Publication Search

80,083 articles from 753 journals · 2,111 citations tracked

Showing 1-20 of 190

Analytics

Khilyatun Niswah; Ahmad Zakiudin

Jurnal Praba : Jurnal Rumpun Kesehatan Umum 2026 STIKES Columbia Asia Medan

Intracerebral hemorrhage (ICH) is the most common type of hemorrhhagic stroke and a leading cause of death and disability in Indonesia. The prevalence of stroke in Indonesia reached 0.83% in 2023, with ICH cases at RSUD dr. Soeselo, Tegal Regency recording 203 cases in 2024 and increasing significantly to 304 cases in 2025. This study aims to describe comprehensive nursing care for a patient with Intracerebral Hemorrhage. The method used was descriptive narrative through a nursing process approach. Nursing assessment of Ny. S (73 years old) revealed subjective data including headache, nausea and vomiting, and weakness in the left hand and foot, while objective data showed blood pressure 180/80 mmHg, MAP 113.3 mmHg, muscle strength of left extremities 2/2, and CT scan results showing a hyperdense lesion (volume 17.17 cc) with perifocal edema in the right thalamus and right corona, partially filling the ventricular system. Four nursing diagnoses were established: decreased intracranial adaptive capacity related to cerebral edema, impaired physical mobility related to decreased muscle strength, knowledge deficit related to lack of information exposure, and risk of falls. Nursing interventions included intracranial pressure management, mobilization support, health education, and fall prevention. After three days of nursing implementation, three nursing diagnoses were resolved, while impaired physical mobility was partially resolved, resulting in discharge planning recommendations including ROM exercises, gradual mobilization, and family involvement in patient care.

Warih Kuncoro Mukti; Indriani Silvia; Donny Nauphar

Jurnal Sains dan Kesehatan (JUSIKA) 2026 Universitas Muhamadiyah Manado

Corona Virus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The first case was identified in Wuhan, China, in December 2019. The World Health Organization declared COVID-19 a Public Health Emergency of International Concern (PHEIC) on January 30, 2020, and a pandemic on March 11, 2020. This study aimed to determine the results of CT Value images on the first and second swab tests of children with COVID-19 in Indramayu. A descriptive design was used with total sampling, involving 54 respondents. Secondary data were analyzed using univariate analysis. On the first swab test, 27 children (50.0%) had a strong positive Ct Value, 26 children (48.1%) were positive, and 1 child (1.9%) had a weak positive Ct Value. On the second swab test, 23 children (71.9%) were positive, 6 children (18.8%) were strong positive, and 3 children (9.4%) were weak positive. All children tested positive on the first swab, while 32 (59.3%) remained positive and 22 (40.7%) became negative on the second swab. Most children showed decreased infection severity, although some remained positive.

Aida Fitri Harahap

Inovasi Kesehatan Global 2026 Lembaga Pengembangan Kinerja Dosen

Chronic Coronary Syndrome (CCS) is a contemporary term that replaces stable coronary artery disease (CAD) and describes a spectrum of clinical conditions resulting from chronic abnormalities of the coronary arteries. This condition is characterized by a mismatch between myocardial oxygen supply and demand that is transient and reversible, commonly presenting as stable angina pectoris. CCS contributes significantly to global cardiovascular morbidity and mortality, including in Indonesia. The underlying pathophysiology primarily involves atherosclerosis and microvascular dysfunction leading to myocardial ischemia. Diagnosis is established through comprehensive history taking, physical examination, and both invasive and non-invasive investigations such as electrocardiography, stress testing, and cardiac imaging. Risk stratification using pre-test probability plays a crucial role in guiding further diagnostic evaluation. The management of CCS aims to relieve symptoms and prevent adverse cardiovascular events through pharmacological and non-pharmacological approaches, as well as revascularization when indicated. Pharmacological therapy includes antianginal agents, antiplatelet drugs, and lipid-lowering agents, while lifestyle modifications such as smoking cessation, healthy diet, and regular physical activity are essential in preventing disease progression. With accurate diagnosis and comprehensive management, the morbidity and mortality associated with CCS can be reduced.

