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Arum Suproborini; Desi Kusumawati; Mochamad Soeprijadi Djoko Laksana; Anindya Kusuma Wardani; Vijimol Vijimol

Journal of Health Sciences, Public Health and Pharmacy 2026 International Forum of Researchers and Lecturers

Background: Diabetes Mellitus (DM) is a disease that cannot be completely cured or cannot even be completely cured. The vile shard plant is empirically used by the community to treat diabetes (DM). This study aims to conduct phytochemical screening and test the activity of 96% ethanol extract of kejibeling leaves (Strobilanthes crispus (L.) Bl.) as a herbal antidiabetic in male white mice (Mus musculus) with alloxan induction. Method: This research is an experimental laboratory research with a true experimental posttest control design using a completely randomized design (CRD) with 5 treatments and 5 replications. Treatment P1 (without treatment) as normal control (N), P2 as positive control (+), P3 as negative control (-), P4 kejibeling leaf extract 250 mg/kg BW, P5 kejibeling leaf extract 500 mg/kg BW. Result:The results of phytochemical screening showed the presence of alkaloids, flavonoids, tannins, saponins, terpenoids and steroids. SPSS results show that the data is normally distributed (p>0.05) and homogeneous (p>0.05). The results of the ANOVA on the treatment of giving keji beling leaf extract 250 mg/Kg BW showed a sig. 0.393 (p>0.05) and treatment of 500 mg/Kg BW obtained a sig value. 0.517 (p>0.05). Conclusion:The conclusion from the research results shows that administering doses of 250 mg/kg BW and 500 mg/kg BW of keji beling leaf extract can reduce blood sugar levels in mice. It is hoped that the results of this research will be useful for the community as an antidiabetic therapy using kejibeling leaves (Strobilanthes crispus (L.) Bl.).

Cindy Eka Lestari; Anita Soraya; Aiza Amelia Surya Ningrat; Kholivia Tri Yuniati; Nayla Ade Shahira +1 more

Jurnal Pengabdian kepada Masyarakat 2026 Pusat Riset dan Inovasi Nasional

Hyperglycemia is a condition of elevated blood sugar levels that can potentially lead to various health complications if not controlled early. This condition is often influenced by unhealthy eating habits, lack of physical activity, and low awareness among adolescents regarding regular blood sugar checks. Adolescents are an age group that is vulnerable to lifestyle changes, putting them at risk of developing metabolic disorders later in life. This community service activity aims to increase adolescent knowledge and awareness regarding the dangers of hyperglycemia and the importance of preventive measures from school age. The activity was carried out at SMK Nurul Ulum Lebaksiu, involving 59 students as participants. The methods used included health education through audio-visual media, interactive lectures, discussions, and Random Blood Sugar (GDS) tests for early detection. The results of the activity showed an increase in student knowledge based on a comparison of pre-test and post-test scores, as well as the implementation of GDS tests on all participants. This activity is expected to foster healthy lifestyle behaviors and increase adolescent awareness of the prevention of non-communicable diseases.

Mohd Fadli Ariansyah; Eka Pandu Cynthia

Prosiding Seminar Nasional Ilmu Teknik 2026 Asosiasi Riset Ilmu Teknik Indonesia

Lifestyle changes, such as smoking habits, low physical activity, and suboptimal sleep patterns, have the potential to affect various health indicators. However, empirical evidence showing a direct link between lifestyle factors and objective health indicators still shows varying results. This study aims to analyze the relationship between lifestyle factors and health indicators in adult respondents, in an effort to provide an empirical picture of behavioral factors related to health conditions. This study used a quantitative approach with a cross-sectional observational analytic design. Data were obtained from 94 respondents who had complete lifestyle data and health examination results. Lifestyle factors analyzed included smoking habits, exercise frequency, and sleep duration, while health indicators included body mass index (BMI), systolic and diastolic blood pressure, blood sugar levels, cholesterol, uric acid, and pulse rate. Data analysis was performed using descriptive statistics, the Shapiro–Wilk normality test, and the Spearman correlation test according to the characteristics of the data distribution. The results showed that smoking habits were significantly associated with diastolic blood pressure (p < 0.05), exercise frequency was significantly associated with BMI and systolic blood pressure (p < 0.05), and sleep duration was significantly associated with uric acid levels (p < 0.05). Meanwhile, the relationship between lifestyle factors and other health indicators did not show statistical significance. These findings indicate that the influence of lifestyle on health is specific to certain indicators and is not evenly distributed across all health parameters. This study concludes that identifying lifestyle factors relevant to certain health indicators is important as a basis for formulating more targeted health promotion strategies.

