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Appendisitis merupakan salah satu kasus kegawatdaruratan bedah yang sering memerlukan tindakan appendektomi dan berpotensi menimbulkan nyeri pasca operasi. Nyeri yang muncul setelah efek anestesi berkurang dapat memengaruhi kenyamanan serta proses pemulihan pasien, sehingga diperlukan manajemen nyeri yang efektif. Salah satu terapi nonfarmakologis yang dapat digunakan sebagai terapi pendamping adalah teknik relaksasi Benson. Penelitian ini bertujuan untuk mengetahui efektivitas teknik relaksasi Benson terhadap penurunan skala nyeri pada pasien pasca operasi appendektomi di ruang Rawat Inap VIP RSUD Boven Digoel. Penelitian ini menggunakan desain studi kasus dengan pendekatan deskriptif. Pengambilan sampel dilakukan secara purposive sampling sesuai dengan kriteria inklusi yang telah ditetapkan, dengan jumlah sampel sebanyak 1 pasien pasca operasi appendektomi. Pengumpulan data dilakukan melalui observasi dan wawancara selama 4 hari. Intervensi berupa teknik relaksasi Benson diberikan untuk membantu mengurangi intensitas nyeri pasien. Hasil penelitian menunjukkan bahwa penerapan teknik relaksasi Benson efektif dalam menurunkan skala nyeri pada pasien pasca operasi appendektomi. Setelah dilakukan intervensi, pasien mengalami penurunan intensitas nyeri secara bertahap sehingga memberikan rasa nyaman selama masa perawatan. Berdasarkan hasil penelitian, teknik relaksasi Benson dapat dijadikan sebagai salah satu terapi nonfarmakologis alternatif dalam manajemen nyeri pasien pasca operasi appendektomi. Diharapkan institusi pelayanan kesehatan, institusi pendidikan, perawat pelaksana, dan peneliti selanjutnya dapat menerapkan dan mengembangkan intervensi ini sebagai bagian dari asuhan keperawatan yang komprehensif.

Komplikasi pasca operasi merupakan salah satu masalah klinis yang sering terjadi pada pasien bedah umum dan dapat berdampak pada peningkatan morbiditas, lama rawat inap, serta biaya pelayanan kesehatan. Berbagai faktor diduga memengaruhi terjadinya komplikasi pasca operasi, antara lain usia, jenis kelamin, lama operasi, jenis anestesi, dan status fisik pasien berdasarkan klasifikasi American Society of Anesthesiologists (ASA). Penelitian ini bertujuan untuk menganalisis faktor risiko yang berhubungan dengan kejadian komplikasi pasca operasi pada pasien bedah umum di rumah sakit. Penelitian menggunakan desain kuantitatif analitik dengan pendekatan cross-sectional terhadap pasien pasca operasi yang memenuhi kriteria inklusi dan eksklusi penelitian. Pengumpulan data dilakukan melalui telaah rekam medis pasien, kemudian dianalisis menggunakan uji bivariat dan multivariat untuk mengetahui hubungan serta faktor yang paling dominan memengaruhi komplikasi pasca operasi. Hasil penelitian menunjukkan bahwa lama operasi, jenis anestesi, dan status ASA merupakan faktor yang paling berpengaruh terhadap kejadian komplikasi pasca operasi. Sementara itu, faktor usia dan jenis kelamin menunjukkan hubungan yang bervariasi pada masing-masing kelompok pasien. Temuan penelitian ini menegaskan pentingnya identifikasi faktor risiko sejak fase preoperatif sebagai upaya pencegahan komplikasi dan peningkatan kualitas pelayanan perioperatif di rumah sakit.

