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Dengue fever remains a major global health challenge, particularly in tropical regions, due to the high transmission of Dengue virus by Aedes aegypti and the limited sustainability of current control strategies. Artocarpus odoratissimus, an endemic Bornean plant, contains diverse secondary metabolites with potential pharmacological activities; however, a systematic synthesis of its biomedical relevance to Dengue is still lacking. This study aimed to systematically evaluate the biomedical potential of A. odoratissimus in Dengue prevention and control through a systematic literature review. This study employed a systematic literature review method following the PRISMA 2020 guidelines. Literature searches were conducted in Scopus, ScienceDirect, SpringerLink, PubMed, Google Scholar, Garuda, SINTA, and other relevant scientific databases for publications from January 2016 to February 2026. A total of 303 records were identified, and after duplicate removal, title and abstract screening, and full-text eligibility assessment, 23 studies were included for narrative synthesis. The findings revealed that A. odoratissimus contains major bioactive compounds, including flavonoids, phenolics, arylbenzofurans, stilbenoids, and prenylated chalcones, which demonstrate antioxidant, anti-inflammatory, immunomodulatory, and potential antiviral activities based on in vitro and molecular docking studies. Fruit peel, seeds, and stem bark exhibited the strongest biological evidence, particularly in reducing oxidative stress, inhibiting inflammatory mediators, and potentially interacting with Dengue viral target proteins. Furthermore, several species within the Artocarpus genus showed larvicidal and ovicidal activities against Aedes aegypti, highlighting the potential development of A. odoratissimus as a plant-based biolarvicide candidate.

Dengue fever remains a major global health challenge, particularly in tropical regions, due to the high transmission of Dengue virus by Aedes aegypti and the limited sustainability of current control strategies. Artocarpus odoratissimus, an endemic Bornean plant, contains diverse secondary metabolites with potential pharmacological activities; however, a systematic synthesis of its biomedical relevance to Dengue is still lacking. This study aimed to systematically evaluate the biomedical potential of A. odoratissimus in Dengue prevention and control through a systematic literature review. This study employed a systematic literature review method following the PRISMA 2020 guidelines. Literature searches were conducted in Scopus, ScienceDirect, SpringerLink, PubMed, Google Scholar, Garuda, SINTA, and other relevant scientific databases for publications from January 2016 to February 2026. A total of 303 records were identified, and after duplicate removal, title and abstract screening, and full-text eligibility assessment, 23 studies were included for narrative synthesis. The findings revealed that A. odoratissimus contains major bioactive compounds, including flavonoids, phenolics, arylbenzofurans, stilbenoids, and prenylated chalcones, which demonstrate antioxidant, anti-inflammatory, immunomodulatory, and potential antiviral activities based on in vitro and molecular docking studies. Fruit peel, seeds, and stem bark exhibited the strongest biological evidence, particularly in reducing oxidative stress, inhibiting inflammatory mediators, and potentially interacting with Dengue viral target proteins. Furthermore, several species within the Artocarpus genus showed larvicidal and ovicidal activities against Aedes aegypti, highlighting the potential development of A. odoratissimus as a plant-based biolarvicide candidate.

Typhoid fever is a febrile illness that commonly occurs in urban areas with poor sanitation. It is usually caused by the consumption of untreated water and contaminated food. Because the S. typhi bacterium can survive in water for days, contamination of surface water—such as wastewater, freshwater, and groundwater—serves as the primary cause of typhoid fever. The patient presented to the Emergency Department of Cut Meutia General Hospital with complaints of high fever for approximately 4 days prior to admission, which had worsened over the past 2 days. The fever fluctuated and was accompanied by chills. It worsened at night and was not influenced by weather or temperature. These symptoms were accompanied by vomiting every time the patient tried to eat, nausea, abdominal pain, headache, and weakness. The patient reported vomiting the contents of their meal every time they ate, leading to a loss of appetite. These symptoms began when the patient first developed a fever. The patient also experienced abdominal pain. Spontaneous bleeding was denied. On physical examination, the patient appeared weak but was alert and oriented. On neck examination, palpable enlargement of the thyroid glands was found on the right and left sides of the neck, measuring 2x2 cm, mobile, and soft. On abdominal examination, increased bowel sounds were noted. Vital signs were normal except for the patient’s febrile temperature. Laboratory tests revealed a Tubex blood test result of scale 4 and a positive dengue IgG serology result.