Adri Adri; Aulia Mustika

Jurnal Riset Ilmu Farmasi dan Kesehatan 2026 Asosiasi Riset Ilmu Kesehatan Indonesia

Cardiovascular dysfunction is a disorder of the blood vessels, such as hypertension, heart failure, and stroke. In 2016, cardiovascular disease was the leading cause of death worldwide, based on data from the World Health Organization (WHO). Coronary Heart Disease (CHD) is the leading cause of death, along with stroke, as shown by the Sample Registration System survey in 2014.This case involves a 64-year-old male, Mr. N, who presented to the emergency department of RSUD dr. Fauziah Bireuen with complaints of chest pain that developed gradually and worsened over the past month. The pain was located across the entire chest and radiated to the back and neck. The pain was described as severe, like being crushed by a heavy load, worsened during strenuous activities such as cutting grass and chopping wood, and relieved when the patient bent forward. The pain could occur at any time, with a Visual Analog Scale (VAS) score of 10 (severe pain). The patient also reported easy fatigue during heavy physical activity over the past month. Laboratory examination revealed elevated leukocytes, mean corpuscular volume (MCV), segmented neutrophils, troponin I, cholesterol, and triglycerides. The patient was diagnosed with extensive anterior ST-elevation myocardial infarction (STEMI) post successful fibrinolytic therapy.

Purwaningsih , Sri; Yusuf, Mochamad; Putranto, Johanes Nugroho Eko; Sudanawidjaja, Melisa Nathania

International Journal of Health and Social Behavior 2026 Asosiasi Riset Ilmu Kesehatan Indonesia

Hypertension is a major modifiable risk factor contributing to the development of Acute Coronary Syndrome (ACS), which includes STEMI, NSTEMI, and unstable angina. The increasing prevalence of hypertension worldwide raises concern regarding its impact on cardiovascular outcomes. This study aimed to describe the profile of ACS patients with hypertension receiving angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) therapy in the Intensive Coronary Care Unit (ICCU) of RSUD Dr. Soetomo Surabaya. Using a descriptive cross-sectional method, data from 91 patients treated between July 2021 and October 2024 were analyzed. Variables included demographic characteristics, clinical classification of ACS, hypertension degree, comorbidities, types and doses of ACEI/ARB administered. The results showed that most patients were male (73%) and aged over 65 years (40%). Chi-square analysis revealed no significant relationship between hypertension degree, ACS classification, or most comorbidities with drug selection or dosage (p>0.05), except for a significant association between coronary heart disease comorbidity and ARB selection. These findings suggest that in hypertensive ACS patients, the choice between ACEI and ARB therapy is predominantly based on individual comorbidity profiles rather than blood pressure severity or ACS type. The study highlights the importance of personalized treatment approaches considering patient comorbidities to optimize cardiovascular outcomes.

Thoha Irfan Darojat; Danang Raharjo; Bagas Ardiyantoro

Jurnal Kesehatan Amanah 2026 Universitas Muhammadiyah Manado

Hypercholesterolemia, defined as elevated levels of cholesterol in the bloodstream, is widely recognized as a major risk factor for cardiovascular diseases, including atherosclerosis and coronary heart disease. Antioxidants play an important role in preventing oxidative damage by neutralizing free radicals through electron donation, thereby helping to reduce lipid peroxidation associated with high cholesterol levels. This study aims to evaluate the cholesterol-lowering activity of the ethyl acetate fraction of buni leaves (Antidesma bunius) through laboratory experimentation. The leaves were extracted using the maceration method with 96% ethanol, followed by fractionation with ethyl acetate to obtain the targeted fraction. The in vitro anticholesterol activity was determined using the Liebermann–Burchard method and measured by UV-Vis spectrophotometry. Data analysis was performed using linear regression to calculate the IC₅₀ value. The results demonstrated that the ethyl acetate fraction exhibited very strong cholesterol-lowering activity, with an IC₅₀ value of 1,659 ppm/µg/mL, indicating promising potential as a natural antihypercholesterolemic agent.

