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This article examines the moral philosophy of Saint Augustine, focusing on the concept of free will and its implications for human sinful actions. The study aims to provide a philosophical and theological understanding of Augustine’s concept of free will and to analyze its correlation with human acts of sin. Augustine conceives of free will as a rational capacity inherent in human beings, enabling them to make conscious choices. In its essence, this freedom is oriented toward the good. However, due to the fallen condition of humanity, the will becomes disordered and is directed toward things that are lower than the highest good. Therefore, there exists an inherent correlation between free will and sinful action, wherein sin is understood as the manifestation of a misused will. Accordingly, the thought of Saint Augustine of Hippo affirms that free will is an essential gift that enables human beings to make conscious choices, including the choice to commit sin. Free will does not stand apart from moral reality; rather, it serves as the foundation for explaining that sin occurs as a result of the deviation of the human will from the highest good, namely God. Thus, it can be asserted that there is a clear, close, and inseparable correlation between Augustine’s concept of free will and human sinful action.

This study aims to analyze the participation of the faithful in the Sacrament of Penance and to identify the pastoral challenges influencing its practice in the Vicariate of West Sulawesi, Archdiocese of Makassar. Theologically, the Sacrament of Penance serves as a means of reconciliation that restores the relationship between humanity, God, and the Church. However, in contemporary contexts, its practice encounters various social, psychological, and pastoral dynamics. This research employed a descriptive quantitative approach involving 267 respondents from four parishes through questionnaire distribution. The data were analyzed using percentage-based statistics to map participation frequency, spiritual motivation, level of understanding, post-sacramental experiences, and perceived obstacles. The findings indicate that although most respondents demonstrate strong theological understanding, sincere spiritual motivation, and positive spiritual experiences after receiving absolution, participation remains largely seasonal and periodic. The principal challenges include psychological factors such as shame and anxiety, structural limitations related to schedule and accessibility, and formative deficiencies such as insufficient ongoing catechesis. The study concludes that the primary issue is not a crisis of faith in the sacrament itself, but a gap between theological awareness and concrete practice, thus calling for more dialogical, communicative, and contextual pastoral renewal.

Sweet corn (Zea mays saccharata Sturt.) is an increasingly popular horticultural commodity in Indonesia, attracting both farmers and consumer. This study aims to evaluate the effectiveness of single‑micronutrient fertilizer Mn‑EDTA (12%) in enhancing the growth and yield of sweet corn (Zea mays saccharata Sturt.). The treatments consisted of control, standard NPK, 0.25 NPK, 0.50 NPK, 0.75 NPK, and 1.00 NPK. The experimental findings demonstrated that the application of single‑micronutrient Mn‑EDTA (12%) fertilizer had a highly significant effect on vegetative growth and yield components of sweet corn, with statistically higher values compared with the control treatment. In general, fertilizer dosages equivalent to 0.25–1.00 NPK produced greater plant height, stem diameter, leaf number, ear length, ear diameter, biomass weight, ear weight with husk, ear weight without husk, plot yield, and productivity than the control. The RAE calculation indicated that the fertilizer was effective when applied at dosages equivalent to 0.75 and 1.00 NPK. The highest effectiveness was observed at the 1.00 NPK dosage, with an RAE value of 101%. Notably, the application of Mn‑EDTA (12%) fertilizer at the 1.00 NPK dosage provided significant field effectiveness, as reflected by the RAE value of 101%. This result implies that the use of single‑micronutrient Mn‑EDTA (12%) fertilizer at the 1.00 NPK dosage increased yield by 1.01 times compared with the yield improvement obtained from the reference fertilizer relative to the control treatment.

