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Diabetes mellitus type 2 is a chronic metabolic disorder that frequently affects elderly patients and is often accompanied by multiple comorbidities. The increasing prevalence of diabetes in the aging population contributes to higher morbidity and mortality, especially when complicated by geriatric syndromes, electrolyte imbalances, and infections such as pneumonia. This study aims to present a case of type 2 diabetes mellitus in an elderly patient with associated geriatric problems, electrolyte disturbances, and pneumonia. The method used is a descriptive case report based on clinical findings, laboratory examinations, and radiological assessment. A 76-year-old male presented with generalized weakness, weight loss, decreased appetite, respiratory symptoms, and functional decline. Physical examination and laboratory findings revealed uncontrolled diabetes, electrolyte imbalance, hypoalbuminemia, and signs of infection. Chest radiography confirmed pneumonia. Management included pharmacological therapy such as antibiotics, fluid and electrolyte correction, and supportive care, along with non-pharmacological interventions including dietary regulation and monitoring. The findings highlight the complexity of managing elderly patients with multiple comorbid conditions, emphasizing the need for a comprehensive and multidisciplinary approach. Early detection and appropriate management are essential to improve clinical outcomes and prevent further complications in geriatric patients with diabetes mellitus.

Skin aging is a natural process that cannot be avoided, but it can be slowed down through proper skin care. The use of natural face masks is one of the safe, affordable, and relatively non-invasive treatment alternatives without long-term side effects. The bandotan plant (Ageratum conyzoides L.) is a weed that grows wild in the Cemani Village area, Sukoharjo Regency. Although often considered worthless, this plant actually contains active compounds such as flavonoids, tannins, and saponins that have the potential to be antioxidants. Therefore, this service activity aims to provide counseling and training to the people of Cemani Village regarding the manufacture of face masks made from bandotan plants. This program is carried out with several procedural stages, starting from the interpretation of problems on the land, followed by the preparation of the timeline for the implementation of activities, then counseling and ending with a workshop session on the procedure for making antiaging masks for bandotan herbs. The program ended with an assessment of the evaluation of the activities. This activity was attended by 20 participants of the Cemani village PKK mobilization team. Based on the pretest and posttest scores, there was an increase in public knowledge about the program carried out with an average of 80 pretests and an increase in the average percentage of posttest scores up to 95.83. In the assessment of the questionnaire, public satisfaction with the implementation of the activity was classified as very satisfied with a score of 92.67.

Skin aging is a natural process that cannot be avoided, but it can be slowed down through proper skin care. The use of natural face masks is one of the safe, affordable, and relatively non-invasive treatment alternatives without long-term side effects. The bandotan plant (Ageratum conyzoides L.) is a weed that grows wild in the Cemani Village area, Sukoharjo Regency. Although often considered worthless, this plant actually contains active compounds such as flavonoids, tannins, and saponins that have the potential to be antioxidants. Therefore, this service activity aims to provide counseling and training to the people of Cemani Village regarding the manufacture of face masks made from bandotan plants. This program is carried out with several procedural stages, starting from the interpretation of problems on the land, followed by the preparation of the timeline for the implementation of activities, then counseling and ending with a workshop session on the procedure for making antiaging masks for bandotan herbs. The program ended with an assessment of the evaluation of the activities. This activity was attended by 20 participants of the Cemani village PKK mobilization team. Based on the pretest and posttest scores, there was an increase in public knowledge about the program carried out with an average of 80 pretests and an increase in the average percentage of posttest scores up to 95.83. In the assessment of the questionnaire, public satisfaction with the implementation of the activity was classified as very satisfied with a score of 92.67.

Skin is the body's outermost organ, enveloping all parts of the human body. When the water content in the stratum corneum (SC) drops below 10%, the skin can become scaly, rough, and dry. Honey possesses humectant, emollient, and antioxidant properties, making it an effective moisturizer. The humectant properties of honey stem from its high sugar content, particularly glucose and fructose. These  sugars form hydrogen bonds with water, helping to retain moisture in the skin and thus providing a hydrating effect. Additionally, honey contains vitamin C, alpha hydroxy acids, and flavonoids, which contribute to the elasticity and firmness of the skin. Therefore, it is important to conduct a narrative review on the use of honey as a moisturizer in topical preparations, which can serve as a reference for future research. The literature search for this review was conducted using databases such as Google Scholar, Garuda Journal, MDPI, ResearchGate, and Publish or Perish, employing specific inclusion and exclusion criteria. The findings concluded that honey can be used as a moisturizer in various dosage forms, including body scrubs, anti-aging and moisturizing creams, serums, peel-off gel masks, lip moisturizers, and lip scrubs. The concentration of honey used in these formulations depends on the dosage form, its intended function in the formula (whether as an active substance, humectant, or emollient), and the comparison of honey concentration with other ingredients.

