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Wanita memiliki banyak masalah  pada  area  vagina.  Kebanyakan  kasus  yang  terjadi  adalah  keputihan.  Keputihan  atau  dalam bahasa  medis  disebut  dengan  flour  albus  merupakan  keluarnya  cairan  yang  berlebihan  dari vagina  yang  bukan  darah  haid. Pengobatan  keputihan  non  farmakologis  dapat  dilakukan  dengan  perubahan  tingkah  laku  personal  hygiene,  psikologis,  serta menggunakan daun sirih. Daun sirih telah terbukti secara ilmiah dapat menghambat pertumbuhan Candida albicans pada berbagai konsentrasi (20-100%).  Berdasarkan  data  yang  didapat  di  Desa Majungan Kecamatan Pademawu kabupaten Pamekasan  pada  tanggal  18  Juli  2025  terdapat remaja usia reproduktif yang mengalami keputihan sejumlah 8 orang, rata –rata usia 18-22 tahun. Berdasarkan data yang didapat di Desa Majungan Kecamatan Pademawu Kabupaten Pamekasan pada tanggal 18 Juli 2025 terdapat remaja usia reproduktif yang mengalami keputihan sejumlah 8 orang dari 35 remaja lainnya,  rata –rata  usia  18-22  tahun  wanita  usia  reproduktif  di  Desa Majungan Kecamatan Pademawu Kabupaten Pamekasan ini belum pernah mengetahui banyak manfaat pada daun sirih hijau, sehingga tim  pengabdian  kepada  Masyarakat  tertarik  untuk  melakukan  Pendidikan  Kesehatan dalam  bentuk  penyuluhan  terkait  manfaat  air  rebusan  daun  sirih  terhadap  fluor  albus pada wanita usia reproduktif di Desa Majungan Kecamatan Pademawu.

Infections and antibiotic resistance pose significant challenges to global healthcare. This study aims to evaluate the antibacterial potential of endophytic fungi isolated from betel leaves (Piper betle L.) against Staphylococcus aureus and Staphylococcus epidermidis. The research involved isolating endophytic fungi using Potato Dextrose Agar (PDA), purifying the isolates, and testing their antibacterial activity through the disk diffusion method. The results revealed that three endophytic fungal isolates produced inhibition zones, with the highest average diameter of 17.46 mm against Staphylococcus aureus and 18.66 mm against Staphylococcus epidermidis. These findings indicate the potential of betel leaf endophytic fungi as a natural source of antibacterial agents. This study underscores the role of endophytic fungi in developing new antibiotics to combat bacterial resistance.    

Herbal Tea Bag Product Made from Chinese Betel Leaf with Combination of Lemongrass and Cardamom. This research aims to: 1) investigate the organoleptic properties of herbal tea bags made from Chinese betel leaf combined with lemongrass and cardamom, and 2) assess the sensory quality of the product through hedonic testing. This experimental study employed an observational method using a sensory evaluation panel consisting of 35 members (5 experts and 30 semi-trained panelists). Data were collected using a questionnaire. The independent variables were the proportion of Chinese betel leaf (2g, 4g, and 6g) and the addition of lemongrass and cardamom (2g) with temperature variations (40°C and 60°C) for 4 hours. The dependent variables were the sensory qualities, including shape, color, aroma, taste, and texture. The control variables included the type of materials, equipment, and processing techniques. Data analysis was performed using two-way anava and Duncan's multiple range test. The results showed that: 1) the proportion of Chinese betel leaf affected the shape and taste, 2) the drying temperature affected the color, taste, and texture, and 3) there was no interaction between the proportion of Chinese betel leaf and the addition of lemongrass and cardamom on the sensory quality of the herbal tea bags.

Diabetes mellitus is one of the chronic diseases whose prevalence is increasing worldwide. This disease is characterized by high blood glucose levels due to impaired insulin production or function, the hormone that regulates blood sugar levels. This study aims to examine the effect of wild betel leaf extract (Piper aduncum) on the inhibition of glucose transport using the ileum of white rats (Rattus norvegicus) with the infusion method. This research is a pre-experimental study with a posttest-only control design using white rats and wild betel leaves. The study demonstrates that wild betel leaves (Piper aduncum L.) and red betel leaves (Piper crocatum) have significant potential in inhibiting glucose transport and reducing blood sugar levels. This is evident from the significant decrease in the rate of glucose transport after the administration of wild betel leaf extract, indicating an inhibitory effect on glucose transporters such as SGLT-1 and GLUT-2.