Laparotomy is a major surgical procedure associated with a high risk of acute postoperative pain. According to Gan (2017), if pain is not properly managed, it can progress to chronic pain. (Toro et al., 2018) reported that severe pain on the first postoperative day is still commonly found in laparotomy patients, while (Small & Laycock, 2020) indicated that moderate to severe pain within the first 24 hours following major surgery remains a significant clinical issue. This study aims to evaluate the effectiveness of pharmacological pain management following laparotomy under general anesthesia, specifically to identify the types of opioid analgesics used, analyze their effectiveness in reducing pain intensity, identify side effects, and examine administration techniques and routes. This study employed a Systematic Literature Review (SLR) method following the PRISMA guidelines. Literature searches were conducted in the PubMed, ScienceDirect, and SpringerLink databases covering the years 2015–2026. The included studies comprised randomized controlled trials (RCTs), cohort studies, and retrospective studies addressing opioid pharmacological pain management in adult patients following laparotomy under general anesthesia. Study quality assessment was performed using the Joanna Briggs Institute (JBI) instrument. A total of 11 studies met the inclusion criteria. The results of the systematic literature review indicate that opioids are effective in reducing postoperative pain following laparotomy under general anesthesia. The most commonly used opioids are morphine, fentanyl, and oxycodone. Of all the opioids reviewed, oxycodone provided the best pain control, while intrathecal morphine was most effective in reducing the need for supplemental opioids during the early postoperative period. Other opioids, such as extended-release dinalbuphine sebacate and tegileridine, are also effective, but the number of studies is still limited. The most common side effects are nausea, vomiting, pruritus, sedation, and dizziness. Pharmacological pain management using opioids is effective in reducing the intensity of postoperative pain following laparotomy under general anesthesia. Morphine, fentanyl, and oxycodone are the most commonly used opioids. Oxycodone and intrathecal morphine have shown good results in improving pain control and reducing the need for supplemental opioids. The selection of opioid type, dosage, and administration technique must be tailored to the patient’s clinical condition to achieve optimal analgesia with minimal side effects.

Fertilization serves as a fundamental component of crop cultivation, wherein the application of mineral nutrients is crucial for plant nourishment, facilitating various physiological processes critical for growth and development. The objective of this study is to establish an optimal recommended dosage that enhances cabbage growth and yield. The experimental design employed in this study was a randomized block design with four replications. The treatments consist of seven fertilization levels, as follows: No fertilization with nitrogen (N), phosphorus (P), or potassium (K) (P0), reference fertilization (P1), 0.5 dose of unbalanced compound fertilizers (P2), 0.75 dose of unbalanced compound fertilizers (P3), 1.0 dose of unbalanced compound fertilizers (P4), 1.25 dose of unbalanced compound fertilizers (P5), and 1.5 dose of unbalanced compound fertilizers (P6). The experiment indicated that the application of unbalanced compound fertilizers enhances cabbage plant growth, as evidenced by increased plant height and leaf number compared to the control treatment. Additionally, fertilization improves yield components relative to untreated plants. The application of 0.5 doses of unbalanced compound fertilizers proves agronomically effective, yielding the highest relative agronomic effectiveness at 169%, meaning a 1.69-fold increase in yield. Economically, the same dosage is also highly beneficial, achieving the highest R/C ratio of 2.35 and generating a profit of Rp. 14,365,150. The study results confirm that unbalanced compound fertilizers were both agronomically effective and economically advantageous. The recommended dosage for cabbage cultivation is 134 kg/ha, applied in two stages: 50% at 1 WAT (weeks after transplanting) and the remaining 50% at 4 WAT.

Indonesia, as a tropical country, is exposed to high levels of ultraviolet (UV) radiation, increasing the risk of skin damage. Sunscreen is widely used as a protective measure indicated by the Sun Protection Factor (SPF) value. This study aimed to evaluate the effect of active ingredient variations on SPF values and other influencing factors. A literature review with a descriptive-comparative approach was conducted using research articles published between 2021 and 2026 from Google Scholar, PubMed, ScienceDirect, and Elsevier. A total of seven eligible articles were analyzed. The results showed that the type of active ingredients, concentration, combination of ingredients, and dosage form significantly influence SPF values. Natural ingredients generally produce low to moderate SPF values, while combinations of active ingredients result in significantly higher SPF due to synergistic effects. Increasing the concentration of active ingredients also leads to higher SPF values. Additionally, dosage forms such as creams, serums, sunscreen powder and foundations affect sunscreen effectiveness through their film-forming ability on the skin. In conclusion, the combination of active ingredients and higher concentrations provides more optimal protection against UV radiation.