Salsabila Nitya; Cut Mourisa

Jurnal Riset Rumpun Ilmu Kesehatan 2025 Pusat riset dan Inovasi Nasional

Hypertension is a primary risk factor for cardiovascular diseases, including stroke, coronary artery disease, atrial fibrillation, and peripheral vascular disease. Often referred to as "The Silent Killer," its onset is frequently asymptomatic, making early detection challenging. Effective interventions, both pharmacological and non-pharmacological, are necessary to manage hypertension and reduce complications. Long-term treatment requires adherence to prescribed medications, with self-care management playing a vital role in minimizing hypertension's adverse effects. Self-efficacy, or an individual's belief in their abilities, is crucial for improving medication adherence and self-care activities. This study aimed to examine the correlation between self-efficacy and self-care management in relation to medication adherence among hypertension patients at RSUD Mandau District. A non-experimental, quantitative, analytic correlation study with a cross-sectional design was conducted, involving 38 hypertension patients. Self-efficacy was measured using the MASES-R (Medication Adherence Self-Efficacy Scale-Revision), medication adherence was assessed with the MMAS-8 (8-item Morisky Medication Adherence Scale), and self-care management was evaluated using the HBP-SCP (Hypertension Self-Care Profile). The findings revealed a significant correlation between self-efficacy and medication adherence (p=0.000, r=0.594). Additionally, self-care management was significantly correlated with medication adherence (p=0.027, r=0.360). In conclusion, self-efficacy and self-care management both significantly correlate with medication adherence in hypertension patients at RSUD Mandau District.

Renti Sinurat; Afnijar Wahyu

Jurnal Ventilator: Jurnal riset ilmu kesehatan dan Keperawatan 2025 Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Background: Cardiac catheterization is the most widely used diagnostic and hemodynamic intervention procedure in the world for the treatment of coronary heart disease (CHD). Cardiac catheterization can cause anxiety in patients who will undergo it. Objective: To analyze the factors that influence the anxiety of patients who will undergo cardiac catheterization. Method: This study is a descriptive analytical study with a cross-sectional approach conducted at Murni Teguh Memorial Hospital Medan. The study population was 40 people, and all of them were used as samples (total sampling). The research instrument was a questionnaire. Data analysis was carried out univariately and bivariately using the Chi-Square test with a significance level of 95% (= 0.05). Results: This study shows that there is a significant influence between knowledge, family support, past experience, and education level on the anxiety of patients who will undergo cardiac catheterization at Murni Teguh Hospital Medan. This is proven by the chi square test with p values for each knowledge (p = 0.000); family support (p = 0.002); past experience (p = 0.003); and education (p=0.003) which are all less than 0.005. Conclusion: Cardiac catheterization patient anxiety is influenced by knowledge, family support, past experience, and education level. Suggestion: It is recommended that further researchers increase the number of samples and independent variables, considering that many factors influence patient anxiety before cardiac catheterization/angiography

Lindawati F. Tampubolon; Lilis Novitarum; Vina Yolanda Sigalingging; Sukemi Saragih

Jurnal Ventilator: Jurnal riset ilmu kesehatan dan Keperawatan 2025 Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Hypertension substantially increases the risk of developing secondary conditions, including stroke, renal disease, coronary heart disease, and heart failure. Early management is therefore essential to prevent complications and adverse outcomes. Evidence indicates that untreated hypertension contributes to approximately 60% of stroke cases. Public knowledge regarding hypertension-related complications remains limited, and many individuals are unable to identify early signs of stroke the most common complication associated with hypertension. This study aimed to assess the knowledge of hypertensive patients regarding stroke risk and management at Santa Elisabeth Hospital Medan in 2024. A descriptive research design was employed. The sample consisted of 67 hypertensive patients attending the outpatient clinic, selected through purposive sampling. Data were presented using frequency distribution tables. The findings revealed that 52.2% of respondents demonstrated poor knowledge, 32.8% had moderate knowledge, and only 14.9% showed good knowledge regarding stroke risk and management. These results underscore the need for patients to adopt healthier lifestyles and for the hospital to strengthen educational efforts by providing more engaging and interactive learning materials for patients and their families.

Hanum Alya Saputri; Tati Karyawati; Arisnawati Arisnawati

Jurnal Mahasiswa Ilmu Kesehatan 2025 STIKes Ibnu Sina Ajibarang

Non-communicable diseases (NCDs) are a major challenge in today's health development. One category of these diseases is hypertension, which is classified as a chronic disease with a relatively high mortality rate. Hypertension serves as a major predictor for various chronic diseases and is a common disease found in the community (Putri et al., 2025). If not managed properly, hypertension can lead to more serious complications such as stroke, coronary heart disease, diabetes, kidney failure, and blindness. Stroke (51%) and coronary heart disease (45%) are the leading causes of death related to hypertension (Pokhrel, 2024). The increasing prevalence of hypertension along with changes in lifestyle and unhealthy eating patterns adds to the global health burden. Therefore, effective management of hypertension is essential to prevent further complications. Appropriate hypertension management and regular monitoring can reduce the risk of related diseases, improve quality of life, and reduce mortality caused by complications of heart disease and stroke. Preventive and promotive efforts through health education are key to reducing the prevalence of hypertension in the community.