Fitriyani, Novia; Rahayu, Henik Tri

International Journal of Health and Social Behavior 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

Type 2 diabetes mellitus (DM type 2) is a chronic metabolic disorder marked by elevated blood glucose due to insulin resistance and impaired insulin secretion. Its prevalence continues to rise worldwide, including in Indonesia. Psychological stress is known to worsen glycemic control by activating the sympathetic nervous system and increasing cortisol levels, which can cause fluctuations in blood glucose. This case report aims to describe the effect of combining Benson relaxation techniques with warm foot soaking on blood glucose regulation in a type 2 DM patient. The subject was Mrs. M, a 52-year-old woman diagnosed with type 2 DM. The intervention was conducted for seven consecutive days and consisted of daily Benson relaxation followed by warm foot soaking for 15–20 minutes. Blood glucose levels were measured before and after each session using a glucometer and analyzed descriptively. After seven days, the patient’s blood glucose level decreased from 248 mg/dL to 186 mg/dL. She also reported improved relaxation, better sleep quality, reduced anxiety, and decreased fatigue. These findings suggest that Benson relaxation helps activate the parasympathetic response and reduce stress hormones, while warm foot soaking supports improved circulation and metabolic processes. In conclusion, the combination of Benson relaxation and warm foot soaking is a simple, safe, and effective complementary therapy to support blood glucose regulation in type 2 DM patients. This intervention can be integrated into self-care routines and community nursing practice as part of evidence-based non-pharmacological management.

Meita Eni Peniar; Tati Karyawati; Muhammad Silahudin

Jurnal Ilmu Keperawatan dan Kebidanan 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

The endocrine system is a ductless body control system that produces hormones to regulate various organs and physiological processes. Hormones act as important biological messengers in the human body. One of the most essential hormones is insulin, which plays a key role in blood sugar regulation. Insufficient insulin production or impaired insulin action can cause disruption of blood glucose control, leading to diabetes mellitus. Diabetes mellitus is a chronic metabolic disorder characterized by persistently high blood glucose levels caused by impaired insulin secretion, insulin action, or both. The purpose of this paper is to apply nursing care to Mr. N, a patient with endocrine system disorders: diabetes mellitus, treated in the Dahlia Ward of Dr. Soeselo Regional Hospital, Tegal Regency. This descriptive case study method was used to explain the nursing process in a structured manner. The main complaint presented by the client was pain in the wound on the left foot. Four nursing diagnoses were identified during the assessment, namely unstable blood glucose levels, acute pain, impaired skin/tissue integrity, and knowledge deficit. Nursing interventions were developed and implemented based on the Standar Diagnosis Keperawatan Indonesia (SDKI), Standar Luaran Keperawatan Indonesia (SLKI), and Standar Intervensi Keperawatan Indonesia (SIKI). The case highlights the importance of comprehensive nursing care in diabetes management, with a focus on blood glucose stabilization, pain management, wound care, and patient education. The results of this study are expected to provide additional references for clinical practice and strengthen the role of nurses in preventing complications of diabetes mellitus.

Mae Septiana; Herry Susanto; Kurnia Wijayanti

Jurnal Ilmu Keperawatan dan Kebidanan 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

Diabetes Mellitus is a complication caused by severe disturbances, particularly in the metabolic composition of carbohydrates, fats, and proteins in the body. The level of patient compliance in taking medication is one of the factors that determine the success of diabetes mellitus therapy. Compliance with treatment plays a crucial role in controlling metabolic conditions, especially in diabetes mellitus patients. The impact of non-compliance with medication in type II diabetes mellitus patients will increase uncontrolled blood sugar levels, which can lead to various complications of organ damage. The purpose of this study was to examine the relationship between medication compliance and blood sugar levels in type 2 diabetes mellitus patients at Harapan Anda Islamic Hospital in Tegal City. This study used a quantitative cross-sectional approach. The sample size was 58 respondents using a purposive sampling technique. Data analysis techniques used univariate and bivariate analysis (chi-square). Characteristics of 58 patients suffering from type 2 diabetes mellitus at Harapan Anda Islamic General Hospital, Tegal City, most of them are aged 46-60 years, with female gender, with most of them having junior high school education, some with working status, with a duration of suffering for >5 years, most with moderate medication adherence and most with normal blood sugar levels. There is a relationship between medication adherence and blood sugar levels in type 2 diabetes mellitus patients at Harapan Anda Islamic General Hospital, Tegal City (0.000). It is hoped that it can provide valuable information for diabetes sufferers about the importance of medication adherence to blood sugar levels so that blood sugar levels can be controlled.