Effervescent granules are a pharmaceutical dosage form that offer advantages in terms of ease of use, improved palatability, and rapid solubility in water. This study aimed to formulate and evaluate the physical properties of vitamin C Effervescent granules using the dry granulation method. The main materials used included ascorbic acid as the active substance, citric acid and tartaric acid as acid sources, and sodium bicarbonate as the base source. Evaluation was carried out on organoleptic properties, flow properties, pH, angle of repose, moisture content, density, compressibility index, and dispersion time. The results showed that the granules met the requirements for organoleptic properties, pH (4–5), angle of repose (38.41°), compressibility index (12.3%), and dissolution time (49.62 seconds). However, the flow property (29.11 seconds) and moisture content (6.47%) did not meet the established standards. These findings indicate that the formulated granules met most of the evaluation parameters but still require optimization, particularly in the drying process and flow properties, to obtain a more stable and high-quality dosage form.

Sweet corn is a high-value horticultural crop with steadily increasing demand for both fresh consumption and use as a raw material in the food industry. This study aims to evaluate the effectiveness of NPK 16-16-16 fertilizer on the growth and yield of sweet corn. The research was conducted at Sindangbarang Experimental Field, Faculty of Agriculture, IPB University from July to October 2025. This experiment used a Randomized Complete Block Design (RCBD) with a single factor, namely the dose of fertilizer application. Treatments were using fertilizer dosages of 0, 50, 0,75, 1,00, and 1,50 NPK 16-16-16, with a control treatment for comparison. During the vegetative phase, sweet corn exhibited similar growth responses across all fertilization levels relative to the control. However, all fertilizer doses significantly improved stover weight, cob weight with and without husk, cob length, cob diameter, yield per plot, and overall productivity compared to the control. The application of NPK 16-16-16 fertilizer at the recommended (1.0) rate achieved the highest relative agronomic effectiveness (103.11%), corresponding to a 1.03-fold yield increase over the control and outperforming the comparison treatment. Application of NPK 16-16-16 at the 1.0 recommended dose is suggested as the most efficient fertilization strategy for sweet corn production, as it maximizes yield and productivity without unnecessary increases in fertilizer input.     

The prevalence of non-communicable degenerative diseases in Indonesia continues to rise, particularly affecting adolescents and productive age populations due to unhealthy lifestyle patterns and free radical exposure. Purple sweet potato leaves (Ipomoea batatas L.), a locally abundant resource often regarded merely as agricultural by-product, contain significant bioactive compounds including polyphenols, flavonoids, anthocyanins, and terpenoids demonstrating potent antioxidant properties with IC50 values of 47.99 ppm. This study employs a qualitative descriptive literature review approach, analyzing 28 scientific publications spanning 2018-2025 sourced from Google Scholar and PubMed databases to examine the potential of purple sweet potato leaves as effervescent tablet raw material for degenerative disease prevention. Findings reveal that bioactive constituents effectively neutralize free radicals, prevent lipid peroxidation, and protect cellular structures from oxidative damage linked to diabetes, cancer, and cardiovascular disorders. The effervescent tablet formulation provides strategic advantages including enhanced solubility, accelerated absorption rates due to elimination of disintegration processes, pleasant carbonation sensation masking unpleasant active ingredient taste, and superior gastrointestinal tolerance. This innovation offers promising prospects for degenerative disease prevention through local food resource utilization, though experimental validation regarding optimal formulation, effective dosage determination, and clinical efficacy assessment remains necessary for practical implementation.