Extrinsic skin aging or photoaging occurs due to repeated and prolonged exposure to ultraviolet (UVA) and ultraviolet B (UVB). Photoaging prevention can be done, one of which is the use of sunscreen. This literature review aims to review the role of sunscreen in photoaging prevention using a variety of existing literature. Sunscreen plays an important role in preventing skin damage caused by sunlight, especially in preventing and repairing skin damage due to sun exposure (photoaging). The addition of antioxidants such as vitamin C, vitamin E, vitamin A, melatonin, polyphenols, Polypodium leucotomos (PLE) extract as well as enzymes such as photoliase and T4N5 has been shown to increase protection against UV, visible light, and infrared-A rays and help repair skin damage. The use of colored sunscreen is recommended for protection from visible light. In addition, education on how to use sunscreen properly, such as reapplying every two to three hours and selecting the appropriate SPF and PA, also plays a big role in maximizing the effectiveness of skin protection from photoaging.

Sappan wood (Caesalpinia sappan L.) is known to contain various bioactive compounds such as saponins, tannins, flavonoids, phenols, brazilin, and gallic acid. These compounds play an important role as antioxidants that can ward off free radicals and absorb UVA and UVB radiation that are harmful to the skin. Ultraviolet radiation is known to accelerate premature aging and cause tissue damage, so a topical formulation is needed that can provide protection while maintaining skin health. This study aims to determine the antioxidant activity and sunscreen ability of sappan wood extract in the form of lip balm with varying extract concentrations. Antioxidant activity was evaluated using the DPPH (1,1-Diphenyl-2-Picrylhydrazyl) method, while the Sun Protection Factor (SPF) value was determined by the Mansyur method using UV-Vis spectrophotometry. Sappan wood extract was formulated into four lip balm preparations, namely F0 (control without extract), F1 (5%), F2 (10%), and F3 (15%). Physical tests including homogeneity, pH, spreadability, adhesiveness, and organoleptic were conducted to ensure the quality of the preparation. The results showed that sappanwood extract had an IC50 value of 23.62 ppm which was categorized as very strong antioxidant activity. In the lip balm formulation, the IC50 values ​​obtained were F0 = 246.76 ppm (very weak), F1 = 92.68 ppm (strong), F2 = 78.03 ppm (strong), and F3 = 63.58 ppm (strong). The SPF test showed a protection value of F0 = 2.11 (minimum), F1 = 13.64 (maximum), F2 = 14.25 (maximum), and F3 = 18.28 (ultra). Thus, lip balm made from sappanwood extract has the potential as a cosmetic preparation that not only meets physical criteria, but also provides high antioxidant activity and effective sunscreen protection.

Memory is a vital biological system in the body that plays a role in storing, processing, and recalling information. Over time, due to aging or external factors, memory function may decline. One possible effort to maintain and improve cognitive performance is through the use of bioactive compounds with antioxidant properties. Avocado (Persea americana Mill.) leaves contain flavonoids, which act as antioxidants and possess neuroprotective effects that may enhance cognitive function, including memory. This study aimed to determine the effect of avocado leaf extract on the memory of male mice and to identify the most effective dose in improving cognitive performance. The extract was obtained using the maceration method with 70% ethanol as the solvent. Memory activity was tested on male mice, which were divided into five groups: negative control, positive control, and three treatment groups given avocado leaf extract at doses of 50, 100, and 200 mg/kgBW. The Y-Maze method was employed to assess memory through two parameters: latency time and error numbers. The results demonstrated that avocado leaf extract significantly improved memory in the test animals. Mice induced with 10% ethanol showed an increase in latency time and error numbers, while the groups treated with avocado leaf extract experienced reductions in both parameters. The most effective dose was 200 mg/kgBW, which produced a latency time difference of 19.5 seconds and an error number difference of 3.57. Therefore, avocado leaf extract shows potential as a natural agent to support and enhance cognitive function.

