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Nutritional problems among adolescents are increasingly associated with unhealthy dietary habits and low physical activity, contributing to the rising prevalence of overweight. According to the 2023 Indonesian Health Survey, overweight prevalence among adolescents ranges from 12% to 16.2%. This study aimed to develop Zea Coffee Tab, a functional beverage made from Robusta coffee and corn silk containing bioactive compounds, including caffeine and flavonoids, which may support metabolism and body fat oxidation. An experimental method with a Completely Randomized Design (CRD) was employed. The evaluated parameters included organoleptic tests (hedonic and hedonic quality) involving 30 semi-trained panelists, proximate analysis, and identification of bioactive compounds. Data were analyzed using the Kruskal–Wallis, Mann–Whitney, One-Way ANOVA, and Duncan’s multiple range tests. Three formulations were tested: F1 (30% Robusta coffee:70% corn silk), F2 (50%:50%), and F3 (70%:30%). The findings showed that F3 was the most preferred formulation, with an acceptance score categorized as “very much liked.” The product contained energy ranging from 319.20–324.26 kcal/100 g, protein 5.12–5.34%, fat 0.48–0.58%, carbohydrates 73.85–74.51%, moisture 9.12–9.66%, ash 2.10–2.32%, caffeine 182.45–205.86 mg/100 g, and flavonoids 4.28–6.03 mg/100 g. Zea Coffee Tab has the potential to serve as a healthy functional beverage for overweight adolescents. Further studies on shelf life and clinical effectiveness are recommended to support product commercialization.

Christian leadership rooted in John 15:1 8 and 13 17 depicts Jesus as the true vine, where leaders, as branches, must abide (remain attached) in Him (Jesus Christ) to bear abundant fruit through divine vision, moral integrity, and passionate service. This analysis explores how the vine metaphor shapes a leadership model that depends on an intimate (attached) relationship with Christ, producing fruit in daily life and ministry. The relationship between the vine and the branches reflects the necessity for church leaders to rely on Christ for guidance, strength, and the ability to serve others effectively. The model emphasizes the importance of nurturing personal spiritual growth, cultivating virtues that align with God’s purpose, and fostering a ministry focused on service and integrity. These principles are relevant for Indonesian church leaders who are called to integrate their faith with contextual ministry. By examining the passage through exegesis and literature review, this article provides insights on developing a Christ centered approach to leadership.

The coal mining industry requires accurate stockpile volume measurements for inventory and production reporting. Conventional methods have limitations in accuracy, efficiency, and safety. This study compares the accuracy and efficiency of coal stockpile volume measurements using a Terrestrial Laser Scanner (TLS) Leica MS60 and an Unmanned Aerial Vehicle (UAV) DJI Matrice 4E, validated by the ASTM D6172-98 standard. Conducted on five Run of Mine (ROM) coal stockpiles covering 13,500 m² at PT XYZ, Lahat, South Sumatra, the TLS method used 43 scan positions, while the UAV employed 430 aerial images with specific flight parameters. Data were processed using Leica Infinity, Surpac, and Agisoft Metashape. The results showed volumes of 94,076 m³ (TLS) and 94,965 m³ (UAV), with a difference of 889 m³ (0.95%). Volume deviations ranged from 0.48% to 1.89%, with an average of 1.42%, all within the ASTM tolerance (<2%). Time efficiency analysis revealed that the UAV method required 200 minutes (3.33 hours), saving 63.3% (approximately 6.17 hours) compared to the TLS method (570 minutes). The largest efficiency gain occurred during field data acquisition, with an 85% reduction in time. This study confirms UAV photogrammetry as a valid, accurate, and efficient alternative for coal stockpile volume measurement in mining.

