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Breast cancer remains a major global health challenge, with treatment effectiveness often limited by drug resistance and the toxic side effects of chemotherapy on normal cells. The exploration of bioactive compounds from natural sources through a medicinal chemistry approach offers a promising alternative strategy. This study aims to examine the molecular mechanisms of action and Structure-Activity Relationships (SAR) of various natural compound scaffolds as potential breast anticancer agents. The method employed was a systematic narrative literature review of 15 recent scientific articles evaluating computational parameters, including molecular docking, as well as in vitro and in vivo activities. The results indicate that polyphenols, flavonoids such as quercetin and EGCG, and curcumin possess strong cytotoxic activity and high binding affinity toward cancer-related target macromolecules. SAR analysis demonstrates that key structural features, including the number and position of free phenolic hydroxyl groups, the presence of gallate ester groups, and conjugated diketone systems, play a crucial role in determining ligand receptor complex stability. These interactions are supported by hydrogen bonding, hydrophobic interactions, and favorable steric compatibility within receptor binding sites. Computational findings further suggest that structural optimization can enhance ligand selectivity and improve pharmacokinetic properties. This study concludes that natural phytochemical scaffolds have significant potential as lead compounds and provide a rational basis for Computer-Aided Drug Design in developing more potent, selective, multi-target, and safer breast anticancer therapies.

This article examines the moral philosophy of Saint Augustine, focusing on the concept of free will and its implications for human sinful actions. The study aims to provide a philosophical and theological understanding of Augustine’s concept of free will and to analyze its correlation with human acts of sin. Augustine conceives of free will as a rational capacity inherent in human beings, enabling them to make conscious choices. In its essence, this freedom is oriented toward the good. However, due to the fallen condition of humanity, the will becomes disordered and is directed toward things that are lower than the highest good. Therefore, there exists an inherent correlation between free will and sinful action, wherein sin is understood as the manifestation of a misused will. Accordingly, the thought of Saint Augustine of Hippo affirms that free will is an essential gift that enables human beings to make conscious choices, including the choice to commit sin. Free will does not stand apart from moral reality; rather, it serves as the foundation for explaining that sin occurs as a result of the deviation of the human will from the highest good, namely God. Thus, it can be asserted that there is a clear, close, and inseparable correlation between Augustine’s concept of free will and human sinful action.

Human happiness does not lie in physical pleasure, victory, wealth, honour, worldly power, a beautiful body, or the senses. People in religious communities seek something deeper, contemplating and acknowledging the highest value in union with God. Thomas Aquinas, in his Summa Contra Gentiles, arguments that human happiness lies in the contemplation of God, through which one attains peace and fulfilment in total self-surrender to God. However, in the lived experience of religious communities, a fear of matters related to sexuality is evident. Indeed, some misunderstand and misinterpret these matters, resulting in monks and nuns who become cold, dry, and rigid, acting in ways that violate sexual morality, thereby disrupting or even destroying—their ministry due to such improper conduct. Based on this, the author recognises the importance of education and the appreciation of sexual values for religious communities. Using a literature review method involving relevant books, journals, articles, and Church documents with a theological approach, it was found that the education of religious people requires aspects of happiness and sexuality education. The results of the study indicate that Thomas Aquinas’s concept of happiness can bridge religious life with sexuality education, which is one aspect that must be understood and lived out. Therefore, the happiness of love and the sexuality education of religious people need to be explored and lived out in the course of living and experiencing life as a religious person.

Sleep duration and sleep quality are essential physiological needs that play a significant role in the emotional and behavioral development of children aged 3–6 years. Adequate sleep supports brain development, cognitive functioning, emotional regulation, and social interaction skills in early childhood. Conversely, poor sleep duration and low sleep quality may negatively affect children’s attention, mood stability, and ability to interact socially with peers and caregivers. This article is a literature review using a systematic review approach that analyzes 10 scientific articles published between 2016–2026 to evaluate the relationship between sleep duration and sleep quality with emotional and behavioral problems in preschool children. The article selection process followed the PRISMA flow diagram, with articles sourced from Google Scholar, PubMed, and ScienceDirect databases. The findings consistently indicate that inadequate sleep duration and poor sleep quality are associated with increased emotional and behavioral problems, including hyperactivity, anxiety, emotional dysregulation, and difficulties in social interaction among children. Furthermore, sleep disturbances were found to negatively influence children’s emotional self-regulation abilities, which are crucial for adaptive behavior. Therefore, ensuring adequate sleep duration and improving sleep quality are important strategies to support optimal emotional and behavioral development in preschool-aged children.