Introduction: The increase in life expectancy among the elderly has directly contributed to the rise in the global elderly population. According to global data, the number of elderly individuals is projected to reach 1.4 billion by 2030. This demographic growth is often accompanied by various health problems associated with aging, such as the decline in vital organ function and the emergence of degenerative diseases. One of the most common degenerative diseases among the elderly is hypertension. Hypertension is widely known as a “silent killer” because it can lead to serious complications, including stroke and heart disease, if not managed properly. A common complaint experienced by individuals with hypertension is headache, particularly in the posterior region, which significantly affects the patient’s quality of life. Management of hypertension can be carried out through pharmacological therapy with antihypertensive drugs as well as non-pharmacological interventions. One of the non-pharmacological approaches increasingly being applied is isometric handgrip exercise, which involves static muscle contractions performed at light to moderate intensity. Method:This study aimed to evaluate the effect of isometric handgrip exercise on pain reduction in patients with hypertension. The research design employed a descriptive case study involving one individual with hypertension who experienced pain complaints. The study was conducted on September 16–18, 2024, at Roujin Home X. The instruments used included observation, interview, and the provision of isometric handgrip exercise therapy. Pain measurement was carried out using a numerical rating scale before and after the intervention. Results:The three-day intervention demonstrated a significant reduction in pain levels. On the first day, the patient reported a pain score of 6, which decreased to 4 on the second day, and further declined to 2 on the third day after the intervention. Conclusion:The findings of this study indicate that isometric handgrip exercise is an effective non-pharmacological method for alleviating acute pain in patients with hypertension. This simple intervention has the potential to be applied as a complementary therapy in elderly care facilities to improve the quality of life of individuals living with hypertension.

Ultraviolet (UV) radiation has been known to cause various adverse effects on the skin, including erythema (commonly referred to as sunburn), premature aging, and, with prolonged exposure, the risk of developing skin cancer. To counteract these harmful effects, sunscreen products are commonly used to protect the skin from UV radiation. The development of natural-based sunscreens is gaining attention due to their potential safety and antioxidant benefits. One promising natural ingredient is thyme (Thymus vulgaris L.), a medicinal herb that contains several secondary metabolites such as flavonoids, alkaloids, and tannins. These compounds possess antioxidant and free radical scavenging properties, making them suitable candidates as active ingredients in sunscreen formulations. This study aims to determine the Sun Protection Factor (SPF) value of thyme herb extract using the UV-Vis spectrophotometric method. A qualitative approach was used to assess the photoprotective potential of the extract. The SPF values were measured at three different concentrations of the extract: 0.5%, 0.75%, and 1.0%. The absorbance of each concentration was recorded at wavelengths ranging from 290 nm to 400 nm using a UV-Vis spectrophotometer. The SPF values were then calculated based on the absorbance data processed using Microsoft Excel. The results revealed that the thyme herb extract exhibited high SPF values at all tested concentrations. Specifically, the SPF values obtained were 36.027 for 0.5%, 36.244 for 0.75%, and 36.516 for 1.0% concentration. All three concentrations fall under the "ultra protection" category, indicating strong UV protective potential. These findings suggest that thyme herb extract can be effectively utilized as a natural active ingredient in the formulation of sunscreen products. Further studies are recommended to explore its stability, safety, and efficacy in topical applications.

Human skin undergoes aging and degenerative processes, like other body tissues. Skin aging is characterized by various structural and functional changes, such as decreased skin elasticity, degradation of elastic fibers, thinning of the epidermis, reduced collagen content, the appearance of wrinkles, and increased skin dryness. One effort to inhibit this process is the use of natural phytochemical compounds with antioxidant and skin-protective activity, such as ferulic acid. Ferulic acid is known to scavenge free radicals and absorb ultraviolet (UV) light. Furthermore, this compound can protect the structure of collagen, elastin, and fibroblast cells from damage, and inhibit the enzymes collagenase and tyrosinase, which play a role in collagen degradation and the formation of hyperpigmentation. This literature review aims to examine the anti-aging activity of ferulic acid based on the results of in vitro and in vivo studies published in the past ten years. The search was conducted through a systematic literature review of relevant scientific articles. The results indicate that ferulic acid has a promising mechanism of action in preventing and slowing skin aging. This compound can improve skin elasticity, suppress melanin production, reduce dark spots, and exhibit anti-inflammatory properties that help reduce redness and inflammation caused by acne. Its antioxidant effects also contribute to slowing the appearance of wrinkles, thus helping maintain a more youthful appearance. Despite its significant potential, further research is needed to better understand its mechanism of action and long-term safety for use on human skin.