This study seeks to interpret the meaning of the lyrics in the song “Ada Titik‑Titik di Ujung Doa” by Sal Priadi through Schleiermacher’s hermeneutic approach. The song reveals a subtle spiritual dimension by means of metaphor and poetic language, portraying prayer as a personal, reflective, and hope‑laden form of inner conversation amid the uncertainty of life in the post‑pandemic era. By adopting a qualitative interpretive method, the research examines the song lyrics through Schleiermacher’s two principal dimensions: grammatical interpretation and psychological interpretation. The analysis shows that prayer in this song is not merely a conventional religious ritual, but an existential expression of human beings facing loss, isolation, and unfulfilled hopes. The phrase “titik‑titik di ujung doa” functions as a symbolic space of incomplete psycho‑spiritual longing, in which prayer is understood as an open, fragmented, and repetitive process, as well as a medium for reconciling with the past and seeking forgiveness for both oneself and others. Within Schleiermacher’s hermeneutic framework, the interpretation of these lyrics suggests that prayer in contemporary Indonesian pop music serves as a representation of human resilience, personal, reflective, and subtly critical of the notion that divine response must always be complete and perfectly resolved.

This study aims to comprehensively evaluate the potential pharmacological activities and safety profiles of seven secondary metabolite compounds (Caffeic Acid, Syringic Acid, Quercetin, Luteolin, p-Coumaric Acid, Ferulic Acid, and Epicatechin) identified in the Bajakah plant (Spatholobus littoralis Hassk.). The research approach integrates in silico analysis using the PubChem database, biological activity prediction via PASS Online, oral toxicity assessment through ProTox-II, and pharmacokinetic evaluation using pkCSM, which were subsequently validated through an empirical literature review. The results indicate that these compounds exhibit significant activity probabilities, particularly as antimutagenic, antiseptic, and antioxidant agents. Luteolin demonstrated the highest antimutagenic potential, while Quercetin showed dominant antioxidant activity. Toxicity profiling revealed that Luteolin and Caffeic Acid possess the highest safety levels (Class 5), whereas Quercetin requires special attention (Class 3). These computational findings strongly correlate with empirical evidence demonstrating that Bajakah extract exhibits broad-spectrum antibacterial activity against Staphylococcus aureus, antifungal activity against Candida albicans, as well as high antioxidant and anti-inflammatory capacities. This study provides a strong molecular foundation for the development of Bajakah as a safe and effective phytopharmaceutical candidate.

This study aims to analyze the phytochemical profile of Sambung Nyawa (Gynura procumbens) leaves as a potential herbal candidate for mild hypertension therapy using in silico methods. Plant samples were examined to identify active compounds documented in the PubChem database. The identified compounds were further analyzed using PASS Online to predict their pharmacological activities, ProTox-II to evaluate toxicity levels, and pkCSM to assess ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) characteristics. The findings reveal that several bioactive compounds present in Sambung Nyawa leaves demonstrate strong predicted anti-hypertensive activity accompanied by minimal toxicological risk. PASS Online analysis indicates potential mechanisms of action, including vascular receptor modulation and mild diuretic properties that may support blood pressure regulation. ProTox-II classification places most compounds in the low-toxicity category, while pkCSM predictions confirm acceptable bioavailability and favorable pharmacokinetic properties. Overall, these results provide a preliminary scientific foundation for the development of Gynura procumbens as an alternative herbal therapy for mild hypertension and support the need for further validation through in vitro and in vivo experimental studies.

This study aims to analyze the potential of eupatorin found in Cat’s Whiskers (Orthosiphon stamineus) as an anticancer agent using in silico methods. Eupatorin was selected due to its promising biological activity reported in previous literature. The research employed compound structure data registered in PubChem, analyzed through PASS Online for pharmacological activity prediction, ProTox-II for toxicity evaluation, and pkCSM for ADMET parameters. The results indicated that eupatorin has a high probability of inhibiting cancer cell proliferation with significant pharmacological activity values. Toxicity predictions showed a safe profile with an LD50 supporting its potential therapeutic use. ADMET analysis demonstrated that eupatorin possesses good bioavailability, adequate absorption and distribution, and minimal metabolic interactions, supporting its efficacy as an anticancer compound. These findings suggest that eupatorin could be an important candidate for herbalbased drug development, particularly for cancer therapy, and provide opportunities for further research through in vitro and in vivo experiments to validate anticancer activity comprehensively.