Laparotomy is a major surgical procedure associated with a high risk of acute postoperative pain. According to Gan (2017), if pain is not properly managed, it can progress to chronic pain. (Toro et al., 2018) reported that severe pain on the first postoperative day is still commonly found in laparotomy patients, while (Small & Laycock, 2020) indicated that moderate to severe pain within the first 24 hours following major surgery remains a significant clinical issue. This study aims to evaluate the effectiveness of pharmacological pain management following laparotomy under general anesthesia, specifically to identify the types of opioid analgesics used, analyze their effectiveness in reducing pain intensity, identify side effects, and examine administration techniques and routes. This study employed a Systematic Literature Review (SLR) method following the PRISMA guidelines. Literature searches were conducted in the PubMed, ScienceDirect, and SpringerLink databases covering the years 2015–2026. The included studies comprised randomized controlled trials (RCTs), cohort studies, and retrospective studies addressing opioid pharmacological pain management in adult patients following laparotomy under general anesthesia. Study quality assessment was performed using the Joanna Briggs Institute (JBI) instrument. A total of 11 studies met the inclusion criteria. The results of the systematic literature review indicate that opioids are effective in reducing postoperative pain following laparotomy under general anesthesia. The most commonly used opioids are morphine, fentanyl, and oxycodone. Of all the opioids reviewed, oxycodone provided the best pain control, while intrathecal morphine was most effective in reducing the need for supplemental opioids during the early postoperative period. Other opioids, such as extended-release dinalbuphine sebacate and tegileridine, are also effective, but the number of studies is still limited. The most common side effects are nausea, vomiting, pruritus, sedation, and dizziness. Pharmacological pain management using opioids is effective in reducing the intensity of postoperative pain following laparotomy under general anesthesia. Morphine, fentanyl, and oxycodone are the most commonly used opioids. Oxycodone and intrathecal morphine have shown good results in improving pain control and reducing the need for supplemental opioids. The selection of opioid type, dosage, and administration technique must be tailored to the patient’s clinical condition to achieve optimal analgesia with minimal side effects.

Providing passive ROM to the extremities can help improve blood circulation, improve respiratory function, and support the recovery of consciousness as assessed using the Aldrete Score. The purpose of this study was to determine the effect of providing early passive ROM mobilization of the extremities on changes in the Aldrete score in patients after general anesthesia. This study used a pre-experimental design with a one-group pretest-posttest approach. The study sample consisted of 57 respondents. The intervention provided was early passive ROM mobilization. The Aldrete score was measured before and after the intervention. Data analysis used the Wilcoxon signed rank test with a significance level of α = 0.05. The results showed that the average Aldrete score before the intervention was 5.89 and after the intervention increased to 9.26. The results of the statistical test showed a p value = 0.0001 (p <0.05), which means that there is a significant effect of providing early passive ROM mobilization of the extremities on increasing the Aldrete score after general anesthesia. From this study, it can be concluded that there is an effect of providing early passive ROM mobilization of the extremities on increasing the Aldrete score after general anesthesia.

Spinal anesthesia is one of the regional anesthesia methods that is often chosen in various surgical procedures, especially in the area of the lower extremities, pelvis, and lower abdomen. The most common complication encountered in this technique is the occurrence of hypotension, which can affect tissue perfusion and hemodynamic stability of the patient. This study aims to examine the incidence of hypotension in spinal anesthesia, including mechanisms, risk factors, and management. The method used in this study is literature review with a scientific source search process conducted through various databases PUBMED, Sciencedirect, Researchgate, and Google Scholar with a publication year range of 2016 to 2026. The results showed that hypotension arises as a consequence of an obstacle in the sympathetic nervous system, which provokes dilation of blood vessels as well as reduced venous return. Risk factors include age, body mass index, patient position, block height, duration of surgery, fluid status, Injection Point, and type of anesthetic drug used. Management is carried out by administering fluids, vasopressors, as well as strict hemodynamic monitoring. A good understanding of the risk factors and mechanisms of hypotension is expected to improve patient safety during spinal anesthesia..