This research explores the narrative of Cain and Abel in Genesis 4:1-16 to dissect the concepts of sin and moral responsibility within a modern Christian context. Amidst the rising tide of individualism and "bystander culture," ethical responsibility toward others is often neglected behind religious formalities. Utilizing a qualitative method with a biblical exegesis approach, this study analyzes narrative structures, the personification of sin, and the dynamics of the dialogue between God and Cain. The findings indicate that sin in this text is understood as a relational failure and a failure of self-mastery, where humans possess the moral authority to conquer destructive impulses. Cain's rhetorical question, “Am I my brother’s keeper?”, is identified as a form of moral erosion leading to social and ecological alienation. However, God’s provision of a “mark” for Cain affirms that divine justice is always accompanied by the grace of providence. This research concludes that moral responsibility is a fundamental essence of humanity that demands the integration of ritual piety and social integrity. These findings are expected to serve as an ethical framework for academic and ecclesiastical communities, particularly in restoring the commitment to be “keepers” of one another amidst contemporary moral crises.

Hypertension is a major modifiable risk factor contributing to the development of Acute Coronary Syndrome (ACS), which includes STEMI, NSTEMI, and unstable angina. The increasing prevalence of hypertension worldwide raises concern regarding its impact on cardiovascular outcomes. This study aimed to describe the profile of ACS patients with hypertension receiving angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) therapy in the Intensive Coronary Care Unit (ICCU) of RSUD Dr. Soetomo Surabaya. Using a descriptive cross-sectional method, data from 91 patients treated between July 2021 and October 2024 were analyzed. Variables included demographic characteristics, clinical classification of ACS, hypertension degree, comorbidities, types and doses of ACEI/ARB administered. The results showed that most patients were male (73%) and aged over 65 years (40%). Chi-square analysis revealed no significant relationship between hypertension degree, ACS classification, or most comorbidities with drug selection or dosage (p>0.05), except for a significant association between coronary heart disease comorbidity and ARB selection. These findings suggest that in hypertensive ACS patients, the choice between ACEI and ARB therapy is predominantly based on individual comorbidity profiles rather than blood pressure severity or ACS type. The study highlights the importance of personalized treatment approaches considering patient comorbidities to optimize cardiovascular outcomes.

The COVID-19 pandemic caused by SARS-CoV-2 has had a significant impact on public health behavior, including the increasing consumption of health supplements as an effort to strengthen immunity. This study aims to describe the level of knowledge of the people of Gedongan Village RT 01 RW 05 regarding the use of health supplements during the pandemic. Health supplements are defined as products that contain vitamins, minerals, amino acids, and herbal ingredients to support the immune system. The study used a descriptive approach with a survey method, involving 106 respondents who were selected purposively. Primary data was obtained through a structured questionnaire that had been validated, then analyzed descriptively. The results showed that the majority of respondents had a level of knowledge in the sufficient category (54%), followed by the poor category (25%) and the good category (21%). Respondents understood the benefits of supplements as a nutritional supplement, but knowledge related to rules of use, appropriate dosage, and potential side effects was limited. Demographic factors such as age, education, and type of work have an effect on knowledge levels, where respondents of productive age, secondary education, and work with cognitive demands show better understanding. The study concludes the need for continuous health education through health workers, especially pharmacists, with an approach according to demographic characteristics to encourage the use of supplements in a rational, safe, and appropriate manner.

Soursop leaves (Annona muricata L.) are known to contain secondary metabolites such as alkaloids, flavonoids, tannins, saponins, and polyphenols, which have antibacterial potential. This study aimed to formulate soursop leaf extract into a gel dosage form and to evaluate its antibacterial activity against Pseudomonas aeruginosa. This research was conducted as an experimental laboratory study. Soursop leaf extract was obtained using the maceration method with 96% ethanol as the solvent and then formulated into gel preparations with extract concentrations of 5%, 10%, and 15%. Physical evaluation of the gel preparations included organoleptic test, homogeneity, pH, spreadability, and viscosity. Antibacterial activity was evaluated using the well diffusion method on Nutrient Agar medium. The results showed that all gel formulations met the physical requirements for topical preparations. The antibacterial activity test demonstrated that the soursop leaf extract gel inhibited the growth of Pseudomonas aeruginosa, with the 15% concentration producing the largest inhibition zone of 10 mm compared to other concentrations. In conclusion, soursop leaf extract gel has potential to be developed as a topical antibacterial agent against Pseudomonas aeruginosa.