Intan Lambang Astrini; Anak Agung Ayu Eka Cahyani; Mardiyah Hayati

Jurnal Kesehatan Amanah 2025 Universitas Muhammadiyah Manado

Dyslipidemia is one of the causes of coronary heart disease and stroke. Hypercholesterolemia can cause atherosclerosis. In recent years, there has been an independent risk factor that is an important factor in the presence of blood vessel wall abnormalities, namely homocysteine. Increased homocysteine has been shown to increase the risk of cardiovascular disease independently. This study is an observational analytical study using a cross-sectional design with a retrospective approach. The sample used was 33 respondents selected through a total sampling technique The results of the test on the relationship between Lipid Profile and homocysteine using statistical testing methods, namely Spearman's Rho, yielded the following results: there is no significant relationship between Total Cholesterol and homocysteine with a Sig value of 0.791 (>0.05) and a correlation coefficient of 0.048; there is no significant relationship between LDL Cholesterol and homocysteine with a Sig value of 0.272 (>0.05) and a correlation coefficient of -0.197; there is a significant relationship between HDL Cholesterol and homocysteine with a Sig value of 0.004 (<0.05) and a correlation coefficient of -0.487; there is a significant relationship between Triglycerides and Homocysteine with a Sig value of 0.047 (<0.05) and a correlation coefficient of 0.348. The conclusion of this study is that there is a significant relationship between HDL Cholesterol and Triglycerides to homocysteine in patients with Dyslipidemia at Prodia Clinical Laboratory Tangerang. Further research is needed with a larger sample size focusing on the gender and age of the respondents.

Fauziah Fauziah; Ellyza Fazlylawati; Nur Afri Liandi Rasmin

Jurnal ilmu Kesehatan Umum 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

Hypertension is one of the global public health issues with serious implications as it may lead to severe complications such as stroke, coronary heart disease, and kidney failure. Elderly individuals are among the most vulnerable groups, with the highest prevalence found in the age group of 65–74 years (57.6%) and those over 75 years (63.8%). Non-pharmacological treatment for hypertension includes regular and consistent elderly gymnastics. This study aims to examine the effect of elderly gymnastics on blood pressure among elderly individuals with hypertension at the Rumoh Sejahtera Geunaseh Sayang Nursing Home, Ulee Kareng, Banda Aceh. The study applied a quasi-experimental design with a deductive approach. The population consisted of 55 elderly individuals, and 17 were selected as the sample using total sampling technique. The elderly gymnastics intervention was conducted three times a week, from April 17th to 22nd, 2025. Blood pressure was measured before and after the intervention using a pre-test and post-test observation sheet. Data analysis was performed using the Wilcoxon test, suitable for non-parametric data. Results showed that on the first day, there was no significant difference in systolic and diastolic blood pressure (p = 0.091). On the second day, systolic blood pressure showed a significant decrease (p = 0.003), while diastolic pressure remained non-significant (p = 0.161). On the third session, a significant reduction occurred in both systolic (p = 0.000) and diastolic (p = 0.001) blood pressure. Conclusion: Elderly gymnastics has an effect on reducing blood pressure in elderly individuals with hypertension. This intervention may serve as an effective and applicable non-pharmacological therapy in daily life.

Fajrin Ziad Syahputra; Dwi Heppy Rochmawati

Jurnal Ilmu Keperawatan dan Kebidanan 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

Coronary heart disease is one of the major health problems that not only affects the physical condition of patients but also impacts their psychological state, particularly anxiety. Anxiety levels in patients with coronary heart disease usually increase when they are about to undergo invasive medical procedures such as Percutaneous Coronary Intervention (PCI). Anxiety can be influenced by several factors, including age, gender, educational level, and occupation. High levels of anxiety may worsen the patient’s clinical condition, making appropriate non-pharmacological interventions highly necessary to help reduce anxiety. This study aims to determine the effect of spiritual support in the form of dzikir on the anxiety levels of patients with coronary heart disease. The research design used was a true experimental design with a pretest-posttest control group design. The sample consisted of 30 respondents who were evenly divided into two groups: 15 respondents in the intervention group and 15 respondents in the control group. The sampling technique used was total sampling. The instrument for measuring anxiety was the Hamilton Anxiety Rating Scale (HARS). The results showed that providing spiritual support in the form of dzikir was effective in reducing patient anxiety, with a p-value of 0.001. In addition, there was a significant difference in post-therapy anxiety levels between the control and intervention groups, with a p-value of 0.019 (p < 0.05). These findings demonstrate that dzikir, as a form of spiritual support, can be used as a non-pharmacological intervention to reduce anxiety in patients with coronary heart disease. Thus, spiritual support can be an important component of nursing care for patients in the ICU.