Dengue Hemorrhagic Fever remained a major public health problem in tropical countries, including Indonesia. This study aimed to analyze trends in prevalence, incidence, and geographical disparities of dengue hemorrhagic fever in Indonesia from 2021 to 2023 using Global Burden of Disease data. A descriptive observational design with a longitudinal approach was applied to analyze national and provincial-level prevalence, incidence, and disease burden. The results showed that dengue prevalence and incidence at the national level gradually declined during the study period, although the magnitude of decline was relatively small. Significant geographical disparities persisted, with higher disease burden observed in several provinces in Sumatra, Kalimantan, and eastern Indonesia. Environmental conditions, population density, and unequal access to health services were considered important contributors to these variations. This study concluded that despite improvements in national dengue control efforts, region-specific and targeted interventions remained essential to reduce disease burden and minimize interprovincial disparities in Indonesia.

Dengue Hemorrhagic Fever (DHF) remains a major public health problem in Indonesia, particularly in densely populated areas. Control efforts require accurate data and spatial analysis to understand disease distribution patterns. Geographic Information System (GIS) is an effective tool for visualizing case distribution and supporting surveillance and planning of control programs at the primary healthcare level. This study aims to describe the spatial distribution of Dengue cases based on medical record data and produce a geographic distribution map to support Dengue control efforts at the Puskesmas level. This study used a quantitative descriptive design with secondary data from medical records at Karangsari Health Center. The sample consisted of 255 DHF patients in 2025, selected using a total sampling technique. Data were processed through editing, geocoding patient addresses, and spatial analysis using QGIS software.The results showed 255 Dengue  cases in 2025 with fluctuating monthly trends, peaking in April and lowest in December. Case distribution was uneven and tended to cluster. High-risk areas accounted for 15.7%–21.2%, moderate-risk areas 9.8%–15.7%, and low-risk areas 7.1%–9.8%. Megu Cilik Village had the highest proportion of cases, while other villages were categorized as moderate and low risk. This pattern indicates that Dengue incidence is influenced by environmental conditions, vector density, host factors, rainfall, and Aedes aegypti presence. GIS provides clearer spatial visualization, helping identify high-risk areas and supporting targeted public health interventions.

Dengue Hemorrhagic Fever (DHF) remains a significant public health problem in tropical countries, including Indonesia. The presence of Aedes aegypti larvae is an important indicator of dengue transmission risk and is influenced by environmental factors, particularly temperature and humidity. This study aimed to analyze the relationship between temperature and humidity and the presence of mosquito larvae in Meteseh Village, Tembalang District, Semarang City. This analytical observational study employed a cross-sectional design involving 100 households selected through quota sampling. Data were collected through direct observation and measurement of temperature and humidity using a thermo-hygrometer, then analyzed using the Chi-square test. The results showed a significant association between temperature and the presence of mosquito larvae (p=0.000), while humidity was not significantly associated with larvae presence (p>0.05). Temperature was identified as a more influential environmental factor in supporting mosquito larvae existence than humidity in the study area. These findings highlight the importance of environmental-based vector control strategies, particularly through management of microhabitat temperature conditions, to support dengue prevention.