Microplastics are extremely small plastic particles that have become a major concern in public health and environmental studies. This literature review aims to discuss the sources of microplastics, their routes of exposure to the human body, their distribution in organs, and their potential health impacts. The method used was a literature review of scientific articles and reports published from 2021 onward, retrieved from Google Scholar, PubMed, ScienceDirect, and official websites of organizations such as the WHO, OECD, and the World Bank. The review findings show that microplastics originate from plastic waste, synthetic clothing, cosmetics, vehicle tires, and food packaging. These particles have been detected in blood, lungs, the placenta, feces, and various human tissues, indicating that human exposure is widespread. However, evidence from human studies is still limited, so cause-and-effect relationships cannot yet be confirmed with certainty. Based on these findings, further research is needed to better understand the long-term health effects of microplastics. In addition, efforts to reduce single-use plastics, improve waste management systems, and increase public education are essential to reduce exposure and prevent future health risks.

This study explores the acceptance of the Free Nutritious Meal Program (MBG) at SD Inpres Gere through William of Ockham's negative rights framework, focusing on freedom from external interference. As a positive rights policy (the right to services), the MBG has the potential to conflict with the principles of individual subjective rights (negative rights). Ockham emphasized that every individual has a personal sovereignty that must be free from interference from external authorities. Using qualitative research methods through literature studies and interviews, this article analyzes the risk of standardizing consumption that can reduce individual autonomy in determining their private needs. The analysis shows that although the MBG has a noble aim to fulfill the right to life, its implementation risks becoming a form of state paternalism that harms citizens' negative freedoms if not accompanied by strict limits on power. This paper concludes that to align with Ockham's principle of individual subjective rights, the MBG program must continue to respect the private space and diversity of individual choices without creating dependency that erodes the sovereignty of legal subjects.

This article discusses the relevance of the concept of the bonum commune (the common good) in the thought of Thomas Aquinas as a moral foundation in the era of digital disruption. The era of digital disruption is characterised by profound changes in the way humans live, interact, and utilise technology. Amidst these developments, a weak moral foundation has led to a lack of technological orientation towards the common good. Without a fundamental moral foundation, technology will be directed solely towards profitability, disregarding human values and fostering an individualistic society. This study employs a qualitative method based on a literature review, analysed through a hermeneutic reading of Aquinas’s principal work, the *Summa Theologica*, as well as literature on digital ethics. The results of the study indicate that the bonum commune is a fundamental ethical principle that can guide the use of digital technology towards justice, social responsibility, and the common good.

The ability to describe graphs accurately in English is an essential academic skill for EFL learners, particularly in higher education contexts where students are required to interpret and communicate visual data. However, many learners still experience difficulties in producing grammatically accurate graph descriptions. This study aims to investigate the level of grammatical accuracy demonstrated by EFL learners in graph description tasks and identify the grammatical aspects that require further improvement. Employing a descriptive qualitative approach, the research analyzed 30 samples of students’ written graph descriptions produced by undergraduate learners. The analysis focused on several grammatical aspects, including subject–verb agreement, tense consistency, article usage, sentence structure, prepositions, and punctuation. The findings reveal that students frequently struggle with subject–verb agreement and article usage, while punctuation errors occurred less frequently. The study highlights that grammatical accuracy remains an important challenge for EFL learners in academic writing tasks involving data interpretation. Therefore, it is recommended that grammar instruction be integrated more intensively into graph description activities in English classes. The findings are expected to contribute to the development of more effective teaching strategies in academic writing instruction for EFL learners.

Drowning is one of the leading causes of accidental death worldwide and remains a major challenge in forensic investigations due to the complexity of determining the exact cause and mechanism of death. This study aimed to analyze forensic investigation methods used to determine the cause of death in drowning cases. The research employed a qualitative descriptive literature review approach by analyzing scientific articles, forensic journals, and medical references related to drowning investigations. Data were collected through literature searches from Google Scholar, PubMed, and Portal Garuda using keywords related to forensic drowning investigations. The findings indicate that forensic investigation in drowning cases requires a comprehensive approach involving external examination, autopsy, laboratory examination, histopathology, diatom analysis, toxicology, and crime scene investigation. Typical forensic findings include foam cone, washerwoman’s hands, cutis anserina, emphysema aquosum, and the presence of foreign materials in the respiratory and digestive tracts. Diatom examination and histopathological analysis also play important roles in strengthening the diagnosis of drowning. The study concludes that an integrated forensic investigation based on scientific evidence is essential to accurately determine the cause and manner of death in drowning cases and to support medicolegal processes in Indonesia.