Jamu is a traditional medicine still widely consumed by the public, but it has the potential to be contaminated with the heavy metals lead (Pb) and cadmium (Cd), which are toxic and can cause health problems, particularly to the liver and kidneys. Heavy metal contamination can originate from raw materials grown in polluted environments and from processing, storage, and packaging that do not meet quality standards, particularly for products that have not undergone official supervision. This study aims to analyze the content of lead and cadmium metals in registered and unregistered herbal medicine products. The analysis was carried out using the Atomic Absorption Spectrophotometry (AAS) method after sample preparation through wet digestion using strong acid. Six herbal medicine dosage forms were analyzed, namely powder, chopped, pills, capsules, cream, and shake parem. Method validation included tests for linearity, precision, limit of detection, and limit of quantification to ensure the reliability of the analysis results. The results showed that all registered herbal medicine samples met the safety requirements for Pb and Cd. In contrast, several unregistered herbal medicine preparations, especially powder, chopped, and cream, did not meet the safety requirements for Cd, while the Pb levels in all samples met the safety requirements for Pb. These findings indicate that unregistered herbal medicines carry a higher risk of heavy metal contamination. Therefore, strengthening quality control, selecting safe raw materials, and increasing compliance with regulations are necessary to ensure the safety of herbal medicine consumption and protect public health.

Community service with the theme of Expired Date (ED) and Beyond Use Date (BUD) aims to improve knowledge and understanding of proper medication storage as an effort to enhance the health of the Gagak Sipat community. Knowledge about medication usage limits and checking product expiration dates educates the public to be more cautious and to avoid health risks that may arise from consuming products that have exceeded their usage period or have expired. The use of medicines beyond their ED and BUD indicates that the drugs may have experienced reduced stability related to storage conditions. Decreased stability of pharmaceutical preparations can affect their physical quality, which in turn impacts the effectiveness and safety of the medication. The educational method used in this program included lectures accompanied by the distribution of leaflets, followed by practical simulations on checking ED and calculating BUD for various dosage forms. The results of this educational activity showed that community members were able to determine the ED and BUD for several pharmaceutical preparations such as tablets, powders, capsules, syrups, eye drops, ear drops, and others. The community in Gagak Sipat village gained an understanding of the risks associated with using medications beyond the BUD, including reduced effectiveness, the risk of microbial contamination, and potentially harmful chemical reactions. It was emphasized that some medications that are expired or used beyond their BUD can pose more serious health risks, especially when used to treat severe diseases.

Skin is the body's outermost organ, enveloping all parts of the human body. When the water content in the stratum corneum (SC) drops below 10%, the skin can become scaly, rough, and dry. Honey possesses humectant, emollient, and antioxidant properties, making it an effective moisturizer. The humectant properties of honey stem from its high sugar content, particularly glucose and fructose. These  sugars form hydrogen bonds with water, helping to retain moisture in the skin and thus providing a hydrating effect. Additionally, honey contains vitamin C, alpha hydroxy acids, and flavonoids, which contribute to the elasticity and firmness of the skin. Therefore, it is important to conduct a narrative review on the use of honey as a moisturizer in topical preparations, which can serve as a reference for future research. The literature search for this review was conducted using databases such as Google Scholar, Garuda Journal, MDPI, ResearchGate, and Publish or Perish, employing specific inclusion and exclusion criteria. The findings concluded that honey can be used as a moisturizer in various dosage forms, including body scrubs, anti-aging and moisturizing creams, serums, peel-off gel masks, lip moisturizers, and lip scrubs. The concentration of honey used in these formulations depends on the dosage form, its intended function in the formula (whether as an active substance, humectant, or emollient), and the comparison of honey concentration with other ingredients.

