelet drugs, and lipid-lowering agents, while lifestyle modifications such as smoking cessation, healthy diet, and regular physical activity are essential in preventing disease progression. With accurate diagnosis and comprehensive management, the morbidity and mortality associated with CCS can be reduced.

The management of expired medications in community health centers (Puskesmas) is crucial because it directly relates to the quality of healthcare services, patient safety, and environmental impact. Medications that have passed their expiration date no longer guarantee effectiveness and safety, and therefore require proper handling in accordance with applicable regulations. Furthermore, improper management can lead to waste and the risk of misuse. This study was conducted to describe the expired medication management system in community health centers (Puskesmas) in Pemalang Regency, specifically regarding separation, recording, reporting, and destruction. This study used a descriptive method with a cross-sectional approach to describe the conditions in the field. The data used were primary data obtained through direct observation and interviews with pharmacists at the community health centers. Sampling was conducted using purposive sampling at five community health centers: Losari, Purwoharjo, Sarwodadi, Rowosari, and Kebandaran. The instrument used was an observation sheet as an interview guide, while the collected data was analyzed descriptively to provide an overview of the implementation of expired medication management. The study results indicate that all community health centers (Puskesmas) have properly separated, recorded, and reported expired medications in accordance with regulations. Overall, the management of expired drugs in health centers in the Pemalang Regency area has been running well and in accordance with the guidelines of the Indonesian Food and Drug Supervisory Agency (BPOM) Regulation Number 20 of 2025 concerning Good Distribution Practices for Medicines (CDOB), reaching 100%.

Rational drug use is one of the essential efforts to improve the quality of pharmaceutical services and ensure patient safety. Evaluation of prescribing patterns can be conducted using prescribing indicators established by the World Health Organization (WHO). This study aimed to describe drug use based on WHO prescribing indicators at Apotek M Bandung during January 2026. The study employed an observational design with retrospective data collection from prescription documents received at the pharmacy. The research sample was determined using a total sampling method in accordance with predefined inclusion and exclusion criteria. The indicators analyzed included the average number of drugs per prescription, the percentage of generic drug prescribing, antibiotic prescribing, injectable drug prescribing, and the use of medicines listed in the National Essential Medicines List (DOEN). The results showed that the average number of drugs per prescription was 2.4 items. The percentage of generic drug prescribing was 84.3%, antibiotic prescribing was 0.5%, and no injectable drugs were prescribed. The percentage of medicines prescribed from the DOEN was 88.20%. Overall, most indicators met WHO standards, except for the average number of drugs per prescription and the use of DOEN medicines, which had not yet reached the ideal values. Based on these findings, it can be concluded that the prescribing pattern at Apotek M Bandung reflects a relatively rational use of medicines; however, further efforts are still required to optimize compliance with WHO prescribing standards

Consumption of ethylene glycol–containing drugs can cause liver damage. This study aimed to evaluate the hepatoprotective potential of Moringa leaf extract (Moringa oleifera L.) on AST and ALT levels, liver morphology, hepatosomatic index, and liver histology in ethylene glycol–induced white rats (Rattus norvegicus L.). A Completely Randomized Design (CRD) was used with 20 male rats divided into five groups: normal control, ethylene glycol control, and three treatment groups (150, 300, and 450 mg/kg BW). Ethylene glycol was administered for 30 days, while the extract was given for 20 days. Blood samples were collected on day 31. Data were analyzed using One Way ANOVA and Duncan’s test. The results showed significant hepatoprotective effects (P = 0.000). AST and ALT levels in the treatment groups differed significantly from the normal control. Liver morphological changes were observed in both control and treatment groups. The hepatosomatic index, number of normal hepatocytes, and central vein diameter also showed significant differences. In conclusion, Moringa leaf extract demonstrates hepatoprotective potential by reducing AST and ALT levels, improving liver morphology, increasing normal hepatocytes, and decreasing central vein diameter, with the optimal dose at 450 mg/kg BW

