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Hypertension is one of the most common non-communicable diseases, posing serious health risks such as heart disease, stroke, and kidney failure. The increasing prevalence of hypertension is mainly due to limited public knowledge about the risks associated with the condition and the importance of consistent, long-term medication adherence to prevent complications. This study aims to examine the relationship between the level of knowledge about hypertension and medication adherence among hypertensive patients. A quantitative research method with a descriptive correlational design was employed. Purposive sampling was used to select respondents, and the data were analyzed using the Chi-Square test. The results showed that the majority of respondents were female (53%), aged between 46 and 64 years (74%), had an elementary school education level (42%), worked as housewives (51%), and had been diagnosed with hypertension for an average of 7 to 10 years (46%). Statistical analysis revealed a p-value of 0.000 (α < 0.05), indicating a significant relationship between the patients’ knowledge level and their adherence to antihypertensive medication. This finding emphasizes the need for continuous health education and counseling to enhance patients’ understanding of hypertension and its management. Effective communication and support strategies are essential in improving medication adherence, which is crucial for preventing hypertension-related complications and improving the quality of life for patients. These results provide valuable insights for healthcare providers to develop targeted interventions.