Combined spinal epidural (CSE) is a regional anesthesia technique that combines the rapid onset of spinal anesthesia with the flexibility and prolonged analgesia of epidural anesthesia, making it a valuable option for major surgery in elderly patients with comorbidities. We report a case of a 76-year-old man with ASA physical status III diagnosed with multiple nephrolithiasis accompanied by bilateral hydronephrosis, who underwent open right nephrolithotomy under CSE anesthesia. The patient had a history of hypertension and mild renal function impairment, placing him at increased perioperative risk. Intraoperatively, hemodynamic parameters remained stable without significant hypotension, vasopressor requirement, or conversion to general anesthesia. Estimated blood loss was approximately 500 mL and was managed with crystalloid replacement without transfusion. Prophylactic antibiotic and adjuvant medications were administered according to surgical standards. Postoperatively, the patient was monitored in the ICU with stable vital signs and adequate pain control achieved through continuous epidural analgesia. This case highlights that CSE can be a safe and effective anesthetic approach for open nephrolithotomy in selected high-risk geriatric patients, providing satisfactory hemodynamic stability and postoperative recovery.

Indonesia merupakan negara yang rawan gempa bumi, seperti yang terjadi di Yogyakarta tahun 2006 yang menimbulkan banyak korban jiwa dan kerusakan besar. Hal ini menunjukkan pentingnya kesiapsiagaan bencana di perguruan tinggi. Mahasiswa sebagai agen perubahan berperan penting dalam mitigasi bencana. Self efficacy atau keyakinan diri menjadi salah satu faktor yang memengaruhi kesiapsiagaan mahasiswa. Penguatan self efficacy di kalangan mahasiswa sangat penting untuk membangun kesiapsiagaan bencana di perguruan tinggi. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian mini video edukasi penanganan kegawatdaruratan gempa bumi terhadap self efficacy mahasiswa keperawatan anestesiologi. Metode penelitian ini menggunakan desain pre-eksperimental dengan pendekatan pretest and postest design tanpa kelompok kontrol. Teknik sampling menggunakan Simple Random Sampling dengan instrumen berupa lembar angket kuisioner. Hasil bivariat menggunakan uji Wilcoxon.  Hasil analisis bivariat menggunakan uji wilcoxon menunjukan perbedaan yang signifikan antara self efficacy sebelum dan sesudah pemberian edukasi video yaitu didapatkan nilai signifikansi atau sig (2-tailed) sebesar 0.000 <0.05. sehingga H0 ditolah dan Ha diterima. Kesimpulannya terdapat pengaruh pemberian mini video edukasi penanganan kegawatdaruratan gempa bumi terhadap self efficacy mahasiswa keperawatan anestesiologi.

Chronic liver disease is a significant health problem and places a significant burden on healthcare services. Deaths from complications of chronic liver disease (cirrhosis and cancer) account for approximately 3.5% of all deaths worldwide each year. Hepatocellular carcinoma (HCC) is a primary liver tumor, accounting for 90% of all liver tumors. Due to limitations in liver transplantation, liver resection is considered the treatment of choice for HCC patients with a single tumor and sufficient liver function reserve. Liver resection and transplantation are the only curative treatment options available for HCC patients. Surgical procedures require anesthesia. General anesthesia is the preferred method for liver tumor resection. There are five main classes of anesthetic agents: intravenous (IV) anesthetics, inhalational anesthetics, IV sedatives, synthetic opioids, and neuromuscular blocking agents. Estimated health risks depend on the extent or severity of liver disease, the nature and timing of surgery, the type of anesthesia, and other comorbidities.