The management of essential drug inventory is a strategic component of hospital pharmaceutical services because it directly influences service continuity, cost efficiency, and the overall quality of healthcare delivery. Poor inventory control can result in excessive stock accumulation, increased risk of drug expiration, inefficient budget utilization, and potential drug shortages that may compromise patient care. This study aims to evaluate the effectiveness of essential drug inventory control at Pekerja General Hospital by applying the ABC-VEN, Economic Order Quantity (EOQ), and Reorder Point (ROP) methods. It also examines differences in inventory management efficiency between 2024 and 2025 based on inventory value, cost of goods sold (COGS), and Inventory Turnover Ratio (ITOR). A mixed-methods approach with a sequential explanatory design was used. Quantitative analysis involved a paired sample t-test comparing inventory data from 2024–2025, while qualitative data were collected through in-depth interviews and analyzed thematically using NVivo. The findings reveal a significant improvement in inventory management in 2025 (p < 0.05), reflected in reduced inventory value and COGS, along with an increased ITOR. However, the implementation of ABC-VEN, EOQ, and ROP methods has not been fully integrated, and challenges such as limited human resources and procurement bureaucracy persist.In conclusion, although inventory control became more efficient in 2025, further integration of inventory methods and strengthening of human resource capacity are necessary to ensure sustainable improvements.

Drug abuse among adolescents has been increasing, including among youth in Papua. According to data from the National Narcotics Agency (BNN) of Papua Province, there was a 1.73% increase in 2023. One of the contributing factors to adolescent involvement in drug abuse is low self-control. This study aimed to provide self-control training to help prevent drug abuse among adolescents independently. The program involved 37 vocational high school students in Jayapura City and employed a one-group pretest–posttest experimental design without a control group. The intervention consisted of self-control training delivered through lectures, discussions, and a structured learning module. The results indicated a significant improvement in self-control before and after the intervention, as evidenced by a significance value of 0.000 (p < 0.05) using a paired sample t-test, with an increase in the mean pre-test score (M = 46; SD = 7) to the mean post-test score (M = 48; SD = 6). These findings suggest that students of SMK Negeri 9 Jayapura experienced an improvement in self-control after participating in the training. Practically, this study demonstrates that self-control training can serve as an effective psychological intervention to address drug abuse and harmful substance use among adolescents. This intervention not only helps reduce addictive behaviors but also has the potential to enhance students’ quality of life and academic achievement.

Drug abuse remains a serious social problem, particularly among adolescents and young adults. The spread of drugs into rural areas highlights the urgent need for preventive efforts through continuous and educational approaches. This Community Service (PkM) activity aimed to increase public knowledge and awareness regarding the dangers of drug abuse through an educational program. The study employed a descriptive quantitative and qualitative approach involving 30 adolescents and young adults from a village in Mojokerto Regency. Data were collected through pre-test and post-test questionnaires, observation, and documentation. The results indicated a significant improvement in participants’ knowledge, with the average score increasing from 56.3 in the pre-test to 82.6 in the post-test. These findings demonstrate that drug abuse education is effective in enhancing community knowledge and awareness as a preventive effort against drug abuse. Therefore, similar educational programs should be implemented continuously with support from various stakeholders to promote a healthy and drug-free community.

The circulation of narcotics as a serious crime in Indonesia faces the reality that some types of narcotics have medical benefits when used in limited quantities and under strict supervision, while cannabis plants remain classified as Class I Narcotics in Law No. 35 of 2009 concerning Narcotics, thereby prohibiting their use in health services. This situation raises legal issues regarding the basis for classification, legal qualifications, and the possibility of updating norms so that cannabis can be used for medical purposes. This study aims to analyze the historical and legal basis for the classification of cannabis, its qualification in the national legal system, and to formulate a normative regulatory concept that allows its use for health services. The method used is normative legal research with a historical and comparative approach, through a literature study of primary and secondary legal materials, which are analyzed descriptively and qualitatively. The results of the study show that the classification of cannabis is rooted in international commitments through the 1961 Single Convention on Narcotic Drugs, which was later ratified and adopted into national law, so that legally cannabis is only permitted for research purposes. however, considering the development of science and practice in various countries, it is necessary to update the norms through the formation of a Ministerial Regulation as mandated by Article 6 paragraph (3) of the Narcotics Law as a limited and controlled first step to open up the use of cannabis in health services without neglecting the principle of preventing abuse.