Advances in technology and research in the field of pharmacy have driven innovation in drug formulation and administration methods to improve the effectiveness and safety of therapy. One of the most widely developed dosage forms is suspension injections, which are sterile preparations containing particles of active ingredients that are insoluble in the carrier fluid. This study aims to review the effects of various administration routes, such as intra-articular, intramuscular, and subcutaneous, on the efficacy and safety of suspension injections. The method used is a literature study analyzing various scientific journals from databases published in the last ten years. The results of the review show that the route of administration has a significant effect on the therapeutic effect, where the intra-articular route provides a strong local effect with low systemic risk, the intramuscular route produces long-term effects and is relatively easy to perform, while the subcutaneous route provides stable drug release over a long period of time. Overall, the choice of injection route for suspension injections should be tailored to the characteristics of the drug, the patient's condition, and the therapeutic goals to achieve optimal, safe, and comfortable treatment outcomes for the patient.

Inflammation is a biological response that occurs as a defense mechanism of the body against tissue damage, infection, or exposure to harmful stimuli. Excessive or prolonged inflammation can lead to various chronic diseases and negatively affect overall health. Natural compounds derived from medicinal plants have gained attention as alternative anti-inflammatory agents due to their relatively lower side effects compared to synthetic drugs. Jatropha curcas is a plant traditionally used in herbal medicine and is known to contain various bioactive compounds. This study aims to examine the effect of Jatropha curcas leaf extract on inflammatory responses. The research method used was an experimental laboratory approach with extract preparation through maceration techniques. The anti-inflammatory effect was evaluated based on changes in inflammatory indicators observed during the treatment process. The results showed that Jatropha curcas leaf extract demonstrated potential anti-inflammatory activity, which was indicated by a reduction in inflammatory signs. The presence of secondary metabolites such as flavonoids, tannins, and saponins is suspected to contribute to this effect. These findings suggest that Jatropha curcas leaf extract has promising potential as a natural anti-inflammatory agent. Further research is recommended to explore dosage optimization and toxicity levels for safe therapeutic use.  

This study aims to evaluate the effectiveness of various doses of 6.25% Poly Aluminium Chloride (PAC) and 0.1% polymer flocculant in reducing Total Suspended Solids (TSS) and assessing pH changes in coal stockpile wastewater at PT PLN Nusantara Power UP Paiton Unit 9. Stockpile wastewater typically contains high levels of suspended solids originating from water spray activities that carry fine coal particles. The coagulation–flocculation process was performed using the jar test method with PAC dosages of 35 ppm, 50 ppm, and 65 ppm, along with flocculant dosages of 6 ppm and 7 ppm. pH and TSS were analyzed before and after treatment to assess process effectiveness. The results indicate that a PAC dosage of 35 ppm combined with a 6 ppm flocculant achieved the highest TSS removal efficiency of 98.15%. Increasing PAC dosage resulted in reduced performance due to overdosing effects, leading to charge destabilization and impaired floc formation. These findings highlight the importance of optimizing coagulant dosage to improve stockpile wastewater quality for safe reuse in operational activities.

The paradigm of Islamic education requires the integration of Western learning theories with an Islamic perspective to create a holistic approach to education. With the rapid development of psychological theories in education, such as behaviorism, cognition, humanism, and constructivism, it is essential to examine their relevance within the context of Islamic education. This article aims to analyze the integration of these theories in Islamic learning, with a focus on their connection to key Islamic concepts such as reward-punishment (pahala-dosa), reflection (tafakkur), self-actualization, mutual assistance (ta'awun), and consultation (syura). This study uses a literature review method with a qualitative approach. Articles were gathered through Google Scholar and Publish or Perish with keywords "Behaviorism in Islamic Education" AND "Cognitive Learning in Islam" AND "Humanistic Approach in Islamic Education" AND "Constructivism in Islamic Education." Of the initial 40 articles obtained, a screening process resulted in 5 articles that met the publication criteria (2020–2025), relevance to the topic, and open access. The review results show that integrating these theories into Islamic education can enrich the learning process by linking moral, social, and spiritual elements that are essential in Islamic teachings. This literature synthesis reveals the importance of integrating psychological theories with the principles of Islamic education to create a more comprehensive and holistic educational system. Further research should develop empirical methodologies and more detailed and practical application models in Islamic education practice.