Muhammad Daniyal; Emelda Emelda

Jurnal ilmu Kesehatan Umum 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

A 64-year-old male patient presented to the emergency department (ED) of RS Cut Meutia with complaints of left-sided chest pain radiating to both arms, which had been occurring for two days prior to his hospital admission. The chest pain was described as sharp, sudden, and progressively worsening, and it persisted without relief from positional changes. The pain intensity was rated as 9/10 and was accompanied by cold sweats and nausea. The patient had a history of type 2 diabetes mellitus for 15 years and had been on antidiabetic medications, although he could not recall the names of the medications. The patient was a smoker but had quit smoking upon being diagnosed with diabetes. Vital signs and general status were within normal limits upon examination. Local examination of the heart revealed a murmur on auscultation. Laboratory results showed anemia, leukocytosis, hyperglycemia, and hypercholesterolemia. Electrocardiography (EKG) indicated signs of inferior STEMI (ST-Elevation Myocardial Infarction). The patient was treated with furosemide 1 amp/12 hours, atorvastatin 1x20 mg, arixtra 1x0.25 mg, aspilet 1x8 mg, clopidogrel 1x75 mg, nitrokaf retard 2x2.5 mg, and bisoprolol 1x2 mg, along with non-pharmacological management, including three-way catheter insertion and oxygen therapy at 2-4 liters per minute. Acute Coronary Syndrome (ACS) carries a poor prognosis if not managed promptly and correctly. Understanding the appropriate management of ACS is crucial in preventing further myocardial occlusion and improving patient outcomes. Therefore, rapid and accurate intervention is vital in improving the prognosis for patients with ACS.

Aldila Sagitaning Putri; Dewi Larasati; Elly Yuniarti Sani

Publikasi Hasil Pengabdian dan Kegiatan Masyarakat 2025 Asosiasi Periset Bahasa Sastra Indonesia

Red beans (Phaseolus vulgaris L.) are a type of legumes (Leguminaceae) that have a high content of starch and fiber. The high fiber content causes red beans to prevent coronary heart disease. Red beans also have a low glycemic index so they can lower cholesterol levels in the blood and the risk of diabetes. Red beans also contain phenolic compounds that act as antioxidants in the body. Red beans are classified as food ingredients that can support the increase in nutritional value because they are classified as a relatively affordable source of vegetable protein. The purpose of this counseling is to provide knowledge and processed skills from local commodities, in this case red beans, to students majoring in Agribusiness of Agricultural Products at SMK Negeri 1 Bawen. This activity was attended by 68 students majoring in Agribusiness and Agricultural Products and 1 assistant teacher from SMK Negeri 1 Bawen, Semarang Regency. The method of this red bean processing extension activity is to increase the knowledge and skills of making processed local food products with several methods: a. The lecture method provides the theory and practice of making kidney bean cookies. b. Practice method of making red bean cut ice. c. The question and answer method, used to provide feedback to participants about the material that has been presented during the activity. d. Evaluation is given by providing pre test and post test. After the implementation, it showed that the target, namely students of SMK Negeri 1 Bawen, increased their knowledge and understood the importance of post-harvest handling and processing of red beans with the practice of making red bean cut ice. This is based on questions and answers, interviews and questionnaires shared before and after the activity. From the results of the questionnaire conducted before and after the activity, it showed that: After the implementation, there was a 50.17% increase in knowledge about kidney bean processing, Knowledge about making kidney beans into cut ice increased by 65.32% and Knowledge of other processed kidney beans such as kidney bean cookies showed that there was an increase of 67.15% after counseling. The conclusions that can be drawn from this counseling activity are (1) Processed red bean extension activities can increase the knowledge and understanding of the participants (2) The responses given by the counseling participants show a fairly satisfactory interest and there is a desire to apply the newly acquired knowledge to be socialized in the surrounding environment.