Low Birth Weight (LBW) refers to infants born with a birth weight of less than 2,500 grams and remains an important issue in neonatal health due to its association with increased neonatal morbidity and mortality. To analyze the determinants of LBW based on primary studies published from 2021 to 2026. A literature review was conducted using the PRISMA approach. Article searches were performed through PubMed, Google Scholar, Scopus, ScienceDirect, and ProQuest using the keywords low birth weight, determinant factors, risk factors, BBLR, and faktor risiko with Boolean operators AND/OR. The inclusion criteria were primary studies, full-text availability, publication in Indonesian or English, and publication years from 2021 to 2026. A total of 20 articles were included, consisting of 15 international articles and 5 national sources. The review showed that LBW is influenced by interrelated maternal, nutritional, obstetric, and sociodemographic factors during pregnancy. The most dominant factors included multiple pregnancy with an adjusted OR of 21.74, maternal food insecurity with an AOR of 6.85, maternal hemoglobin level <11 g/dL with an AOR of 5.21, lack of iron-folic acid supplementation with an AOR of 4.17, maternal age ≤20 years with an AOR of 3.42, pregnancy interval <1 year with an adjusted OR of 2.92, missed antenatal care visits with an AOR of 2.74, smoking during pregnancy with an OR of 2.18, and maternal hypertension with an AOR of 1.94. LBW is influenced by multiple interrelated factors; therefore, efforts to reduce its incidence should focus on evidence-based interventions, particularly through optimizing antenatal care services, improving maternal nutritional status, and early detection of pregnancy.

This study aims to examine the components of the Christian Religious Education (CRE) curriculum in the family, its design and development, and its concrete implementation. The research employs a qualitative approach with a descriptive design through library research, using data sources such as books, academic journals, and relevant articles. The data were analyzed using descriptive qualitative techniques to produce a systematic and in-depth description. The findings show that the CRE curriculum in the family consists of interconnected components, namely objectives, content, strategies, methods, and evaluation, which must be implemented in an integrated manner. Faith education in the family is carried out through methods such as role modeling, habituation, teaching, discussion, mentoring, and practical application. Effective strategies include parental role modeling, dialogical communication, and love-based discipline. The implementation of the curriculum is realized through concrete activities such as family prayer, family worship, Bible reading, and the application of Christian values in daily life. In conclusion, the success of Christian Religious Education in the family largely depends on the active role and consistency of parents in implementing the curriculum in a holistic and continuous manner. With the right approach, the family can become an effective center of faith education in shaping children who are faithful, character-driven, and prepared to face life’s challenges.

This study aims to examine the methods, models, strategies, as well as the design and development of the Christian Religious Education curriculum within the family. The research employs a qualitative approach with a descriptive type through library research, using data sources such as books, scientific journals, and relevant articles. The results of this study indicate that faith education in the family should be carried out holistically through various methods such as modeling, habituation, teaching, and mentoring. In addition, educational models such as the theocentric, relational, and participatory models provide clear direction in nurturing children’s faith. Effective strategies include modeling, dialogical communication, spiritual habituation, mentoring, and discipline based on love. Meanwhile, a simple family-based curriculum that includes objectives, materials, methods, media, and evaluation is essential to support a well-directed educational process. The success of Christian Religious Education in the family largely depends on the active role and consistency of parents in implementing methods, models, strategies, and curriculum in an integrated manner. With the right approach, the family can become an effective center of faith education in shaping children who are faithful, have strong character, and are prepared to face life’s challenges.