Safitri Rahmat; Nadila Nadila; Deswita Deswita; Sasmita Putri Hairani; Yeyen Yeyen +1 more

Polygon : Jurnal Ilmu Komputer dan Ilmu Pengetahuan Alam 2025 Asosiasi Riset Ilmu Matematika dan Sains Indonesia

Various recent studies have shown that natural active compounds contained in traditional and fermented plants play a crucial role in supporting human health. These compounds include flavonoids, polyphenols, tannins, saponins, alkaloids, organic acids, probiotics, and other phenolic compounds. Detection of these compounds is usually carried out through specific chemical reactions that allow researchers to more precisely identify the bioactive components. Their biological activities are diverse, including antioxidant, antibacterial, anti-inflammatory, and antimicrobial properties, which work to protect the body from cell damage and infection. Natural compounds are considered promising agents for disease prevention and health promotion due to their broad biological activities. The fermentation process has been shown to increase the content of bioactive compounds while lowering the pH of the medium, creating conditions unfavorable for the growth of pathogenic bacteria. Furthermore, probiotics that develop during fermentation play a role in maintaining the balance of the gut microbiota, strengthening the immune system, and improving digestive health. Fermented products are widely recognized as functional foods because they contain beneficial probiotics and enhanced bioactive compounds. These naturally derived products, rich in secondary metabolites, have also been shown to have significant physiological effects, such as lowering cholesterol levels, controlling blood sugar, and maintaining stable blood pressure. This makes natural ingredients and fermented products not only sources of nutrition but also have great potential for development as functional foods and traditional herbal medicines. This highlights the importance of integrating traditional knowledge with modern scientific approaches in developing functional foods and herbal medicines. Therefore, research on natural bioactive compounds and the role of fermentation in enhancing their effectiveness is highly relevant to supporting sustainable public health.

Angelina Jessica Simbolon; Utari Christya Wardhani; Sri Muharni

Jurnal Ilmu Keperawatan dan Kebidanan 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

Increased blood sugar levels due to the body's impaired insulin production are a sign of a chronic metabolic disease known as diabetes mellitus. As seen in Batam, cases of diabetes mellitus in Indonesia are relatively high. This study aims to determine how long type II diabetes mellitus wounds last in Batam City. This study used a cross-sectional approach to conduct quantitative descriptions. This study involved 60 people. The Chi-Square test was used to conduct data analysis. The results showed that there was a significant correlation between age and the healing time of diabetes mellitus wounds, with a sig P value of 0.001 <0.05; gender had a significant correlation, with a sig P value of 0.007 <0.05; sugar control had a significant correlation, with a sig P value of 0.001 <0.5; and anemia had a significant correlation, with a sig P value of 0.001 <0.5. The results indicate that there is a relationship between these variables and the healing time of type II diabetes mellitus wounds. It is hoped that this study can be used as literature for further research.

Sjaiful Bachri; Alexander Halim Santoso; Edwin Destra; Daniel Goh; Gracienne Gracienne

Karunia: Jurnal Hasil Pengabdian Masyarakat Indonesia 2025 Fakultas Teknik Universitas Maritim AMNI Semarang

Consumption of sweetened beverages contributes to increased blood glucose levels that lead to the risk of pre-diabetes and type II diabetes mellitus. Fasting blood sugar examination is an early screening tool to detect hidden metabolic disorders and educate the public about the importance of controlling sugar consumption. The examination was conducted through capillary blood sampling and point-of-care testing (POCT) analysis of 91 adult participants. Education was delivered in the form of a leaflet emphasizing the impact of sweetened beverage consumption on glucose regulation and the risk of insulin resistance. The results were classified into three categories: normal, pre-diabetes, and diabetes. The majority of participants (86.8%) were in the normoglycemic category. As many as 9.9% were classified as pre-diabetes and 3.3% were in the diabetes category. The average fasting blood sugar of the participants was 89.5 ± 20.1 mg/dL. These results emphasize the need for counseling regarding limiting the consumption of sweetened beverages to maintain stable blood glucose. Fasting blood sugar examination accompanied by education about sweetened beverages contributes to early detection of the risk of glucose disorders. Interventions based on examination results have the potential to increase awareness of fluid consumption patterns and encourage healthier lifestyle changes.   Keywords: Fasting Blood Sugar, Sugary Drinks, Pre-Diabetes, Type II Diabetes Mellitus, Nutrition Education