Skin damage can adversely affect a person's health and physical appearance. One of the factors causing is exposure to free radicals that can trigger various skin problems such as premature aging, hyperpigmentation, to skin cancer. The combination of astaxanthin and carrot extract (Daucus carota L.) can be a natural approach that is promising for skin care because it contains antioxidant carotenoids. Astaxanthin and carrot extract are formulated in the form of emulgel preparations to optimize their effectiveness when used on the surface of the skin. The success of an emulgel preparation is not only determined by its active ingredient, but also by the physical characteristics of the preparation. This study aims to determine the optimum formulation of the combination of carbopol 940, triethanolamine, and aquadest in making emulgel preparations with active substances Astaxanthin and carrot extract in order to obtain physical properties that meet the standards. Optimization is carried out using the D-Optimal Mixture Design method through the Design Expert® software version 13.0.0. The evaluated parameters include pH, viscosity, scattering power, and adhesion. This study produced an optimum formulation of emulgel with a composition of 940 1.5% carbopol as much as 40.697 grams, TEA as much as 0.5 grams, and aquadest amounted to 15,188 grams. This formula shows a pH of 5,783 ± 0.0249, viscosity 24,856.7 ± 2,829.61 cps, 5,113 ± 0.4216 cm spread power, as well as the adhesion of 1,873 ± 0.1641 seconds. Based on the analysis using the D-optimal method, Tea is known as the most influential component of the physical characteristics of the Astaxanthin combination emulgel and carrot extract.

Sunlight is the main source of energy for life, but ultraviolet radiation can have negative impacts on the skin, such as sunburn, pigmentation, wrinkles, premature aging, and the risk of skin damage due to excessive exposure. One way to protect the skin from these effects is to use sunscreen. Carrots contain antioxidant compounds that can bind free radicals and prevent cell damage due to oxidation, so they have the potential to be used as a natural ingredient in making sunscreen. This research aims to formulate and test the physical properties of carrot extract lotion as a sunscreen and determine the extract concentration that has the optimal Sun Protection Factor (SPF) value. The method used is experimental by making lotion formulations, testing their physical properties, and measuring the SPF value of each formulation. The research results showed that the KN, F1, F2, and F3 lotion formulations had a semi-solid form which met the formulation requirements. However, KN's SPF value is only 1.23 which does not meet sunscreen standards. Meanwhile, F1 has SPF 8.3 (extra effect category), F2 with SPF 15.06 and F3 with SPF 24.1 (ultra category). F3 shows the best results because with SPF 24.1, this formulation is close to SPF 25 which can protect the skin for up to 4 hours with twice daily use. The higher the concentration of carrot extract, the better its effectiveness in lotion formulation as a sunscreen.

Indonesia is renowned for its rich tropical flora diversity, and Kalimantan Island stands out for its exceptional fruit variety. Three fruits, ramania, kapul, and ihau fruits, have drawn particular interest due to their potential health benefits and possible uses in the food and pharmaceutical industries. Nevertheless, these fruits are rarely explored comprehensively. So, this study offers a better understanding of the diverse fruits found in Kalimantan through a comparative analysis of literature data. This literature review aims to provide valuable insights into the nutritional and bioactive properties of these fruits and highlights their potential health benefits. The results from various previous studies exhibited that the exotic and indigenous fruits from Kalimantan, including ramania, kapul, and ihau fruits, are packed with essential nutrients like proteins, fats, carbohydrates, vitamins, and bioactive compounds that act as anti-aging, anti-bacterial, anticancer, antioxidants, and other bioactivities. Moreover, Kalimantan's exotic and indigenous fruits also have great potential as ingredients for functional food or pharmaceutical production. However, further research is necessary to fully explore their potential and innovative applications in various industries.