This study explored the analgesic effectiveness of ethanol extract of red betel leaf (Piper crocatum) in white rats (Mus musculus L.) induced with acetic acid. A total of 15 rats were divided into five groups with different treatments, and the number of twitching movements as a pain response was measured for one hour. The extract was prepared using 96% ethanol solvent, and the analgesic effect was analyzed using the writhing test method. The results showed that the extract contained flavonoids, alkaloids, tannins, and saponins, which might contribute to its analgesic properties. It was found that the higher the dose of extract administered, the greater the inhibition of pain that occurred, with a dose of 800 mg/kgBB showing optimal analgesic effectiveness, almost equivalent to paracetamol as a positive control. Statistical analysis showed significant differences between treatment groups, with doses of 200 mg/kgBB and 400 mg/kgBB showing lower effectiveness. This study recommends further exploration of the therapeutic benefits of red betel leaf extract and formulation development for wider medical applications.  

Decoction water betel leaf is a traditional Balinese medicine containing the active compound hydroxychavikol, has antioxidant and antidyslipemic activity. From the results of the study it was reported that decoction water of betel leaf contains the active compound hydroxycavicol (HC). The active compound hiroksikavikol has activity as an antioxidant and antidyslipidemia. As an anti-oxidant, it can scavenge ROS and inhibit the activity of free radicals. As an antidyslipidemia, it can normalize lipid metabolism by lowering total cholesterol, triglyceride, LDL and VLDL levels and increasing blood serum HDL levels. Oxidative stress and dyslipidemia are major risk factors for heart disease caused by atherosclerosis. Atherosclerosis is the occurrence of plaque formation in the lumen of blood vessels triggered by oxidative stress through endothelial cell dysfunction, inflammation and lipid peroxidation. Oxidative stress causes endothelial cell dysfunction, increased contractility, VSMC growth, monocyte invasion and lipid peroxidation, inflammation and increased deposition of extracellular protein matrix. Based on these things, it was concluded that HC loloh boiled water of betel leaf has antioxidant and antidyslipidemic activity to prevent heart disease.

Postpartum infection is likely to originate from infected perineal suture wounds. These suture wounds are caused by episiotomy or infected incisions and due to tears in the birth canal or perineal tears. This study aims to determine the Effect of Green Betel Leaf Boiled Water in Accelerating Perineal Wound Healing at the Beutong Ateuh Health Center, Beutong Ateuh Banggalang District, Nagan Raya Regency, Aceh Province in 2024. This type of research is a quasi-experimental research method with a Post test with control group design. The population is all postpartum mothers who experience grade I-II perineal wounds at the Beutong Ateuh Health Center, Beutong Ateuh Banggalang District, Nagan Raya Regency, Aceh Province, as many as 22 people. The number of samples used was 22 people obtained using the Total sampling technique. The data analysis technique used the paired sample t-test value. The results obtained in this study were from 22 respondents, there was a difference in the effect of green betel leaf decoction in accelerating the healing of perineal wounds in the intervention group and the control group with the independent sample t test obtained results for the value of p = 0.000 meaning p <0.05.

Background: In 2020, there were 2.9 million cases of perineal rupture in mothers giving birth, it is estimated that this will reach 6.8 million in 2050. Childbirth is a process that is vulnerable to various complications that can endanger the mother. Vaginal delivery is more susceptible to tearing of the perineum to varying degrees. Red betel leaves contain essential oils, hydroxycabicol, chabicol, carbibetol, allylcatechol, cineole, tanim, diastase, sugar and starch. Objective: to determine changes in wound healing before and after being given red betel leaf decoction Method: Case study with application to 2 respondents. Respondents were given red betel leaf decoction twice a day in the morning and evening for 5 consecutive days. Wounds were measured using the REEDA scale. Results: After applying red betel leaf decoction, the results showed a decrease in the rate of wound healing in both respondents, there was a decrease in scores from previously Mrs. E 10 becomes 0 (good wound healing) and Mrs. S 11 becomes 1 (poor wound healing). Conclusion: There were changes and differences in the rate of wound healing before and after giving red betel leaf decoction to the two respondents.   Keywords: , ,

