Publication Search

Ibuprofen is an antipyretic and anti-inflammatory drug classified as Biopharmaceutics Classification System (BCS) class II, characterized by low water solubility and high permeability. Its limited solubility may reduce the dissolution rate and influence therapeutic effectiveness. This study aimed to formulate ibuprofen suppositories using cocoa butter (oleum cacao) as the suppository base through the melting method. Each suppository was prepared with a total weight of 2500 mg containing 125 mg ibuprofen, oleum cacao as the base, tween 80 as an emulsifier, and liquid paraffin as a mold lubricant. Before formulation, a displacement value test was performed to determine the exact amount of base required. The prepared suppositories were evaluated through organoleptic examination, weight uniformity, melting time, and dissolution testing. The evaluation results demonstrated that the suppositories possessed acceptable physical characteristics, uniform weight distribution, appropriate melting properties, and satisfactory dissolution behavior. Based on these findings, ibuprofen suppositories formulated with oleum cacao fulfilled pharmaceutical quality requirements in accordance with the Indonesian Pharmacopoeia standards.

Background: According to the 2020 Ministry of Health Profile, fever accounts for 7.3% of infant deaths in Indonesia. Fever is a common complaint in children, with 20–40% of parents reporting their child's illness each year. Approximately 19–30% of patients visiting doctors are children, and fever is one of the primary complaints. If not treated promptly, fever can lead to complications such as seizures and decreased consciousness. Fever management can be done through pharmacological (antipyretic, NSAID, diazepam) or non-pharmacological measures, one of which is by applying compresses. Objective: To determine the effectiveness of dry warm compresses and water tepid sponge compresses on reducing body temperature in pediatric patients at Pati Islamic Hospital. Method: Quantitative research with a quasi-experimental two-group pre–post test design using a purposive sampling technique. Results: The application of water tepid sponge compresses showed a significant decrease in temperature with an average difference of 1.2°C, while dry warm compresses only reduced the temperature by a difference of 0.2°C. Conclusion: Water tepid sponge compresses are more effective than dry warm compresses in reducing body temperature in children with fever at Pati Islamic Hospital.

One chemical substance that can enhance the function and activity of the immune system is an immunomodulator. Immunomodulators can be found in various plants, including sembung leaves (Blumea balsamifera). This study aims to evaluate the potential of sembung leaf extract as an immunomodulator in experimental animals using a systematic literature review method. Articles were collected based on the keywords “immunomodulatory,” “sembung leaves,” and “body immunity” from the Google Scholar, Science Direct, and PubMed databases. The results of animal studies indicate that the administration of ethanol extracts of Sembung leaves at various doses has potential as an immunomodulator with anti-inflammatory, antipyretic, diuretic, and antidiarrheal effects. Additionally, Sembung leaf extracts have been shown to effectively inhibit bacterial growth and act as anti-inflammatory, diuretic, antipyretic agents, and anti-diarrheal.

The inventory of medicinal plants involves collecting and organizing data regarding natural resources for resource management planning and serving as a database to reveal the potential of plants in a given area. This study aims to inventory the types of medicinal plants found in the home gardens of the residents of Negeri Latu, Amalatu District, West Seram Regency. The data collection methods employed were exploration and descriptive surveys. The gathered data was subsequently analyzed to identify the benefits or uses of the plants based on relevant literature. The results indicate that 57 species of medicinal plants were found in the home gardens of the residents of Negeri Latu. These plants possess various properties, including antidiabetic, antimalarial, anti-inflammatory, antioxidant, anticholesterol, anticancer, antidysentery, analgesic, antipyretic, and mosquito-repellent effects. This finding highlights the significant potential of home gardens in Negeri Latu as a rich natural resource of medicinal plants. The diversity of plant species reflects the local traditional knowledge of utilizing flora as a natural solution to various health issues.

Fever is a condition characterized by an increase in body temperature as a response to infection or inflammation, and it is one of the most common clinical symptoms in various diseases. The excessive use of synthetic antipyretics such as paracetamol can lead to side effects; therefore, safer and natural-based alternatives are needed. This study aims to determine the antipyretic activity of betel leaf and to compare its effectiveness with that of paracetamol.This research was conducted using an experimental laboratory method with a completely randomized design. The test subjects were male white rats (Rattus norvegicus) of the Wistar strain, induced with fever using a 20% yeast suspension. The rats were divided into five groups: negative control, positive control (paracetamol), and three treatment groups with low, medium, and high doses of the extract. Body temperature was measured every 30 minutes for 180 minutes after treatment. The data were statistically analyzed using one-way ANOVA followed by Tukey's post hoc test.The results showed that the [plant extract] exhibited significant antipyretic activity (p < 0.05) compared to the negative control, especially at medium and high doses. The effectiveness of the highest dose was comparable to that of paracetamol. This antipyretic effect is presumed to be associated with the presence of flavonoids and tannins that may inhibit the synthesis of prostaglandin E2 (PGE2), a key mediator in the fever response.In conclusion,betel leaf has potential as an effective natural antipyretic agent and may be developed as a safer herbal-based alternative for fever treatment.

Fever is the body's response to infection or inflammation, which often indicates a certain medical condition. One common treatment for fever is the use of antipyretic drugs. The purpose of this study was to evaluate the effectiveness of antipyretic drugs in lowering body temperature in adult patients with fever. The method used was a clinical trial with a randomized controlled trial (RCT) design, involving 100 adult patients with fever ≥38°C. Patients were divided into two groups: the group receiving antipyretic drugs (paracetamol) and the placebo group. Body temperature measurements were taken every 2 hours for 24 hours after drug administration. The results showed that the group receiving antipyretic drugs experienced a significant decrease in body temperature compared to the placebo group (p <0.05). The side effects that appeared were relatively mild and not dangerous..