Bay leaves are one of the toga plants (family medicinal plants) which can be used to stop excessive defecation. Apart from that, bay leaves can also be used to treat gout, stroke, high cholesterol, improve blood circulation, stomach inflammation, itching and diabetes. Therefore, there is a need for education in the form of counseling regarding the use of bay leaves and how to process them as herbal medicine to help cure diseases. Kaffir lime is a natural ingredient in various food and beverage products in Indonesia and other Asian countries. Kaffir lime plants contain compounds including essential oils which are also rich in benefits such as antioxidants, antimicrobials, antileuchemicals, antitussives, insecticides, illaricides and phenolic compounds such as flavonoids, flavanones, flavones, flavonols and glycerolipids which according to research function as a source of antioxidants, anti-inflammatory , antiviral, anti-allergic, and anti-carcinogenic, anti-aging for the human body. The planting of kitchen spices in the form of bay plants and orange leaves is grown using organic and environmentally friendly materials.

Elderly is an age group that is susceptible to disease due to decreased function in the body due to the aging process. Uric acid is produced by every living thing as a result of the main metabolic process, namely a chemical process in the cell nucleus that functions to support survival. To overcome complaints of pain that appear in patients with gout, there are various pharmacological and non-pharmacological therapies. The usual pharmacological therapy is taking painkillers, namely the Nonstereoidal Antiinflammatory Drugs (NSAID) group. Complementary therapy is a natural therapy including herbal therapy in the form of bay leaves. The aim of the study was to describe a decrease in uric acid levels by giving bay leaf boiled water to the elderly at the Cilacap Dewanata Institution. The results of this study were obtained after therapy by giving boiled bay leaf water, the patient was more comfortable, the pain was reduced, the last day's observations of vital signs (TTV) showed Td: 110/80 mmHg, Respiration: 20 x/minute, Pulse: 96 x /minute pain scale 2. In conclusion, the application of giving bay leaf boiled water is proven to be able to overcome the problem of diagnosing acute pain associated with physical injury agents, the implementation of self-invasion care was carried out for 3 days, with extraction the results of reduced pain.

Excessive exposure to sunlight is a source of free radicals that cause damage to the skin such as redness, dullness, and aging, so skincare containing antioxidants is needed, one of which is a face mist made from carrot root extract. The carrot (Daucus carota L) is a plant rich in antioxidants such as β-carotene and vitamin C which can counteract free radicals. This research aims to determine whether carrot tuber extract can be formulated in a face mist preparation and to determine the value of antioxidant activity in the carrot tuber extract face mist preparation. The method used in this study is the experimental method. Preparation of carrot root extract was carried out using the maceration method with 70% ethanol solvent. Facemist carrot root extracts was made with various concentrations of FI 1%, FII 3%, and FIII 5%. All preparations were subjected to physical stability (organoleptic, pH, spray spreadability, dry time, and homogeneity) and antioxidant activity tests using the DPPH method. The results of physical stability stated that all formulas met the physical quality requirements. The antioxidant activity value of carrot tuber extracts facemist at concentrations of 1%, 3%, and 5% has an IC₅₀ value of 41.31ppm, 34.64ppm, and 28.80ppm respectively. This value is in the very strong category. The conclusion of this study is that carrot root extract can be formulated as a face mist preparation and has a very strong antioxidant value.

The challenges of the 21st century nursing world demand that nursing educators be able to prepare future nurses who can adapt to changes in the health care system, new technologies, changes in information systems (computerized), changes in pharmacological therapy, increased workload for nurses, increased infectious diseases in the community. , increasing cases of antibiotic-resistant infections, increasing aging population, and increasing number of chronic and co-morbid conditions (Aiken, Clarke, Cheung, Sloane, & Silber, 2003). Nurse educators are responsible for preparing graduates who can adapt to this rapidly changing health system. The simulation learning strategy is proposed as a suitable method to overcome this problem and can bridge the gap between education and clinical practice in hospitals. This literature search aims to analyze the results of related research that focuses on the effect of Simulation-Based Learning on the critical thinking of nursing students. This study was conducted using the review method of research results from 2010 – 2020 which have been published in electronic media such as ProQuest, Pubmed, and CINAHL. The number of journals obtained was 10 journals and 6 of them met the criteria. The conclusion of the research results obtained was that simulation is an interactive teaching-learning process, learning knowledge about critical care from a simulation of real patient situations, learning clinical skills and presenting holistic patient care by playing a role , and bridging the theory-practice gap to enhance critical thinking. In addition, simulations can hone critical thinking skills through feedback from simulators and monitor displays, develop communication skills through teamwork, and improve task delegation skills in complex situations.