Afriani Kusumawati; Rumi, Amelia; Rudi Safaruddin; Arya Dibyo Adisaputra

Adi Widya: Jurnal Pengabdian Masyarakat 2025 Lembaga Penelitian dan Pengabdian Masyarakat

Diabetes is a chronic disease that makes the body lose its ability to produce insulin or begin to use it less efficiently leading to high blood sugar. Without proper treatment, over time, this disease can lead to more serious health problems such as heart disease, vision loss, and kidney disease. Early detection and prevention are crucial in mitigating these risks. This study focuses on conducting an early screening for diabetes among high school students at SMA Negeri 1 Palu. Additionally, this activity aims to educate students at SMA Negeri 1 Palu on the importance of maintaining a healthy lifestyle by managing their sugar intake according to daily caloric needs. The program utilized an interactive educational approach, incorporating demonstration tools and discussions to enhance engagement and understanding. A total of 68 students participated in this initiative which was evaluated through a final assessment measuring knowledge improvement and awareness of diabetes prevention.

Ika Dini Akmalia; Muhammad Suwignyo Prayogo; Sindi Wulandari

Jurnal Cakrawala Pendidikan dan Biologi 2025 Asosiasi Riset Ilmu Pendidikan Indonesia

Green grass jelly (Cyclea barbata) leaves are one of the herbal plants found in Indonesia and have various potential health benefits. This plant is known to contain bioactive compounds such as flavonoids, tannins, and alkaloids that act as antioxidants, anti-inflammatories, and help regulate blood sugar levels in the body. The utilization of green grass jelly leaves is not only as a refreshing traditional drink ingredient, but also as a source of natural medicine that is environmentally friendly and easily accessible to the community.This activity aims to increase awareness and knowledge of students and teachers about the benefits of green grass jelly leaves, as well as teach simple but effective processing techniques to produce value-added processed products.The research method used descriptive qualitative method.The results of this activity showed an increase in participants' understanding and skills in processing green grass jelly leaves into products that are suitable for consumption, as well as fostering interest in utilizing herbal plants as part of a healthy lifestyle.

Dian Ramadhan; Dheni Koerniawan

Jurnal ilmu Kesehatan Umum 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

Background: Diabetes mellitus is a metabolic disorder caused by increased blood glucose levels in the bloodstream or hyperglycemia, which is caused by abnormalities in insulin secretion or abnormalities in insulin work. Physical activity can also affect blood sugar levels, one of which is the physical activity of foot exercises which is recommended for people with diabetes mellitus. Objective: To determine the effectiveness of foot exercise activities in reducing blood glucose levels in diabetes mellitus sufferers. Method: The research design used a descriptive method with a nursing process approach with a case study design. This research was carried out by providing foot exercise physical activity intervention for 3 consecutive days. Results: Based on the application of EBP, the results obtained from 3 patients who experienced a decrease in blood glucose levels before and after being given foot exercise therapy, there was an average decrease in P1 of 13.66mg/dL, P2 of 11.66mg/dL, and P3 of 13mg/dL every day. Suggestion: It is hoped that the results of this research can provide insight to diabetes mellitus sufferers in efforts to manage diabetes mellitus with foot exercise physical activity and be able to apply it.

Mira Andayani; Suci Amin; Dilgu Meri; Rifa Yanti

Jurnal ilmu Kesehatan Umum 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

Diabetes mellitus is disease chronic many​ occurs throughout the world. Prevalence disease this Keep going increased, with 8.5% of adults (equivalent to with 422 million people) suffering from Diabetes Mellitus at the global level. Research this aiming for identify management health of Diabetes Mellitus patients in the work area Health Center Meskom. Research this use method studies case with design descriptive. Research results show that 8 respondents (40%) did activity sports, while 12 respondents (60%) did not exercise. As many as 7 respondents (35%) routinely monitor blood sugar levels, while 13 respondents (65%) did not do monitoring. Respondents who regulate pattern Eat totaling 9 people (45%), while 11 respondents (55%) did not arrange pattern eating. As for 8 respondents (40%) running management health, while 12 respondents (60%) did not do it. Management health in Diabetes Mellitus patients aiming For control blood sugar levels, preventing complications term length, and increase quality life patient. Output study this designed in form article scientific. Research results show that good blood sugar control, including​ monitoring level glucose regularly, can lower risk complications like retinopathy, neuropathy, and disease cardiovascular. Optimal management involves combination use drugs, patterns controlled eating, as well as sport in a way regular.