Dengue Hemorrhagic Fever (DHF) remains a significant public health problem in tropical countries, including Indonesia. The presence of Aedes aegypti larvae is an important indicator of dengue transmission risk and is influenced by environmental factors, particularly temperature and humidity. This study aimed to analyze the relationship between temperature and humidity and the presence of mosquito larvae in Meteseh Village, Tembalang District, Semarang City. This analytical observational study employed a cross-sectional design involving 100 households selected through quota sampling. Data were collected through direct observation and measurement of temperature and humidity using a thermo-hygrometer, then analyzed using the Chi-square test. The results showed a significant association between temperature and the presence of mosquito larvae (p=0.000), while humidity was not significantly associated with larvae presence (p>0.05). Temperature was identified as a more influential environmental factor in supporting mosquito larvae existence than humidity in the study area. These findings highlight the importance of environmental-based vector control strategies, particularly through management of microhabitat temperature conditions, to support dengue prevention.

Introduction: Dengue fever is a viral infection transmitted through the bite of infected female Aedes aegypti mosquito, caused by four dengue virus serotypes (DEN-1 to DEN-4), with clinical manifestations ranging from asymptomatic to severe disease and may be accompanied by warning sign. Concurrent infections, such as acute diarrhea, may worsen outcomes, particularly in children. Case Report: A nine-month-old female presented with a five-day history of intermittent fever and watery diarrhea. Additional symptoms included vomiting, lethargy, and decreased appetite. Physical examination showed a moderately ill appearance and sunken eyes. Laboratory findings revealed positive dengue IgM, negative dengue IgG, thrombocytopenia (22,000/µL), and hematocrit of 37%. The patient was diagnosed with dengue fever with warning sign and acute diarrhea. Management included intravenous crystalloid fluids, antipyretics, antibiotics, H2 receptor antagonists, and zinc supplementation. Conclusion: Dengue with warning sign and concurrent acute diarrhea in children increases the risk of morbidity and mortality. Early and appropriate management is essential to prevent disease progression and improve clinical outcomes.

Dengue Hemorrhagic Fever (DHF) is a disease caused by the dengue virus and transmitted through the bite of the Aedes aegypti mosquito. According to the WHO, 40% of the world's population is at risk of dengue fever, with a significant increase in cases in the last two decades, especially in 2019. After declining during the Covid-19 pandemic, cases surged again in 2023, including in previously unaffected areas. In Indonesia, Ministry of Health data shows an increasing trend in cases, with 186,324 cases and 1,120 deaths by week 35 of 2024. Environmental factors and community behavior influence the spread of dengue-causing mosquitoes. This study aims to determine the relationship between these factors and the incidence of dengue fever in Central Lampung Regency. This study aims to determine the relationship between environmental factors and community behavior with the incidence of Dengue Hemorrhagic Fever (DHF) in Central Lampung Regency. This study is an observational analytical study using a case control study design. The research instruments used were questionnaires and observation sheets. The data analysis technique used the chi square test. From the results of the study it is known that out of 9 variables, 4 variables have a relationship with the incidence of DHF, namely the availability of container covers (p value = 0.023 <0.05), frequency of container drainage (p value = 0.001 <0.05), the presence of larvae in containers (p value = 0.006 <0.05), and respondent attitudes (p value = 0.023 <0.05). Based on research in Central Lampung Regency, of the nine variables examined, four were shown to be associated with the incidence of Dengue Hemorrhagic Fever (DHF). Therefore, it is crucial to raise public awareness and routinely implement Dengue Prevention (PSN) or 3M, both independently and collectively. Dengue prevention needs to be carried out not only through sanctions (punishment), but also through a promotive and preventive approach involving individuals, communities, environmental policies, and supervision from relevant agencies. These efforts must be comprehensive and sustainable, involving all levels of society.

Dengue fever is a disease commonly found in tropical and subtropical regions. This disease can cause severe symptoms, such as very high fever, accompanied by nausea, vomiting, headache, abdominal pain, and leukopenia (decrease in white blood cells). This infectious disease, known as dengue hemorrhagic fever (DHF), is a viral infection transmitted by the Aedes Aegyppti mosquito. This study aims to classify dengue-prone areas using the K-Means Algorithm, and to classify the factors that cause dengue in Purwodadi District, Grobogan Regency. The clustering results using the K-Means algorithm with Rapidminer tool from 266 data produced 3 clusters: cluster 0 (blue) with 138 patients dominated by Kuripan, Purwodadi, Ngambak villages, cluster 1 (green) with 31 patients in Ngraji, Nambuhan, Cingkrong villages, and cluster 2 (orange) with 97 patients in Danyang, Kalongan, Pulorejo villages. This study is expected to provide additional information for stakeholders in controlling dengue cases and increase awareness of the importance of environmental cleanliness as a preventive measure.