Snack bars are known to meet consumers' needs for nutrition, taste and practicality. There needs to be additional raw materials that are high in nutrients so that the products produced are beneficial to the body and also provide health effects. One plant that is high in nutrients and also provides benefits for the body is the Moringa plant. Moringa is known to contain more than 90 types of nutrients, namely in the form of essential vitamins, minerals, amino acids, anti-aging and anti-inflammatory. Our body needs antioxidants that can help protect the body from free radical attacks, considering that very many free radicals come from outside the body, namely in the form of foods that contain preservatives, dyes, fats, pesticides, pollution, dust and ultraviolet radicals. The process of making snack bars, roasting temperature and the proportion of flour are among those that can affect the characteristics and maturity levels of the resulting product. This study was conducted to determine the effect of temperature and flour formulations on sensory, texture profiles and antioxidants. The study used RALf (complete random design of factorial) 2 factors. From the results of this study obtained the results of roasting temperature affecting the profile value of the texture parameters hardness / hardness, gummieness / stickiness, chewieness / chewing power but has no effect on the results of antioxidant activity and hedonic sensory. The formulation of cornstarch and moringa flour on the results of the texture profile affects the parameters of resielience / snack bars. Formulation of corn flour snack bars and Moringa flour has a real effect on the antioxidant activity value of corn flour snack bars and moringa flour. Where the addition of moringa as much as 10% with a temperature of 120oC has a value of %ibhibisi as much as 87.66 and flour formulations also have a real effect on all hedonic sensory parameters, namely aroma, color,  taste and overall.

Skincare are very important for facial care. There are various skin problems one of which is premature aging and dull skin. The perpose of the writer is to know and explain the process making mangosteen skin serum and white rice as anti-aging and brightening, to find out and explain the benefits of mangosteen skin and white rice as anti-aging and brightening and to explain the public acceptance of the mangosteen skin serum and the white rice as anti-aging and brightening. the methoud used is observation, documentation, experiment, interview, questionares and literature. The third experiment produced the composition are 2ml glyserin, 1,5ml mangosteen extract, 1,5ml white rice extract, 5ml aquades, 0,5ml phenoxythanol, 1gr allantoin and 0,5g hydroxtethyl cellulose. Gives off the color beige, nice smell, thick texture and a moist application. After 14 times use, the face will feel moist, bright and fine line and wrikles on the faces are camouflaged. Based on public trials, the average output of 30 panels is the third product with an average of 3,43. The second product has an average of 3,26 and the first product hasan average of 2,93. Thus, it can be concluded that products could be the innovation of problems of premature aging and dull skin

Nutmeg (Myristica fragrans) is a spice plant that produces essential oils of economic value. Especially the myristicin compounds contained in nutmeg oil have potential as antioxidants and also anti-aging. The content of nutmeg which shows antifungal activity is flavonoids, saponins and alkaloids. Flavonoids as antifungal compounds work by interfering with the permeability of fungal cell membranes and changing organic components and nutrient transport which ultimately results in toxic effects on fungi. This study aims to determine the chemical content and whether the nutmeg extract can be formulated in cream preparations as well as the results of the physical properties test on the preparation of the nutmeg (Myristica fragrans) ethanol extract of cream. The type of research used in this study was experimental research in the laboratory. Nutmeg (Myristica Fragrans), phytochemical screening test on nutmeg extract, cream preparation formulation, cream physical properties test (organoleptic test, pH test, homogeneity test, cream type test). Nutmeg extraction was carried out using the maceration method using 70% ethanol. The results of phytochemical screening of the ethanol extract of nutmeg (Myristica fragrans) indicated the presence of alkaloids, flavonoids, and saponins. The preparation of cream of ethanol extract of nutmeg (Myristica fragrans) using a Vaseline album base ratio of F1 (10%), F2 (15%) and F3 (20%) had stable physical properties.