. This research was conducted to identify differences in morphology and anatomy of betel leaves from the Piperaceae family and the Araceae family. In Warung Peuteuy Village, Cicalengka District, there are several species of betel leaves from the Piperaceaae and Araceae families which have different anatomical characteristics and leaf shapes. This study aims to determine the differences in terms of anatomical and morphological characteristics of betel leaves from the Piperacea family and the Araceae family. This research is descriptive in nature by explaining and describing the morphological and anatomical characters of 3 types of betel plants, namely green betel, red betel and ivy betel. Variations in the morphology of betel leaves from the Piperaceae family and the Araceae family can be observed from leaf type, leaf width, leaf length, leaf shape, leaf color, leaf edge, leaf tip, leaf base, leaf veins, petiole color, petiole length, surface, phyllotaxis. Variations in the anatomy of betel leaves from the Piperaceae family and the Araceae family can be observed from variations in the shape of ergastic objects, variations in the number of epidermis layers, number of hypodermis layers, number of palisade parenchyma layers, number of sponge parenchyma layers.  

Chinese Betel Plant (Paperomia pellucida) is an herbal plant that has benefits for treating diseases such as acne, ulcers, antidiabetic, antioxidant, anti-inflammatory, antimicrobial, and antibacterial. The content of bioactive compounds from Chinese betel include alkaloids, flavonoids, steroids, saponins, tannins, triterpenoids, and carbohydrates. The aim The purpose of this study was to determine the effect of steeping Chinese betel and  on reducing blood glucose levels in male mice. This method used is an experimental method at the Pharmacology Laboratory D3 Pharmacy FMIPA Bengkulu University. The test animals used were three groups, namely the positive control treatment group that received glibenclamide, the negative control treatment group received aquadest, and the 2% Chinese betel steeping treatment group. The results showed that Chinese betel curd was reduced from 125 mg/dl to 93 mg/dl and there was no hypoglycemic decrease in blood glucose due to glibenclamide. From the results of the study it can be concluded that the administration of Chinese betel and glibenclamide steeping is effective in lowering blood glucose levels in male mice.

Flour albus or vaginal discharge is a problem that often occurs in women. Efforts that can be made to reduce the occurrence of flour albus include pharmacological (drugs from doctors) and non-pharmacological. The use of natural ingredients as herbal medicine is considered safer than the use of modern medicine because the side effects of herbal medicine are relatively small if used correctly. Betel leaves can be used as a cure for flour albus because they have the power to kill germs. The content of betel leaves is usually used in cleaning soap specifically for women. Objective: to determine the effect of green betel leaf decoction in reducing vaginal discharge in women of childbearing age. Method: pre-experimental research design (one-group pre-post test design). The sampling technique used purposive sampling totaling 15 people. Data analysis used the dependent t test to see the effect before (pre test) and after (post test) using boiled green betel leaf water by washing it directly into the vaginal area. Research results: respondents experienced a decrease in the scale of vaginal discharge from itchy to non-itchy, a reduction in the level of turbidity and viscosity. increased breast milk production obtained from the pretest and posttest. The results of the dependent t test showed a Z value of -2.111 and Asymp Sig of 0.004 <0.005. The conclusion of this study states that there is an effect of betel leaf decoction on vaginal discharge in women of childbearing age  

Background: Reproductive and sexual health is the right of an individual, family and society regardless of status, race, age, gender, religion, sexual orientation, economics and social status. According to data from the 2019 Indonesian Demographic and Health Survey (SDKI), in Indonesia, one of the complaints frequently encountered in clinics and maternal and child health (KIA) is vaginal discharge/fluor albus. Efforts to reduce vaginal discharge can be done by means of pharmacological therapy (drugs) or non-pharmacological therapy, one of which is using boiled water from betel leaves. Betel leaves contain essential oils consisting of betlephenol, kavikol, sesquiterpenes, hydrocicavicol, cavibetol, estragol, eugenol, and carvacrol, and among these substances are kavikol, euginol and ethanol which can be used to treat vaginal discharge. Objective: To determine the effect of boiled betel leaf water to reduce complaints of flour albus in women of childbearing age. Research Location : This research was conducted in the village of Serakat Jaya on 32 women of childbearing age who experienced vaginal discharge. Research Method : The research design used was a pre-experimental design type one group pretest-posttest (initial test, single group final test). The data analysis used was the Wilcoxon Signed Rank Test. Results : The research shows a p-value < 0.001 p < 0.05 which shows that boiled water from betel leaves has an effect on reducing complaints of flour albus.