Hospitalization is a condition that requires a child to be admitted to the hospital. This situation causes children to experience anxiety, restlessness, and fear. One of the nursing interventions to reduce anxiety due to hospitalization is play therapy. A form of play therapy appropriate for preschool children is puzzle play therapy. Puzzle play therapy is an activity in which children arrange pieces of pictures or specific shapes to form a complete image. This therapy encourages children to develop patience, stimulates concentration, and provides feelings of comfort and enjoyment, thereby reducing anxiety. The method used in preparing this Final Nursing Scientific Paper was a descriptive case study with the implementation of puzzle play therapy. The respondents consisted of three children experiencing anxiety due to hospitalization. Puzzle play materials and the Facial Image Scale (FIS) were used as measurement tools. The intervention was conducted over three consecutive days, with a duration of 15 minutes per session. The results showed a decrease in anxiety levels after puzzle play therapy: respondent 1 decreased from anxiety scale 5 to scale 1, respondent 2 from scale 4 to scale 1, and respondent 3 from scale 5 to scale 1. It can be concluded that puzzle play therapy is effective in reducing anxiety due to hospitalization in preschool children with dengue hemorrhagic fever. The implementation of puzzle play therapy is expected to become a routine nursing intervention to reduce hospitalization-related anxiety in preschool children with dengue hemorrhagic fever.

The high cost of colloid fluids and the large number of patients are concerns in determining which treatment standard should be chosen from several treatment alternative, where the total cost for 43 cases with a combination of crystalloid colloid fluids is IDR 209.370.993 while the total cost for 45 cases of crystalloid fluids is only UDR 146.492.268 which causes hospital losses. This study aims to determine the difference in the cost-effectiveness between crystalloid fluids and crystalloid-colloid combinations in hospitalized dengue fever patients without shock at Tangerang City Hospital. The research design used was cross-sectional with a comparative quantitative analysis method, where cost effectiveness was analyzed using the Average Cost Effectiveness Ratios (ACER) method. There were two groups of study samples: the first group, 25 patients who received crystalloid fluids, and the second group, 23 patients who received crystalloid-colloid combination fluids. This study showed a difference in the average hospitalization costs for dengue patients between crystalloid fluid therapy and crystalloid-colloid combination therapy. Hospitalization costs for dengue patients were lower in the crystalloid fluid group, with a significant difference (p=0.000). It was also found that crystalloid fluids were more cost-effective than the crystalloid-colloid combination. The implications of the study results consist of theoretical implications and practical implications. Based on the results of the analysis carried out, the crystalloid solutions are more cost-effective than crystalloid-colloid combinations. This finding can be used as a consideration in making decisions and policies that are in accordance with quality control and cost control for patients covered by the National Health Insurance (BPJS Health insurance).

Dengue Hemorrhagic Fever (DHF) remains a major public health problem in endemic areas, including Olat Rarang Hamlet, Labuhan Sumbawa Village. Effective dengue prevention requires active community involvement supported by entomological surveillance data. This community service activity aimed to enhance community awareness and participation in dengue prevention through the implementation of the 3M Plus Movement integrated with an entomological surveillance approach using the House Index (HI), Container Index (CI), and Breteau Index (BI) indicators. The activity was conducted on December 6, 2025, involving local community members and public health students. The methods included health education, larval surveys in houses and water-holding containers, and community-based mosquito breeding site eradication. The results indicated that houses and containers positive for Aedes larvae were still present, reflecting a moderate risk of dengue transmission. However, the implementation of the 3M Plus Movement improved community knowledge, awareness, and participation in vector control. Integrating the 3M Plus Movement with entomological surveillance is an effective promotive and preventive strategy based on community empowerment for sustainable dengue prevention.