Joni Siagian; Khairunnisa Batubara; Amelia Dini Anggraini Silalahi

Karunia: Jurnal Hasil Pengabdian Masyarakat Indonesia 2025 Fakultas Teknik Universitas Maritim AMNI Semarang

This Community Service (PkM) activity is intended to solve problems that exist in certain community groups in adulthood. Hypertension can result in dangerous diseases such as heart disease and stroke if not treated in the long term. The PkM team provides education to provide solutions. The PkM activity implementation team collaborates with the local village government. The method used in this activity is counseling on hypertension from a team of nursing lecturers and nursing students during Field Learning Practice starting from anthropometric examination activities, blood pressure, blood sugar supplemented by interviews with the community. The respondents used in this educational activity were 35 people. The output of the PkM that has been implemented is in the form of reports and publications of articles so that they can be accessed by all parties who need related articles.

Alexander Halim Santoso; Steven Hizkia Licius; Andrew Philo; Ryan Dafano Putra Mahendri

Karunia: Jurnal Hasil Pengabdian Masyarakat Indonesia 2025 Fakultas Teknik Universitas Maritim AMNI Semarang

Non-communicable diseases (NCDs) are a global health challenge, especially in low- and middle-income countries. Early identification of NCDs in the productive age group is very important considering the contribution of the productive age group to the national workforce and its impact on the health of future generations. This community service activity aims to increase awareness and participation in school-based non-communicable disease screening programs, especially at St. Yoseph High School, East Jakarta. The implementation of screening activities includes anthropometric examinations, blood pressure, blood sugar, and short interviews. Students with unhealthy lifestyles, such as lack of physical activity and unbalanced diets, are at high risk of developing non-communicable diseases. This activity encourages public awareness of the importance of maintaining health to prevent non-communicable diseases. This can reduce the global health burden and the economic burden for advanced disease care. Thus, this activity can improve the quality of life of the productive age population in the future.

Shopya Nur Maulidina; Asha Grace Sicilia; Pratiwi Cahya Wardhani; Harun Wahyudi; Usnal Aini

Journal of Educational Innovation and Public Health 2025 Pusat Riset dan Inovasi Nasional

Diabetes mellitus (DM) is a chronic disease in the form of a metabolic disorder characterized by an increase in blood sugar levels above normal limits. The purpose of this study was to determine the relationship between Self Care and Quality of Life in Type 2 Diabetes Mellitus Patients at the Internal Medicine Polyclinic of Bhakti Asih General Hospital, Tangerang City in 2024. Self care is an independent action that includes diet, exercise, and foot care to control blood sugar. Quality of life is a good or bad condition of diabetes mellitus patients in viewing their disease. The design of this study used a quantitative method with a cross-sectional approach. The population in this study were Diabetes Mellitus patients at the Internal Medicine Polyclinic of Bhakti Asih General Hospital in September 2024, totaling 169 respondents. The sampling technique for this study used purposive sampling. Data analysis used univariate and bivariate analysis using Pearson product moment. The results showed that the majority of self care was good as many as 128 (75.7%) and good quality of life as many as 125 (74.0%). The results of the bivariate analysis showed that there was a relationship between self care and quality of life <0.001. This study concluded that optimal self-care has a positive impact on the quality of life of patients. The results of this study concluded that there is a Relationship between Self-Care and Quality of Life in Type 2 Diabetes Mellitus Patients.