Betel is a native Indonesian plant that grows creeping or protruding on the trunk of other trees. Not only for ornamental plants, betel leaves are also believed to be able to overcome various diseases. Betel leaf can also be used for vaginal discharge whose healing properties have been clinically tested. A woman is more prone to vaginal discharge during pregnancy because during pregnancy there are hormonal changes which one of the factors is an increase in the amount of fluid production and a decrease in vaginal acidity. Objective: To determine the effect of giving betel leaf boiled water to reduce vaginal discharge in pregnant women. Method: This type of research is a quasy experiment with a non equivalent control group. The study was conducted by providing intervention in the experimental group in the form of betel leaf decoction, while in the control group was not given. Results: In the experimental group, the difference in healing leucorrhoea had an average of 13.1. In the control group, the difference in healing vaginal discharge had an average of 7.9. The results of the statistical test obtained a p value of 0.015 < α (0.05), so there was a difference in the difference in healing leucorrhoea in the experimental and control groups at the Wulan Mardikaningtyas, Amd.Keb PMB in Sukoharjo City (p = 0.015). Conclusion: Betel leaf boiled water is effective for reducing vaginal discharge in pregnant women.

Ikan cupang merupakan salah satu komoditas ikan hias air tawar yang banyak diminati baik di pasar domestik maupun internasional (ekspor). Waktu yang digunakan peneliti dalam penelitian ini adalah tanggal 13 Oktober 2022 Lokasi penelitian ini berada di Medan Johar. Pemijahan ikan cupang diawali dengan perawatan ikan cupang jantan yaitu mengeluarkan busa dari mulutnya kemudian diletakkan di permukaan sebagai sarang untuk bertelur. Setelah itu sang jantan akan mencari betina yang siap dijadikan indukan. mitra. Setelah ikan jantan mendapatkan pasangan yang cocok, ikan betina akan melepaskan sel telur yang diikuti dengan keluarnya sel sperma oleh ikan jantan. Telur yang telah dibuahi akan dibawa oleh pejantan ke buih yang ada di permukaan. Pada masa hingga menetas, ikan jantan akan menjaga telur-telur tersebut hingga benar-benar menetas. Bahkan hingga anakan cupang mandiri. Jika ada buih yang pecah maka mereka akan segera membuat buih yang sama agar telur benar-benar bisa menetas. Daun ketapang mengandung senyawa aktif berupa antosianin dan tanin, namun pigmen tanin lebih dominan yang berpotensi menjadi sumber zat warna. Kandungan tanin pada ketapang dapat menghasilkan warna coklat, sedangkan antosianin menghasilkan warna merah. Penggunaan daun ketapang dapat menurunkan pH air sekitar 5 pH dan membuat air menjadi lebih gelap dan kondisi ini dapat membantu reproduksi ikan.    

Hyperglycemia occurs when the body's condition is too much blood glucose that exceeds normal limits in the body because the body does not produce insulin properly. Betel leaves and ginger rhizomes have long been used by the people in Indonesia as traditional medicines that are believed to reduce blood glucose levels. This study aims to determine the effectiveness of betel leaves and ginger rhizomes empirically to reduce blood glucose levels in hyperglycemia male rats. Betel leaves and rhizomes of ginger are made in the form of infusions and used on 30 heads of hyperglycemia mice divided into 6 groups. Normal group, negative group induced alloxane, positive group (glibenklamide), betel leaf infusion group, ginger rhizome infusion group, betel leaf infusion combination group and ginger rhizome infusion, testing was carried out for 30 days. Data were analyzed with IBM SPSS 20.0 ANOVA and post hoc tukey HSD assays. The results showed that betel leaf infusion at a dose of 2 ml / kg BB and ginger rhizome infusion dose of 2ml / kg BB single administration could reduce blood glucose levels while in combination administration it was seen that there was less effective in reducing blood glucose levels in male white rats.    