Haikal Eko Fahrianto Rahawarin; Irwan Irwan; Denny Jolanda

Jurnal Ilmu Kesehatan 2025 Lembaga Pengembangan Kinerja Dosen

Heart failure is a major cause of morbidity and mortality worldwide. Based on data from the World Health Organization (WHO), one of the most non-communicable diseases in the world is cardiovascular disease, whose spectrum is heart failure. To diagnose heart failure, a clinical history, physical examination and investigations are required. This study aims to determine the characteristics of heart failure patients at the heart polyclinic of RSUD Dr. M. Haulussy Ambon City March 2022. This research is a descriptive study. The number of samples in the study was determined using a categorical descriptive formula and the samples were taken using a simple consecutiv sampling technique. The data obtained were analyzed using the Statistical Package for the Social Science (SPSS). The results showed that from 74 samples of heart failure patients, 37 people aged >60 years (50%), 42 men (56.8%), 55 people had a history of coronary heart disease (74.3%). , as many as 21 people had a history of hypertension grade 1 (35.1%), as many as 7 people had a history of diabetes mellitus (9.5%), as many as 27 people took diuretic drugs (36.5%), as many as 34 people had a history of smoking (45.9%), as many as 31 people had a history of hospitalization (41.9%), as many as 26 people had a history of arrhythmias (35.1%), as many as 8 people had a history of valve abnormalities (10.8%).

Kevin Wijaya; Razoki Razoki; Roy Indrianto Bangar

Jurnal Kesehatan dan Kedokteran 2025 Lembaga Pengembangan Kinerja Dosen

Elevated blood cholesterol levels are known to be a major risk factor for cardiovascular disease. Hypercholesterolemia can trigger atherosclerosis, which in turn increases the risk of coronary heart disease and stroke. One approach to managing cholesterol levels is through the use of natural ingredients with antihyperlipidemic activity. White turmeric (Curcuma zedoaria Rosc) is an herbal plant long used in traditional medicine and contains bioactive compounds such as curcuminoids and essential oils. These compounds are reported to have antioxidant and anti-inflammatory activities, as well as potential as agents for lowering blood lipid levels. Herbal-based therapies are increasingly considered as safe alternatives to synthetic drugs in managing hyperlipidemia. This study aims to evaluate the effectiveness of a microencapsulated preparation of white turmeric ethanol extract in reducing total cholesterol levels in male rats (Rattus norvegicus) induced by a high-fat diet. The study was conducted experimentally using 25 rats divided into six treatment groups. The groups consisted of normal controls, negative controls, positive controls using simvastatin, and three treatment groups given white turmeric extract microcapsules at concentrations of 0.25%, 0.50%, and 0.75%. The microencapsulation technique was applied to improve the stability and bioavailability of the turmeric extract. Cholesterol levels were measured before and after treatment. The results showed that the treatment group with the 0.25% concentration produced the most significant cholesterol reduction, from 110 mg/dL to 59 mg/dL. These findings indicate that even at a relatively low concentration, microencapsulated turmeric extract can significantly reduce cholesterol levels in vivo. Therefore, it can be concluded that white turmeric extract in microcapsule form is effective in lowering total cholesterol levels, especially at the 0.25% dose. This suggests that Curcuma zedoaria microcapsules hold promise as a natural therapeutic option for managing hypercholesterolemia and reducing cardiovascular risk.  

