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The aim of this study was to test the effectiveness of aloe vera gel extract (Aloe Vera) against the Propinibacterium acnes bacteria, which is the main cause of acne on human skin. Aloe vera is known by the scientific name Aloe Vera L. and has long been used by people as an ingredient in cosmetics, skin care, wound healing and hair fertilizer. The methods used in this literature review include sampling aloe vera gel extract, testing antibacterial activity against Propionibacterium acnes bacteria, and data analysis to determine the effectiveness of the extract. Although there are differences in testing methods and concentrations used, most studies show this extract is effective in inhibiting Propionibacterium acnes bacteria. The conclusion of this review provides a safer alternative for treating acne using herbal products compared to using antibiotics.

The skin is the widest organ that makes up the human body which is the outermost and covers the entire surface of the body. The outermost location causes the skin to receive stimulation for the first time such as touch stimulation, pain, or bad influences from outside. This causes the skin to stretch due to disease. One of the most common skin diseases suffered by people is acne. Acne occurs generally triggered by the bacterium Propionibacterium acnes (gram positive bacteria). Effective acne treatment can use antibiotics, but inappropriate use of antibiotics can lead to resistance. Therefore it is necessary to have alternative therapies from plants that have the potential as antibacterial. One of the natural ingredients from plants that have antibacterial properties is mangosteen (Garcinia mangostana Linn.)This research was conducted using a descriptive experimental method with the aim of knowing the presence of antibacterial activity in cream preparations of ethanol extract of mangosteen rind (Garcinia mangostana Linn.) against Propionibacterium acnes bacteria as seen from the inhibition of bacteria with varying concentrations of 10%, 15% and 25% by using paper disc diffusion method and solid liquid dilution method. The positive control used clindamycin cream and the negative control used 1% DMSO. Analysis of the diameter of the inhibition data was carried out using the One Way ANOVA test. The preparation formulation that has the largest diameter in the diffusion test is F3 with a concentration of 25% with an average inhibition of 6.36 in the medium category.  The MIC and KBM values in the dilution method were at a concentration of 12.5%. The results of a normally distributed One Way ANOVA are measured with a value (P> 0.05). Mangosteen peel extract (Garcinia mangostana Linn.) has antibacterial activity against Propionibacterium acnes bacteria.    

Daun Binahong (Anredera cordifolia) merupakan tumbuhan fungsional karena sebagian besar dapat dimanfaatkan sebagai obat. Daun binahong memiliki kandungan metabolis sekunder yaitu alkaloid flavonoid tanin dan saponin yang memiliki aktivitas sebagai antibakteri. Metode yang di gunakan yaitu metode sumuran. Penelitian ini secara umum bertujuan untuk mengetahui kandungan kimia yang ada di dalam daun binahong dan daya hambat ekstrak daun binahong (Anredera cordifolia) sebagai antibakteri terhadap biakan bakteri Propionibacterium acnes, subjek pada penelitian ini adalah ekstrak etanol daun binahong. Objek pada penelitian ini adalah daya hambat antibakteri ekstrak etanol daun binahong. Sebagai kontrol positif yang di gunakan adalah kloramfenikol. Ekstrak diperoleh dengan cara maserasi menggunakan pelarut etanol 70%. Ekstrak etanol daun binahong yang diperoleh dibuat dalam 3 seri konsentrasi 5%, 10% dan 15% kemudian diujikan pada bakteri propionibacterium acnes, nilai KHM pada bakteri propionibacterium acnes yang diperoleh pada konsentrasi 5% tidak memiliki zona hambat 0 mm untuk konsentrasi 10% dengan luas zona hambat yang terbentuk sebesar 13 mm dan konsentrasi 15% dengan luas zona hambat yang terbentuk sebesar 20 mm. Berdasarkan hasil penelitian ekstrak etanol daun binahong memiliki daya hambat terhadap bateri Propionibacterium acnes.