Introduction: Dengue Hemorrhagic Fever (DHF) is a serious disease transmitted by the aedes aegypti mosquito. Dengue Hemorrhagic Fever (DHF) is an infectious disease transmitted through the bite of the Aedes aegypti mosquito and is still a public health problem. The high incidence of dengue fever is often caused by a lack of knowledge, attitudes, and actions of the community in carrying out appropriate prevention efforts. The goal is to identify the picture of community behavior in dengue prevention, including aspects of knowledge, attitudes, and actions. Method: was a quantitative descriptive with 100 respondents selected by random sampling in East Sidomulyo Village, Marpoyan Damai. Data were collected through questionnaires and analyzed univariately. Results: The variables of community behavior were obtained in the knowledge of most of the people who were low as many as 52 respondents (52%), most of the people's attitudes were obtained negative attitudes as many as 77 respondents (77%), the actions of the community mostly had less actions with the number of 59 respondents (59%), and the behavior of the community was relatively low. Conclusions and Suggestions: This study shows that the majority of the people of East Sidomulyo Village have lacking knowledge, attitudes, and actions in the prevention of dengue. Low preventive behavior is caused by a lack of knowledge and concern. Intensive, community based education is needed to raise awareness and preventive measures in an ongoing manner.

Dengue Hemorrhagic Fever (DHF) is a life-threatening disease caused by the dengue virus, which consists of four serotypes: DEN-1, DEN-2, DEN-3, and DEN-4. Laboratory examinations supporting DHF diagnosis include complete blood count, urine analysis, serological tests, and viral identification using Reverse Transcriptase Polymerase Chain Reaction (RT-PCR). Prevention efforts focus on eliminating Aedes aegypti mosquito larvae through the implementation of 3M Plus, as well as using mosquito bite prevention products such as aromatherapy candles that are simple and practical for community use. Mancasan Baki Village, Sukoharjo, has experienced a high incidence of dengue cases, including fatalities, highlighting the need for community education on the genetic characteristics and molecular diagnostics of the dengue virus and preventive measures using innovative products. Educational activities were conducted through community presentations and demonstrations on making aromatherapy candles. The effectiveness of the program was measured by comparing participants’ knowledge before and after the intervention. The average pretest score was 6.63, which increased to 8.89 in the posttest. Statistical analysis using a t-test showed a significant difference (p < 0.05). Participant satisfaction results indicated that 64.5% rated the program as good, 32.5% as very good, and 3% as fairly good.

The GEBRAK (Mosquito Nest Movement) program is a community service activity that aims to increase public awareness and ability to prevent the spread of Dengue Hemorrhagic Fever (DHF) through the eradication of mosquito nests. This activity was carried out in Jambean Hamlet, Kras District, Kediri Regency, involving 20 families. The methods used include health counseling, direct education at residents' homes, and sowing of Abates powder. The results of the activities showed an increase in public understanding of dengue prevention and active participation in the implementation of the program. This program is expected to be a model for other regions in efforts to control dengue vectors. This activity took place in partnership with the UPTD of the Kras Health Center and residents of Jambean Village, Kras District, Kediri Regency, East Java

