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Exclusive breastfeeding was a good investment for children. Breast milk (ASI) is food that can be given to babies aged 0-6 months and breast milk has many benefits. Therefore, mothers must have good knowledge, attitudes and self-confidence towards exclusive breastfeeding. To determine the relationship between knowledge and attitudes in giving exclusive breastfeeding to Prenatal Breastfeeding Self-Efficacy in the Bandarharjo Community Health Center Working Area, Semarang City. Type of quantitative research with a cross sectional approach. The sample was pregnant women. The technique used was purposive sampling of 100 respondents. The correlation test used was the Spearman rho test. Using the Spearman correlation test of maternal knowledge on PBSE, the p-value was 0.014 (<0.05). There was a significant relationship between mother's knowledge of PBSE with a correlation of 0.246, which was weak with a positive correlation or close relationship. Meanwhile, attitudes towards PBSE resulted in a p-value of 0.000 (<0.05). There is a significant relationship between the mother's attitude towards PBSE, a correlation of 0.358, namely moderate with a positive correlation or close relationship. There was a relationship between knowledge and attitudes in giving exclusive breastfeeding to prenatal breastfeeding self-efficacy.