Medical personnel compliance in prescribing drugs according to the National Formulary (ForNas) is essential to ensure rational therapy, improve service quality, and enhance efficiency in health financing at government health facilities. However, compliance remains a challenge at Johar Baru Regional General Hospital, Central Jakarta. This study aimed to analyze factors influencing medical personnel compliance with ForNas-based prescribing, including drug availability, management policies, and the knowledge, attitudes, norms, and perceptions of medical staff.A qualitative approach was used through in-depth interviews with medical personnel, heads of supporting service sections, and pharmacy unit leaders. The study also involved observation and review of hospital formulary documents, minimum service standards reports for 2024, and monitoring and evaluation reports on prescribing compliance for 2024 and January June 2025. Data were analyzed using thematic analysis supported by NVivo software.The findings indicate that compliance is influenced by medical personnel’s understanding of ForNas policies, clinical experience, and professional attitudes toward prescribing standards. Management factors such as supervision, technological support, and procurement systems also play important roles. Limited drug stocks and suboptimal control systems were identified as major obstacles.The hospital is recommended to strengthen compliance by updating clinical practice guidelines, developing a ForNas-based hospital formulary, improving management support, optimizing information technology systems, ensuring drug availability, and proposing additional ForNas drugs to the Ministry of Health.

Drug abuse (NAPZA) has become a serious threat among students and poses significant risks to their physical health, psychological well-being, and future development. Therefore, preventive efforts through structured education and mentoring programs are essential. This community service activity aims to describe the process and outcomes of a drug abuse prevention mentoring program conducted at SMP Negeri 2 Bulu, Temanggung. The program applied a participatory approach consisting of four stages: coordination with the school, educational socialization on the dangers of drugs, follow-up activities through discussions and student reflections, and evaluation to measure students’ understanding. The educational sessions were delivered using interactive lectures, question-and-answer methods, and visual learning media to enhance students’ engagement and comprehension. The results indicate an increase in students’ knowledge and awareness regarding the types, impacts, and prevention strategies of drug abuse. Moreover, students demonstrated more positive attitudes and a stronger commitment to avoiding drugs as a form of self-protection for their health and future. This program is expected to serve as a school-based preventive education model to reduce drug abuse among students through collaboration between teachers, schools, and the wider community.

Childhood tuberculosis remains a significant public health challenge, particularly in developing countries where malnutrition and limited diagnostic resources increase disease severity and mortality. Children are at high risk of rapid progression from latent infection to active disease due to immature immune systems. We report a case of a 1-year-old girl presenting with cough, fever, shortness of breath, and poor growth. Chest radiograph showed consolidation and infiltrates in the right paracardial area consistent with pulmonary tuberculosis. The patient was treated with first-line anti-tuberculosis drugs, including rifampicin and pyrazinamide, along with nutritional support, resulting in significant clinical improvement and discharge on day eight. This case emphasizes the importance of early recognition and management of tuberculosis in young children with risk factors such as malnutrition and incomplete immunization. Preventive strategies such as BCG vaccination, contact screening, family education, and access to tuberculosis preventive therapy are essential to reduce morbidity and mortality in childhood TB.

Hypertensive disorders of pregnancy remain a leading cause of maternal and perinatal morbidity and mortality worldwide. Nifedipine and labetalol are commonly recommended as first-line antihypertensive agents during pregnancy; however, evidence regarding their comparative effectiveness and safety is still evolving. This systematic review aimed to evaluate and compare the effectiveness and safety of nifedipine versus labetalol in the management of gestational hypertension, chronic hypertension, and preeclampsia. The review was conducted according to PRISMA 2020 guidelines. A comprehensive literature search was performed in PubMed, ScienceDirect, and Google Scholar for randomized controlled trials published between 2016 and December 2025. Studies comparing nifedipine monotherapy with labetalol monotherapy and reporting systolic and/or diastolic blood pressure outcomes were included. Six RCTs involving 2,806 pregnant women met the inclusion criteria. Both drugs were effective in reducing blood pressure. Nifedipine demonstrated a faster onset of blood pressure reduction, particularly in acute hypertensive emergencies, with mean differences ranging from 12 to 17 minutes compared with labetalol. No significant differences were observed in long-term blood pressure control or neonatal outcomes. Maternal adverse effects were generally mild and comparable. Overall, both agents exhibit similar efficacy and safety profiles, with nifedipine offering advantages in rapid blood pressure control in acute settings.