Brotowali stem (Tinospora crispa L.) is a plant that grows abundantly in Central Kalimantan and has been empirically used for generations as an antidiabetic remedy by the Dayak Ngaju community. Brotowali stem contains secondary metabolite compounds, including alkaloids, which possess various pharmacological activities, one of which is antidiabetic activity. This study aimed to determine the alkaloid content of Tinospora crispa stem extract in aquadest, ethyl acetate, and n-hexane fractions. The research employed an observational descriptive method by analyzing qualitative data through color reaction tests and quantitative data using UV-Vis spectrophotometry to determine alkaloid levels. The qualitative analysis results showed positive color reactions indicating the presence of alkaloid compounds. Quantitative analysis using UV-Vis spectrophotometry revealed that the total alkaloid content in the aquadest fraction was 20.19 mg or 20.19%, in the n-hexane fraction was 20.54 mg or 20.54%, and in the ethyl acetate fraction was 31.07 mg or 31.07%. The highest total alkaloid content was found in the ethyl acetate fraction. In conclusion, the extract of Tinospora crispa stem positively contains alkaloids, with the highest alkaloid content obtained in the ethyl acetate fraction at 31.07%.

Bitter melon (Momordica charantia) is a medicinal plant traditionally used to control blood glucose levels and improve digestive health. These benefits are closely associated with its bioactive metabolite content. This article aims to characterize the bioactive metabolites of bitter melon and to review their potential bioactivity in glycemic control and digestive function. The method employed includes a literature-based characterization of metabolites, identification of major classes of active compounds, and evaluation of analytical techniques commonly applied in natural product research, such as phytochemical screening, chromatography, and spectroscopic analysis. The results indicate that bitter melon contains various bioactive metabolites, including flavonoids, alkaloids, saponins, triterpenoids, and polyphenols, which contribute to blood glucose reduction by enhancing insulin sensitivity and inhibiting glucose absorption. Furthermore, these compounds support digestive health by improving digestive enzyme activity, exhibiting anti-inflammatory effects, and maintaining gut microbial balance. In conclusion, bitter melon represents a promising source of natural bioactive compounds with significant potential for application in health and pharmaceutical development.

This meta-review evaluates the effectiveness of diverse mental health programs targeting Syrian refugees in Turkey over the period 2015-2023 through a systematic synthesis of 47 studies involving a total of 12,847 participants. Meta-regression results demonstrate a statistically significant reduction in Post-Traumatic Stress Disorder symptoms, with a large effect size (d = -0.86, 95% CI [-1.02, -0.70], p < .001), as well as a significant reduction in depressive symptoms (d = -0.72, 95% CI [-0.88, -0.56], p < .001) following intervention. Among the therapeutic approaches examined, Cognitive Behavioral Therapy exhibited the strongest therapeutic effect (β = 0.45, p < .001), followed by Eye Movement Desensitization and Reprocessing (β = 0.38, p < .001). Further moderator analysis revealed that group-based interventions were more effective than individual approaches (OR = 1.86, 95% CI [1.42, 2.30]). At the same time, program duration of 12-16 weeks showed a strong correlation with optimal clinical outcomes (r = 0.67, p < .001). These findings extend the results of Acarturk et al. (2022) regarding the effectiveness of CBT and reinforce the argument advanced by Shehadeh et al. (2016) concerning the superiority of group-based approaches, while also indicating a longer optimal intervention duration than previously reported. In contrast to the meta-analysis by Antuña-Camblor & Hernández (2025), which emphasized EMDR, this study identifies CBT as superior to EMDR among Syrian refugees in Turkey. The novelty of this study lies in its comprehensive analysis of program moderator factors and the identification of the most effective intervention duration parameters for the target population.