Postoperative nausea and vomiting (PONV) is one of the most common complications following surgery under general anesthesia, with an incidence of 20–70% in the general population and exceeding 80% in high-risk patients. PONV can reduce patient comfort, delay recovery, and increase the risk of dehydration, electrolyte imbalance, and surgical wound dehiscence. This article aims to analyze the effectiveness of single antiemetic therapy compared with combination antiemetic therapy in reducing the incidence of PONV in adult patients after general anesthesia, based on evidence from randomized controlled trials (RCTs). This study applied the Arksey and O’Malley framework for analysis. Literature was obtained from ScienceDirect, PubMed, and the Cochrane Library, published between 2020 and 2025. Identification and selection of studies followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (Moher et al., 2009). A total of 10 articles were included and analyzed, focusing on outcomes such as the incidence of nausea and vomiting, complete response rates, and the need for rescue antiemetic therapy. The findings indicate that single antiemetic therapy remains effective in low-risk patients, whereas combination antiemetic therapy with multiple mechanisms of action provides more optimal protection, particularly in high-risk patients. These results provide an evidence-based foundation for healthcare professionals in selecting the most effective PONV prevention strategies according to individual patient risk and clinical conditions.

Hypotension following spinal anesthesia is a frequent perioperative complication, particularly among pregnant patients, with an incidence ranging from 60% to 80%. This condition may compromise uteroplacental perfusion and pose serious risks to both mother and fetus. Leg elevation represents a simple, safe, inexpensive, and effective non-pharmacological intervention that functions through gravitational autotransfusion, enhancing venous return and improving cardiac output. This scoping review was conducted using the Joanna Briggs Institute (JBI) methodology and the PRISMA-ScR framework, guided by the PICO approach. The population included adult patients undergoing spinal anesthesia, with the intervention consisting of elevating the legs at an angle of 20–30° or approximately 30 cm for 10–15 minutes, compared with the standard supine position. Literature searches were performed through PubMed  and Google Scholar, focusing on primary studies published within the last five years. Of the 130 articles identified, 10 met the inclusion criteria and were analyzed descriptively. The findings demonstrate that leg elevation significantly increases systolic and diastolic blood pressure as well as mean arterial pressure (MAP), while reducing the incidence of post-spinal hypotension. The technique also decreases vasopressor requirements without notable adverse effects, particularly in obstetric populations. Based on the available evidence, leg elevation is recommended as an effective and feasible initial non-pharmacological strategy for preventing hypotension after spinal anesthesia, especially in resource-limited clinical settings, with an optimal elevation of 20–30° for 10–15 minutes.

Anesthesiology and emergency care require rapid and accurate clinical decision-making. Artificial intelligence (AI) offers substantial potential to support triage, monitoring, and decision-making in critical and emergency anesthesiology settings. This scoping review maps the use of AI in clinical decision-making and emergency patient management in anesthesiology and identifies existing research gaps. A literature search was conducted in ScienceDirect, PubMed, Cochrane Library, and Google Scholar for articles in Indonesian or English published between 2020 and 2025. Study selection followed Tricco’s scoping review framework, and methodological quality was assessed using Joanna Briggs Institute (JBI) tools. Ten articles met the inclusion criteria. AI was shown to improve triage accuracy and efficiency (predictive accuracy up to 99.1% and reductions in waiting time of around 30%). Machine learning models effectively predicted critical care needs and emergency risk, while AI-based clinical decision support systems (CDSS) enhanced the speed and quality of clinical decisions. Key challenges include data bias, ethical and privacy issues, clinician readiness, and integration with hospital information systems. AI and CDSS have strong potential to improve patient safety and clinical decision-making in emergency anesthesiology. Strengthening AI literacy, supportive regulation, and transparent, context-appropriate predictive models are needed for safe and sustainable implementation.