Amid the accelerating rhythm of digital culture, academic competition, and the changing patterns of student life in higher education, the formation of Muslim student character has become an increasingly urgent concern. A campus mosque can no longer be viewed merely as a place of worship; it must also be understood as a strategic nonformal Islamic educational space that nurtures spirituality, morality, social awareness, and student identity in a more contextual way. This study aims to analyze the role of the campus mosque as a space for shaping Muslim student character through the Islamic mentoring program at Masjid Syamsul Ulum, Telkom University. This research employs a descriptive qualitative approach based on document study and thematic analysis of scholarly articles, mentoring program documents, and relevant works on campus mosques, religious moderation, and student character education. The findings show that the mentoring program at Masjid Syamsul Ulum is systematically designed through a clear structure, curriculum, methods, evaluation tools, and mentor regeneration, all of which are integrated with the institutional values of Harmony, Excellence, and Integrity. Socioculturally, the program functions not only as a medium for religious instruction but also as a process of value internalization, habituation of religious practice, strengthening of moderation, and construction of Muslim student identity within a technology-oriented university environment. This study proposes a conceptual understanding that the campus mosque can serve as a strategic space for shaping Muslim students who are religious, moderate, collaborative, and adaptive in the digital era.

Early marriage is a social phenomenon that remains prevalent in Indonesia and gives rise to various problems in family life. This article aims to analyze the implications of early marriage in light of the Code of Canon Law (CCL) Nos. 1055 and 1056 in the context of Catholic couples. This study employs a qualitative method with a descriptive-analytical approach through a literature review of books, scientific journals, and Church documents. The findings indicate that the CIC affirms marriage as a sacred covenant between a man and a woman oriented toward the bonum coniugum (the good of the couple), openness to children, and characterized by unity and indissolubility. In the context of early marriage, various implications were identified, such as emotional immaturity that triggers domestic conflicts, a high risk of divorce, low levels of education, and impacts on the health of mothers and children. Additionally, early marriage also indicates a weak understanding of the sacramental dimension and family responsibilities, including childrearing. Thus, CIC Nos. 1055 and 1056 provide an important normative foundation that marriage requires human, spiritual, and social maturity for the realization of a wholesome and prosperous Catholic family.

The development of digital technology in the Society 5.0 era presents both challenges and opportunities in history teaching, particularly regarding teachers’ ability to integrate technology and adapt to changes in students’ learning styles. This study aims to analyse the challenges faced by teachers and the strategies employed in digital-based history teaching. The method used is a Systematic Literature Review (SLR) employing the PRISMA approach, involving the stages of identification, screening, eligibility assessment, and inclusion of scientific articles published between 2020 and 2025. From the selection process, 25 relevant articles were identified for qualitative descriptive analysis. The findings indicate that teachers’ digital literacy levels remain at a moderate level and are unevenly distributed, thereby affecting the sub-optimal integration of technology into teaching. Furthermore, changes in students’ learning styles which are increasingly technology-oriented require more interactive and contextual pedagogical innovations. On the other hand, the use of digital media has proven capable of enhancing student motivation and learning outcomes, although this is still hindered by limitations in infrastructure and teachers’ technical competencies. The abundance of historical information on the internet also poses challenges regarding the validity of sources, thus necessitating the strengthening of digital literacy and critical thinking. The implications of this research underscore the importance of the ongoing development of teachers’ digital skills, the improvement of educational facilities, and the implementation of innovative teaching models to ensure that history teaching becomes more relevant and effective, and is capable of fostering critical thinking skills in pupils in the digital age.

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction, communication difficulties, and restricted and repetitive behaviors. In addition to these core symptoms, children with ASD often experience gastrointestinal disturbances that are thought to be related to the gut–brain axis. One non-pharmacological intervention that has been widely studied to reduce ASD symptoms is the gluten-free casein-free (GFCF) diet. However, evidence regarding its effectiveness in improving behavioral symptoms remains inconsistent. This study aims to review previous research on the impact of gluten and casein consumption on behavioral symptoms in children with ASD using a narrative literature review approach. Literature searches were conducted in PubMed, ScienceDirect, and Google Scholar for articles published between 2014 and 2024 using the keywords Autism Spectrum Disorder (ASD), behavior, GFCF diet, gluten, and casein. The review results indicate that most studies report potential benefits of the GFCF diet in improving certain behavioral symptoms in children with ASD, particularly hyperactivity, behavioral problems, stereotypical behavior, attention, and cognitive function. Some studies also show improvements in autism evaluation scores after dietary implementation over a specific period. However, findings remain inconsistent due to differences in study design, sample size, intervention duration, dietary adherence, and the heterogeneity of ASD characteristics among children. In conclusion, the GFCF diet has potential as a complementary intervention to improve certain behavioral symptoms in children with ASD, but further high-quality studies with larger samples are needed to confirm its effectiveness more consistently.