Jamu is a traditional medicine still widely consumed by the public, but it has the potential to be contaminated with the heavy metals lead (Pb) and cadmium (Cd), which are toxic and can cause health problems, particularly to the liver and kidneys. Heavy metal contamination can originate from raw materials grown in polluted environments and from processing, storage, and packaging that do not meet quality standards, particularly for products that have not undergone official supervision. This study aims to analyze the content of lead and cadmium metals in registered and unregistered herbal medicine products. The analysis was carried out using the Atomic Absorption Spectrophotometry (AAS) method after sample preparation through wet digestion using strong acid. Six herbal medicine dosage forms were analyzed, namely powder, chopped, pills, capsules, cream, and shake parem. Method validation included tests for linearity, precision, limit of detection, and limit of quantification to ensure the reliability of the analysis results. The results showed that all registered herbal medicine samples met the safety requirements for Pb and Cd. In contrast, several unregistered herbal medicine preparations, especially powder, chopped, and cream, did not meet the safety requirements for Cd, while the Pb levels in all samples met the safety requirements for Pb. These findings indicate that unregistered herbal medicines carry a higher risk of heavy metal contamination. Therefore, strengthening quality control, selecting safe raw materials, and increasing compliance with regulations are necessary to ensure the safety of herbal medicine consumption and protect public health.

This study aims to analyze the effect of Tungsten Inert Gas (TIG) welding parameter variations on the mechanical and metallurgical properties of AISI 304 austenitic stainless steel, which is widely used in construction and industrial applications due to its excellent corrosion resistance and joint strength. The research focuses on identifying the optimal welding current to minimize welding defects and enhance joint structural integrity. Welding current was varied at three levels, namely 100 A, 125 A, and 135 A, while other parameters such as welding speed, argon shielding gas flow rate, and electrode type were kept constant. Mechanical properties were evaluated through Micro-Vickers hardness testing conducted in the weld metal, Heat Affected Zone (HAZ), and base metal, as well as tensile testing to determine ultimate tensile strength and elongation. In addition, non-destructive testing using the dye penetrant method was performed to detect surface welding discontinuities. Metallographic analysis was carried out using optical microscopy following an etching process to observe grain morphology, grain size, and the formation of microstructural phases. The results are expected to demonstrate a correlation between increased heat input due to higher welding current and changes in mechanical properties and microstructure, particularly in the HAZ. This study provides practical guidance for determining optimal TIG welding parameters for AISI 304 to achieve high tensile strength, homogeneous hardness distribution, and a stable microstructure resistant to intergranular corrosion.

The global energy crisis and climate change are driving the development of biodiesel as a renewable energy source. Graphite as an additive shows significant potential in improving the efficiency and reducing emissions of biodiesel. This study maps graphite-biodiesel research in Southeast Asia using a meta analysis of systematic reviews of 68 publications from Scopus, Web of Science, and ScienceDirect from 2015-2024. The results show that Malaysia leads in publication contributions (32%), followed by Thailand (28%) and Indonesia (18%). The optimal graphite concentration of 50 ppm increases brake thermal efficiency by 8.3% and reduces CO (15.7%), HC (12.4%), and smoke (18.9%) emissions, although there is an increase in NOx (6.8%). Palm oil methyl ester dominated the research (56%). Indonesia has strategic opportunities with abundant feedstock and graphite deposits, but faces challenges in research infrastructure, limited international collaboration, and the absence of an integrated national roadmap. Infrastructure investment, human resource strengthening, and industry academia collaboration are needed to accelerate national biodiesel research.