Indonesia, considered the country with the second-highest level of biodiversity in the world after Brazil, possesses extraordinary biological wealth that remains underutilized. The field of traditional medicine utilizes natural resources to prevent and treat physical and mental disorders. Periwinkle, or Catharanthus roseus, is one of the most widely used plants due to its abundance of bioactive phytochemicals, such as alkaloids, flavonoids, saponins, and tannins. The ethanol extract from Periwinkle leaves has the potential to act as a natural antipyretic agent that can reduce body temperature during fever. The purpose of this study is to review and analyze previous research findings on the antipyretic effects of ethanol extract from Periwinkle leaves on mice (Mus musculus). According to a literature review from various sources, the ethanol extract of Periwinkle leaves demonstrates a comparable level of effectiveness to synthetic antipyretic drugs in lowering the body temperature of fever-induced mice. Furthermore, the content of active compounds and the antipyretic performance of this plant are influenced by its variety and environmental factors. Body temperature begins to decrease one hour after extract administration and reaches its peak reduction at the third hour. Therefore, Periwinkle may serve as an alternative natural antipyretic remedy. However, further research is necessary to standardize its usage and conduct clinical trials on humans.

Background: Self-medication is defined as using medicinal products to treat the disorders or symptoms diagnosed by oneself, Self-Medication is common practice worldwide in both developed and developing countries, Regulations usually distinguish between prescription-only medicines (POM) and over the counter (OTC) drugs. inappropriate self-treatment can pose various risks including drug side effects, recurrence of symptoms, drug resistance, etc. the purpose of this study was to investigate the knowledge, attitude, and practice of medical students towards self-medication.  Subjects and Methods: A cross-sectional study was carried out among five stages that were selected by the simple random sampling for choosing the students. Data collections were performed from the beginning of March to October 2023. Data were collected with A four-part researcher questionnaire. It was designed to address the students’ knowledge, attitude, and practice. Statistical analysis was performed using Statistical Package for the Social Sciences 23 software. Results: Out of 462 questionnaires distributed, 445 questionnaires were completed; giving a response rate of 96.3%. According to the results, 310 (69.7%) students had carried out self-medication within the past one year. Common cold was the most common ailment treated with self-medication (73.9%) and antipyretics analgesics (64.5%) were the most used drugs. The primary information sources used by the students were their academic knowledge and books (47.4%). Health problems are not serious the most reason for self-medication in the study and lack of knowledge about medicine the highest causes for not taking medication. Conclusion: students’ knowledge of self-medication appears to be good and significantly high. As well self-medication was highly practiced among the students. Therefore, medical students should be viewed as important contributors to the public health care system, and future health professionals should be properly educated on good pharmacy practice and responsible self-medication.

Durian leaves have secondary metabolites, namely flavonoids. Flavonoids have shown a wide range of bioactivity, one of which is an antipyretic effect which can be used as a febrifuge. This study aims to examine the antipyretic activity of the ethanol extract of durian leaves (Durio zibethinus L.) against male white rats (Rattus norvegicus) induced by DPT-HB-Hib vaccine. This study uses an experimental method. In this study, durian leaf extract was processed by maceration using 96% ethanol, then treated with secondary metabolites of simplicia and its ethanol extract. To pay for the antipyretic activity of durian leaves (Durio zibethinus L.) the test animals used were 25 and divided into 5 groups, namely negative control (CMC 0.5%), positive control (Paracetamol 1%) and the test dose group, namely the administration of leaf extract durian 200 mg/kg, 300 mg/kg and 400 mg/kg. Each rat was induced intramuscularly with the DPT-HB-Hib vaccine. Temperature measurements were carried out rectally with initial temperature measurements at 5 minute intervals 3 times, 1 hour after induction and 30 minutes for 3 hours. The data obtained were analyzed using the One-way ANOVA (Analysis of Variance) test and the Tukey HSD test. Based on the results of the study, it was shown that the results of the phytochemical screening of durian leaves contained flavonoids, saponins, tannins, alkaloids, steroids/triterpenoids. Of the three doses that experienced a decrease in temperature that was not significantly different from paracetamol, namely at a control dose of 300 mg/kg, because this decrease in temperature was almost close to paracetamol which was positive.

Fever can be interpreted as a body temperature that is higher (>37°C) than normal temperature because of the temperature control center in the hypothalamus, the temperature control center balances temperature during health or fever by regulating the formation and release of heat. For this reason, the purpose of this study was to determine the antipyretic effectiveness of various concentrations of extracts. In this study, 5% peptone was used to induce fever in 15 white rats which were divided into 5 treatment groups. Groups 1 was given 1% NaCMC as a negative control, groups 2 was given paracetamol 9 mg/200gBB) as a positive control, groups 3 was given 10% lire leaf extract (2 mg/200gBB), groups 4 was given 20% lire leaf extract (4 mg/200gBB), and groups 5 was given 40% lire leaf extract (8 mg/200gBB). This results of this study obtained extract levels of 7,44% and there was a weak antipyretic effect at concentrations of 10% and 20% lire leaf extract, while the greatest antipyretic effect was found in 40% lire leaf extract, almost comparable to 9 mg paracetamol.