Cervical cancer is one of the most common cancers worldwide and is largely caused by Human Papillomavirus (HPV) infection, particularly types 16 and 18. The development of this cancer is influenced by the E6 and E7 oncoproteins, which disrupt the function of p53 and Rb proteins, as well as the involvement of cellular signaling pathways such as PI3K/AKT/mTOR and EGFR. Limitations of conventional therapies, such as resistance and side effects, drive the need for more targeted and selective therapeutic agents. This study aims to analyze the main molecular targets of cervical cancer and the medicinal chemistry approaches used in its therapeutic development. The method involved a review of 12 open access articles using molecular docking, molecular dynamics, QSAR, and network pharmacology approaches. The findings identified two main target groups: viral targets comprising the HPV E6 and E7 oncoproteins, and cellular targets including the PI3K/AKT/mTOR pathway, EGFR, PARP1, CDK1, and VEGFR. Various medicinal chemistry strategies, from structure-based and ligand-based drug design to multi-target network pharmacology approaches, proved effective in identifying potential inhibitor candidates. Bioactive compounds such as quercetin, gossypol, bixin, and rutin demonstrated stable interactions with these targets. However, further experimental validation is needed to support the development of clinically effective and safe therapies.

The contemporary ecological crisis demonstrates an imbalance in the relationship between humans and nature that is not only ecological, but also theological and moral. This article aims to analyze the ecological crisis from the perspective of Augustine of Hippo through the concepts of free will (liberum arbitrium) and the order of love (ordo amoris), as well as their relevance to the relationship between humans and nature. This study employs a qualitative approach using the library research method. The primary data sources are secondary literature, namely books and academic studies discussing Augustine’s philosophical and theological thought, supported by journal articles, Church documents, and contemporary ecotheological studies. The data were analyzed using descriptive-analytical and hermeneutic methods. The results of the study indicate that the ecological crisis originates from the disorientation of human will influenced by excessive self-love, which gives rise to an anthropocentric and exploitative attitude toward nature. From Augustine’s perspective, the restoration of the relationship between humans and nature requires an order of love directed toward God as the highest good. Therefore, the ecological crisis is understood as a spiritual crisis that demands an inner transformation of humanity in establishing an ethical relationship with all creation.

This article examines the relationship between Artificial Intelligence (AI), the concept of sensus communis proposed by Nicholas of Cusa (1401–1464), and the formation of religious communities. Through a theoretical-philosophical analysis, the author argues that sensus communis as the integrative capacity of the human intellect that unifies sensory, rational, and intuitive dimensions offers a normative epistemological framework for critically addressing the reductionism inherent in algorithmic AI. The main finding indicates that AI constitutes only a partial simulacrum of the integrative capacity of human reason and, therefore, cannot replace the ontological-transcendental dimension of authentic formation. Accordingly, this article proposes a model of critical-integrative formation grounded in three pillars: the selective use of AI, the preservation of AI-free spaces, and hermeneutical integration. The relevance of Cusa’s thought for contemporary religious formation is articulated in three contributions: docta ignorantia as a formative habitus, coincidentia oppositorum as a paradigm of dialogue, and ontological participation as the foundation of knowledge.

This article examines Romans 14:7-9 as a foundational biblical text for the concept of life ownership in New Testament ethics. Using a historical-exegetical and theological-systematic approach, it demonstrates that the passage clearly declares that neither life nor death belongs to the individual believer. Both are to be lived and died “to the Lord,” affirming that Christians are ultimately the possession of Christ as Kyrios. This theocentric view directly challenges the modern secular principle of radical patient autonomy that underpins euthanasia and physician-assisted suicide. The study provides a detailed exegesis of Romans 14:7-9 in its literary and historical context, explores parallel New Testament texts on life ownership, and discusses its ethical implications for contemporary medical practice. It argues that Romans 14:7-9 offers strong biblical grounds for rejecting active euthanasia while supporting compassionate palliative care that honors human dignity until natural death. In the Indonesian context, where euthanasia is legally prohibited, this perspective provides a robust theological foundation for Christian bioethics and public policy. A truly good death, according to the New Testament, is one that occurs in submission to the sovereignty of the risen Lord.