Stefanus Rio Pendamenta Tarigan; Razoki Razoki; Erida Novriani

Jurnal Kesehatan dan Kedokteran 2025 Lembaga Pengembangan Kinerja Dosen

Dyslipidemia is a lipid metabolism disorder characterized by elevated levels of total cholesterol, triglycerides, and low-density lipoprotein (LDL) accompanied by decreased levels of high-density lipoprotein (HDL). This condition is a major risk factor for atherosclerosis, coronary heart disease, and stroke. One plant with potential as an antidyslipidemic agent is bay leaves (Syzygium polyanthum). These leaves are known to contain active compounds such as flavonoids, saponins, tannins, alkaloids, and polyphenols that have antioxidant and hypolipidemic activities. The potential of natural compounds from medicinal plants to reduce blood cholesterol levels has gained significant attention in recent years. This study aims to evaluate the effectiveness of microencapsulated ethanol extract of bay leaves in reducing total cholesterol levels in white rats (Rattus norvegicus) induced by a high-cholesterol diet. The experimental study design employed was a laboratory-based true experimental method with a post-test control group design. A total of 25 male rats were used and divided into six groups: normal control, negative control (high cholesterol diet without therapy), positive control (simvastatin), and three groups treated with bay leaf extract microencapsulates at doses of 0.25%, 0.5%, and 0.75%. The treatment was given for 14 days, then total cholesterol levels were measured using an enzymatic method. The results showed that the group with a dose of 0.75% experienced the highest decrease in total cholesterol levels, namely -70 mg/dL, greater than the simvastatin group (-49 mg/dL). Statistical analysis using One Way ANOVA showed a significant difference compared to the negative control (p < 0.001). These findings indicate that the 0.75% dose of microencapsulated Syzygium polyanthum extract demonstrated an effect equal to or greater than simvastatin. Thus, it can be concluded that bay leaf ethanol extract microencapsulates are effective in reducing total cholesterol levels in hypercholesterolemic rats. This suggests that Syzygium polyanthum microencapsulation has the potential to be developed as an alternative phytotherapy for cholesterol reduction.

Ulfa Zahara; Aulia Mustika; Nanda Nanda

Jurnal ilmu Kesehatan Umum 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

ST-Elevation Myocardial Infarction (STEMI) is one of the manifestations of acute coronary syndrome (ACS) and is a leading cause of disability and death worldwide. The mortality rate for STEMI is reported to reach 6%–14% of all ACS deaths. Reperfusion therapy is the primary treatment, with fibrinolytics an important option, especially in healthcare facilities that do not have the capacity to perform primary Percutaneous Coronary Intervention (PCI) in less than 12 hours. The success of fibrinolytics is influenced by various risk factors, such as hypertension, dyslipidemia, diabetes mellitus, a history of heart disease, and the duration of the attack. This study aims to determine the relationship between these factors and the success rate of fibrinolytics in STEMI patients. This study used a retrospective descriptive design with a cross-sectional method. The sampling technique used total sampling of patients diagnosed with STEMI and receiving fibrinolytic therapy according to inclusion and exclusion criteria at Dr. Fauziah Hospital. Statistical analysis was performed using the Chi-Square correlation test to assess the relationship between clinical variables and fibrinolytic success. The results showed no significant association between hyperglycemia (p = 0.823), hypertension (p = 0.240), or a history of heart disease (p = 0.704) and fibrinolytic success. Similarly, the onset of stroke variable did not show a significant association with reperfusion outcomes. In conclusion, classic risk factors such as hyperglycemia, hypertension, and a history of heart disease were not associated with fibrinolytic success in STEMI patients at Dr. Fauziah Hospital. These results suggest that fibrinolytic success is likely influenced by other factors, such as timing of drug administration, protocol adherence, and individual variation in response to therapy. Further research with a larger sample size and a prospective design is recommended to strengthen these findings.

Aqilla Lutfiah; Aulia Mustika

Jurnal Ilmu Keperawatan dan Kebidanan 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

Acute Coronary Syndrome (ACS) is an emergency condition in which a group of symptoms of acute ischemic chest pain are part of coronary heart disease (CHD) and require immediate treatment. The prevalence of CHD in Aceh is higher than the national average of 1.6% or around 20,244 people. This study is expected to describe the prevalence, number of deaths (mortality) and average length of stay (LOS) of STEMI patients during hospitalization so that this data can significantly enhance knowledge for health practitioners and be used as a warning to be more aware of STEMI incidents in Aceh. This study uses a retrospective descriptive research design with a research sample of all patients diagnosed with ACS with ST-Elevation who were hospitalized at Dr. Fauziah Hospital in June 2022-June 2023. The data collection technique is total sampling obtained from medical record data. It was concluded that the majority of patients were male, namely 80.7% (71 patients), the highest age was 45-60 years with 45 cases (51.1%). History of CHD was the dominant risk factor (62% of cases). The most dominant type of ACS with ST-Elevation was Anterior STEMI as many as 32 cases (52.3%) with onset <12 hours (51% of cases) and predominantly came with KILLIP I (62.5% of cases). The most dominant management was with conservative therapy 56 cases (61.4%). The average length of patient care was 5 days (45.1%) and the most outcomes with outpatients as many as 72 cases (81.8%).