Latar Belakang: Lahan basah merupakan ekosistem yang kaya akan keanekaragaman hayati, namun juga menjadi habitat yang ideal bagi berbagai vektor penyakit, terutama nyamuk. Penyakit Demam Berdarah Dengue (DBD) adalah salah satu penyakit yang ditularkan oleh nyamuk Aedes aegypti. Masyarakat Kelurahan Pebatuan sepakat bahwa jumlah nyamuk di daerah kelolaan sangat mengganggu dan kondisi got yang sangat kotor perlu ditangani. Tujuan: Untuk meningkatkan pengetahuan masyarakat tentang pentingnya menghindari gigitan nyamuk dan penyakit DBD Metode: Penyuluhan dan demonstrasi pembuatan spray anti nyamuk berbahan alami yakni kulit jeruk nipis, serai, cengkeh, dan campuran minyak zaitun. Hasil: Meningkatnya pengetahuan warga mengenai DBD perihal pemanfaatan spray anti nyamuk berbahan alami dengan adanya peningkatan sebesar 31,4 poin. Dan warga aktif melakukan pencegahan DBD dengan membersihkan lingkungan sekitar, penyuluhan yang dilakukan memperoleh respon positif dari masyarakat Kesimpulan: Pada kegiatan pengabdian ini efektif dalam meningkatkan pengetahuan dan kesadaran masyarakat tentang pencegahan DBD melalui pemanfaatan spray anti nyamuk berbahan alami serta menjaga kebersihan lingkungan sebagai upaya berkelanjutan dalam mengurangi risiko penyebaran penyakit

Dengue Fever (DHF) is an endemic disease caused by the dengue virus with the vector Aedes aegypty. This disease is still a major health problem in Indonesia. Dengue fever often occurs in communities with high levels of pollution, such as dirty and unkempt environments. The increase in dengue fever cases in Indonesia has led many manufacturers to create mosquito repellent products, tools and medicines that can kill mosquitoes with various types of products and brands. However, many products sold on the market can be said to be less environmentally friendly and sometimes not good for health. This community service activity was carried out on February 22 2025. The method used was by giving a pre-test and post-test regarding the community's knowledge of natural anti-mosquito ingredients, followed by socialization, education and production directly with the KKN team. The results of this service show the achievement of an increase in public knowledge about how to make anti-mosquito spray from 10 questions answered "yes" to 60 questions answered "yes", as well as the success of the community in making anti-mosquito spray from lemongrass stalks independently.  

Dengue Fever (DHF) is an endemic disease caused by the dengue virus with the vector Aedes aegypty. This disease is still a major health problem in Indonesia. Dengue fever often occurs in communities with high levels of pollution, such as dirty and unkempt environments. The increase in dengue fever cases in Indonesia has led many manufacturers to create mosquito repellent products, tools and medicines that can kill mosquitoes with various types of products and brands. However, many products sold on the market can be said to be less environmentally friendly and sometimes not good for health. This community service activity was carried out on February 22 2025. The method used was by giving a pre-test and post-test regarding the community's knowledge of natural anti-mosquito ingredients, followed by socialization, education and production directly with the KKN team. The results of this service show the achievement of an increase in public knowledge about how to make anti-mosquito spray from 10 questions answered "yes" to 60 questions answered "yes", as well as the success of the community in making anti-mosquito spray from lemongrass stalks independently.

This community service activity aimed to control the population of Aedes aegypti mosquitoes, which are the main vector of Dengue Hemorrhagic Fever (DHF), through the making and utilization of ovitraps in Sawa Village, Sawa District, North Konawe Regency. The methods applied in this program included field observation and door-to-door socialization to the community regarding the function, benefits, and procedure of making ovitraps. The socialization was designed to provide practical knowledge and raise awareness among residents about the importance of preventing mosquito breeding as part of DHF control efforts. A total of 30 households were involved as direct participants in this activity, and 30 ovitrap units were successfully made and distributed evenly to each household. The results showed that the community responded enthusiastically and expressed interest in adopting the ovitraps as a preventive measure. In addition, participants reported gaining new understanding about their active role in maintaining environmental health and reducing the risk of DHF transmission. The involvement of the community not only ensured that the ovitraps were effectively utilized, but also encouraged sustainable behavior in mosquito control practices. Overall, this program demonstrated that simple, low-cost, and community-based interventions such as ovitraps, combined with education and awareness campaigns, can contribute significantly to reducing the breeding sites of Aedes aegypti mosquitoes and lowering the potential spread of DHF in endemic areas.