Hypotension is the most common complication following spinal anesthesia due to sympathetic nerve blockade, which leads to vasodilation and decreased venous return. One of the preventive measures is patient positioning, such as Trendelenburg and supine positions. This study aimed to determine the effect of both positions on the incidence of post-spinal hypotension at Bhayangkara Hospital TK III Padang. This research applied a quantitative observational analytic design involving 55 elective surgical patients, consisting of Trendelenburg position (n=32) and supine position (n=23). Data were collected through direct observation and blood pressure measurement using NIBP. Data analysis included univariate, bivariate with Spearman Rank test, and Mann-Whitney U test. The results showed that most respondents were female (60%) and classified as ASA I (56.4%). Post-spinal hypotension occurred in 41.8% of patients with systolic <90 mmHg, 27.3% with diastolic <60 mmHg, and 30.9% with a ≥20% decrease from baseline. Bivariate analysis revealed a significant association between patient position and hypotension (p<0.001; rho=0.466). The Mann-Whitney U test showed a significant increase in blood pressure in both positions (p<0.001), but the Trendelenburg position was more protective compared to supine. In conclusion, patient position has a significant effect on the incidence of hypotension after spinal anesthesia. The Trendelenburg position is more effective in preventing hypotension than the supine position, making it a valuable clinical consideration in anesthetic practice.

Surgery is one of the medical procedures divided into three periods of pre operative, intra operative, and post operative. At least 11% of the global disease burden comes from conditions that can actually be addressed through surgery. Surgical procedures will certainly require anesthesia, one of which is general anesthesia with the Endotracheal Tube (ETT) intubation technique. Endotracheal Tube (ETT) intubation can cause various complications, the most common being postoperative sore throat. One of the risk factors for sore throat after Endotracheal Tube (ETT) intubation is the duration of surgery. This research is a quantitative study with a descriptive correlational design and a cross-sectional approach. The sample in this study consisted of 30 patients undergoing surgery with general anesthesia using the Endotracheal Tube (ETT) intubation technique, determined by quota sampling. The research instruments used were a clock to measure the duration of surgery and an observation sheet containing the measurement of sore throat level using the Numeric Rating Scale (NRS). Data analysis in this study included univariate and bivariate analyses, with the latter tested using the Spearman rank test. The results of the Spearman rank test between the variables of surgical duration and postoperative sore throat in general anesthesia with the Endotracheal Tube (ETT) intubation technique showed a p = 0.000 and an r = 0.912, which means that the two variables have a significant and positive relationship in line with a very strong correlation strength. This indicates that the longer the duration of surgery, the higher the postoperative sore throat scale in general anesthesia with the Endotracheal Tube (ETT) intubation technique.

Both regional and general anesthesia techniques carry the risk of hypotension through different mechanisms. Regional anesthesia often causes hypotension due to sympathetic nerve blockade, which leads to peripheral vasodilation and a decrease in blood pressure. On the other hand, general anesthesia lowers blood pressure through its depressive effects on the cardiovascular system. Hypotension occurs more frequently in patients undergoing regional anesthesia compared to general anesthesia. This study aims to determine the relationship between anesthesia techniques and the incidence of post-anesthesia hypotension in Sectio Caesarea (SC) patients at RSUD dr. Soedirman Kebumen. This study uses a correlation analytic method with the Chi-Square test and a cross-sectional approach. Samples were taken using purposive sampling, consisting of 60 patients, 30 who received general anesthesia and 30 who received regional anesthesia. The research method involved blood pressure observation, which was then analyzed. The results showed that 26 patients (43.3%) in the regional anesthesia group experienced hypotension, while only 1 patient (1.7%) in the general anesthesia group experienced hypotension, with a p-value of 0.000. Based on these results, it can be concluded that there is a significant relationship between anesthesia techniques and the occurrence of hypotension, where regional anesthesia poses a higher risk for post-anesthesia hypotension in SC patients.