The rise of disease outbreaks caused by microorganisms such as SARS, bird flu, HIV and COVID-19 has made people use products that contain antiseptics such as soap and hand sanitizer. However, if used continuously it will dissolve the layer of fat and sebum on the skin so that the skin becomes sensitive, dry, and irritated. The development of antiseptic products can be done with natural ingredients such as green betel leaf extract (Piper betle L). It is known that green betel leaf (Piper betle L) has long been used in traditional medicine and can be a natural antiseptic ingredient for making hand sanitizer. This study aims to determine the formulation of hand sanitizer from betel leaf extract (Piper betle L) accompanied by a physical stability test. The materials used in this study were methyl paraben, triethanolamine (TEA), glycerin, aquadest, 95% ethanol, lime juice, green betel leaf extract obtained from the reflux extraction process. The research was conducted by varying the betel leaf extract 55%, 60%, 65%, 70%, 75%. Tests were carried out by covering organoleptic observations (shape, color, odor), pH, homogeneity, dispersion.

Daun sirih merupakan tanaman herbal yang banyak tersedia di Indonesia. Daun sirih banyak mengandung minyak atsiri, polifenol, dan flavonoid. Antioksidan yang sangat bermanfaat bagi kesehatan sehingga berpotensi sebagai sumber bahan pangan fungsional. Salah satunya dapat dimanfaatkan ekstraknya untuk pembuatan permen jelly. Daun suji ditambahkan sebagai pewarna alami dari permen jelly. Penelitian ini bertujuan untuk mengetahui konsentrasi ekstrak daun sirih dan daun suji yang optimal dalam pembuatan permen jelly. Selain itu juga bertujuan untuk mengetahui aktivitas antioksidan dari permen Jelly yang dihasilkan. Permen jelly yang dihasilkan diharapkan dapat memenuhi standar mutu SNI dan disukai oleh konsumen. Penelitian dilakukan dengan menggunakan Rancangan Acak lengkap (RAL) faktorial yang terdiri dari dua faktor. Faktor pertama yaitu konsentrasi ekstrak daun sirih 1, 3, dan 5% dan faktor kedua konsentrasi ekstrak daun suji 0, 2, dan 4%. Hasil penelitian menunjukkan bahwa kombinasi perlakuan yang mempunyai aktivitas antioksidan maksimal dan disukai konsumen adalah konsentrasi ekstrak daun sirih 5% dan konsentrasi ekstrak daun suji 2%. Permen jelly tersebut mempunyai karakteristik : aktivitas antioksidan 90,62%; total fenol 2,23 mg ekuivalen asam galat/100 g; kadar air 18,43%; kadar abu 1,49%; kadar gula total 42,21%; kekenyalan 15,85 mm devision; warna hijau tua (3,07); tekstur kenyal (3,47); rasa sirih sedikit pahit (2,07); dan disukai (2,47).Kata kunci: Permen jelly, daun sirih, daun suji, antioksidan

Antioksidan bermanfaat bagi kesehatan karena dapat menangkal radikal bebas yang menyerang jaringan tubuh dan berperan untuk mempertahankan mutu produk pangan. Tanaman sumber antioksidan salah satunya yaitu daun sirih merah, bunga rosela, dan jahe. Salah satu usaha yang akan dilakukan adalah mengolah daun sirih merah, bunga rosela, dan jahe menjadi sirup. Penelitian ini bertujuan untuk menghasilkan formulasi sirup “sijala” yang memiliki aktivitas antioksidan tinggi, berkualitas, dan disukai konsumen, serta mengetahui karakteristik kimia, fisika, dan sensori sirup “sijala” dengan variasi persentase kadar ekstrak sirih merah-bunga rosela dan kadar filtrat jahe. Penelitian ini dilakukan dengan metode rancangan acak lengkap (RAL) faktorial dengan dua faktor yaitu persentase kadar ekstrak sirih merah-rosela (0,5-1,5 %; 1,0-2,5%; dan 1,5-3,5%) dan kadar filtrat jahe (0, 4, 8, dan 12%). Hasil penelitian menunjukkan bahwa kombinasi perlakuan persentase kadar ekstrak sirih merah-rosela dan kadar filtrat jahe yang memiliki sifat fungsional dan lebih disukai panelis adalah perlakuan 1,5% sirih merah-3,5% rosela dengan kadar filtrat jahe 8%. Sirup tersebut memiliki karakteristik: aktivitas antioksidan 94,60% RSA DPPH ; kadar vitamin C 197,12 mg /100 g ; derajat keasaman 3,20 ; viskositas 25,12 dPas ; warna sirup merah muda (1,80) ; sedikit ada flavor jahe (1,66) dan rasa yang sedikit pahit (1,93).Kata kunci: Sirup, daun sirih merah, bunga rosela, jahe, antioksidan.