Hypertension and diabetes mellitus are two highly prevalent non-communicable diseases that often coexist as comorbidities, significantly increasing the risk of cardiovascular complications. The coexistence of these conditions accelerates the onset of atherosclerosis, diabetic nephropathy, and kidney failure, thereby requiring more comprehensive clinical management. One of the key parameters in diabetes management is fasting blood glucose (FBG), which reflects the balance of glucose metabolism after a fasting period. Chronic hyperglycemia is known to contribute to endothelial dysfunction, increased peripheral vascular resistance, and activation of the sympathetic nervous system and renin-angiotensin-aldosterone system, ultimately leading to elevated blood pressure. This study employed a systematic literature review approach, analyzing articles published between 2021 and 2025. Narrative synthesis was conducted across various study designs, including cross-sectional, cohort, and meta-analysis studies. The findings indicate that most studies support a significant association between FBG levels and blood pressure, although some reported varying results. Cohort studies provide stronger evidence that elevated FBG increases the risk of new-onset hypertension. Age, treatment adherence, and lifestyle factors were also identified as confounding variables influencing outcomes. Overall, the evidence highlights that glycemic control through FBG monitoring is essential in managing hypertension among diabetic patients. Multidisciplinary strategies, patient education, and strengthening of primary healthcare services are required to reduce cardiovascular risks. Longitudinal studies are recommended to deepen the understanding of the relationship between FBG and blood pressure and to reinforce the scientific basis for evidence-based clinical interventions.

The objective of this study is to comprehensively examine and analyze the influence of microstructure on the mechanical properties of metallic materials. Microstructure is known to play a crucial role in determining the mechanical behavior of metals; therefore, a thorough understanding of this relationship is essential for the development of engineering materials. This study adopts a systematic literature review approach, employing descriptive analysis and meta-analysis of recent scientific publications obtained from various reputable academic databases. The analysis results indicate that microstructure is a significant determinant of the mechanical characteristics of metallic materials, including strength, ductility, and resistance to deformation. The most influential microstructural parameters include grain size, phase distribution, crystallographic orientation, dislocation density, and the presence and characteristics of precipitates. Among these parameters, grain size has been shown to be the most dominant factor. The Hall–Petch strengthening mechanism demonstrates that grain refinement can increase the tensile strength of materials by approximately 200 to 300 percent. In addition, materials with multi-phase microstructures, such as dual-phase steels and TRIP steels, exhibit an excellent combination of strength and ductility compared to single-phase materials. Based on the meta-analysis results, each metallic material system exhibits a trade-off between strength and ductility, whereby an increase in strength is generally accompanied by a reduction in ductility. These findings indicate that achieving an optimal combination of mechanical properties for specific application requirements necessitates a comprehensive and integrated microstructural engineering approach.

The increasing prevalence of metabolic syndrome and chronic kidney disease underscores the need for simple, low-cost, and community-applicable screening indicators. This study aimed to evaluate the association between basic anthropometric parameters and blood pressure, metabolic indicators, and renal function among adults in the Badui Luar community. A cross-sectional design was employed involving 41 participants who underwent anthropometric assessment, biochemical measurements, and blood pressure evaluation. Pearson correlation analysis was used to examine linear associations between variables. The results demonstrated that neck circumference exhibited significant correlations with dyslipidemia components, including LDL (r = 0.377), TC/HDL ratio (r = 0.516), and HDL (r = –0.433), indicating cervical adiposity as a strong marker of atherogenic risk. Calf circumference showed protective correlations with fasting glucose (r = –0.352) and eGFR (r = 0.322), suggesting the metabolic relevance of peripheral muscle mass in glycemic regulation and renal status. Body mass index showed a weak correlation with systolic blood pressure (r = 0.149), whereas waist and hip circumferences exhibited mild, clinically insignificant correlations with triglycerides and total cholesterol. Overall, these findings highlight that simple anthropometric measures—particularly neck and calf circumference—may serve as early indicators of cardiometabolic and renal risk in community-based screening. Further longitudinal studies with larger and more heterogeneous populations are required to validate these associations and determine the predictive power of anthropometric indicators.