Tiwi Ade Maharani; Asha Grace Sicilia; Irfan Ilmi; Dalva Gumilar

Jurnal ilmu Kesehatan Umum 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

The wound healing duration in Diabetes Mellitus (DM) patients is influenced by factors such as age, nutritional status, blood sugar levels, diet adherence, physical activity, and medication compliance. In diabetic foot ulcer cases, healing is often impaired, increasing the risk of amputation if not properly managed. This study investigates factors affecting wound healing duration in DM patients at Hanifah Pratama Clinic, Tangerang City. A quantitative cross-sectional design was used, with a sample of 40 DM patients with diabetic foot ulcers selected through total sampling. Instruments included weight scales and height meters for nutritional status, Easy Touch® GCU for blood glucose levels, the Morisky Medication Adherence Scale (MMAS) for medication compliance, and the Bates-Jensen Wound Assessment Tool (BWAT) for wound assessment. Data analysis utilized the Chi-Square bivariate test and backward logistic regression multivariate test. Results showed that nutritional status significantly influenced wound healing duration (p < 0.05), with an OR of 28.884 (95% CI 2.760-302.240), indicating that patients with good nutritional status are 28.884 times more likely to heal faster. In conclusion, nutritional status is the dominant factor affecting wound healing duration in DM patients at Hanifah Pratama Clinic. This study highlights the importance of improving treatment quality and wound care while encouraging better nutritional interventions in diabetic foot ulcer management.

Fifin Oktaviani; Heldi Candra; Hilda Muliana

International Journal of Health and Social Behavior 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

The screening and education program on the prevention of degenerative diseases was conducted in the coastal community of Panjang Island, Batam. This initiative aimed to address the high prevalence of degenerative diseases such as diabetes, hypertension, and dyslipidemia through health screenings and community education. The study involved 55 participants, primarily pre-elderly individuals, and included examinations of blood pressure, cholesterol, blood sugar, and uric acid. The results revealed that 65.5% of participants had hypertension (34.5% with Stage 1 and 31% with Stage 2), while 69.1% had high cholesterol levels. Blood sugar screening indicated that 14.5% of participants had elevated glucose levels. Uric acid levels were high in 47.3% of participants, predominantly among women. Additionally, 78% of respondents with comorbidities presented abnormalities in at least one biochemical parameter. Educational sessions resulted in a 26.4% increase in knowledge about disease prevention and healthy lifestyles. The program highlighted the importance of regular health screenings, lifestyle modifications, and community empowerment for sustainable health improvements. Collaboration with local health centers and the establishment of health cadres are recommended for ongoing support and monitoring of degenerative disease prevention efforts.

Faria Handayani; Fitriany Suangga; Ennimay Ennimay

Jurnal Ilmu Keperawatan dan Kebidanan 2025 Asosiasi Riset Ilmu Kesehatan Indonesia

Diabetes is a chronic disease in the form of a metabolic disorder characterized by blood sugar levels that exceed normal limits and one of them is Diabetes Mellitus Type II. Effective education to improve self-management in Type II Diabetes Mellitus sufferers. Non-compliance with Diabetes Mellitus treatment is currently still a quite important problem in the management of Diabetes Mellitus patients. To find out and analyze the effect of education on the level of compliance with medication and diet in Type II Diabetes Mellitus Patients at the Bintan Regency Regional Hospital. The research used Pre-experimental, with a One Group Pretest Posttest research design by analyzing the effect of providing education on the level of compliance with taking medication and diet in Type II Diabetes Mellitus Patients at the Bintan Regency Hospital. The results of the analysis of the Wilcoxon signed ranks test, the level of compliance with taking medication and dietary behavior after being given education was better than before being given education with a significance value of P < 0.0001, less than 0.05, meaning that there was a significant influence before and after being given education on the level of compliance. taking medicine and diet. For future researchers, the problem of patient education should be deepened so that patients understand more about the disease they are suffering from.

Rahmat Ismail; Ahlan Sangkal

International Journal of Public Health 2024 Asosiasi Riset Ilmu Kesehatan Indonesia

Takokak fruit is one of the plants that can be used to lower blood sugar levels. This study aims to identify the bioactive compounds of ethanol extract of takokak fruit and test the antidiabetic ethyl acetate fraction. Antidiabetic testing was carried out by in vivo testing using the Oral Glucose Tolerance Test (OGTT) method to see the decrease in blood glucose levels using white rats as test animals. The test results showed that takokak fruit contains flavonoids, steroids, and tannins. Fractionation is the process of extracting compounds from the extract using two types of solvents that do not mix with each other. The results of the antidiabetic test showed that the ethyl acetate fraction with glibenclamide as a comparator had the ability as an antidiabetic measured by the amount of difference in the decrease in blood glucose levels in the test animal group T₃₀ to T₁₂₀. From the results obtained, the average decrease in blood glucose levels in the negative control group (Na CMC) was 5.8 mg/dL, the positive control group (Glibenclamide) 21.03 mg/dL, and the fraction group 9.86 mg/dL. Takokak fruit has antidiabetic activity. Compounds that have antidiabetic activity are flavonoids, tannins, and steroids.