Postoperative consciousness recovery in patients who have received general anesthesia sometimes experiences delays, which can lead to postponing the transfer of patients to the recovery room. One approach that nurses can use to accelerate consciousness recovery after general anesthesia is by adjusting the patient’s sleeping position. This study aims to determine the effect of the semi-Fowler position on the length of consciousness recovery in postoperative patients with general anesthesia. The research method is quasi-experimental with a posttest-only control group design. The sample consisted of 42 postoperative patients with general anesthesia at RSUD dr. H. Soewondo Kendal, divided into two groups: the intervention group and the control group, selected using consecutive sampling technique. Data analysis was performed using the independent sample t-test. The results showed that most patients were aged 36-45 years, male, with the most commonly used anesthetic being Laryngeal Mask Airway (LMA) and the duration of surgery was less than 1 hour. The average consciousness recovery time for patients in the semi-Fowler position was 11.19 minutes, categorized as quick recovery. Meanwhile, the average consciousness recovery time for patients in the supine position was 15.0 minutes, also categorized as quick recovery. The analysis showed a significant effect of the semi-Fowler position on the consciousness recovery time (p-value = 0.048). In conclusion, the semi-Fowler position can accelerate consciousness recovery time by 3.81 minutes compared to the supine position in postoperative patients with general anesthesia.

This study aims to comparatively analyze the effects of two types of inhalation anesthetics, ether and chloroform, on Wistar rats, focusing on three main parameters: induction time, duration of anesthesia, and side effects. Selecting the appropriate anesthetic method is crucial in animal studies to ensure animal welfare and the validity of the results. Twenty male Wistar rats, with an average body weight of 200–250 grams and 10–12 weeks of age, were randomly divided into two treatment groups of 10 rats each. The first group was anesthetized using ether, while the second group was anesthetized using chloroform, with doses adjusted to achieve adequate levels of anesthesia. Measurements were made of the induction time, which is the interval from the start of anesthetic exposure until the loss of the pedal reflex; the duration of anesthesia, which is the length of time until the rat regains consciousness; and clinical observations of any side effects that appear, both during and after anesthesia. The results showed that the ether group had a relatively longer induction time than the chloroform group. However, ether provided a longer and more stable duration of anesthesia, with a better recovery rate. In contrast, chloroform produced a shorter induction time but was accompanied by a shorter duration of anesthesia and a higher risk of side effects, particularly liver dysfunction and respiratory depression. These findings reinforce previous reports that chloroform has significant potential toxicity, and its use in animal research should be limited. Based on these results, ether is recommended as a relatively safe inhalation anesthetic option for laboratory procedures in Wistar rats, although its use still requires strict supervision and appropriate handling procedures to ensure the safety of both researchers and experimental animals.

Praktik klinik penting bagi mahasiswa kesehatan untuk menerapkan teori ke praktik nyata, namun, insiden keselamatan pasien di Indonesia terus meningkat, dengan laporan insiden keselamatan pasien pada tahun 2019 mencapai 7.465 kasus. Oleh karena itu, mahasiswa keperawatan anestesiologi perlu kesiapan terkait patient safety sebelum praktik. Penelitian ini bertujuan mengetahui pengaruh video edukasi patient safety terhadap kesiapan mahasiswa Keperawatan Anestesiologi Universitas ‘Aisyiyah Yogyakarta. Metode yang digunakan adalah quasi experimental dengan desain pretest-posttest control group yang melibatkan 66 responden dengan teknik simple random sampling. Data dianalisis menggunakan uji Wilcoxon dan Mann Whitney. Hasil menunjukkan rata-rata skor pengetahuan dan sikap mahasiswa kelompok intervensi meningkat setelah edukasi, dengan pengaruh signifikan video edukasi terhadap kesiapan mahasiswa (p = 0,000). Kesimpulannya, video edukasi efektif meningkatkan kesiapan mahasiswa dalam menghadapi praktik klinik.