Education in the modern era requires students not only to master cognitive knowledge, but also to have the ability to think critically, analytically, creatively, and problem solving skills independently. Therefore, the application of the Problem Based Learning (PBL) model and the Learning Strategy for Improving Thinking Ability (SPPKB) is considered relevant and ideal in the context of Christian Religious Education (PAK) to integrate faith values with the reality of daily life. This study uses a literature study method by examining scientific journals, books, and academic articles to analyze the definition, essence, characteristics, and steps of PBL which include the introduction of authentic cases, problem solving, investigation planning, independent learning, solution synthesis, presentation of results, and reflection. PBL has proven to be effective in increasing learning motivation, collaboration, and internalization of Christian moral values, although it has limitations in the relatively long time requirement and the demands of teacher competence as facilitators. Meanwhile, SPPKB emphasizes intellectual stimulus, exploration of ideas, data processing, in-depth analysis, and metacognitive reflection to form a systematic and independent mindset in dealing with religious ethical issues. These two student-centered learning strategies complement each other in forming students who are dynamic, reflective, critical, and responsible as Christian personalities through flexible and contextual learning adaptations in PAK.

This study aims to examine pragmatic aspects, particularly speech acts and implicatures, in the lyrics of the song “Sedia Aku Sebelum Hujan” by Idgitaf. By applying a qualitative descriptive method through pragmatic content analysis techniques, this study examines locutionary, illocutionary, and perlocutionary speech acts based on Austin's theory, as well as conversational implicatures based on Grice's framework. The results show that the song lyrics are dominated by expressive and commissive illocutionary acts that serve to express sacrifice, vulnerability, and unconditional commitment. Locutionary acts play a role in constructing a literal narrative about protection and relationship inequality, while perlocutionary acts are aimed at evoking feelings of security and gratitude in the listener. Furthermore, the study of implicature reveals deeper implied meanings related to self-sacrifice, acceptance of inequality in relationships, and anticipatory commitment, which are often conveyed through the metaphors of “rain” and “war”. This study concludes that the power of lyrics lies not only in explicit romantic expressions, but also in the strategic use of language to perform actions and convey implicit values of devotion, reflecting the complex dynamics of human relationships, even when they are unbalanced. These findings emphasize the importance of pragmatic analysis in fully understanding the communicative and artistic impact of song lyrics.

This research is based on the awareness that music functions both as an artistic expression and as a cosmological representation embedded within the cultural structures of traditional societies. The Siwaluh Jabu traditional house in Lingga Village, North Sumatra, was selected as the object of study to examine the relationship between music and the cosmological views of the Karo people. The purpose of this study is to reveal the meaning of music within cultural practices and rituals carried out in the Siwaluh Jabu House, as well as to explore musical elements that reflect the continuity between humans, ancestors, and the universe. This research employs a qualitative approach, with data collected through literature review, participatory observation, and interviews with traditional leaders and local artists. The data analysis was conducted through data reduction, classification, data presentation, and drawing of conclusion. The results of the study show that music both the vocal mantra “ole…ah…ole” and the Gendang Lima Sendalanen ensemble contains symbolic values that interpret wood as a natural element, sustain social connections between groups, and reinforce the social system embedded in the spatial organization of the Siwaluh Jabu traditional house. Music serves as a medium of spiritual and cultural communication that unites the physical and metaphysical dimensions of life. The implications of this research enrich the perspective of music culture and emphasize the importance of preserving traditional music as a local knowledge system integrated with the cosmology of the Karo people.

Persistent elevation of blood glucose levels defines diabetes mellitus, a chronic metabolic disorder that occurs when insulin production is insufficient, diminished sensitivity of insulin receptors, or a combination of both factors. The medicinal properties of red ginger (Zingiber officinale var. rubrum) are attributed to its rich content of bioactive compounds, including gingerol and shogaol, which are considered key contributors to its various therapeutic effects. The effectiveness of red ginger extract in lowering blood glucose levels in experimental mice was evaluated in this study. A true experimental design with a quantitative approach was applied, employing a pretest–posttest control group format. The study involved twelve samples, which were randomly allocated into four separate groups. The treatment phase was conducted over a period of seven days. Findings revealed mean values of 10.4 prior to the intervention and 15.2 afterward, indicating a notable increase. A significant difference between pre-treatment and post-treatment measurements in group K1 was revealed by the statistical analysis, which yielded a P-value of 0.001 (P < 0.05). It was observed that red ginger extract, given at 100 mg per kilogram of body weight, effectively reduced blood glucose levels in the mice studied..