Komunikasi terapeutik penting dalam keperawatan anestesiologi, terutama untuk mengatasi kecemasan pasien pre operasi. Self-efficacy mahasiswa berperan dalam efektivitas komunikasi tersebut. Penelitian ini bertujuan mengetahui hubungan self-efficacy dengan penerapan komunikasi terapeutik pada mahasiswa Keperawatan Anestesiologi Universitas ‘Aisyiyah Yogyakarta. Desain penelitian kuantitatif korelasional dengan pendekatan cross-sectional, melibatkan 60 mahasiswa semester 6. Instrumen yang digunakan adalah General Self-Efficacy Scale (GSES) dan kuesioner komunikasi terapeutik. Hasil menunjukkan mayoritas mahasiswa memiliki self-efficacy tinggi (85%) dan komunikasi terapeutik baik (95%). Terdapat hubungan signifikan antara keduanya (p = 0,000; r = 0,588). Disimpulkan bahwa self-efficacy berhubungan positif dengan penerapan komunikasi terapeutik. Disarankan institusi memperkuat pembelajaran dan praktik komunikasi terapeutik untuk meningkatkan self-efficacy mahasiswa.

Prinsip tujuh benar obat merupakan pedoman penting bagi perawat saat memberikan obat kepada pasien, meliputi benar pasien, benar obat, benar dosis, benar rute, benar waktu, benar dokumentasi, dan benar pendidikan atau informasi kesehatan. Pengetahuan yang baik mengenai prinsip ini sangat penting bagi mahasiswa keperawatan anestesiologi untuk mencegah kesalahan dalam pemberian obat. Penelitian ini bertujuan mengetahui pengaruh edukasi e-pocket book prinsip benar obat terhadap tingkat pengetahuan mahasiswa D4 Keperawatan Anestesiologi Universitas ‘Aisyiyah Yogyakarta. Metode yang digunakan adalah pre-experimental design dengan pendekatan one group pre-test dan post-test dengan sampel 60 mahasiswa angkatan 2023 D4 Keperawatan Anestesiologi yang dipilih secara Simple Random Sampling. Instrumen penelitian berupa kuesioner pengetahuan prinsip benar obat dan analisis data menggunakan uji Wilcoxon. Hasil penelitian menunjukkan adanya pengaruh signifikan edukasi e-pocket book terhadap peningkatan pengetahuan mahasiswa, yang dibuktikan dengan nilai p sebesar 0,000 (p < 0,05). Kesimpulannya, edukasi e-pocket book efektif meningkatkan pengetahuan mahasiswa tentang prinsip tujuh benar obat dan diharapkan dapat membantu saat praktik klinik di rumah sakit.

Pemulihan kesadaran setelah general anestesi merupakan fase kritis yang dipengaruhi oleh berbagai faktor, salah satunya adalah penggunaan sevoflurane sebagai agen anestesi inhalasi. Waktu pulih sadar yang terlalu lama dapat berisiko menimbulkan komplikasi pascaoperasi dan memperpanjang waktu perawatan di ruang pemulihan. Variasi dalam penggunaan volume persentase sevoflurane dapat memengaruhi waktu pulih sadar pasien. Penelitian ini bertujuan untuk mengetahui hubungan antara persentase sevoflurane dengan lama pulih sadar pasien yang menjalani anestesi umum di Instalasi Bedah Sentral RSU PKU Muhammadiyah Bantul. Metode penelitian ini menggunakan desain deskriptif korelasi dengan pendekatan kuantitatif dan rancangan cross-sectional. Sampel terdiri dari pasien dewasa (19–59 tahun) yang menjalani operasi dengan anestesi umum menggunakan agen inhalasi sevoflurane. Instrumen pengumpulan data meliputi lembar observasi, jam, dan data dari mesin anestesi. Analisis data dilakukan menggunakan uji korelasi Spearman Rank. Hasil penelitian dari 60 jumlah responden yang diteliti, responden yang mengalami pulih sadar lama sebanyak 21 responden (35,0%), lalu pulih sadar sedang sebanyak 24 responden (40,0%), dan yang mengalami pulih sadar cepat sebanyak 15 responden (25,0%). Hasil uji Spearman Rank menunjukkan nilai signifikansi (p-value) 0,000 < 0,05, yang mengindikasikan adanya korelasi positif antara kedua variabel tersebut.